Macdonald Wick - Academia.edu (original) (raw)
Papers by Macdonald Wick
Poultry Science, Aug 1, 2000
Skeletal muscle development is, in part, regulated by myoblast-extracellular matrix interactions ... more Skeletal muscle development is, in part, regulated by myoblast-extracellular matrix interactions mediated by the transmembrane integrin family of heterodimeric receptors. The avian genetic muscle weakness, low score normal (LSN), exhibits modified myotube and sarcomere structure that may be associated with altered integrin expression. Protein expression of the β1 integrin subunit was measured during normal and LSN Pectoralis major muscle development at 14, 16, and 18 d of embryonic development, and 1 d and 1 and 6 wk posthatch. During embryonic development, integrin expression was downregulated. However, by 1 wk posthatch, integrin levels were upregulated and remained elevated through
PubMed, May 5, 2005
One way to combat or treat breast cancer, the most common cancer among women, is to decrease or p... more One way to combat or treat breast cancer, the most common cancer among women, is to decrease or prevent proliferation of cancerous cells. Many animal species of agricultural importance have been selected for various growth traits, typically through altered proliferative capacity of some cell types. Previous studies in two lines of cattle divergently selected for serum IGF-I concentration have shown that low IGF-I cattle had increased growth rates and high IGF-I cattle had decreased growth rates. Serum from either the high or low IGF-I lines of cattle were administered to MCF-7 breast cancer cell lines and doubling times were determined. The MCF-7 cells treated with serum from cattle with high serum IGF-I concentrations took 26% longer to double than MCF-7 cells treated with serum from cattle with low serum IGF-I concentrations. In conclusion, model systems employing agricultural animals may provide novel insight into mechanisms of cell proliferation.
Ciencia Y Tecnologia Alimentaria, 1998
Resumen en: Fish muscle protein presents unique properties such as reduced frozen storage stabili... more Resumen en: Fish muscle protein presents unique properties such as reduced frozen storage stability and setting phenomena. Both two are associated with myosin inter...
PubMed, 1994
This manuscript describes the chicken sarcomeric myosin heavy chain (MyHC) multigene family and h... more This manuscript describes the chicken sarcomeric myosin heavy chain (MyHC) multigene family and how it differs from the sarcomeric MyHC multigene families of other vertebrates. Data is discussed that suggests the chicken fast MyHC multigene family has undergone recent expansion subsequent to the divergence of avians and mammals, and has been subjected to multiple gene conversion-like events. Similar to human and rodent MyHC multigene families, the chicken multigene family contains sarcomeric MyHC genes that are differentially regulated in developing embryonic, fetal, and neonatal muscles. However, unlike mammalian genes, chicken fast MyHC genes expressed in developing muscles are also expressed in mature muscle fibers as well. The potential significance of conserved and divergent sequences with the MyHC rod domain of five fast chicken isoforms that have been cloned and sequenced is also discussed.
Translational animal science, Apr 1, 2020
De Gruyter eBooks, Dec 31, 1990
PubMed, Mar 14, 2007
Background: Experimental data at the molecular, cellular and organismal levels have implicated di... more Background: Experimental data at the molecular, cellular and organismal levels have implicated dietary components in cancer. Exposure to numerous growth factors, hormones and environmental agents, that can regulate signaling events, is involved in carcinogenesis. Research targets on gene-nutrient interactions may give useful information for the development of a novel diet-based intervention for the at-risk population. Materials and methods: To examine the proteomic effect of a low level dietary compound on potential breast cancer, primary human breast epithelial cells were isolated and cultured in media with or without zeranol, an anabolic, non-estrogenic growth promoter with estrogenic activity, used in beef cattle and naturally found in some fungus in grain. The cells then underwent proteomic analysis. Results: 2-D electrophoresis showed that protein disulfide isomerase (PDI) was up-regulated 5-fold in the breast epithelial cells exposed to zeranol. PDI has been shown to be up-regulated in a variety of cancerous tissues, although this is the first reported up-regulation of PDI in breast tissue. Conclusion: PDI may be a useful marker of dietary exposure to zeranol.
Poultry Science, Jul 1, 2013
Poultry Science, Nov 1, 2012
Poultry Science, Jul 1, 2009
Biochimica et biophysica acta (N), Aug 1, 1997
Poultry Science, May 1, 1999
Livestock Science, Jul 1, 2013
Journal of Muscle Foods, Jul 1, 2001
ABSTRACT
Cytotechnology, Feb 28, 2008
Scientific Reports, Mar 4, 2020
Rapid Communications in Mass Spectrometry, Nov 6, 2017
There have been growing interests in modeling studies to understand oxidation of volatile organic... more There have been growing interests in modeling studies to understand oxidation of volatile organic compounds in the gas phase and their mass transfer to the aqueous phase for their potential roles in cloud chemistry, formation of secondary organic aerosols, and fate of atmospheric organics. Temperature-dependent Henry's law constants, key parameters in the atmospheric models to account for mass transfer, are often unavailable. In the present work, we investigated gas−liquid equilibriums of isoprene, limonene, α-pinene, and linalool using a bubble column technique. These compounds, originating from biogenic sources, were selected for their implications in atmospheric cloud chemistry and secondary organic aerosol formation. We reported Henry's law constants (K H), first order loss rates (k), and gas phase diffusion coefficients over a range of temperatures relevant to the lower atmosphere (278−298 K) for the first time. The measurement results of K H values for isoprene, limonene, α-pinene, and linalool at 298 K were 0.
Poultry Science, Aug 1, 2000
Skeletal muscle development is, in part, regulated by myoblast-extracellular matrix interactions ... more Skeletal muscle development is, in part, regulated by myoblast-extracellular matrix interactions mediated by the transmembrane integrin family of heterodimeric receptors. The avian genetic muscle weakness, low score normal (LSN), exhibits modified myotube and sarcomere structure that may be associated with altered integrin expression. Protein expression of the β1 integrin subunit was measured during normal and LSN Pectoralis major muscle development at 14, 16, and 18 d of embryonic development, and 1 d and 1 and 6 wk posthatch. During embryonic development, integrin expression was downregulated. However, by 1 wk posthatch, integrin levels were upregulated and remained elevated through
PubMed, May 5, 2005
One way to combat or treat breast cancer, the most common cancer among women, is to decrease or p... more One way to combat or treat breast cancer, the most common cancer among women, is to decrease or prevent proliferation of cancerous cells. Many animal species of agricultural importance have been selected for various growth traits, typically through altered proliferative capacity of some cell types. Previous studies in two lines of cattle divergently selected for serum IGF-I concentration have shown that low IGF-I cattle had increased growth rates and high IGF-I cattle had decreased growth rates. Serum from either the high or low IGF-I lines of cattle were administered to MCF-7 breast cancer cell lines and doubling times were determined. The MCF-7 cells treated with serum from cattle with high serum IGF-I concentrations took 26% longer to double than MCF-7 cells treated with serum from cattle with low serum IGF-I concentrations. In conclusion, model systems employing agricultural animals may provide novel insight into mechanisms of cell proliferation.
Ciencia Y Tecnologia Alimentaria, 1998
Resumen en: Fish muscle protein presents unique properties such as reduced frozen storage stabili... more Resumen en: Fish muscle protein presents unique properties such as reduced frozen storage stability and setting phenomena. Both two are associated with myosin inter...
PubMed, 1994
This manuscript describes the chicken sarcomeric myosin heavy chain (MyHC) multigene family and h... more This manuscript describes the chicken sarcomeric myosin heavy chain (MyHC) multigene family and how it differs from the sarcomeric MyHC multigene families of other vertebrates. Data is discussed that suggests the chicken fast MyHC multigene family has undergone recent expansion subsequent to the divergence of avians and mammals, and has been subjected to multiple gene conversion-like events. Similar to human and rodent MyHC multigene families, the chicken multigene family contains sarcomeric MyHC genes that are differentially regulated in developing embryonic, fetal, and neonatal muscles. However, unlike mammalian genes, chicken fast MyHC genes expressed in developing muscles are also expressed in mature muscle fibers as well. The potential significance of conserved and divergent sequences with the MyHC rod domain of five fast chicken isoforms that have been cloned and sequenced is also discussed.
Translational animal science, Apr 1, 2020
De Gruyter eBooks, Dec 31, 1990
PubMed, Mar 14, 2007
Background: Experimental data at the molecular, cellular and organismal levels have implicated di... more Background: Experimental data at the molecular, cellular and organismal levels have implicated dietary components in cancer. Exposure to numerous growth factors, hormones and environmental agents, that can regulate signaling events, is involved in carcinogenesis. Research targets on gene-nutrient interactions may give useful information for the development of a novel diet-based intervention for the at-risk population. Materials and methods: To examine the proteomic effect of a low level dietary compound on potential breast cancer, primary human breast epithelial cells were isolated and cultured in media with or without zeranol, an anabolic, non-estrogenic growth promoter with estrogenic activity, used in beef cattle and naturally found in some fungus in grain. The cells then underwent proteomic analysis. Results: 2-D electrophoresis showed that protein disulfide isomerase (PDI) was up-regulated 5-fold in the breast epithelial cells exposed to zeranol. PDI has been shown to be up-regulated in a variety of cancerous tissues, although this is the first reported up-regulation of PDI in breast tissue. Conclusion: PDI may be a useful marker of dietary exposure to zeranol.
Poultry Science, Jul 1, 2013
Poultry Science, Nov 1, 2012
Poultry Science, Jul 1, 2009
Biochimica et biophysica acta (N), Aug 1, 1997
Poultry Science, May 1, 1999
Livestock Science, Jul 1, 2013
Journal of Muscle Foods, Jul 1, 2001
ABSTRACT
Cytotechnology, Feb 28, 2008
Scientific Reports, Mar 4, 2020
Rapid Communications in Mass Spectrometry, Nov 6, 2017
There have been growing interests in modeling studies to understand oxidation of volatile organic... more There have been growing interests in modeling studies to understand oxidation of volatile organic compounds in the gas phase and their mass transfer to the aqueous phase for their potential roles in cloud chemistry, formation of secondary organic aerosols, and fate of atmospheric organics. Temperature-dependent Henry's law constants, key parameters in the atmospheric models to account for mass transfer, are often unavailable. In the present work, we investigated gas−liquid equilibriums of isoprene, limonene, α-pinene, and linalool using a bubble column technique. These compounds, originating from biogenic sources, were selected for their implications in atmospheric cloud chemistry and secondary organic aerosol formation. We reported Henry's law constants (K H), first order loss rates (k), and gas phase diffusion coefficients over a range of temperatures relevant to the lower atmosphere (278−298 K) for the first time. The measurement results of K H values for isoprene, limonene, α-pinene, and linalool at 298 K were 0.