Mustafa Usanmaz - Academia.edu (original) (raw)

Papers by Mustafa Usanmaz

Medical Science and Discovery, Jan 21, 2023

Objective: This study aims to examine the relationship between serum vitamin D levels and hematol... more Objective: This study aims to examine the relationship between serum vitamin D levels and hematological parameters, and body mass index. Material and Methods: It was carried out in the internal medicine outpatient clinic of Ayancık State Hospital between April 2017 and November 2020. Information about the sociodemographic and laboratory values of the patients was obtained from the hospital information system. The patients were divided into two groups as those with vitamin D levels below 20 ng/ml and those with over 30 ng/ml. Vitamin D levels and hematological parameters of all patients were examined. Results: Of the 343 patients included in the study, 277 were women. When vitamin D levels were evaluated, vitamin D levels were significantly lower in women (82.7%; n:244) according to gender (p=0.023). When vitamin D levels are assessed according to age, It was observed that the vitamin D level of the patients included in the study, especially in the advanced age group, was low. There was no significant difference between vitamin D levels and body mass index (p=0.138). Age, MCV, MPV, HDL, Calcium (Ca), Phosphorus, Vitamin B-12, Vitamin D levels were found to be significantly higher in female patients with adequate vitamin D levels (p<0.05). Conclusion: In our study, it was observed that there was a significant relationship between vitamin D levels, age, gender, platelet level, monocyte, MCV, neutrophil, protein, HDL, calcium, and vitamin B12 levels. Beside the treatment and clinical examinations, it is necessary to monitor and evaluate the vitamin D levels of the patients, as well as hematological, biochemical and endocrinological parameter changes.

Türk hijiyen ve deneysel biyoloji dergisi, 2022

Hemodiyaliz hastalarında kan kültürü sonuçlarının değerlendirilmesi Evaluation of blood culture r... more Hemodiyaliz hastalarında kan kültürü sonuçlarının değerlendirilmesi Evaluation of blood culture results in hemodialysis patients Selim GÖRGÜN 1 (ID), Mustafa USANMAZ 2 (ID) ÖZET Amaç: Hemodiyaliz kronik böbrek yetmezliği (KBY) gelişen hastalarda hayat kurtarıcı invaziv bir işlemdir. Ancak, bu işlemde kateter uygulamasına bağlı olarak sıklıkla hasta ölümlerine neden olan enfeksiyonlar gelişebilmektedir. Bu enfeksiyonlar hastaların kan ve/ veya kateter kültürlerinin izlenmesi ile tespit edilir. Bu çalışmada, epidemiyolojik verilere katkı sunmak amacıyla hemodiyaliz uygulanan KBY hastalarının kan kültürü sonuçlarının bir analizi yapılmıştır. Yöntem: Bu çalışmada 2017-2020 yılları arasında SBÜ Samsun Eğitim ve Araştırma Hastanesi Hemodiyaliz Ünitesi'nde kateter enfeksiyonu olduğu düşünülen hastaların kültür sonuçları retrospektif olarak değerlendirildi. Laboratuvara gönderilen kan kültürleri bir hafta süre boyunca hemokültür cihazında (Render, China) inkübe edildi ve üreme varlığı takip edildi. Cihazda üreme görülen örneklere otomatik bakteri identifikasyon cihazı VITEK® 2 (BioMérieux, France) ile tanımlama ve antibiyogram işlemi yapıldı. Bulgular: Kateter ilişkili bakteriyemi ve kateter enfeksiyonu düşünülerek kan kültürü istenen 56 hastanın 34 (%60,7)'ü erkek ve 22 (%39,3)'si kadındır. Hastaların

European Review for Medical and Pharmacological Sciences, Nov 1, 2022

Flora the Journal of Infectious Diseases and Clinical Microbiology

Istanbul University - DergiPark, Jul 26, 2022

Objective: Carbapenem resistance in bacterial species belonging to the Enterobacteriaceae family ... more Objective: Carbapenem resistance in bacterial species belonging to the Enterobacteriaceae family has become an increasingly important health problem worldwide. We aimed to investigate the effect of broad-spectrum antibiotic use on the development of carbapenem resistance. Methods: A total of 82673 patients whose culture samples were sent to the microbiology laboratory from various polyclinics of our hospital between January 2019 and August 2021. Those with Gramnegative enteric bacterial growth in their cultures and those with carbapenem-resistant Gramnegative enteric bacterial growth in their cultures were recorded. Results: The patients included in the study consisted of 71 (56.8%) females and 54 (43.2%) males. Of 125 patients, 91 (73.1%) had a history of antibiotic use in the last 12 months. Carbapenemresistant Gram-negative enteric bacterial growth was detected in the culture of 125 (33.2%) of 376 patients. Among the patients with a history of broad-spectrum antibiotic use, the ratio of those with carbapenem-resistant Gram-negative bacterial growth in their cultures was significantly higher than those without a history of antibiotic use (0.19% vs. 0.05%; p<0.001). It was determined that the risk of developing carbapenem resistance increased by 3.49 times in those with a history of antibiotic use (Odds ratio =3.49; 95% CI: 1.92-6.33). Conclusion: The results obtained in our study indicate that broad-spectrum antibacterial use may be associated with the development of carbapenem resistance in Gram-negative enteric bacteria. Detailed studies will provide important information for a clearer determination of this possible relationship.

Journal of biotechnology and strategic health research, Apr 3, 2022

Aim In this study, to evaluate the clinical course and prognosis in COVID-19 patients, to evaluat... more Aim In this study, to evaluate the clinical course and prognosis in COVID-19 patients, to evaluate the hematological and biochemical parameters at the time of admission to the hospital. Material and Method is retrospective study was performed in a multicenter study in April and October 2020. Demographic characteristics, clinical features, age, gender and length of stay of patients who exitus (EX) and were discharged due to COVID-19 were examined. Results Of the patients (n:180) included in the study, 89 were female and 91 were male. ere was a signi cant di erence between the patients who were discharged from the hospital and died gender and complaints at the time of admission (p<0.05). ere was no signi cant di erence between age distribution and comorbid factors (p>0.05). While the length of stay, platelet (PLT), mean corpuscular volume (MCV), serum C-reactive protein (CRP), albumin, lymphocyte, monocyte, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase (LDH), ferritin, international normalized ratio (INR), Plateletcrit (PCT), troponin, and white blood cell counts are all increased in EX. ere is a statistically signi cant di erence in red blood cell distribution width (RDW) between EX and discharge patients (p<0.05), as well as in monocyte/albumin ratios, procalcitonin/albumin ratios, CRP/albumin ratios, LDH/albumin ratios, and ürea/albumin ratios. ere is not signi cant for lymphocyte/monocyte ratio (p>0.05). While the RDW, monocyte/albumin, PCT/albumin, CRP/albumin, LDH/albumin, and ürea/albumin ratios are increased in EX patients, the PCT/PLT and MPV/PLT ratios are increased in discharged patients. Conclusion In th s study, we demonstrated that hematolog cal and b ochem cal markers may be ut l zed as an early prognost c nd cator for pat ents dent f ed w th COVID-19.

Medical Science and Discovery, May 17, 2022

Objective: This study was conducted to determine the levels of hopelessness and fear of COVID-19 ... more Objective: This study was conducted to determine the levels of hopelessness and fear of COVID-19 in individuals during the COVID-19 pandemic period. Material and Methods: In this cross-sectional study was concluded Sinop Province, Turkey, from July 2020 to September 2020. The study sample consisted of 1200 individuals living in Sinop who agreed to participate in the study. An interview form was filled by the researcher for the individuals who decided to participate in the study. Results: Of the 1200 participants, 537 (44.75%) were male, and 663 (55.25%) were female, with a mean age of 38.96. Participants had mild hopelessness (8.42%) and moderate COVID-19 fear (20.74%). There was a direct correlation between the COVID-19 Fear Scale and the Beck Hopelessness Scale. A statistically significant correlation was found between age, education, and fear of COVID-19 (respectively, p=0.001; p=0.010). A statistically significant correlation was found between the number of days the participants went out per week and income and fear of COVID-19 (respectively, p=0.001; p=0.001). There was also a significant difference between work and hopelessness (p=0.033). While there is a weak negative relationship between the fear of COVID-19 and the number of days individuals go out per week; A weak positive correlation was found with age (r=-0.109; r=0.098, respectively). Conclusion: Due to the rapid spread of the pandemic, it was considered that policymakers and officials should develop effective behavioral strategies to reduce the mental consequences of the pandemic in society.

Medical Science and Discovery

Objective: The COVID-19 disease, which first appeared in Wuhan, China, at the end of 2019, soon a... more Objective: The COVID-19 disease, which first appeared in Wuhan, China, at the end of 2019, soon affected the whole world. This study aims to examine the relationship between the demographic characteristics and clinical symptoms of COVID-19 patients and mortality rates during the COVID-19 pandemic period. Material and Methods: This retrospective observational study was done on the files of 671 dead or living patients with laboratory-confirmed COVID-19 pneumonia hospitalized in Sinop State Hospital in Turkey from February to September of 2020. The demographic features such as sex, age, and comorbidities such as diabetes, hypertension, etc., and clinical symptoms of the disease such as fever, cough, shortness of breath, respiratory distress, weakness, head rotation, etc., were recorded. Results: The total mean age of the patients was 56.08 years. The most common symptoms were cough, fever, respiratory distress, shortness of breath, and the most common comorbidities were hypertension, d...

Medical Science and Discovery

Objective: As the coronavirus disease 2019 (COVID-19) pandemic continues, clinical and laboratory... more Objective: As the coronavirus disease 2019 (COVID-19) pandemic continues, clinical and laboratory predictors of progression to serious and lethal types of the illness are urgently needed. We aimed to investigate how well hematologic, biochemical, and immunologic biomarkers could distinguish between patients with and without severe or fatal COVID-19. Material and Methods: This retrospective study was performed in the internal medicine departments of two institutions. Data were collected from the hospital database, and the medical files of 280 adult COVID-19 were reviewed. The relationship between hematologic and biochemical parameters which include C-reactive protein (CRP)/albumin, urea/albumin, and lactate dehydrogenase (LDH)/albumin ratios and length of hospitalization, disease severity, and survival were investigated. Results: Our series consisted of 280 adult COVID-19 patients (147 women, 133 men) with an average age of 58.34 ± 18.64 (range: 19 to 93). Most patients (n=171, 61.1...

Aim: Acinetobacter baumannii is a nosocomial infectious agent that may be resistant to several an... more Aim: Acinetobacter baumannii is a nosocomial infectious agent that may be resistant to several antimicrobial drugs, including colistin. Colistin is a crucial antimicrobial agent in resistant A. baumannii infections. Colistin resistance varies between countries and regions worldwide. This study aimed to evaluate the studies on colistin resistance of A. baumannii strains in different regions of Turkey, show the increasing colistin resistance in years, and discuss the solution suggestions. Methods: The online electronic database was searched for studies evaluating the antibacterial efficacy of colistin combined with other antibiotics or alone in clinical samples of patients with A. baumannii infection. Results: In our study, colistin susceptibility was found to be between 81.8%-100% in Turkey. The lowest susceptibility to colistin for A. baumannii strains was reported in the Aegean Region (81.8-100%), followed by Black Sea (82.4-100%), Southeast Anatolia (94-96%), Central Anatolia (95....

Revista da Associação Médica Brasileira, 2021

OBJECTIVE: This study investigates whether C-reactive protein, platelet-lymphocyte ratio, and neu... more OBJECTIVE: This study investigates whether C-reactive protein, platelet-lymphocyte ratio, and neutrophil-lymphocyte ratio could be useful to predict mortality in COVID-19. METHODS: Data of 635 patients with COVID-19 followed up in Sinop Ataturk State Hospital from February to May 2020 were evaluated retrospectively. Diagnosis of COVID-19 was made according to the interim guidance of the World Health Organization. Patients were grouped into two groups based on mortality as survived and non-survived patients. Age, gender, neutrophil-lymphocyte ratio, plateletlymphocyte ratio, and C-reactive protein of the groups were investigated and compared. RESULTS: The mean age of the participants was 55.8±22.3 years. Among the patients, 584 survived and 51 patients died. Age was significantly different between the groups, 54.2±22.3 in the survived group and 75.6±11.1 in the dead group (p=0.000). In addition, neutrophil, C-reactive protein, and neutrophil-lymphocyte ratio values were significantly higher in the dead group (p=0.000). plateletlymphocyte ratio was slightly higher in the dead group, but this difference was not significant (p=0.42). The area under the curve values for age, lymphocyte, platelet, C-reactive protein, and neutrophil-lymphocyte ratio are 0.797, 0.424, 0.485, 0.778, and 0.729, respectively. CONCLUSIONS: Our results showed that neutrophil-lymphocyte ratio and C-reactive protein are significantly higher in patients leading to death and could be effective biomarkers in predicting COVID-19 fatality. Furthermore, C-reactive protein could be used as an independent biomarker to predict death in patients with COVID-19, regardless of gender and age (p=0.000).

Medicine Science | International Medical Journal, 2020

To investigate anxiety, depression, and Obsessive-Compulsive Disorders (OCDs) among the healthcar... more To investigate anxiety, depression, and Obsessive-Compulsive Disorders (OCDs) among the healthcare workers (HCWs) to compare the healthcare workers in COVID positive services with the control group. This cross-sectional study was conducted on 198 subjects participating in the study. To test the difference between the two groups involved in COVID-19 hospitalization section and normal section in Anxiety, Depression, and Obsessive-Compulsive Disorders Scale, two sample independent t-tests, however, Welch-Satterthwaite P Values were considered for test significance. The categorical variables (sex, branch type, etc.) were also tested using the Chi-Square test to make sure that the two samples were not influenced by the demographics of the population. 198 subjectspartici pated in the study, among whom 72% were female and 28.3% were male. 130 participants (66%) worked in COVID and 68 participants (35%) worked in other sections.The mean age of the two samples was close to 35 and most of them (~45%) were nurses. 57% of the pooled samples had Emergency Response Experience (ERE).There was no significant difference between the two groups regarding sex, education, marital status, and ERE, however, the branch type showed major differences between the two groups(P-value < 0.08). The age difference between the two groups was also insignificant. Working in the COVID-19 section significantly increased anxiety scores from 9.62 to 13.15 with a P-value of <0.03. Obsessive-Compulsive Disorders Scale also significantly increased from 19.72 to 26.6. Working in the COVID-19 section roughly doubled the depression score from 7.49 to 14.71 with a p-value of <0.0001. It is concluded that the health care workers in the COVID-19 section had significantly increased obsessive-compulsive disorders, depression, and anxiety as compared to the control group. Both groups showed no significant difference in terms of age, sex, education, marital status, and ERE. The psychological impact of the COVID-19 pandemic among the frontline HCWs should be understood well. The important public health measure is to protectthem to overcome this global pandemic.

The Eurasian journal of medicine, 2011

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic fever. Disseminated intr... more Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic fever. Disseminated intravascular coagulation (DIC) is an important complication of this disease, especially in severe and fatal cases. Antithrombin (AT) acts as an anticoagulant by inactivating thrombin, Factor IX, Factor X and Factor XI. We conducted this study to investigate the AT levels and their prognostic value in CCHF. Twenty-eight confirmed CCHF patients were included in this study. Diagnosis of the disease was made by CCHF IgM and/or PCR positivity. Patients were grouped based on the severity criteria described previously. The patients with platelet counts <20 000×10(6) cell/L, white blood counts >10×10(9) cell/L, prothrombin times >60 seconds, aspartate aminotransferase levels >700 IU/L or alanine aminotransferase levels >900 IU/L were accepted as severe cases. Patients whose illnesses were self-limited and who did not require blood component replacement were accepted as mild cases, an...

Medical Science and Discovery, Jan 21, 2023

Objective: This study aims to examine the relationship between serum vitamin D levels and hematol... more Objective: This study aims to examine the relationship between serum vitamin D levels and hematological parameters, and body mass index. Material and Methods: It was carried out in the internal medicine outpatient clinic of Ayancık State Hospital between April 2017 and November 2020. Information about the sociodemographic and laboratory values of the patients was obtained from the hospital information system. The patients were divided into two groups as those with vitamin D levels below 20 ng/ml and those with over 30 ng/ml. Vitamin D levels and hematological parameters of all patients were examined. Results: Of the 343 patients included in the study, 277 were women. When vitamin D levels were evaluated, vitamin D levels were significantly lower in women (82.7%; n:244) according to gender (p=0.023). When vitamin D levels are assessed according to age, It was observed that the vitamin D level of the patients included in the study, especially in the advanced age group, was low. There was no significant difference between vitamin D levels and body mass index (p=0.138). Age, MCV, MPV, HDL, Calcium (Ca), Phosphorus, Vitamin B-12, Vitamin D levels were found to be significantly higher in female patients with adequate vitamin D levels (p<0.05). Conclusion: In our study, it was observed that there was a significant relationship between vitamin D levels, age, gender, platelet level, monocyte, MCV, neutrophil, protein, HDL, calcium, and vitamin B12 levels. Beside the treatment and clinical examinations, it is necessary to monitor and evaluate the vitamin D levels of the patients, as well as hematological, biochemical and endocrinological parameter changes.

Türk hijiyen ve deneysel biyoloji dergisi, 2022

Hemodiyaliz hastalarında kan kültürü sonuçlarının değerlendirilmesi Evaluation of blood culture r... more Hemodiyaliz hastalarında kan kültürü sonuçlarının değerlendirilmesi Evaluation of blood culture results in hemodialysis patients Selim GÖRGÜN 1 (ID), Mustafa USANMAZ 2 (ID) ÖZET Amaç: Hemodiyaliz kronik böbrek yetmezliği (KBY) gelişen hastalarda hayat kurtarıcı invaziv bir işlemdir. Ancak, bu işlemde kateter uygulamasına bağlı olarak sıklıkla hasta ölümlerine neden olan enfeksiyonlar gelişebilmektedir. Bu enfeksiyonlar hastaların kan ve/ veya kateter kültürlerinin izlenmesi ile tespit edilir. Bu çalışmada, epidemiyolojik verilere katkı sunmak amacıyla hemodiyaliz uygulanan KBY hastalarının kan kültürü sonuçlarının bir analizi yapılmıştır. Yöntem: Bu çalışmada 2017-2020 yılları arasında SBÜ Samsun Eğitim ve Araştırma Hastanesi Hemodiyaliz Ünitesi'nde kateter enfeksiyonu olduğu düşünülen hastaların kültür sonuçları retrospektif olarak değerlendirildi. Laboratuvara gönderilen kan kültürleri bir hafta süre boyunca hemokültür cihazında (Render, China) inkübe edildi ve üreme varlığı takip edildi. Cihazda üreme görülen örneklere otomatik bakteri identifikasyon cihazı VITEK® 2 (BioMérieux, France) ile tanımlama ve antibiyogram işlemi yapıldı. Bulgular: Kateter ilişkili bakteriyemi ve kateter enfeksiyonu düşünülerek kan kültürü istenen 56 hastanın 34 (%60,7)'ü erkek ve 22 (%39,3)'si kadındır. Hastaların

European Review for Medical and Pharmacological Sciences, Nov 1, 2022

Flora the Journal of Infectious Diseases and Clinical Microbiology

Istanbul University - DergiPark, Jul 26, 2022

Objective: Carbapenem resistance in bacterial species belonging to the Enterobacteriaceae family ... more Objective: Carbapenem resistance in bacterial species belonging to the Enterobacteriaceae family has become an increasingly important health problem worldwide. We aimed to investigate the effect of broad-spectrum antibiotic use on the development of carbapenem resistance. Methods: A total of 82673 patients whose culture samples were sent to the microbiology laboratory from various polyclinics of our hospital between January 2019 and August 2021. Those with Gramnegative enteric bacterial growth in their cultures and those with carbapenem-resistant Gramnegative enteric bacterial growth in their cultures were recorded. Results: The patients included in the study consisted of 71 (56.8%) females and 54 (43.2%) males. Of 125 patients, 91 (73.1%) had a history of antibiotic use in the last 12 months. Carbapenemresistant Gram-negative enteric bacterial growth was detected in the culture of 125 (33.2%) of 376 patients. Among the patients with a history of broad-spectrum antibiotic use, the ratio of those with carbapenem-resistant Gram-negative bacterial growth in their cultures was significantly higher than those without a history of antibiotic use (0.19% vs. 0.05%; p<0.001). It was determined that the risk of developing carbapenem resistance increased by 3.49 times in those with a history of antibiotic use (Odds ratio =3.49; 95% CI: 1.92-6.33). Conclusion: The results obtained in our study indicate that broad-spectrum antibacterial use may be associated with the development of carbapenem resistance in Gram-negative enteric bacteria. Detailed studies will provide important information for a clearer determination of this possible relationship.

Journal of biotechnology and strategic health research, Apr 3, 2022

Aim In this study, to evaluate the clinical course and prognosis in COVID-19 patients, to evaluat... more Aim In this study, to evaluate the clinical course and prognosis in COVID-19 patients, to evaluate the hematological and biochemical parameters at the time of admission to the hospital. Material and Method is retrospective study was performed in a multicenter study in April and October 2020. Demographic characteristics, clinical features, age, gender and length of stay of patients who exitus (EX) and were discharged due to COVID-19 were examined. Results Of the patients (n:180) included in the study, 89 were female and 91 were male. ere was a signi cant di erence between the patients who were discharged from the hospital and died gender and complaints at the time of admission (p<0.05). ere was no signi cant di erence between age distribution and comorbid factors (p>0.05). While the length of stay, platelet (PLT), mean corpuscular volume (MCV), serum C-reactive protein (CRP), albumin, lymphocyte, monocyte, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase (LDH), ferritin, international normalized ratio (INR), Plateletcrit (PCT), troponin, and white blood cell counts are all increased in EX. ere is a statistically signi cant di erence in red blood cell distribution width (RDW) between EX and discharge patients (p<0.05), as well as in monocyte/albumin ratios, procalcitonin/albumin ratios, CRP/albumin ratios, LDH/albumin ratios, and ürea/albumin ratios. ere is not signi cant for lymphocyte/monocyte ratio (p>0.05). While the RDW, monocyte/albumin, PCT/albumin, CRP/albumin, LDH/albumin, and ürea/albumin ratios are increased in EX patients, the PCT/PLT and MPV/PLT ratios are increased in discharged patients. Conclusion In th s study, we demonstrated that hematolog cal and b ochem cal markers may be ut l zed as an early prognost c nd cator for pat ents dent f ed w th COVID-19.

Medical Science and Discovery, May 17, 2022

Objective: This study was conducted to determine the levels of hopelessness and fear of COVID-19 ... more Objective: This study was conducted to determine the levels of hopelessness and fear of COVID-19 in individuals during the COVID-19 pandemic period. Material and Methods: In this cross-sectional study was concluded Sinop Province, Turkey, from July 2020 to September 2020. The study sample consisted of 1200 individuals living in Sinop who agreed to participate in the study. An interview form was filled by the researcher for the individuals who decided to participate in the study. Results: Of the 1200 participants, 537 (44.75%) were male, and 663 (55.25%) were female, with a mean age of 38.96. Participants had mild hopelessness (8.42%) and moderate COVID-19 fear (20.74%). There was a direct correlation between the COVID-19 Fear Scale and the Beck Hopelessness Scale. A statistically significant correlation was found between age, education, and fear of COVID-19 (respectively, p=0.001; p=0.010). A statistically significant correlation was found between the number of days the participants went out per week and income and fear of COVID-19 (respectively, p=0.001; p=0.001). There was also a significant difference between work and hopelessness (p=0.033). While there is a weak negative relationship between the fear of COVID-19 and the number of days individuals go out per week; A weak positive correlation was found with age (r=-0.109; r=0.098, respectively). Conclusion: Due to the rapid spread of the pandemic, it was considered that policymakers and officials should develop effective behavioral strategies to reduce the mental consequences of the pandemic in society.

Medical Science and Discovery

Objective: The COVID-19 disease, which first appeared in Wuhan, China, at the end of 2019, soon a... more Objective: The COVID-19 disease, which first appeared in Wuhan, China, at the end of 2019, soon affected the whole world. This study aims to examine the relationship between the demographic characteristics and clinical symptoms of COVID-19 patients and mortality rates during the COVID-19 pandemic period. Material and Methods: This retrospective observational study was done on the files of 671 dead or living patients with laboratory-confirmed COVID-19 pneumonia hospitalized in Sinop State Hospital in Turkey from February to September of 2020. The demographic features such as sex, age, and comorbidities such as diabetes, hypertension, etc., and clinical symptoms of the disease such as fever, cough, shortness of breath, respiratory distress, weakness, head rotation, etc., were recorded. Results: The total mean age of the patients was 56.08 years. The most common symptoms were cough, fever, respiratory distress, shortness of breath, and the most common comorbidities were hypertension, d...

Medical Science and Discovery

Objective: As the coronavirus disease 2019 (COVID-19) pandemic continues, clinical and laboratory... more Objective: As the coronavirus disease 2019 (COVID-19) pandemic continues, clinical and laboratory predictors of progression to serious and lethal types of the illness are urgently needed. We aimed to investigate how well hematologic, biochemical, and immunologic biomarkers could distinguish between patients with and without severe or fatal COVID-19. Material and Methods: This retrospective study was performed in the internal medicine departments of two institutions. Data were collected from the hospital database, and the medical files of 280 adult COVID-19 were reviewed. The relationship between hematologic and biochemical parameters which include C-reactive protein (CRP)/albumin, urea/albumin, and lactate dehydrogenase (LDH)/albumin ratios and length of hospitalization, disease severity, and survival were investigated. Results: Our series consisted of 280 adult COVID-19 patients (147 women, 133 men) with an average age of 58.34 ± 18.64 (range: 19 to 93). Most patients (n=171, 61.1...

Aim: Acinetobacter baumannii is a nosocomial infectious agent that may be resistant to several an... more Aim: Acinetobacter baumannii is a nosocomial infectious agent that may be resistant to several antimicrobial drugs, including colistin. Colistin is a crucial antimicrobial agent in resistant A. baumannii infections. Colistin resistance varies between countries and regions worldwide. This study aimed to evaluate the studies on colistin resistance of A. baumannii strains in different regions of Turkey, show the increasing colistin resistance in years, and discuss the solution suggestions. Methods: The online electronic database was searched for studies evaluating the antibacterial efficacy of colistin combined with other antibiotics or alone in clinical samples of patients with A. baumannii infection. Results: In our study, colistin susceptibility was found to be between 81.8%-100% in Turkey. The lowest susceptibility to colistin for A. baumannii strains was reported in the Aegean Region (81.8-100%), followed by Black Sea (82.4-100%), Southeast Anatolia (94-96%), Central Anatolia (95....

Revista da Associação Médica Brasileira, 2021

OBJECTIVE: This study investigates whether C-reactive protein, platelet-lymphocyte ratio, and neu... more OBJECTIVE: This study investigates whether C-reactive protein, platelet-lymphocyte ratio, and neutrophil-lymphocyte ratio could be useful to predict mortality in COVID-19. METHODS: Data of 635 patients with COVID-19 followed up in Sinop Ataturk State Hospital from February to May 2020 were evaluated retrospectively. Diagnosis of COVID-19 was made according to the interim guidance of the World Health Organization. Patients were grouped into two groups based on mortality as survived and non-survived patients. Age, gender, neutrophil-lymphocyte ratio, plateletlymphocyte ratio, and C-reactive protein of the groups were investigated and compared. RESULTS: The mean age of the participants was 55.8±22.3 years. Among the patients, 584 survived and 51 patients died. Age was significantly different between the groups, 54.2±22.3 in the survived group and 75.6±11.1 in the dead group (p=0.000). In addition, neutrophil, C-reactive protein, and neutrophil-lymphocyte ratio values were significantly higher in the dead group (p=0.000). plateletlymphocyte ratio was slightly higher in the dead group, but this difference was not significant (p=0.42). The area under the curve values for age, lymphocyte, platelet, C-reactive protein, and neutrophil-lymphocyte ratio are 0.797, 0.424, 0.485, 0.778, and 0.729, respectively. CONCLUSIONS: Our results showed that neutrophil-lymphocyte ratio and C-reactive protein are significantly higher in patients leading to death and could be effective biomarkers in predicting COVID-19 fatality. Furthermore, C-reactive protein could be used as an independent biomarker to predict death in patients with COVID-19, regardless of gender and age (p=0.000).

Medicine Science | International Medical Journal, 2020

To investigate anxiety, depression, and Obsessive-Compulsive Disorders (OCDs) among the healthcar... more To investigate anxiety, depression, and Obsessive-Compulsive Disorders (OCDs) among the healthcare workers (HCWs) to compare the healthcare workers in COVID positive services with the control group. This cross-sectional study was conducted on 198 subjects participating in the study. To test the difference between the two groups involved in COVID-19 hospitalization section and normal section in Anxiety, Depression, and Obsessive-Compulsive Disorders Scale, two sample independent t-tests, however, Welch-Satterthwaite P Values were considered for test significance. The categorical variables (sex, branch type, etc.) were also tested using the Chi-Square test to make sure that the two samples were not influenced by the demographics of the population. 198 subjectspartici pated in the study, among whom 72% were female and 28.3% were male. 130 participants (66%) worked in COVID and 68 participants (35%) worked in other sections.The mean age of the two samples was close to 35 and most of them (~45%) were nurses. 57% of the pooled samples had Emergency Response Experience (ERE).There was no significant difference between the two groups regarding sex, education, marital status, and ERE, however, the branch type showed major differences between the two groups(P-value < 0.08). The age difference between the two groups was also insignificant. Working in the COVID-19 section significantly increased anxiety scores from 9.62 to 13.15 with a P-value of <0.03. Obsessive-Compulsive Disorders Scale also significantly increased from 19.72 to 26.6. Working in the COVID-19 section roughly doubled the depression score from 7.49 to 14.71 with a p-value of <0.0001. It is concluded that the health care workers in the COVID-19 section had significantly increased obsessive-compulsive disorders, depression, and anxiety as compared to the control group. Both groups showed no significant difference in terms of age, sex, education, marital status, and ERE. The psychological impact of the COVID-19 pandemic among the frontline HCWs should be understood well. The important public health measure is to protectthem to overcome this global pandemic.

The Eurasian journal of medicine, 2011

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic fever. Disseminated intr... more Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic fever. Disseminated intravascular coagulation (DIC) is an important complication of this disease, especially in severe and fatal cases. Antithrombin (AT) acts as an anticoagulant by inactivating thrombin, Factor IX, Factor X and Factor XI. We conducted this study to investigate the AT levels and their prognostic value in CCHF. Twenty-eight confirmed CCHF patients were included in this study. Diagnosis of the disease was made by CCHF IgM and/or PCR positivity. Patients were grouped based on the severity criteria described previously. The patients with platelet counts <20 000×10(6) cell/L, white blood counts >10×10(9) cell/L, prothrombin times >60 seconds, aspartate aminotransferase levels >700 IU/L or alanine aminotransferase levels >900 IU/L were accepted as severe cases. Patients whose illnesses were self-limited and who did not require blood component replacement were accepted as mild cases, an...