M. Vignini - Academia.edu (original) (raw)
Papers by M. Vignini
Giornale Italiano di Dermatologia e Venereologia
Skin Pharmacology and Physiology, 1993
We have employed morphometric computerized analysis to quantify changes in atrophic skin. Atrophy... more We have employed morphometric computerized analysis to quantify changes in atrophic skin. Atrophy was induced on volunteers by means of the Duhring chamber assay, using two commercial corticosteroids with a steroid-free base as control. After 20 days, atrophy was assessed by subjective examination and rated on a five-point scale. After 10 and 20 days, positive replicas of the areas under test were obtained. Photographic reproductions of these replicas were stored in the image memory of an interactive automatic computerized image analysis system, Kontron Zeiss Ibas 2, and processed with a suitable program. After selection of the measurement area by means of a circular measurement window, the 'continuous tone' image was converted to a 'binary' one by means of a dynamic discrimination function, in order to perform an automatic evaluation of the percentage area corresponding to the shadows cast by the surface markings. Morphometric computerized analysis proved to be a sensitive method for quantifying skin atrophy. A high degree of correspondence with subjective examination was shown. The method allows an objective differentiation between a mid-potency and a high-potency topical corticosteroid.
Clinical and Experimental Dermatology, 1990
Giornale Italiano di Dermatologia e Venereologia
ABSTRACT
Journal of the European Academy of Dermatology and Venereology, 2015
Journal of investigational allergology & clinical immunology, 2012
Acta dermato-venereologica, 1994
Topical treatment of psoriasis with calcipotriol has been proven effective. The efficacy of calci... more Topical treatment of psoriasis with calcipotriol has been proven effective. The efficacy of calcipotriol has been compared to that of topical corticoids in a number of studies using subjective visual scoring systems such as the PASI index. The purpose of this study was to compare, with objective data, the efficacy of calcipotriol and clobetasol propionate 0.05% in the treatment of plaque type psoriasis. Transepidermal water loss (TEWL) and laser Doppler velocimetry (LDV) were used to monitor restoration of water barrier and normalization of blood flow, respectively, in psoriatic plaques of the limbs of 24 male patients during 3 weeks of treatment. Data were compared to subjective evaluation using the PASI index of the same areas. Significant differences were recorded during treatment in both groups. The results correlated well with the PASI score. Clobetasol was faster in restoring barrier function than calcipotriol. However, no significant differences were detected between the two ...
Archives for dermatological research. Archiv für dermatologische Forschung, Jan 31, 1977
We have studied psoriatic subjects with normal weight and with overweight without inherited diabe... more We have studied psoriatic subjects with normal weight and with overweight without inherited diabetic familiarity. The results seem to indicate the existence in psoriasis of an endogenous insulin-resistence. In this prospective the hypothesis that psoriasis carries a diabetogen risk is suggested.
Trends in Human Hair Growth and Alopecia Research, 1989
Page 1. Effects of a topical preparation on some hair growth parameters, evaluated utilizing a mo... more Page 1. Effects of a topical preparation on some hair growth parameters, evaluated utilizing a morphometric computerized analysis C. PELFINI, D. FIDELI, A. SPEZIALI and M. VIGNINI, Department of Dermatology, University of Pavia, Italy Received 17 March I986 ...
Skin Pharmacology and Physiology, 2000
The quantification of allergic patch test reactions to several compounds was evaluated on patient... more The quantification of allergic patch test reactions to several compounds was evaluated on patients using laser Doppler velocimetry (LDV), transepidermal water loss and colorimetry. The correlation between visual scores and instrumental measurements was investigated by the implementation of a modern statistical method: a classification tree. The LDV showed the highest correlation with the severity of the reaction. The best prediction
Digestive and Liver Disease, 2003
Clinical and Experimental Dermatology, 1989
CORRESPONDENCE 261 trienes B4, C4, and D4 are potent chemo-attractants, and have been shown to st... more CORRESPONDENCE 261 trienes B4, C4, and D4 are potent chemo-attractants, and have been shown to stimulate keratinocyte proliferation in vitro^ and could therefore be responsible for the worsening of PV. Another possible mechanism is via the decreased production of prostaglandins (Pg) and a consequent decrease of cAMP level in the epidermis.'
Clinical and Experimental Dermatology, 2011
Serum neopterin may be considered a diagnostic marker of the degree of activation of the immune s... more Serum neopterin may be considered a diagnostic marker of the degree of activation of the immune system. This preliminary study was performed to measure serum neopterin levels in patients with acute spontaneous urticaria (ASU), chronic spontaneous urticaria (CSU) and atopic dermatitis (AD). In total, 180 patients [96 men, 84 women; mean age 23.1 years; 41 with spontaneous urticaria (13 ASU and 28 CSU), 48 with AD] and 96 healthy controls were enrolled in the study. Patients with ASU had the highest neopterin levels, and all three groups of patients (ASU, CSU and AD) had higher values than normal subjects. This preliminary study demonstrates that serum neopterin could be a biomarker of immune activation in patients with SU or AD.
British Journal of Dermatology, 1987
Archives for Dermatological Research, 1977
We have studied psoriatic subjects with normal weight and with overweight without inherited diabe... more We have studied psoriatic subjects with normal weight and with overweight without inherited diabetic familiarity. The results seem to indicate the existence in psoriasis of an endogenous insulin-resistence. In this prospective the hypothesis that psoriasis carries a diabetogen risk is suggested.
Annals of Allergy, Asthma & Immunology, 2003
IgE cross-reactivity between pollen and food allergens represents the molecular basis for oral al... more IgE cross-reactivity between pollen and food allergens represents the molecular basis for oral allergy syndrome (OAS).
Giornale Italiano di Dermatologia e Venereologia
Skin Pharmacology and Physiology, 1993
We have employed morphometric computerized analysis to quantify changes in atrophic skin. Atrophy... more We have employed morphometric computerized analysis to quantify changes in atrophic skin. Atrophy was induced on volunteers by means of the Duhring chamber assay, using two commercial corticosteroids with a steroid-free base as control. After 20 days, atrophy was assessed by subjective examination and rated on a five-point scale. After 10 and 20 days, positive replicas of the areas under test were obtained. Photographic reproductions of these replicas were stored in the image memory of an interactive automatic computerized image analysis system, Kontron Zeiss Ibas 2, and processed with a suitable program. After selection of the measurement area by means of a circular measurement window, the 'continuous tone' image was converted to a 'binary' one by means of a dynamic discrimination function, in order to perform an automatic evaluation of the percentage area corresponding to the shadows cast by the surface markings. Morphometric computerized analysis proved to be a sensitive method for quantifying skin atrophy. A high degree of correspondence with subjective examination was shown. The method allows an objective differentiation between a mid-potency and a high-potency topical corticosteroid.
Clinical and Experimental Dermatology, 1990
Giornale Italiano di Dermatologia e Venereologia
ABSTRACT
Journal of the European Academy of Dermatology and Venereology, 2015
Journal of investigational allergology & clinical immunology, 2012
Acta dermato-venereologica, 1994
Topical treatment of psoriasis with calcipotriol has been proven effective. The efficacy of calci... more Topical treatment of psoriasis with calcipotriol has been proven effective. The efficacy of calcipotriol has been compared to that of topical corticoids in a number of studies using subjective visual scoring systems such as the PASI index. The purpose of this study was to compare, with objective data, the efficacy of calcipotriol and clobetasol propionate 0.05% in the treatment of plaque type psoriasis. Transepidermal water loss (TEWL) and laser Doppler velocimetry (LDV) were used to monitor restoration of water barrier and normalization of blood flow, respectively, in psoriatic plaques of the limbs of 24 male patients during 3 weeks of treatment. Data were compared to subjective evaluation using the PASI index of the same areas. Significant differences were recorded during treatment in both groups. The results correlated well with the PASI score. Clobetasol was faster in restoring barrier function than calcipotriol. However, no significant differences were detected between the two ...
Archives for dermatological research. Archiv für dermatologische Forschung, Jan 31, 1977
We have studied psoriatic subjects with normal weight and with overweight without inherited diabe... more We have studied psoriatic subjects with normal weight and with overweight without inherited diabetic familiarity. The results seem to indicate the existence in psoriasis of an endogenous insulin-resistence. In this prospective the hypothesis that psoriasis carries a diabetogen risk is suggested.
Trends in Human Hair Growth and Alopecia Research, 1989
Page 1. Effects of a topical preparation on some hair growth parameters, evaluated utilizing a mo... more Page 1. Effects of a topical preparation on some hair growth parameters, evaluated utilizing a morphometric computerized analysis C. PELFINI, D. FIDELI, A. SPEZIALI and M. VIGNINI, Department of Dermatology, University of Pavia, Italy Received 17 March I986 ...
Skin Pharmacology and Physiology, 2000
The quantification of allergic patch test reactions to several compounds was evaluated on patient... more The quantification of allergic patch test reactions to several compounds was evaluated on patients using laser Doppler velocimetry (LDV), transepidermal water loss and colorimetry. The correlation between visual scores and instrumental measurements was investigated by the implementation of a modern statistical method: a classification tree. The LDV showed the highest correlation with the severity of the reaction. The best prediction
Digestive and Liver Disease, 2003
Clinical and Experimental Dermatology, 1989
CORRESPONDENCE 261 trienes B4, C4, and D4 are potent chemo-attractants, and have been shown to st... more CORRESPONDENCE 261 trienes B4, C4, and D4 are potent chemo-attractants, and have been shown to stimulate keratinocyte proliferation in vitro^ and could therefore be responsible for the worsening of PV. Another possible mechanism is via the decreased production of prostaglandins (Pg) and a consequent decrease of cAMP level in the epidermis.'
Clinical and Experimental Dermatology, 2011
Serum neopterin may be considered a diagnostic marker of the degree of activation of the immune s... more Serum neopterin may be considered a diagnostic marker of the degree of activation of the immune system. This preliminary study was performed to measure serum neopterin levels in patients with acute spontaneous urticaria (ASU), chronic spontaneous urticaria (CSU) and atopic dermatitis (AD). In total, 180 patients [96 men, 84 women; mean age 23.1 years; 41 with spontaneous urticaria (13 ASU and 28 CSU), 48 with AD] and 96 healthy controls were enrolled in the study. Patients with ASU had the highest neopterin levels, and all three groups of patients (ASU, CSU and AD) had higher values than normal subjects. This preliminary study demonstrates that serum neopterin could be a biomarker of immune activation in patients with SU or AD.
British Journal of Dermatology, 1987
Archives for Dermatological Research, 1977
We have studied psoriatic subjects with normal weight and with overweight without inherited diabe... more We have studied psoriatic subjects with normal weight and with overweight without inherited diabetic familiarity. The results seem to indicate the existence in psoriasis of an endogenous insulin-resistence. In this prospective the hypothesis that psoriasis carries a diabetogen risk is suggested.
Annals of Allergy, Asthma & Immunology, 2003
IgE cross-reactivity between pollen and food allergens represents the molecular basis for oral al... more IgE cross-reactivity between pollen and food allergens represents the molecular basis for oral allergy syndrome (OAS).