Madhusudan Reddy - Academia.edu (original) (raw)

Papers by Madhusudan Reddy

Research paper thumbnail of Effect of Atropine Premedication on Cardiac Autonomic Function During Electroconvulsive Therapy: A Randomized Crossover Study

The journal of ECT, Jan 2, 2017

Electroconvulsive therapy (ECT) results in significant cardiovascular changes. The acute cardiac ... more Electroconvulsive therapy (ECT) results in significant cardiovascular changes. The acute cardiac autonomic changes during ECT remain unexplored. The primary objective of this study was to compare autonomic dysfunction with and without atropine premedication during ECT and secondarily to evaluate dysautonomia across psychiatric diagnoses before and after ECT. In this crossover study, 41 psychiatric patients were monitored during 82 ECT sessions. Patients were randomized either to receive atropine or not to receive atropine during their second ECT session and were crossed over during their third session. Heart rate, blood pressure, and oxygen saturation were continuously monitored from stimulus application until 300 seconds after ECT. Demographic characteristics and ANSiscope indices derived pre- and post-ECT were collected. Autonomic dysfunction (%) before ECT was similar between atropine and no-atropine sessions (32.4 ± 15.7 vs 32.8 ± 16.7; 95% confidence interval, -7.6 to 6.7; P = ...

Research paper thumbnail of Comparative study of fiberoptic guided versus intubating laryngeal mask airway assisted awake orotracheal intubation in patients with unstable cervical spine: a randomized controlled trial

Minerva anestesiologica, Jan 20, 2017

A safe airway technique minimizes intubation-associated cervical-spine movement and consequent ne... more A safe airway technique minimizes intubation-associated cervical-spine movement and consequent neurological injury in patients with unstable cervical spine (UCS). Awake fiberoptic-guided intubation (FGI) is preferred in patients with UCS. Alternatively, intubating laryngeal mask airway assisted intubation (ILMA-AI) can be performed both during elective and emergency, requires less expertise and is cost-effective. This study evaluated cervical-spine movement during FGI and ILMA-AI in patients with UCS. This was a parallel-group randomized controlled trial performed at a tertiary neurosciences hospital. Thirty-two patients with UCS scheduled for corrective surgery were allocated equally to receive FGI or ILMA-AI according to centralized computer-generated randomization. Primary outcome measure was cervical-spine movement as assessed using fluoroscopy at C1/2 level during intubation. Secondary outcomes were movement at C2/3 and new-onset motor deficit after intubation. All the sixteen ...

Research paper thumbnail of Synthesis of titanium containing silica ZSM-48 (TS-48) using hexamethonium hydroxide as template

Catalysis Lett, 1994

Titanium containing silica analog of ZSM-48 (TS-48) has been synthesized by a new method using he... more Titanium containing silica analog of ZSM-48 (TS-48) has been synthesized by a new method using hexamethonium hydroxide as a template. Titanium incorporation in the framework was evidenced from unit cell volume expansion, framework IR spectra and diffuse reflectance UV-Vis spectra.

Research paper thumbnail of Biodegradation of 2-picoline by immobilized cells of Bacillus cereus GMHS

Bioinfolet a Quarterly Journal of Life Sciences, 2009

Research paper thumbnail of Use of Dexmedetomidine Along With Local Infiltration Versus General Anesthesia for Burr Hole and Evacuation of Chronic Subdural Hematoma (CSDH)

Journal of Neurosurgical Anesthesiology, 2016

In neurosurgery, chronic subdural hematoma (CSDH) is a very common clinical entity. Both general ... more In neurosurgery, chronic subdural hematoma (CSDH) is a very common clinical entity. Both general anesthesia (GA) and local anesthesia with or without sedation are used for the surgical treatment of CSDH. Sedation with dexmedetomidine has been safely used for various diagnostic and therapeutic procedures. However, its effectiveness against GA has not been evaluated for surgical treatment of CSDH. We tried to compare dexmedetomidine sedation technique with the GA technique for surgical treatment of CSDH. In this prospective-randomized study, 76 patients undergoing surgery for CSDH were divided into 2 groups using computer-generated randomized tables; Dex group ([n=38]; received IV bolus of dexmedetomidine 1 mcg/kg over 10 min followed by maintenance infusion 0.5 mcg/kg/h) and GA group ([n=38; of which 4 patients were dropped out]; received endotracheal intubation with balanced anesthesia). Both anesthesia techniques (Dex group; n=35/38 [92.1%] and GA group; n=34/34 [100%]) were successfully used for surgical treatment of CSDH. Significantly less time for anesthesia onset (14.2±4.2 vs. 20.5±3.4 min, P=0.001), total duration of surgery (77.1±23.9 vs. 102.7± 24.8 min, P=0.001), and recovery from anesthesia (7.4±5.9 vs. 13.2±6.5 min, P=0.004) was observed in the Dex group compared with GA group. Perioperative hemodynamic fluctuations were more common in the GA group as against the Dex group. Postoperative complications (n=2 vs. 9, P=0.021) and length of hospital stay (1.05±0.23 vs. 1.79±2.1 d, P=0.007) were significantly less in the Dex group as against the GA group. Dexmedetomidine sedation with local anesthesia is a safe and effective technique for burr hole and evacuation of CSDH. It is associated with significantly shorter operative time, lesser hemodynamic fluctuations, postoperative complications, and length of hospital stay, thus it is a better alternative to GA.

Research paper thumbnail of ChemInform Abstract: VS-12: A Novel Large-Pore Vanadium Silicate with ZSM-12 Structure

Research paper thumbnail of Investigation of brazing of Ba(Zn0.33Ta0.67)O3 ceramic with Ti6Al4V alloy

Ceramics International, 2016

Research paper thumbnail of Bandgap studies on anatase titanium dioxide nanoparticles

Materials Chemistry and Physics, Feb 1, 2003

Titanium dioxide, predominantly in the anatase phase with an average grain size of 5-10 nm, has b... more Titanium dioxide, predominantly in the anatase phase with an average grain size of 5-10 nm, has been synthesized by the hydrazine method. These nanocrystalline particles show a blue shift in the absorption edge of the diffuse reflectance ultraviolet spectrum of about 10 nm compared to that of commercially available titania. Synthesized samples were characterized by X-ray diffraction and transmission electron microscopy for their structural properties and UV-Vis absorption spectroscopy for the bandgap studies. The absorption spectra show a linear fit for the direct transition. The optical and electrical properties of the samples have been studied and the Arrhenius plots of electrical conductivity both for the as-prepared anatase TiO 2 and the one subsequently reduced in hydrogen atmosphere at 673 K show a distinct difference in the activation energy. The hydrogen-annealed sample shows a typical semiconducting behavior whereas the as-prepared sample indicates a phonon contribution to the conductivity around 300 K.

Research paper thumbnail of Undetected iliac artery injury presenting as acute intraoperative hypotension during lumbar disc surgery

DOAJ is hosted by Lund University, Sweden DOAJ acknowledges support from INASP DOAJ acknowledges ... more DOAJ is hosted by Lund University, Sweden DOAJ acknowledges support from INASP DOAJ acknowledges support from the National Library of Sweden DOAJ acknowledges support from Swedish Library Association Sponsor of Long Term Archiving DOAJ ...

Research paper thumbnail of Anesthetic factors and outcome in children undergoing indirect revascularization procedure for moyamoya disease: An Indian perspective

Neurology India, 2015

Moya Moya disease (MMD) is one of the most common cerebro-vascular diseases in children resulting... more Moya Moya disease (MMD) is one of the most common cerebro-vascular diseases in children resulting in stroke. Surgical revascularization aims at improving the perfusion to the 'at-risk' ischemic brain. Several factors including peri-operative anesthetic related ones, affect the outcome in these children. This study was performed with the aim to explore the role of anesthetic techniques, pharmacological agents and perioperative management strategies on the neurological outcome following an indirect revascularization procedure for the treatment of MMD. This was a retrospective chart review of pediatric indirect revascularization procedures for MMD during a three year period at a tertiary neurosciences hospital in southern India. Demographic details, disease characteristics and variables related to anesthetic management were obtained from the patient's charts and analyzed. The main outcome measure was occurrence of postoperative new neurological complications; and, the secondary outcome was length of hospital stay after surgery. Twenty-two children underwent thirty indirect revascularization procedures, of which four patients had new postoperative neurological complications. One child died due to bilateral cerebral infarcts following bilateral surgery as a single stage under the same anesthesia. Female gender and a higher opioid dose were associated with occurrence of postoperative neurological deficits. Younger age, prolonged anesthetic duration and occurrence of postoperative neurological deficits were associated with prolonged postoperative hospital stay. However, none of these factors were predictive of either an adverse neurological outcome or a prolonged hospital stay. In this study, anesthetic techniques or medications did not influence the occurrence of postoperative neurological deficits or prolonged hospital stay after an indirect revascularization procedure in children with MMD.

Research paper thumbnail of INGIT: Limited Domain Formulaic Translation from Hindi Strings to Indian Sign Language

We report a cross-modal translation system from Hindi strings to Indian Sign Language (ISL) for p... more We report a cross-modal translation system from Hindi strings to Indian Sign Language (ISL) for possible use in the Indian Railways reservation counters. INGIT adopts a semantically mediated formulaic framework for Hindi-ISL mapping. An in-depth investigation into the structure of ISL forms the groundwork for INGIT. Some representational and mapping issues concerning cross-modal translation are identified and an implementation design is evolved. We adopt the Construction Grammar approach for handling formulaic inputs in terms of a construction lexicon with single constituents as well as larger phrases, with direct semantic mappings at each level. We present results based on a small corpus collected at a railway counter, for which translations were validated from native ISL signers. The work builds upon a semantic module worked out for Hindi and ISL.

Research paper thumbnail of Effect of Al Sources on the Synthesis and Acidic Characteristics of Mesoporous Aluminosilicates of MCM-41 Type

Studies in Surface Science and Catalysis, 1998

... Synthesis and Acidic Characteristics of Mesoporous Aluminosilicates of MCM-41 Type Ill Kondam... more ... Synthesis and Acidic Characteristics of Mesoporous Aluminosilicates of MCM-41 Type Ill KondamMadhusudan Reddy and Chunshan ... Others 7.73 7.07 0.37 6.28 7.25 0.18 3.76 10.69 a) Alumina (S-2); b) H-Mordenite (CBV20A); c) HY (LZ-Y62) A 97 97 .m ,mJ ~: 95 ...

Research paper thumbnail of In reply: is dexmedetomidine really superior to propofol?

Journal of Anesthesia, 2015

and endpoints, data on control and treatment groups provide fair information for estimating sampl... more and endpoints, data on control and treatment groups provide fair information for estimating sample size. It is better to perform sample size calculations for different outcome parameters and choose the largest sample size. We agree that sedation for diagnostic angiography needs to be evaluated further in patients of different grades of SAH.

Research paper thumbnail of Unusual manifestation of blood transfusion reaction as diffuse operative site oozing, hypotension and brain swelling

Journal of anaesthesiology, clinical pharmacology, 2011

Research paper thumbnail of A comparative study of dexmedetomidine and propofol as sole sedative agents for patients with aneurysmal subarachnoid hemorrhage undergoing diagnostic cerebral angiography

Journal of Anesthesia, 2014

Subarachnoid hemorrhage is an acute neurological emergency requiring urgent confirmation of the d... more Subarachnoid hemorrhage is an acute neurological emergency requiring urgent confirmation of the diagnosis for planning definitive management. Due to altered consciousness, most patients require sedation for conducting this procedure smoothly. Currently, it is unclear if any one particular sedative drug has a favorable profile in patients undergoing cerebral angiography. The aim of this study was to compare the traditionally used sedative drug propofol with a newer alternative, dexmedetomidine, in patients with subarachnoid hemorrhage undergoing cerebral angiography. Sixty adult patients with good grade subarachnoid hemorrhage undergoing diagnostic cerebral angiography were prospectively randomized to receive either propofol (n = 30) or dexmedetomidine (n = 30) following ethics committee approval and informed consent. Compared to dexmadetomidine, propofol was associated with an earlier time for onset of sedation (2.3 ± 1.9 min vs. 15.4 ± 5.7 min; P < 0.001), but with an increased number of adverse respiratory events (11/30 vs 1/30; P = 0.003) and movement during the procedure (5/30 vs. 0/30; P = 0.05), necessitating additional supplementation of sedation (13/30 vs. 7/30; P = 0.17) and repetition of the imaging sequences. The total procedure time and time for recovery were similar for the propofol and dexmedetomidine groups, while the heart rate was lower in patients in the dexmedetomidine group. Dexmedetomidine appears to be superior to propofol as a sole sedative agent for sedation during cerebral angiography in patients with subarachnoid hemorrhage.

Research paper thumbnail of Successful anesthetic management for microsurgical excision of ruptured cerebellar arteriovenous malformation with trapped endovascular microcatheter

Journal of Anaesthesiology Clinical Pharmacology, 2014

Microsurgical excision and good anesthetic management of arteriovenous malformation (AVM) that ru... more Microsurgical excision and good anesthetic management of arteriovenous malformation (AVM) that ruptures during endovascular embolization can ensure good outcome despite per-procedural catastrophe. This case report illustrates the successful anesthetic management of microsurgical excision of ruptured AVM with entrapped microcatheter and highlights the role of the anesthesiologist in careful monitoring of the patient's hemodynamic status and communicating any changes to the radiology team to facilitate check angiography to diagnose the intracranial complication. This case highlights the need for anticipating and defining a catastrophe plan in advance of each interventional neuroradiology procedure as complications are rapid and require good multidisciplinary communication to ensure safe and successful outcomes.

Research paper thumbnail of Dexmedetomidine anesthesia enhances spike generation during intra-operative electrocorticography: A promising adjunct for epilepsy surgery

Epilepsy Research, 2015

Anesthetic-induced suppression of cortical electrical activity is a major concern during epilepsy... more Anesthetic-induced suppression of cortical electrical activity is a major concern during epilepsy surgery. Dexmedetomidine (Dex) has been recently evaluated in a few small series for its effect on the electrocorticographic spikes intra-operatively. In this prospective study, electrocorticogram (ECoG) was monitored during dexmedetomidine infusion in 34 patients (M:F=23:11, age=29.2 ± 10.9 years; duration of epilepsy=15.3 ± 8.9 years) undergoing anterior temporal lobe resection with amygdalo-hippocampectomy for drug-resistant mesial temporal lobe epilepsy (Right: 18, Left: 16). Anesthesia was induced with thiopental/propofol and maintained with oxygen-N2O-isoflurane. ECoG was recorded for 5 min after the end tidal MAC of N2O and isoflurane were decreased to zero; anesthesia was maintained with O2:Air=50:50, vecuronium and fentanyl. ECoG was recorded using a 4-contact strip electrode for: (a) 5 min prior to dexmedetomidine (PreDEX), (b) 5 min during dexmedetomidine infusion (DEX; 1 μg/kg) and (c) 5 min after stopping dexmedetomidine (PostDEX). The ECoG spikes were manually counted in all the channels. The mean spike rate in the 2 channels with maximum spikes (MAX CH A and MAX CH B) was normalized to a 3-min duration. RM-ANOVA and post hoc comparison of three phases were used to compare the spike rates. The mean spike rate during Dex phase was higher compared to preDEX (MAX CH B: p=0.007 and MAX CH A: p=0.079) and PostDEX (MAX CH B: p=0.17, MAX CH A: p=0.79) phases. The spike rate increased in 67.6% patients, while 11.8% patients showed ≤ 25% reduction and 20.6% patients showed >25% reduction in spike frequency. Dexmedetomidine is useful during intra-operative ECoG recording in epilepsy surgery as it enhances or does not alter spike rate in most of the cases, without any major adverse effects.

Research paper thumbnail of Synthesis of nanocrystalline Ni1−xCoxMnxFe2−xO4: a material for liquefied petroleum gas sensing

Sensors and Actuators B: Chemical, 2003

... L. Satyanarayana a , K. Madhusudan Reddy b and Sunkara V. Manorama Corresponding Author Conta... more ... L. Satyanarayana a , K. Madhusudan Reddy b and Sunkara V. Manorama Corresponding Author Contact Information , E-mail The Corresponding Author , b [Author vitae]. a NMR Group, Indian Institute of Chemical Technology, Hyderabad 500007, India. ...

Research paper thumbnail of Non-awakening from anesthesia following posterior fossa surgery due to skull pin-induced tension pneumocephalus

Research paper thumbnail of Massive cerebral air embolism during stent-assisted coiling of internal carotid artery aneurysm

Research paper thumbnail of Effect of Atropine Premedication on Cardiac Autonomic Function During Electroconvulsive Therapy: A Randomized Crossover Study

The journal of ECT, Jan 2, 2017

Electroconvulsive therapy (ECT) results in significant cardiovascular changes. The acute cardiac ... more Electroconvulsive therapy (ECT) results in significant cardiovascular changes. The acute cardiac autonomic changes during ECT remain unexplored. The primary objective of this study was to compare autonomic dysfunction with and without atropine premedication during ECT and secondarily to evaluate dysautonomia across psychiatric diagnoses before and after ECT. In this crossover study, 41 psychiatric patients were monitored during 82 ECT sessions. Patients were randomized either to receive atropine or not to receive atropine during their second ECT session and were crossed over during their third session. Heart rate, blood pressure, and oxygen saturation were continuously monitored from stimulus application until 300 seconds after ECT. Demographic characteristics and ANSiscope indices derived pre- and post-ECT were collected. Autonomic dysfunction (%) before ECT was similar between atropine and no-atropine sessions (32.4 ± 15.7 vs 32.8 ± 16.7; 95% confidence interval, -7.6 to 6.7; P = ...

Research paper thumbnail of Comparative study of fiberoptic guided versus intubating laryngeal mask airway assisted awake orotracheal intubation in patients with unstable cervical spine: a randomized controlled trial

Minerva anestesiologica, Jan 20, 2017

A safe airway technique minimizes intubation-associated cervical-spine movement and consequent ne... more A safe airway technique minimizes intubation-associated cervical-spine movement and consequent neurological injury in patients with unstable cervical spine (UCS). Awake fiberoptic-guided intubation (FGI) is preferred in patients with UCS. Alternatively, intubating laryngeal mask airway assisted intubation (ILMA-AI) can be performed both during elective and emergency, requires less expertise and is cost-effective. This study evaluated cervical-spine movement during FGI and ILMA-AI in patients with UCS. This was a parallel-group randomized controlled trial performed at a tertiary neurosciences hospital. Thirty-two patients with UCS scheduled for corrective surgery were allocated equally to receive FGI or ILMA-AI according to centralized computer-generated randomization. Primary outcome measure was cervical-spine movement as assessed using fluoroscopy at C1/2 level during intubation. Secondary outcomes were movement at C2/3 and new-onset motor deficit after intubation. All the sixteen ...

Research paper thumbnail of Synthesis of titanium containing silica ZSM-48 (TS-48) using hexamethonium hydroxide as template

Catalysis Lett, 1994

Titanium containing silica analog of ZSM-48 (TS-48) has been synthesized by a new method using he... more Titanium containing silica analog of ZSM-48 (TS-48) has been synthesized by a new method using hexamethonium hydroxide as a template. Titanium incorporation in the framework was evidenced from unit cell volume expansion, framework IR spectra and diffuse reflectance UV-Vis spectra.

Research paper thumbnail of Biodegradation of 2-picoline by immobilized cells of Bacillus cereus GMHS

Bioinfolet a Quarterly Journal of Life Sciences, 2009

Research paper thumbnail of Use of Dexmedetomidine Along With Local Infiltration Versus General Anesthesia for Burr Hole and Evacuation of Chronic Subdural Hematoma (CSDH)

Journal of Neurosurgical Anesthesiology, 2016

In neurosurgery, chronic subdural hematoma (CSDH) is a very common clinical entity. Both general ... more In neurosurgery, chronic subdural hematoma (CSDH) is a very common clinical entity. Both general anesthesia (GA) and local anesthesia with or without sedation are used for the surgical treatment of CSDH. Sedation with dexmedetomidine has been safely used for various diagnostic and therapeutic procedures. However, its effectiveness against GA has not been evaluated for surgical treatment of CSDH. We tried to compare dexmedetomidine sedation technique with the GA technique for surgical treatment of CSDH. In this prospective-randomized study, 76 patients undergoing surgery for CSDH were divided into 2 groups using computer-generated randomized tables; Dex group ([n=38]; received IV bolus of dexmedetomidine 1 mcg/kg over 10 min followed by maintenance infusion 0.5 mcg/kg/h) and GA group ([n=38; of which 4 patients were dropped out]; received endotracheal intubation with balanced anesthesia). Both anesthesia techniques (Dex group; n=35/38 [92.1%] and GA group; n=34/34 [100%]) were successfully used for surgical treatment of CSDH. Significantly less time for anesthesia onset (14.2±4.2 vs. 20.5±3.4 min, P=0.001), total duration of surgery (77.1±23.9 vs. 102.7± 24.8 min, P=0.001), and recovery from anesthesia (7.4±5.9 vs. 13.2±6.5 min, P=0.004) was observed in the Dex group compared with GA group. Perioperative hemodynamic fluctuations were more common in the GA group as against the Dex group. Postoperative complications (n=2 vs. 9, P=0.021) and length of hospital stay (1.05±0.23 vs. 1.79±2.1 d, P=0.007) were significantly less in the Dex group as against the GA group. Dexmedetomidine sedation with local anesthesia is a safe and effective technique for burr hole and evacuation of CSDH. It is associated with significantly shorter operative time, lesser hemodynamic fluctuations, postoperative complications, and length of hospital stay, thus it is a better alternative to GA.

Research paper thumbnail of ChemInform Abstract: VS-12: A Novel Large-Pore Vanadium Silicate with ZSM-12 Structure

Research paper thumbnail of Investigation of brazing of Ba(Zn0.33Ta0.67)O3 ceramic with Ti6Al4V alloy

Ceramics International, 2016

Research paper thumbnail of Bandgap studies on anatase titanium dioxide nanoparticles

Materials Chemistry and Physics, Feb 1, 2003

Titanium dioxide, predominantly in the anatase phase with an average grain size of 5-10 nm, has b... more Titanium dioxide, predominantly in the anatase phase with an average grain size of 5-10 nm, has been synthesized by the hydrazine method. These nanocrystalline particles show a blue shift in the absorption edge of the diffuse reflectance ultraviolet spectrum of about 10 nm compared to that of commercially available titania. Synthesized samples were characterized by X-ray diffraction and transmission electron microscopy for their structural properties and UV-Vis absorption spectroscopy for the bandgap studies. The absorption spectra show a linear fit for the direct transition. The optical and electrical properties of the samples have been studied and the Arrhenius plots of electrical conductivity both for the as-prepared anatase TiO 2 and the one subsequently reduced in hydrogen atmosphere at 673 K show a distinct difference in the activation energy. The hydrogen-annealed sample shows a typical semiconducting behavior whereas the as-prepared sample indicates a phonon contribution to the conductivity around 300 K.

Research paper thumbnail of Undetected iliac artery injury presenting as acute intraoperative hypotension during lumbar disc surgery

DOAJ is hosted by Lund University, Sweden DOAJ acknowledges support from INASP DOAJ acknowledges ... more DOAJ is hosted by Lund University, Sweden DOAJ acknowledges support from INASP DOAJ acknowledges support from the National Library of Sweden DOAJ acknowledges support from Swedish Library Association Sponsor of Long Term Archiving DOAJ ...

Research paper thumbnail of Anesthetic factors and outcome in children undergoing indirect revascularization procedure for moyamoya disease: An Indian perspective

Neurology India, 2015

Moya Moya disease (MMD) is one of the most common cerebro-vascular diseases in children resulting... more Moya Moya disease (MMD) is one of the most common cerebro-vascular diseases in children resulting in stroke. Surgical revascularization aims at improving the perfusion to the 'at-risk' ischemic brain. Several factors including peri-operative anesthetic related ones, affect the outcome in these children. This study was performed with the aim to explore the role of anesthetic techniques, pharmacological agents and perioperative management strategies on the neurological outcome following an indirect revascularization procedure for the treatment of MMD. This was a retrospective chart review of pediatric indirect revascularization procedures for MMD during a three year period at a tertiary neurosciences hospital in southern India. Demographic details, disease characteristics and variables related to anesthetic management were obtained from the patient's charts and analyzed. The main outcome measure was occurrence of postoperative new neurological complications; and, the secondary outcome was length of hospital stay after surgery. Twenty-two children underwent thirty indirect revascularization procedures, of which four patients had new postoperative neurological complications. One child died due to bilateral cerebral infarcts following bilateral surgery as a single stage under the same anesthesia. Female gender and a higher opioid dose were associated with occurrence of postoperative neurological deficits. Younger age, prolonged anesthetic duration and occurrence of postoperative neurological deficits were associated with prolonged postoperative hospital stay. However, none of these factors were predictive of either an adverse neurological outcome or a prolonged hospital stay. In this study, anesthetic techniques or medications did not influence the occurrence of postoperative neurological deficits or prolonged hospital stay after an indirect revascularization procedure in children with MMD.

Research paper thumbnail of INGIT: Limited Domain Formulaic Translation from Hindi Strings to Indian Sign Language

We report a cross-modal translation system from Hindi strings to Indian Sign Language (ISL) for p... more We report a cross-modal translation system from Hindi strings to Indian Sign Language (ISL) for possible use in the Indian Railways reservation counters. INGIT adopts a semantically mediated formulaic framework for Hindi-ISL mapping. An in-depth investigation into the structure of ISL forms the groundwork for INGIT. Some representational and mapping issues concerning cross-modal translation are identified and an implementation design is evolved. We adopt the Construction Grammar approach for handling formulaic inputs in terms of a construction lexicon with single constituents as well as larger phrases, with direct semantic mappings at each level. We present results based on a small corpus collected at a railway counter, for which translations were validated from native ISL signers. The work builds upon a semantic module worked out for Hindi and ISL.

Research paper thumbnail of Effect of Al Sources on the Synthesis and Acidic Characteristics of Mesoporous Aluminosilicates of MCM-41 Type

Studies in Surface Science and Catalysis, 1998

... Synthesis and Acidic Characteristics of Mesoporous Aluminosilicates of MCM-41 Type Ill Kondam... more ... Synthesis and Acidic Characteristics of Mesoporous Aluminosilicates of MCM-41 Type Ill KondamMadhusudan Reddy and Chunshan ... Others 7.73 7.07 0.37 6.28 7.25 0.18 3.76 10.69 a) Alumina (S-2); b) H-Mordenite (CBV20A); c) HY (LZ-Y62) A 97 97 .m ,mJ ~: 95 ...

Research paper thumbnail of In reply: is dexmedetomidine really superior to propofol?

Journal of Anesthesia, 2015

and endpoints, data on control and treatment groups provide fair information for estimating sampl... more and endpoints, data on control and treatment groups provide fair information for estimating sample size. It is better to perform sample size calculations for different outcome parameters and choose the largest sample size. We agree that sedation for diagnostic angiography needs to be evaluated further in patients of different grades of SAH.

Research paper thumbnail of Unusual manifestation of blood transfusion reaction as diffuse operative site oozing, hypotension and brain swelling

Journal of anaesthesiology, clinical pharmacology, 2011

Research paper thumbnail of A comparative study of dexmedetomidine and propofol as sole sedative agents for patients with aneurysmal subarachnoid hemorrhage undergoing diagnostic cerebral angiography

Journal of Anesthesia, 2014

Subarachnoid hemorrhage is an acute neurological emergency requiring urgent confirmation of the d... more Subarachnoid hemorrhage is an acute neurological emergency requiring urgent confirmation of the diagnosis for planning definitive management. Due to altered consciousness, most patients require sedation for conducting this procedure smoothly. Currently, it is unclear if any one particular sedative drug has a favorable profile in patients undergoing cerebral angiography. The aim of this study was to compare the traditionally used sedative drug propofol with a newer alternative, dexmedetomidine, in patients with subarachnoid hemorrhage undergoing cerebral angiography. Sixty adult patients with good grade subarachnoid hemorrhage undergoing diagnostic cerebral angiography were prospectively randomized to receive either propofol (n = 30) or dexmedetomidine (n = 30) following ethics committee approval and informed consent. Compared to dexmadetomidine, propofol was associated with an earlier time for onset of sedation (2.3 ± 1.9 min vs. 15.4 ± 5.7 min; P < 0.001), but with an increased number of adverse respiratory events (11/30 vs 1/30; P = 0.003) and movement during the procedure (5/30 vs. 0/30; P = 0.05), necessitating additional supplementation of sedation (13/30 vs. 7/30; P = 0.17) and repetition of the imaging sequences. The total procedure time and time for recovery were similar for the propofol and dexmedetomidine groups, while the heart rate was lower in patients in the dexmedetomidine group. Dexmedetomidine appears to be superior to propofol as a sole sedative agent for sedation during cerebral angiography in patients with subarachnoid hemorrhage.

Research paper thumbnail of Successful anesthetic management for microsurgical excision of ruptured cerebellar arteriovenous malformation with trapped endovascular microcatheter

Journal of Anaesthesiology Clinical Pharmacology, 2014

Microsurgical excision and good anesthetic management of arteriovenous malformation (AVM) that ru... more Microsurgical excision and good anesthetic management of arteriovenous malformation (AVM) that ruptures during endovascular embolization can ensure good outcome despite per-procedural catastrophe. This case report illustrates the successful anesthetic management of microsurgical excision of ruptured AVM with entrapped microcatheter and highlights the role of the anesthesiologist in careful monitoring of the patient's hemodynamic status and communicating any changes to the radiology team to facilitate check angiography to diagnose the intracranial complication. This case highlights the need for anticipating and defining a catastrophe plan in advance of each interventional neuroradiology procedure as complications are rapid and require good multidisciplinary communication to ensure safe and successful outcomes.

Research paper thumbnail of Dexmedetomidine anesthesia enhances spike generation during intra-operative electrocorticography: A promising adjunct for epilepsy surgery

Epilepsy Research, 2015

Anesthetic-induced suppression of cortical electrical activity is a major concern during epilepsy... more Anesthetic-induced suppression of cortical electrical activity is a major concern during epilepsy surgery. Dexmedetomidine (Dex) has been recently evaluated in a few small series for its effect on the electrocorticographic spikes intra-operatively. In this prospective study, electrocorticogram (ECoG) was monitored during dexmedetomidine infusion in 34 patients (M:F=23:11, age=29.2 ± 10.9 years; duration of epilepsy=15.3 ± 8.9 years) undergoing anterior temporal lobe resection with amygdalo-hippocampectomy for drug-resistant mesial temporal lobe epilepsy (Right: 18, Left: 16). Anesthesia was induced with thiopental/propofol and maintained with oxygen-N2O-isoflurane. ECoG was recorded for 5 min after the end tidal MAC of N2O and isoflurane were decreased to zero; anesthesia was maintained with O2:Air=50:50, vecuronium and fentanyl. ECoG was recorded using a 4-contact strip electrode for: (a) 5 min prior to dexmedetomidine (PreDEX), (b) 5 min during dexmedetomidine infusion (DEX; 1 μg/kg) and (c) 5 min after stopping dexmedetomidine (PostDEX). The ECoG spikes were manually counted in all the channels. The mean spike rate in the 2 channels with maximum spikes (MAX CH A and MAX CH B) was normalized to a 3-min duration. RM-ANOVA and post hoc comparison of three phases were used to compare the spike rates. The mean spike rate during Dex phase was higher compared to preDEX (MAX CH B: p=0.007 and MAX CH A: p=0.079) and PostDEX (MAX CH B: p=0.17, MAX CH A: p=0.79) phases. The spike rate increased in 67.6% patients, while 11.8% patients showed ≤ 25% reduction and 20.6% patients showed >25% reduction in spike frequency. Dexmedetomidine is useful during intra-operative ECoG recording in epilepsy surgery as it enhances or does not alter spike rate in most of the cases, without any major adverse effects.

Research paper thumbnail of Synthesis of nanocrystalline Ni1−xCoxMnxFe2−xO4: a material for liquefied petroleum gas sensing

Sensors and Actuators B: Chemical, 2003

... L. Satyanarayana a , K. Madhusudan Reddy b and Sunkara V. Manorama Corresponding Author Conta... more ... L. Satyanarayana a , K. Madhusudan Reddy b and Sunkara V. Manorama Corresponding Author Contact Information , E-mail The Corresponding Author , b [Author vitae]. a NMR Group, Indian Institute of Chemical Technology, Hyderabad 500007, India. ...

Research paper thumbnail of Non-awakening from anesthesia following posterior fossa surgery due to skull pin-induced tension pneumocephalus

Research paper thumbnail of Massive cerebral air embolism during stent-assisted coiling of internal carotid artery aneurysm