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Papers by Madhavi Kasturi

Research paper thumbnail of Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs

IntechOpen eBooks, Nov 15, 2022

Solubility plays a key role to achieve desired concentration of drug in systemic circulation and ... more Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of poorly aqueous soluble drugs. Initially, liquid medication (liquid drug or drug solution or suspension in hydrophilic liquid vehicle) is transformed to free-flowing, non-sticky, compressible powder by the addition of suitable carrier material and coating materials for the development of liquisolid compacts. The postulated mechanism for enhanced solubility was improved wettability of drug and enhanced surface area of molecularly dispersed drug in the liquid environment. Pre-and post-the compression tests were performed for the developed liquisolid compacts to obtain optimized formulation. For the optimized compacts, FTIR and DSC studies were performed for determining drug-excipient compatibility; SEM and PXRD studies were performed to study the solid-state characterization. Furthermore, accelerated stability studies were performed for optimized liquisolid compacts for 6 months according to ICH guidelines and the results were compared with freshly prepared formulations. In conclusion, liquisolid compact formulation was proved to be safe, economic and alternative approach to formulate solid oral dosage forms of poorly aqueous soluble drugs.

Research paper thumbnail of Development and Characterization of Ramipril Loaded Solid self Nanoemulsifying Drug Delivery System SNEDDS for Improved Oral Delivery of Lipophilic Drugs

SNEDDS are lipid based liquid formulations which are defined as self nanoemulsifying drug deliver... more SNEDDS are lipid based liquid formulations which are defined as self nanoemulsifying drug delivery systems (SNEDDS) that offer potential vehicle for improved oral delivery of poorly water soluble and low bioavailable drugs. The primary goal of the present work was to formulate solid SNEDDS (SSNEDDS) in order to improve the solubility of highly lipophilic drug Ramipril. The main intention behind choosing SNEDDS formulation for Ramipril was that lipid based formulations enhance solubility of lipophilic drugs and as a result dissolution rate and absorption may be further enhanced. SNEDDS are generally liquid form preparations obtained by homogenously mixing drug along with oils, surfactants and co-surfactants using cyclomixer. After screening various vehicles for solubility studies, Capmul MCM C8, Gelucire 50/13 and Transcutol P were selected as oil, surfactant and co-surfactant respectively in order to prepare ramipril loaded SNEDDS. Nine different liquid SNEDDS (L-SNEDDS) formulation...

Research paper thumbnail of Novel co-processed superdisintegrants in the development of fast dissolving tablet of venlafaxine hydrochloride

Journal of Pharmacy Research, 2018

Research paper thumbnail of Enhancement of Aqueous Solubility of Etoposide Using Solid Dispersion Technique

Objective: The objective of present research work was to enhance the aqueous solubility of Etopos... more Objective: The objective of present research work was to enhance the aqueous solubility of Etoposide using solid dispersion technique. Methods: Formulation of solid dispersion by using different polymers and their different ratio with the used of solid dispersion technique. Solid dispersion formulation F-1 to F-9 were prepared by using different type and different concentration of polymers like PEG-6000, PEG-4000 poloxomer 407 and ethanol respectively. Results: The solid dispersion formulation were within the acceptable limits and drug release rates of all prepared solid dispersion formulations were distinctly higher as compared to pure drug. F3 formulation shows higher solubility than other formulations. All the Preformulation parameters were evaluated such as organoleptic characterization of drug sample, melting point, pH, and identification of drug samples by using UV spectroscopy and FTIR analytical method, preparation of calibration curves, solubility studies of drug sample b...

Research paper thumbnail of Liquisolid Technique as a Promising Tool to Enhance Solubility and Dissolution of Poorly Water Soluble Drug Valsartan

Journal of Drug Delivery and Therapeutics, 2017

“Liquisolid Technique” considered as new technique to enhance solubility and dissolution rate... more “Liquisolid Technique” considered as new technique to enhance solubility and dissolution rate of poorly water soluble drugs. These formulations are prepared by mixing drug in liquid state (solution, suspension or emulsion using non-volatile solvent) with carrier and coating material to form dry, free-flowing, readily compressible powder. In the current research work liquisolid technique is employed to enhance solubility and dissolution of antihypertensive drug Valsartan, which is poorly water soluble (0.021mg/ml) possessing very low bioavailability of 23%. Liquisolid formulation VLS9, containing Tween 80 (non-volatile solvent), Avicel PH102 (carrier) and Aerosil 200 (coating material) showed better flow properties and high in-vitro dissolution profile.

Research paper thumbnail of Formulation and Evaluation of Liquisolid Compacts of BCS Class II Drug Ketoprofen

Journal of Pharmaceutical Research International

Aims: The main objective of the current research work is to develop liquisolid compacts of BCS Cl... more Aims: The main objective of the current research work is to develop liquisolid compacts of BCS Class II drug ketoprofen with an intention to enhance the solubility of drug by applying liquisolid technique. Place and Duration of Study: Smriti College of Pharmaceutical Education between June 2018 June 2019. Methodology: Initially liquid medication was obtained by dissolving drug in suitable solvent. Saturation solubility studies were performed in various hydrophilic non-volatile solvents to select the solvent showing highest solubility for drug. This liquid medication was admixed with calculated amounts of carrier material (Avicel PH 102) and coating material (Cab-O-Sil) using Spireas mathematical model in order to obtain liquisolid formulations. Further, this powder mass of liquisolid system was compressed to form Ketoprofen liquisolid compact formulations ranging from TK1 to TK9. They were further subjected to post compression evaluation tests such as weight variation, hardness, fri...

Research paper thumbnail of Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs

IntechOpen eBooks, Nov 15, 2022

Solubility plays a key role to achieve desired concentration of drug in systemic circulation and ... more Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of poorly aqueous soluble drugs. Initially, liquid medication (liquid drug or drug solution or suspension in hydrophilic liquid vehicle) is transformed to free-flowing, non-sticky, compressible powder by the addition of suitable carrier material and coating materials for the development of liquisolid compacts. The postulated mechanism for enhanced solubility was improved wettability of drug and enhanced surface area of molecularly dispersed drug in the liquid environment. Pre-and post-the compression tests were performed for the developed liquisolid compacts to obtain optimized formulation. For the optimized compacts, FTIR and DSC studies were performed for determining drug-excipient compatibility; SEM and PXRD studies were performed to study the solid-state characterization. Furthermore, accelerated stability studies were performed for optimized liquisolid compacts for 6 months according to ICH guidelines and the results were compared with freshly prepared formulations. In conclusion, liquisolid compact formulation was proved to be safe, economic and alternative approach to formulate solid oral dosage forms of poorly aqueous soluble drugs.

Research paper thumbnail of Development and Characterization of Ramipril Loaded Solid self Nanoemulsifying Drug Delivery System SNEDDS for Improved Oral Delivery of Lipophilic Drugs

SNEDDS are lipid based liquid formulations which are defined as self nanoemulsifying drug deliver... more SNEDDS are lipid based liquid formulations which are defined as self nanoemulsifying drug delivery systems (SNEDDS) that offer potential vehicle for improved oral delivery of poorly water soluble and low bioavailable drugs. The primary goal of the present work was to formulate solid SNEDDS (SSNEDDS) in order to improve the solubility of highly lipophilic drug Ramipril. The main intention behind choosing SNEDDS formulation for Ramipril was that lipid based formulations enhance solubility of lipophilic drugs and as a result dissolution rate and absorption may be further enhanced. SNEDDS are generally liquid form preparations obtained by homogenously mixing drug along with oils, surfactants and co-surfactants using cyclomixer. After screening various vehicles for solubility studies, Capmul MCM C8, Gelucire 50/13 and Transcutol P were selected as oil, surfactant and co-surfactant respectively in order to prepare ramipril loaded SNEDDS. Nine different liquid SNEDDS (L-SNEDDS) formulation...

Research paper thumbnail of Novel co-processed superdisintegrants in the development of fast dissolving tablet of venlafaxine hydrochloride

Journal of Pharmacy Research, 2018

Research paper thumbnail of Enhancement of Aqueous Solubility of Etoposide Using Solid Dispersion Technique

Objective: The objective of present research work was to enhance the aqueous solubility of Etopos... more Objective: The objective of present research work was to enhance the aqueous solubility of Etoposide using solid dispersion technique. Methods: Formulation of solid dispersion by using different polymers and their different ratio with the used of solid dispersion technique. Solid dispersion formulation F-1 to F-9 were prepared by using different type and different concentration of polymers like PEG-6000, PEG-4000 poloxomer 407 and ethanol respectively. Results: The solid dispersion formulation were within the acceptable limits and drug release rates of all prepared solid dispersion formulations were distinctly higher as compared to pure drug. F3 formulation shows higher solubility than other formulations. All the Preformulation parameters were evaluated such as organoleptic characterization of drug sample, melting point, pH, and identification of drug samples by using UV spectroscopy and FTIR analytical method, preparation of calibration curves, solubility studies of drug sample b...

Research paper thumbnail of Liquisolid Technique as a Promising Tool to Enhance Solubility and Dissolution of Poorly Water Soluble Drug Valsartan

Journal of Drug Delivery and Therapeutics, 2017

“Liquisolid Technique” considered as new technique to enhance solubility and dissolution rate... more “Liquisolid Technique” considered as new technique to enhance solubility and dissolution rate of poorly water soluble drugs. These formulations are prepared by mixing drug in liquid state (solution, suspension or emulsion using non-volatile solvent) with carrier and coating material to form dry, free-flowing, readily compressible powder. In the current research work liquisolid technique is employed to enhance solubility and dissolution of antihypertensive drug Valsartan, which is poorly water soluble (0.021mg/ml) possessing very low bioavailability of 23%. Liquisolid formulation VLS9, containing Tween 80 (non-volatile solvent), Avicel PH102 (carrier) and Aerosil 200 (coating material) showed better flow properties and high in-vitro dissolution profile.

Research paper thumbnail of Formulation and Evaluation of Liquisolid Compacts of BCS Class II Drug Ketoprofen

Journal of Pharmaceutical Research International

Aims: The main objective of the current research work is to develop liquisolid compacts of BCS Cl... more Aims: The main objective of the current research work is to develop liquisolid compacts of BCS Class II drug ketoprofen with an intention to enhance the solubility of drug by applying liquisolid technique. Place and Duration of Study: Smriti College of Pharmaceutical Education between June 2018 June 2019. Methodology: Initially liquid medication was obtained by dissolving drug in suitable solvent. Saturation solubility studies were performed in various hydrophilic non-volatile solvents to select the solvent showing highest solubility for drug. This liquid medication was admixed with calculated amounts of carrier material (Avicel PH 102) and coating material (Cab-O-Sil) using Spireas mathematical model in order to obtain liquisolid formulations. Further, this powder mass of liquisolid system was compressed to form Ketoprofen liquisolid compact formulations ranging from TK1 to TK9. They were further subjected to post compression evaluation tests such as weight variation, hardness, fri...