Magda El-shenawee - Academia.edu (original) (raw)

Papers by Magda El-shenawee

Research paper thumbnail of Time of flight THz imaging of 3D ex-vivo breast cancer tumor tissues

This research represents experimental use of a pulsed terahertz time-domain imaging system to obt... more This research represents experimental use of a pulsed terahertz time-domain imaging system to obtain time of flight (in-depth) reflection scans from three-dimensional ex-vivo breast cancer tumor tissue. Image processing and volumetric techniques are performed on these THz scans to analyze and enhance the tumor image and assess its boundaries.

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Research paper thumbnail of Time of flight estimation for breast cancer margin thickness using embedded tumors

Proceedings of SPIE, Mar 7, 2016

This work aims to enact a quick and reasonable estimation of breast cancer margin thickness using... more This work aims to enact a quick and reasonable estimation of breast cancer margin thickness using time of flight analysis of embedded breast cancer tissue. A pulsed terahertz system is used to obtain reflection imaging scans from breast cancer tumors that are formalin-fixed and embedded in paraffin blocks. Time of flight analysis is then used to compare the reflection patterns seen within the block to pathology sections and paraffin-embedded sections that are taken throughout the depth of the tumor in order to estimate the three-dimensional boundaries of the tumor.

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Research paper thumbnail of Regional spectroscopy of paraffin-embedded breast cancer tissue using pulsed terahertz transmission imaging

Proceedings of SPIE, Mar 7, 2016

This work seeks to obtain the properties of paraffin-embedded breast cancer tumor tissues using t... more This work seeks to obtain the properties of paraffin-embedded breast cancer tumor tissues using transmission imaging and spectroscopy. Formalin-fixed and paraffin-embedded breast tumors are first sectioned into slices of 20 μm and 30 μm and placed between two tsurupica slides. The slides are then scanned in a pulsed terahertz system using transmission imaging. The tissue regions in adjacent pathology section are compared to the transmission imaging scan in order to define a region of points over which to average the electrical properties results from the scan.

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Research paper thumbnail of Terahertz tomographic imaging of freshly excised human breast tissues

Journal of medical imaging, May 14, 2019

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Research paper thumbnail of A phantom study of terahertz spectroscopy and imaging of micro- and nano-diamonds and nano-onions as contrast agents for breast cancer

Biomedical Physics & Engineering Express, Sep 14, 2017

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Research paper thumbnail of Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Biomedical Optics Express, Aug 30, 2016

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Research paper thumbnail of Terahertz Imaging of Excised Breast Tumor Tissue on Paraffin Sections

IEEE Transactions on Antennas and Propagation, May 1, 2015

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Research paper thumbnail of Margin assessment of three-dimensional breast cancer phantoms using terahertz imaging

Proceedings of SPIE, Mar 18, 2016

This work focuses on pulsed terahertz imaging for the application of surgical margin assessment o... more This work focuses on pulsed terahertz imaging for the application of surgical margin assessment of breast cancer. Various phantom tissue types and orientations are tested here to refine imaging methodology that can detect breast cancer up to 0.5-1.0 mm from the edge of the sample. The depth of the cancer within the sample is estimated using time of flight analysis of the reflected peaks in the pulsed time domain signal. Breast tissue phantoms have been designed to resemble fresh infiltrating ductal carcinoma, fibroglandular tissue, and fatty tissue of the breast to accomplish this work.

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Research paper thumbnail of Cancer detection in excised breast tumors using terahertz imaging and spectroscopy

Biomedical spectroscopy and imaging, Jul 9, 2019

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Research paper thumbnail of Pulsed terahertz imaging of fresh and fixed human breast cancer tissue

This work investigates the use of terahertz imaging for differentiating between cancer and health... more This work investigates the use of terahertz imaging for differentiating between cancer and healthy tissue regions in freshly excised breast cancer tumors. Bulk tissue specimens are obtained fresh in a nutrient medium from a biobank and scanned on a pulsed terahertz system in the reflection mode to produce the reflection image. Tissues are then sent for histopathology processing, and the subsequent pathology slides are compared against the fresh tissue image for correlation. The results show the significant ability of terahertz imaging for distinguishing breast cancer from fibroglandular and fatty tissue in fresh tissue sections.

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Research paper thumbnail of Development of breast cancer tissue phantoms for terahertz imaging

Proceedings of SPIE, Mar 18, 2016

The goal of this work was to develop phantoms that match the refractive indices and absorption co... more The goal of this work was to develop phantoms that match the refractive indices and absorption coefficients between 0.15 and 2.0 THz of the freshly excised tissues commonly found in breast tumors. Since a breast cancer tumor can contain fibrous and fatty tissues alongside the cancerous tissues, a phantom had to be developed for each. In order to match the desired properties of the tissues, oil in water emulsions were solidified using the proven phantom component TX151. The properties of each potential phantom were verified through THz time-domain spectroscopy on a TPS Spectra 3000. Using this method, phantoms for fibrous and cancerous tissue were successfully developed while a commercially available material was found which matched the optical properties of fatty tissue.

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Research paper thumbnail of Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors

Journal of Visualized Experiments, Apr 5, 2020

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Research paper thumbnail of Terahertz Imaging of Three-Dimensional Dehydrated Breast Cancer Tumors

Journal of Infrared, Millimeter, and Terahertz Waves, Mar 18, 2017

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Research paper thumbnail of Nondestructive Imaging of Packaged Microelectronics using Pulsed Terahertz Technology

IMAPS symposia and conferences, Oct 1, 2017

This work presents the use of terahertz reflection imaging for nondestructive evaluation of packa... more This work presents the use of terahertz reflection imaging for nondestructive evaluation of packaged microelectronics. Power MOSFETs and SRAM devices are placed in a pulsed terahertz imaging system in the reflection mode with an incident angle of 30°. From the received signal at each point on the sample under test, the internal structure of the device can be clearly seen. For transistors, terahertz nondestructive imaging has been successful in determining die size and location as well as the bond wire size, number, and connections. High-pass frequency filters are utilized to enhance the image quality for viewing the bond wires. In addition, the terahertz B-scans are used to determine additional information including the vertical position of the bond wires and the die inside the packaged device. For the SRAM, the terahertz nondestructive imaging shows similar effectiveness in defining the layout of the metal connections inside the package and the wire positions. Thus terahertz imaging is shown to have a strong potential for nondestructive evaluation of these devices.

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Research paper thumbnail of Z-scan terahertz imaging of embedded three-dimensional breast cancer tissue

The terahertz (THz) frequency range is a rapidly developing field in electromagnetics today. Biom... more The terahertz (THz) frequency range is a rapidly developing field in electromagnetics today. Biomedical imaging has become a key area of focus for THz applications due to improved depth resolution over microwave imaging while still having greater penetration than optical frequencies. THz imaging is sensitive to water content, which serves as a strong contrast factor in cancer detection and imaging.

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Research paper thumbnail of The linear sampling method for the acceleration of the level set algorithm

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Research paper thumbnail of Terahertz imaging of breast cancer margin using the Linear Sampling Method

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Research paper thumbnail of Cancer Classification of Freshly Excised Murine Tumors with Ordered Orthogonal Projection

This paper proposes a low dimension feature extraction method for cancer classification with tera... more This paper proposes a low dimension feature extraction method for cancer classification with terahertz (THz) images of freshly excised murine tumors. In THz imaging, the properties of various tissue regions, such as cancer, fat, and muscle, are embedded in the shape of reflected THz pulses. We propose to extract such information by projecting the frequency domain THz waveforms onto a series of ordered orthogonal basis. Experiment results demonstrated that the proposed algorithm can achieve reasonably accurate detection results for fresh tissues with three regions.

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Research paper thumbnail of Efficient Microwave Imaging Algorithm Based on Hybridization of the Linear Sampling and Level Set Methods

IEEE Transactions on Antennas and Propagation, Jul 1, 2013

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Research paper thumbnail of Terahertz spectroscopy for the characterization of excised human breast tissue

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Research paper thumbnail of Time of flight THz imaging of 3D ex-vivo breast cancer tumor tissues

This research represents experimental use of a pulsed terahertz time-domain imaging system to obt... more This research represents experimental use of a pulsed terahertz time-domain imaging system to obtain time of flight (in-depth) reflection scans from three-dimensional ex-vivo breast cancer tumor tissue. Image processing and volumetric techniques are performed on these THz scans to analyze and enhance the tumor image and assess its boundaries.

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Research paper thumbnail of Time of flight estimation for breast cancer margin thickness using embedded tumors

Proceedings of SPIE, Mar 7, 2016

This work aims to enact a quick and reasonable estimation of breast cancer margin thickness using... more This work aims to enact a quick and reasonable estimation of breast cancer margin thickness using time of flight analysis of embedded breast cancer tissue. A pulsed terahertz system is used to obtain reflection imaging scans from breast cancer tumors that are formalin-fixed and embedded in paraffin blocks. Time of flight analysis is then used to compare the reflection patterns seen within the block to pathology sections and paraffin-embedded sections that are taken throughout the depth of the tumor in order to estimate the three-dimensional boundaries of the tumor.

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Research paper thumbnail of Regional spectroscopy of paraffin-embedded breast cancer tissue using pulsed terahertz transmission imaging

Proceedings of SPIE, Mar 7, 2016

This work seeks to obtain the properties of paraffin-embedded breast cancer tumor tissues using t... more This work seeks to obtain the properties of paraffin-embedded breast cancer tumor tissues using transmission imaging and spectroscopy. Formalin-fixed and paraffin-embedded breast tumors are first sectioned into slices of 20 μm and 30 μm and placed between two tsurupica slides. The slides are then scanned in a pulsed terahertz system using transmission imaging. The tissue regions in adjacent pathology section are compared to the transmission imaging scan in order to define a region of points over which to average the electrical properties results from the scan.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Terahertz tomographic imaging of freshly excised human breast tissues

Journal of medical imaging, May 14, 2019

Bookmarks Related papers MentionsView impact

Research paper thumbnail of A phantom study of terahertz spectroscopy and imaging of micro- and nano-diamonds and nano-onions as contrast agents for breast cancer

Biomedical Physics & Engineering Express, Sep 14, 2017

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Biomedical Optics Express, Aug 30, 2016

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Terahertz Imaging of Excised Breast Tumor Tissue on Paraffin Sections

IEEE Transactions on Antennas and Propagation, May 1, 2015

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Margin assessment of three-dimensional breast cancer phantoms using terahertz imaging

Proceedings of SPIE, Mar 18, 2016

This work focuses on pulsed terahertz imaging for the application of surgical margin assessment o... more This work focuses on pulsed terahertz imaging for the application of surgical margin assessment of breast cancer. Various phantom tissue types and orientations are tested here to refine imaging methodology that can detect breast cancer up to 0.5-1.0 mm from the edge of the sample. The depth of the cancer within the sample is estimated using time of flight analysis of the reflected peaks in the pulsed time domain signal. Breast tissue phantoms have been designed to resemble fresh infiltrating ductal carcinoma, fibroglandular tissue, and fatty tissue of the breast to accomplish this work.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Cancer detection in excised breast tumors using terahertz imaging and spectroscopy

Biomedical spectroscopy and imaging, Jul 9, 2019

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Pulsed terahertz imaging of fresh and fixed human breast cancer tissue

This work investigates the use of terahertz imaging for differentiating between cancer and health... more This work investigates the use of terahertz imaging for differentiating between cancer and healthy tissue regions in freshly excised breast cancer tumors. Bulk tissue specimens are obtained fresh in a nutrient medium from a biobank and scanned on a pulsed terahertz system in the reflection mode to produce the reflection image. Tissues are then sent for histopathology processing, and the subsequent pathology slides are compared against the fresh tissue image for correlation. The results show the significant ability of terahertz imaging for distinguishing breast cancer from fibroglandular and fatty tissue in fresh tissue sections.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Development of breast cancer tissue phantoms for terahertz imaging

Proceedings of SPIE, Mar 18, 2016

The goal of this work was to develop phantoms that match the refractive indices and absorption co... more The goal of this work was to develop phantoms that match the refractive indices and absorption coefficients between 0.15 and 2.0 THz of the freshly excised tissues commonly found in breast tumors. Since a breast cancer tumor can contain fibrous and fatty tissues alongside the cancerous tissues, a phantom had to be developed for each. In order to match the desired properties of the tissues, oil in water emulsions were solidified using the proven phantom component TX151. The properties of each potential phantom were verified through THz time-domain spectroscopy on a TPS Spectra 3000. Using this method, phantoms for fibrous and cancerous tissue were successfully developed while a commercially available material was found which matched the optical properties of fatty tissue.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors

Journal of Visualized Experiments, Apr 5, 2020

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Terahertz Imaging of Three-Dimensional Dehydrated Breast Cancer Tumors

Journal of Infrared, Millimeter, and Terahertz Waves, Mar 18, 2017

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Nondestructive Imaging of Packaged Microelectronics using Pulsed Terahertz Technology

IMAPS symposia and conferences, Oct 1, 2017

This work presents the use of terahertz reflection imaging for nondestructive evaluation of packa... more This work presents the use of terahertz reflection imaging for nondestructive evaluation of packaged microelectronics. Power MOSFETs and SRAM devices are placed in a pulsed terahertz imaging system in the reflection mode with an incident angle of 30°. From the received signal at each point on the sample under test, the internal structure of the device can be clearly seen. For transistors, terahertz nondestructive imaging has been successful in determining die size and location as well as the bond wire size, number, and connections. High-pass frequency filters are utilized to enhance the image quality for viewing the bond wires. In addition, the terahertz B-scans are used to determine additional information including the vertical position of the bond wires and the die inside the packaged device. For the SRAM, the terahertz nondestructive imaging shows similar effectiveness in defining the layout of the metal connections inside the package and the wire positions. Thus terahertz imaging is shown to have a strong potential for nondestructive evaluation of these devices.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Z-scan terahertz imaging of embedded three-dimensional breast cancer tissue

The terahertz (THz) frequency range is a rapidly developing field in electromagnetics today. Biom... more The terahertz (THz) frequency range is a rapidly developing field in electromagnetics today. Biomedical imaging has become a key area of focus for THz applications due to improved depth resolution over microwave imaging while still having greater penetration than optical frequencies. THz imaging is sensitive to water content, which serves as a strong contrast factor in cancer detection and imaging.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The linear sampling method for the acceleration of the level set algorithm

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Terahertz imaging of breast cancer margin using the Linear Sampling Method

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Cancer Classification of Freshly Excised Murine Tumors with Ordered Orthogonal Projection

This paper proposes a low dimension feature extraction method for cancer classification with tera... more This paper proposes a low dimension feature extraction method for cancer classification with terahertz (THz) images of freshly excised murine tumors. In THz imaging, the properties of various tissue regions, such as cancer, fat, and muscle, are embedded in the shape of reflected THz pulses. We propose to extract such information by projecting the frequency domain THz waveforms onto a series of ordered orthogonal basis. Experiment results demonstrated that the proposed algorithm can achieve reasonably accurate detection results for fresh tissues with three regions.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Efficient Microwave Imaging Algorithm Based on Hybridization of the Linear Sampling and Level Set Methods

IEEE Transactions on Antennas and Propagation, Jul 1, 2013

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Terahertz spectroscopy for the characterization of excised human breast tissue

Bookmarks Related papers MentionsView impact