Maddalena Illario - Academia.edu (original) (raw)
Uploads
Papers by Maddalena Illario
International Journal of Integrated Care
Journal of Cardiovascular Medicine, Feb 1, 2018
Journal of Aging Research, 2016
Cellular Signalling, May 1, 2009
Practical issues in geriatrics, 2023
Clinical and Translational Allergy, Oct 26, 2020
Journal of Alzheimer's Disease, Apr 23, 2019
Current Diabetes Reviews, Nov 18, 2015
International Journal of Environmental Research and Public Health, Nov 30, 2022
Annali di igiene : medicina preventiva e di comunita, 2021
BACKGROUND Demographic changes have forced communities and people themselves to reshape ageing co... more BACKGROUND Demographic changes have forced communities and people themselves to reshape ageing concepts and approaches and try to develop actions towards active and healthy ageing. In this context, the European Commission launched different private-public partnerships to develop new solutions and answers on questions related to this topic. The European Innovation Partnership on Active and Healthy Ageing, including topic related action groups as well reference sites committed towards a common action to facilitate active and healthy ageing, has contributed key elements for interventions, scaled up best practices and evaluated impact of their action to drive innovation across many regions in Europe over the past years. METHODS This paper describes action taken by A3 action group in the European Innovation Partnership on Active and Healthy Ageing. This paper gives an overview of how the partnership combined the view on frailty coming from public health as well as the clinical management...
Circulation, 2010
The molecular mechanism underlying Cardiac hypertrophy involves, among others, abnormal intracell... more The molecular mechanism underlying Cardiac hypertrophy involves, among others, abnormal intracellular Ca++ dynamics. Ca++/Calmodulin protein kinase II (CaMKII) activation mediates Ca++ signaling in the hypertrophic transduction pathways. Nevertheless, the mechanism by which CaMKII integrates with other pathways is incompletely understood. We showed that phenylephrine (PE) induces cell proliferation through CaMKII and ERK complex formation, promoting phosphorylation and nuclear localization of both proteins. We hypothesize that the association with ERK, promotes nuclear localization in hypertrophic cardiomyocytes. In H9C2 cardiomyoblasts, PE induces both ERK and CaMKII activation and interaction which can both be reduced by the non selective CaMKs inhibitor KN93, by the selective CaMKII inhibitor AntCaNtide, and by the MEK/ERK inhibitor UO126. Next, we found that PE induces a time-dependent accumulation of both ERK and CaMKII into the nucleus, prevented by AnTCaNtide and UO126 pretre...
Translational Medicine @ UniSa, 2019
The demographic projections on the European population predict that people aged over 60 will incr... more The demographic projections on the European population predict that people aged over 60 will increase by about two million/year in the next decades. Since 2012, the Campania Reference Site of the European Innovation Partnership on Active and Healthy Ageing supports the innovation of the Regional Health System, to face up demographic changes and sustainability. Campania Reference Site provides the opportunity to connect loco-regional stakeholders in social and health care services (universities, healthcare providers, social services, local communities and municipalities), with international organizations, in order to adopt and scale up innovative solutions and approaches. This paper describes the building process of Campania Reference Site and the main results achieved, that have been allowing it to become a hub for open innovation in the field of active and healthy aging at regional, national and international level.
Translational Medicine @ UniSa, 2019
Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing ... more Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, ...
Translational Medicine @ UniSa, 2017
Although there is evidence of a growing awareness of the problem, no official policy statements o... more Although there is evidence of a growing awareness of the problem, no official policy statements or regulatory guidelines on polypharmacy have been released up to date by Italian Health Authorities. Medication review, application of appropriateness criteria and computerized prescription support systems are all possible approaches in order to improve the quality of prescribing in older persons. More focused training courses on multimorbidity and polytherapy management are encouraged. Furthermore a multidisciplinary approach integrating different health care professionals (physicians, pharmacists, and nurses) may positively impact on reducing the sense of fear related to discontinue or substitute drugs prescribed by others; the fragmentation of therapy among different specialists; reducing costs; and improving adverse drug reaction detection and reporting. Aiming at achieving the individualized pharmacotherapy, a multidisciplinary approach starting with identification of patients and r...
Translational Medicine @ UniSa, 2021
International Journal of Integrated Care, 2020
Allergy, 2020
Large differences in COVID‐19 death rates exist between countries and between regions of the same... more Large differences in COVID‐19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS‐CoV‐2 binds to its receptor, the angiotensin‐converting enzyme 2 (ACE2). As a result of SARS‐CoV‐2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID‐19. The nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT1R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables co...
Allergy, 2020
BackgroundIn allergic rhinitis, a relevant outcome providing information on the effectiveness of ... more BackgroundIn allergic rhinitis, a relevant outcome providing information on the effectiveness of interventions is needed. In MASK‐air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for work is used as a relevant outcome. This study aimed to assess the performance of the work VAS work by comparing VAS work with other VAS measurements and symptom‐medication scores obtained concurrently.MethodsAll consecutive MASK‐air users in 23 countries from 1 June 2016 to 31 October 2018 were included (14 189 users; 205 904 days). Geolocalized users self‐assessed daily symptom control using the touchscreen functionality on their smart phone to click on VAS scores (ranging from 0 to 100) for overall symptoms (global), nose, eyes, asthma and work. Two symptom‐medication scores were used: the modified EAACI CSMS score and the MASK control score for rhinitis. To assess data quality, the intra‐individual response variability (IRV) index was calculated.ResultsA strong correlation was ob...
Clinical and translational allergy, 2016
The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health ... more The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support...
International Journal of Integrated Care
Journal of Cardiovascular Medicine, Feb 1, 2018
Journal of Aging Research, 2016
Cellular Signalling, May 1, 2009
Practical issues in geriatrics, 2023
Clinical and Translational Allergy, Oct 26, 2020
Journal of Alzheimer's Disease, Apr 23, 2019
Current Diabetes Reviews, Nov 18, 2015
International Journal of Environmental Research and Public Health, Nov 30, 2022
Annali di igiene : medicina preventiva e di comunita, 2021
BACKGROUND Demographic changes have forced communities and people themselves to reshape ageing co... more BACKGROUND Demographic changes have forced communities and people themselves to reshape ageing concepts and approaches and try to develop actions towards active and healthy ageing. In this context, the European Commission launched different private-public partnerships to develop new solutions and answers on questions related to this topic. The European Innovation Partnership on Active and Healthy Ageing, including topic related action groups as well reference sites committed towards a common action to facilitate active and healthy ageing, has contributed key elements for interventions, scaled up best practices and evaluated impact of their action to drive innovation across many regions in Europe over the past years. METHODS This paper describes action taken by A3 action group in the European Innovation Partnership on Active and Healthy Ageing. This paper gives an overview of how the partnership combined the view on frailty coming from public health as well as the clinical management...
Circulation, 2010
The molecular mechanism underlying Cardiac hypertrophy involves, among others, abnormal intracell... more The molecular mechanism underlying Cardiac hypertrophy involves, among others, abnormal intracellular Ca++ dynamics. Ca++/Calmodulin protein kinase II (CaMKII) activation mediates Ca++ signaling in the hypertrophic transduction pathways. Nevertheless, the mechanism by which CaMKII integrates with other pathways is incompletely understood. We showed that phenylephrine (PE) induces cell proliferation through CaMKII and ERK complex formation, promoting phosphorylation and nuclear localization of both proteins. We hypothesize that the association with ERK, promotes nuclear localization in hypertrophic cardiomyocytes. In H9C2 cardiomyoblasts, PE induces both ERK and CaMKII activation and interaction which can both be reduced by the non selective CaMKs inhibitor KN93, by the selective CaMKII inhibitor AntCaNtide, and by the MEK/ERK inhibitor UO126. Next, we found that PE induces a time-dependent accumulation of both ERK and CaMKII into the nucleus, prevented by AnTCaNtide and UO126 pretre...
Translational Medicine @ UniSa, 2019
The demographic projections on the European population predict that people aged over 60 will incr... more The demographic projections on the European population predict that people aged over 60 will increase by about two million/year in the next decades. Since 2012, the Campania Reference Site of the European Innovation Partnership on Active and Healthy Ageing supports the innovation of the Regional Health System, to face up demographic changes and sustainability. Campania Reference Site provides the opportunity to connect loco-regional stakeholders in social and health care services (universities, healthcare providers, social services, local communities and municipalities), with international organizations, in order to adopt and scale up innovative solutions and approaches. This paper describes the building process of Campania Reference Site and the main results achieved, that have been allowing it to become a hub for open innovation in the field of active and healthy aging at regional, national and international level.
Translational Medicine @ UniSa, 2019
Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing ... more Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, ...
Translational Medicine @ UniSa, 2017
Although there is evidence of a growing awareness of the problem, no official policy statements o... more Although there is evidence of a growing awareness of the problem, no official policy statements or regulatory guidelines on polypharmacy have been released up to date by Italian Health Authorities. Medication review, application of appropriateness criteria and computerized prescription support systems are all possible approaches in order to improve the quality of prescribing in older persons. More focused training courses on multimorbidity and polytherapy management are encouraged. Furthermore a multidisciplinary approach integrating different health care professionals (physicians, pharmacists, and nurses) may positively impact on reducing the sense of fear related to discontinue or substitute drugs prescribed by others; the fragmentation of therapy among different specialists; reducing costs; and improving adverse drug reaction detection and reporting. Aiming at achieving the individualized pharmacotherapy, a multidisciplinary approach starting with identification of patients and r...
Translational Medicine @ UniSa, 2021
International Journal of Integrated Care, 2020
Allergy, 2020
Large differences in COVID‐19 death rates exist between countries and between regions of the same... more Large differences in COVID‐19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS‐CoV‐2 binds to its receptor, the angiotensin‐converting enzyme 2 (ACE2). As a result of SARS‐CoV‐2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID‐19. The nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT1R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables co...
Allergy, 2020
BackgroundIn allergic rhinitis, a relevant outcome providing information on the effectiveness of ... more BackgroundIn allergic rhinitis, a relevant outcome providing information on the effectiveness of interventions is needed. In MASK‐air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for work is used as a relevant outcome. This study aimed to assess the performance of the work VAS work by comparing VAS work with other VAS measurements and symptom‐medication scores obtained concurrently.MethodsAll consecutive MASK‐air users in 23 countries from 1 June 2016 to 31 October 2018 were included (14 189 users; 205 904 days). Geolocalized users self‐assessed daily symptom control using the touchscreen functionality on their smart phone to click on VAS scores (ranging from 0 to 100) for overall symptoms (global), nose, eyes, asthma and work. Two symptom‐medication scores were used: the modified EAACI CSMS score and the MASK control score for rhinitis. To assess data quality, the intra‐individual response variability (IRV) index was calculated.ResultsA strong correlation was ob...
Clinical and translational allergy, 2016
The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health ... more The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support...