MV Aguilar - Academia.edu (original) (raw)
Papers by MV Aguilar
En este trabajo se ha estudiado cómo influye la duración del período de tratamiento sobre el efec... more En este trabajo se ha estudiado cómo influye la duración del período de tratamiento sobre el efecto que en los niveles plasmáticos de glucosa y colesterol total tiene la interacción de AS-CL Se han tratado ratas Wistar macho en crecimiento con 5 g/g de comida de As (As20 5) y/o Cr(CrCI3 ) durante dos períodos de tiempo distintos: 6 y 12 semanas. Los resultados obtenidos muestran que la interacción As-Cr no afecta prácticamente al metabolismo glucídico en ninguno de los dos períodos estudiados: 96,61 vs 98,76 y 99,66 vs 100,01 , respectivamente. Sin embargo, en los niveles de colesterol total la administración de Cr compensa, en los dos periodos, la acción ejercida por el As, acción que tras 12 semanas de tratamiento es claramente tóxica duplicando los niveles detectados en el grupo control.The influence of treatrnent period on the effect of As-Cr interaction on plasma glucose and cholesterol levels has been studied. Growing Wistar rats have been do sed with 5g/g food of As(AsP5) and...
Journal of Neural Transmission, 1998
We compared CSF and serum levels of iron, copper, manganese, and zinc, measured by atomic absorpt... more We compared CSF and serum levels of iron, copper, manganese, and zinc, measured by atomic absorption spectrophotometry, in 26 patients patients with Alzheimer's disease (AD) without major clinical signs of undernutrition, and 28 matched controls. CSF zinc levels were significantly decreased in AD patients as compared with controls (p < 0.05). The serum levels of zinc, and the CSF and serum levels of iron, copper, and manganese, did not differ significantly between AD-patient and control groups. These values were not correlated with age, age at onset, duration of the disease, and scores of the MiniMental State Examination in the AD group. Weight and body mass index were significantly lower in AD patients than in controls. Because serum zinc levels were normal, the possibility that low CSF zinc levels were due to a deficiency of dietary intake seems unlikely. However, it is possible that they might be related to the interaction of beta-amyloid and/or amyloid precursor protein with zinc, that could result in a depletion of zinc levels.
European Food Research and Technology, 2007
Acta Neurologica Scandinavica, 1995
Journal of Agricultural and Food Chemistry, 2003
Journal of Trace Elements in Medicine and Biology, 2002
Nutrición Hospitalaria
Chromium picolinate has been implicated as a lipid and carbohydrate reducing agent, and therefore... more Chromium picolinate has been implicated as a lipid and carbohydrate reducing agent, and therefore it may be a valuable adjunct to the treatment and prevention of diabetes and heart disease. This compound is inexpensive and apparently nontoxic. In this work, we have determined the influence of its administration (100, 200, 500 micrograms Cr/ml, for 7 and 21 days) on hepatic content of Zn, Mn, Cu and Fe of male Wistar rats. The results show a variation of the levels of these elements after the administration of chromium picolinate, although the differences are only significantly (p < 0.01) in the case of Mn. This influence is dose-dependent, occurring a decrease of 72% in the group treated with 500 micrograms/ml (Pic-500) respect to the content of control group.
Acta Neurologica Scandinavica, 1995
Some investigators reported pharmacogenetic differences in the metabolism of sulfur-containing dr... more Some investigators reported pharmacogenetic differences in the metabolism of sulfur-containing drugs and lower plasma sulfate levels in patients with Parkinson's disease (PD) compared with controls. However, other group did not confirm these findings. We studied the plasma levels of sulfate by indirect atomic absorption spectrophotometry in 55 PD patients and 57 age and sex-matched controls. The plasma sulfate levels did not differ significantly between PD patients and control groups (mean +/- SEM 73 +/- 8 and 75 +/- 7 mg/l, respectively). They were not influenced by antiparkinsonian drugs and they did not correlate with age at onset, duration, Hoehn & Yahr staging or activities of daily living subscale of the Unified Parkinson's disease rating scale. There was a low but significant correlation of plasma sulfate levels with motor examination (r = -0.39, p < 0.05) and total score (r = -0.33, p < 0.05) of this scale in the PD group. These data suggest that plasma sulfate...
Veterinary and human toxicology, 1995
The effect of the administered arsenic (As) dose and the dichromate ion (Cr) on the methylation p... more The effect of the administered arsenic (As) dose and the dichromate ion (Cr) on the methylation process of arsenic was studied in rats exposed to arsenate to elucidate the biotransformation of As. After oral administration of different As (V) and Cr (VI) concentrations, the different As metabolites (inorganic, methylarsonic acid [MMA] and dimethylarsinic acid [DMA] were separated by cation-exchange chromatography and measured by atomic absorption spectrophotometry. Administration of high doses of As produced enzymatic saturation and non-enzymatic depletion, with decreases in DMA levels. The presence of the dichromate ion supported arsenate methylation as it favored reduction of As (V) to As (III), but Cr (VI) produced a significant decrease in the total As excreted.
Veterinary and human toxicology, 1995
The absorption of inorganic pentavalent arsenic (As) by the rat small intestine was investigated ... more The absorption of inorganic pentavalent arsenic (As) by the rat small intestine was investigated using 2 different procedures: In vivo determination of overall extent of gastrointestinal absorption; and an intestinal perfusion technique. The aim was to determine the effect of concentration and the interaction with phosphate and dichromate anions on gastrointestinal absorption of As to understand the mechanism of As absorption at intestinal level. The results indicate there is a direct relationship, although not proportional, between the received dose and the absorbed amount of As. Intestinal absorption of As appears carried out by a saturable transport process. The phosphate produces a pronounced decrease in the intestinal absorption of As due to the fact that phosphate and As can share the same transport mechanism which is an active secondary carrier-mediated system depending on Na+ and H+ gradient. Addition of dichromate to perfusion buffers significantly (p > 0.05) increased A...
Nutrición Hospitalaria
Commercialized like dietetic supplement, chromium picolinate has been promoted to favour the incr... more Commercialized like dietetic supplement, chromium picolinate has been promoted to favour the increase of muscle mass and the loss of weight, due to its' effect on the action of insulin. To evaluate the effect of supplementation of the diet with chromium (500 microg/kg) in the form of chromium picolinate (CrPic) (12 days) on growth and protein turnover in rats at different growth stages (infantile and puberal). No significant effect of CrPic on bodyweight gain, feed intake and feed conversion rate was observed at any of the stages of development studied. CrPic seems to increase the muscle mass, either by stimulating protein anabolism due to the involution of the insulin by chromium, or by reducing protein catabolism. Since the use of chromium picolinate could jeopardize the correct renal function and its' beneficial effects are not evident, it should always be consumed with caution.
Veterinary and human toxicology, 1995
The absorption of inorganic pentavalent arsenic (As) by the rat small intestine was investigated ... more The absorption of inorganic pentavalent arsenic (As) by the rat small intestine was investigated using 2 different procedures: In vivo determination of overall extent of gastrointestinal absorption; and an intestinal perfusion technique. The aim was to determine the effect of concentration and the interaction with phosphate and dichromate anions on gastrointestinal absorption of As to understand the mechanism of As absorption at intestinal level. The results indicate there is a direct relationship, although not proportional, between the received dose and the absorbed amount of As. Intestinal absorption of As appears carried out by a saturable transport process. The phosphate produces a pronounced decrease in the intestinal absorption of As due to the fact that phosphate and As can share the same transport mechanism which is an active secondary carrier-mediated system depending on Na+ and H+ gradient. Addition of dichromate to perfusion buffers significantly (p > 0.05) increased A...
It is of fully interest the use of the authocthonous products to solve, at the present time. Peru... more It is of fully interest the use of the authocthonous products to solve, at the present time. Peru's nutritional problems. With this purpose, a vegetal food valuation is carried out corresponding to the legominous, vegetables, greens, tubercles and fruits group. The authoctonous food composition has been commented and compared in relation to an already known food product, and has been taken as a reference in order of being able to settle comparisons. In general and in all the cases, we are talking about of extremely useful foof products from a nutritional point of view, which are better than those food products usually consumed, in order that its promotion would be profitable and could be appointed to have an effective use within the available resources.
Nutricion Hospitalaria, 2009
Introduccion: La poblacion de Guadalajara tradicionalmente ha ingerido una dieta mediterranea con... more Introduccion: La poblacion de Guadalajara tradicionalmente ha ingerido una dieta mediterranea con las variaciones tipicas de la zona central de la peninsula, esta dieta ha variado en los ultimos anos. La adquisicion de habitos de vida erroneos se pueden traducir, especialmente en los jovenes, en unas conductas alimentarias no saludables. Objetivo: Evaluar la calidad de la dieta, mediante el indice de alimentacion saludable (IAS) y el porcentaje de adhesion a la dieta mediterranea (% ADM), de una poblacion adolescente (n = 467) y su relacion con diferentes parametros fisiologicos y sociodemograficos. Metodo: Se ha realizado un estudio nutricional sobre la calidad de la dieta en una poblacion adolescente de Guadalajara de 467 jovenes (12-17 anos) mediante cuestionarios de frecuencia de consumo de siete dias y socioeconomicos. Asi mismo, se ha determinado la ingesta de nutrientes y el indice de alimentacion saludable (IAS) utilizando el programa de nutricion DIAL©. Resultados: Los resu...
American Journal of Enology and Viticulture, 1987
The analysis and speciation of arsenic in must and wine samples was carried out with an ion excha... more The analysis and speciation of arsenic in must and wine samples was carried out with an ion exchange column combined with hydride-generation atomic spectrometry. The changes in the chemical species of arsenic that occur during the wine fermentation process were examined.
Información del artículo Ingesta de nutrientes en una población juvenil. Prevalencia de sobrepeso... more Información del artículo Ingesta de nutrientes en una población juvenil. Prevalencia de sobrepeso y obesidad.
Nutricion Hospitalaria, 2008
Objetivo: Estudiar la relacion existente entre la calidad del desayuno y de su omision sobre el r... more Objetivo: Estudiar la relacion existente entre la calidad del desayuno y de su omision sobre el rendimiento academico de un colectivo de adolescentes. Metodo: Se ha realizado un estudio nutricional sobre la calidad del desayuno de una poblacion adolescente de Guadalajara de 467 jovenes (12-17 anos) mediante cuestionarios de frecuencia de consumo de siete dias. Asimismo, se han recogido datos sociodemograficos y calificaciones academicas de dichos jovenes. Resultados: La mayoria de los alumnos encuestados consume un desayuno deficiente ya que tan solo un 4,88% toma un desayuno completo. Las chicas de 15-17 anos son las que toman un desayuno de inferior calidad ya que un 8,33% de estas alumnas omiten el desayuno. Un 68,29% ingieren desayunos de calidad mejorable. Esta calidad del desayuno esta directamente relacionada con la calificacion media obtenida durante el curso 2003-04. Relacion que no es tan clara cuando se consideran seis asignaturas obligatorias en las distintas orientacion...
Fundamento : dada la relevancia de la nutricion en la osteoporosis, en un intento de prevenirla m... more Fundamento : dada la relevancia de la nutricion en la osteoporosis, en un intento de prevenirla mejor que de curarla, se hace necesario conocer las posibles desviaciones dieteticas habidas en la poblacion y corregirlas. Metodos : en dos grupos de lumnos, 91 de Medicina y 82 de Farmacia, de la Universidad de Alcala de Henares, se hizo una encuesta dietetica de 7 dias en la que se valora la ingesta de proteinas, grasas, hidratos de carbono (H de C), vitamina D, calcio (Ca), fosforo (P), magnesio (Mg), Fluor (F) y zinc (Zn).
![Research paper thumbnail of [Repercussions of chromium picolinate in the protein metabolism based on the age]](https://attachments.academia-assets.com/78593045/thumbnails/1.jpg)
](Nutricion hospitalaria, 2006
ANTECEDENTS Commercialized like dietetic supplement, chromium picolinate has been promoted to fav... more ANTECEDENTS Commercialized like dietetic supplement, chromium picolinate has been promoted to favour the increase of muscle mass and the loss of weight, due to its' effect on the action of insulin. OBJECTIVE To evaluate the effect of supplementation of the diet with chromium (500 microg/kg) in the form of chromium picolinate (CrPic) (12 days) on growth and protein turnover in rats at different growth stages (infantile and puberal). RESULTS AND DISCUSSION No significant effect of CrPic on bodyweight gain, feed intake and feed conversion rate was observed at any of the stages of development studied. CrPic seems to increase the muscle mass, either by stimulating protein anabolism due to the involution of the insulin by chromium, or by reducing protein catabolism. CONCLUSIONS Since the use of chromium picolinate could jeopardize the correct renal function and its' beneficial effects are not evident, it should always be consumed with caution.
En este trabajo se ha estudiado cómo influye la duración del período de tratamiento sobre el efec... more En este trabajo se ha estudiado cómo influye la duración del período de tratamiento sobre el efecto que en los niveles plasmáticos de glucosa y colesterol total tiene la interacción de AS-CL Se han tratado ratas Wistar macho en crecimiento con 5 g/g de comida de As (As20 5) y/o Cr(CrCI3 ) durante dos períodos de tiempo distintos: 6 y 12 semanas. Los resultados obtenidos muestran que la interacción As-Cr no afecta prácticamente al metabolismo glucídico en ninguno de los dos períodos estudiados: 96,61 vs 98,76 y 99,66 vs 100,01 , respectivamente. Sin embargo, en los niveles de colesterol total la administración de Cr compensa, en los dos periodos, la acción ejercida por el As, acción que tras 12 semanas de tratamiento es claramente tóxica duplicando los niveles detectados en el grupo control.The influence of treatrnent period on the effect of As-Cr interaction on plasma glucose and cholesterol levels has been studied. Growing Wistar rats have been do sed with 5g/g food of As(AsP5) and...
Journal of Neural Transmission, 1998
We compared CSF and serum levels of iron, copper, manganese, and zinc, measured by atomic absorpt... more We compared CSF and serum levels of iron, copper, manganese, and zinc, measured by atomic absorption spectrophotometry, in 26 patients patients with Alzheimer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (AD) without major clinical signs of undernutrition, and 28 matched controls. CSF zinc levels were significantly decreased in AD patients as compared with controls (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). The serum levels of zinc, and the CSF and serum levels of iron, copper, and manganese, did not differ significantly between AD-patient and control groups. These values were not correlated with age, age at onset, duration of the disease, and scores of the MiniMental State Examination in the AD group. Weight and body mass index were significantly lower in AD patients than in controls. Because serum zinc levels were normal, the possibility that low CSF zinc levels were due to a deficiency of dietary intake seems unlikely. However, it is possible that they might be related to the interaction of beta-amyloid and/or amyloid precursor protein with zinc, that could result in a depletion of zinc levels.
European Food Research and Technology, 2007
Acta Neurologica Scandinavica, 1995
Journal of Agricultural and Food Chemistry, 2003
Journal of Trace Elements in Medicine and Biology, 2002
Nutrición Hospitalaria
Chromium picolinate has been implicated as a lipid and carbohydrate reducing agent, and therefore... more Chromium picolinate has been implicated as a lipid and carbohydrate reducing agent, and therefore it may be a valuable adjunct to the treatment and prevention of diabetes and heart disease. This compound is inexpensive and apparently nontoxic. In this work, we have determined the influence of its administration (100, 200, 500 micrograms Cr/ml, for 7 and 21 days) on hepatic content of Zn, Mn, Cu and Fe of male Wistar rats. The results show a variation of the levels of these elements after the administration of chromium picolinate, although the differences are only significantly (p < 0.01) in the case of Mn. This influence is dose-dependent, occurring a decrease of 72% in the group treated with 500 micrograms/ml (Pic-500) respect to the content of control group.
Acta Neurologica Scandinavica, 1995
Some investigators reported pharmacogenetic differences in the metabolism of sulfur-containing dr... more Some investigators reported pharmacogenetic differences in the metabolism of sulfur-containing drugs and lower plasma sulfate levels in patients with Parkinson's disease (PD) compared with controls. However, other group did not confirm these findings. We studied the plasma levels of sulfate by indirect atomic absorption spectrophotometry in 55 PD patients and 57 age and sex-matched controls. The plasma sulfate levels did not differ significantly between PD patients and control groups (mean +/- SEM 73 +/- 8 and 75 +/- 7 mg/l, respectively). They were not influenced by antiparkinsonian drugs and they did not correlate with age at onset, duration, Hoehn & Yahr staging or activities of daily living subscale of the Unified Parkinson's disease rating scale. There was a low but significant correlation of plasma sulfate levels with motor examination (r = -0.39, p < 0.05) and total score (r = -0.33, p < 0.05) of this scale in the PD group. These data suggest that plasma sulfate...
Veterinary and human toxicology, 1995
The effect of the administered arsenic (As) dose and the dichromate ion (Cr) on the methylation p... more The effect of the administered arsenic (As) dose and the dichromate ion (Cr) on the methylation process of arsenic was studied in rats exposed to arsenate to elucidate the biotransformation of As. After oral administration of different As (V) and Cr (VI) concentrations, the different As metabolites (inorganic, methylarsonic acid [MMA] and dimethylarsinic acid [DMA] were separated by cation-exchange chromatography and measured by atomic absorption spectrophotometry. Administration of high doses of As produced enzymatic saturation and non-enzymatic depletion, with decreases in DMA levels. The presence of the dichromate ion supported arsenate methylation as it favored reduction of As (V) to As (III), but Cr (VI) produced a significant decrease in the total As excreted.
Veterinary and human toxicology, 1995
The absorption of inorganic pentavalent arsenic (As) by the rat small intestine was investigated ... more The absorption of inorganic pentavalent arsenic (As) by the rat small intestine was investigated using 2 different procedures: In vivo determination of overall extent of gastrointestinal absorption; and an intestinal perfusion technique. The aim was to determine the effect of concentration and the interaction with phosphate and dichromate anions on gastrointestinal absorption of As to understand the mechanism of As absorption at intestinal level. The results indicate there is a direct relationship, although not proportional, between the received dose and the absorbed amount of As. Intestinal absorption of As appears carried out by a saturable transport process. The phosphate produces a pronounced decrease in the intestinal absorption of As due to the fact that phosphate and As can share the same transport mechanism which is an active secondary carrier-mediated system depending on Na+ and H+ gradient. Addition of dichromate to perfusion buffers significantly (p > 0.05) increased A...
Nutrición Hospitalaria
Commercialized like dietetic supplement, chromium picolinate has been promoted to favour the incr... more Commercialized like dietetic supplement, chromium picolinate has been promoted to favour the increase of muscle mass and the loss of weight, due to its' effect on the action of insulin. To evaluate the effect of supplementation of the diet with chromium (500 microg/kg) in the form of chromium picolinate (CrPic) (12 days) on growth and protein turnover in rats at different growth stages (infantile and puberal). No significant effect of CrPic on bodyweight gain, feed intake and feed conversion rate was observed at any of the stages of development studied. CrPic seems to increase the muscle mass, either by stimulating protein anabolism due to the involution of the insulin by chromium, or by reducing protein catabolism. Since the use of chromium picolinate could jeopardize the correct renal function and its' beneficial effects are not evident, it should always be consumed with caution.
Veterinary and human toxicology, 1995
The absorption of inorganic pentavalent arsenic (As) by the rat small intestine was investigated ... more The absorption of inorganic pentavalent arsenic (As) by the rat small intestine was investigated using 2 different procedures: In vivo determination of overall extent of gastrointestinal absorption; and an intestinal perfusion technique. The aim was to determine the effect of concentration and the interaction with phosphate and dichromate anions on gastrointestinal absorption of As to understand the mechanism of As absorption at intestinal level. The results indicate there is a direct relationship, although not proportional, between the received dose and the absorbed amount of As. Intestinal absorption of As appears carried out by a saturable transport process. The phosphate produces a pronounced decrease in the intestinal absorption of As due to the fact that phosphate and As can share the same transport mechanism which is an active secondary carrier-mediated system depending on Na+ and H+ gradient. Addition of dichromate to perfusion buffers significantly (p > 0.05) increased A...
It is of fully interest the use of the authocthonous products to solve, at the present time. Peru... more It is of fully interest the use of the authocthonous products to solve, at the present time. Peru's nutritional problems. With this purpose, a vegetal food valuation is carried out corresponding to the legominous, vegetables, greens, tubercles and fruits group. The authoctonous food composition has been commented and compared in relation to an already known food product, and has been taken as a reference in order of being able to settle comparisons. In general and in all the cases, we are talking about of extremely useful foof products from a nutritional point of view, which are better than those food products usually consumed, in order that its promotion would be profitable and could be appointed to have an effective use within the available resources.
Nutricion Hospitalaria, 2009
Introduccion: La poblacion de Guadalajara tradicionalmente ha ingerido una dieta mediterranea con... more Introduccion: La poblacion de Guadalajara tradicionalmente ha ingerido una dieta mediterranea con las variaciones tipicas de la zona central de la peninsula, esta dieta ha variado en los ultimos anos. La adquisicion de habitos de vida erroneos se pueden traducir, especialmente en los jovenes, en unas conductas alimentarias no saludables. Objetivo: Evaluar la calidad de la dieta, mediante el indice de alimentacion saludable (IAS) y el porcentaje de adhesion a la dieta mediterranea (% ADM), de una poblacion adolescente (n = 467) y su relacion con diferentes parametros fisiologicos y sociodemograficos. Metodo: Se ha realizado un estudio nutricional sobre la calidad de la dieta en una poblacion adolescente de Guadalajara de 467 jovenes (12-17 anos) mediante cuestionarios de frecuencia de consumo de siete dias y socioeconomicos. Asi mismo, se ha determinado la ingesta de nutrientes y el indice de alimentacion saludable (IAS) utilizando el programa de nutricion DIAL©. Resultados: Los resu...
American Journal of Enology and Viticulture, 1987
The analysis and speciation of arsenic in must and wine samples was carried out with an ion excha... more The analysis and speciation of arsenic in must and wine samples was carried out with an ion exchange column combined with hydride-generation atomic spectrometry. The changes in the chemical species of arsenic that occur during the wine fermentation process were examined.
Información del artículo Ingesta de nutrientes en una población juvenil. Prevalencia de sobrepeso... more Información del artículo Ingesta de nutrientes en una población juvenil. Prevalencia de sobrepeso y obesidad.
Nutricion Hospitalaria, 2008
Objetivo: Estudiar la relacion existente entre la calidad del desayuno y de su omision sobre el r... more Objetivo: Estudiar la relacion existente entre la calidad del desayuno y de su omision sobre el rendimiento academico de un colectivo de adolescentes. Metodo: Se ha realizado un estudio nutricional sobre la calidad del desayuno de una poblacion adolescente de Guadalajara de 467 jovenes (12-17 anos) mediante cuestionarios de frecuencia de consumo de siete dias. Asimismo, se han recogido datos sociodemograficos y calificaciones academicas de dichos jovenes. Resultados: La mayoria de los alumnos encuestados consume un desayuno deficiente ya que tan solo un 4,88% toma un desayuno completo. Las chicas de 15-17 anos son las que toman un desayuno de inferior calidad ya que un 8,33% de estas alumnas omiten el desayuno. Un 68,29% ingieren desayunos de calidad mejorable. Esta calidad del desayuno esta directamente relacionada con la calificacion media obtenida durante el curso 2003-04. Relacion que no es tan clara cuando se consideran seis asignaturas obligatorias en las distintas orientacion...
Fundamento : dada la relevancia de la nutricion en la osteoporosis, en un intento de prevenirla m... more Fundamento : dada la relevancia de la nutricion en la osteoporosis, en un intento de prevenirla mejor que de curarla, se hace necesario conocer las posibles desviaciones dieteticas habidas en la poblacion y corregirlas. Metodos : en dos grupos de lumnos, 91 de Medicina y 82 de Farmacia, de la Universidad de Alcala de Henares, se hizo una encuesta dietetica de 7 dias en la que se valora la ingesta de proteinas, grasas, hidratos de carbono (H de C), vitamina D, calcio (Ca), fosforo (P), magnesio (Mg), Fluor (F) y zinc (Zn).
Nutricion hospitalaria, 2006
ANTECEDENTS Commercialized like dietetic supplement, chromium picolinate has been promoted to fav... more ANTECEDENTS Commercialized like dietetic supplement, chromium picolinate has been promoted to favour the increase of muscle mass and the loss of weight, due to its' effect on the action of insulin. OBJECTIVE To evaluate the effect of supplementation of the diet with chromium (500 microg/kg) in the form of chromium picolinate (CrPic) (12 days) on growth and protein turnover in rats at different growth stages (infantile and puberal). RESULTS AND DISCUSSION No significant effect of CrPic on bodyweight gain, feed intake and feed conversion rate was observed at any of the stages of development studied. CrPic seems to increase the muscle mass, either by stimulating protein anabolism due to the involution of the insulin by chromium, or by reducing protein catabolism. CONCLUSIONS Since the use of chromium picolinate could jeopardize the correct renal function and its' beneficial effects are not evident, it should always be consumed with caution.