Maggie Meeks - Academia.edu (original) (raw)

Papers by Maggie Meeks

Nursing praxis in Aotearoa New Zealand, Oct 2, 2023

ngā māramatanga hē hei hīkoi tuatahi mō te akoranga whakawhiti mōhiotanga, me te whakapiki i te w... more ngā māramatanga hē hei hīkoi tuatahi mō te akoranga whakawhiti mōhiotanga, me te whakapiki i te whakawhitinga kōrero me te mahi hei tira. Ngā kupu matua: pāhekoheko, whakawhiti kōrero, akoranga whakawhiti umanga, ngā ākonga tākuta, ngā ākonga tapuhi, i mua o te rēhita, te whakahoahoa.

Journal of The American Dietetic Association, Sep 1, 2003

Berghahn Books, Dec 31, 2023

Berghahn Books, Jun 11, 2023

Doctoral thesis, UCL (University College London)., 2002

Establishing a Left-Right axis 2.1 Summary 2.2 Abnormalities of the left-right axis 2.3 Ciliary d... more Establishing a Left-Right axis 2.1 Summary 2.2 Abnormalities of the left-right axis 2.3 Ciliary defects and laterality 51 4 2.4 Situs ambiguous/isomerism sequence 53 2.5 Development of the left-right axis 55 2.6 Left-right signalling pathways 2.6.1 Left-right signalling in Chickens 60 2.6.2 Left-right signalling in Mice 63 2.6.3 Left-right signalling in Xenopus 66 2.6.4 Relevance to Human Laterality 68 Chapter 3 Primary Ciliary Dyskinesia 3.1 Summary 3.2 Historical background 3.3 Prevalence of PCD 3.4 Genetics 3.5 Clinical features and diagnostic criteria 3.6 Management, prognosis and complications 3.7 Animal Models 3.7.1 Dog, Pig and Cat 3.7.2 Rat and Mouse 3.7.3 Chlamydomonas.

Routledge eBooks, Nov 16, 2022

Pediatric Pulmonology, Apr 1, 2000

This article summarizes the current state of the scientific and clinical knowledge that relates t... more This article summarizes the current state of the scientific and clinical knowledge that relates to primary ciliary dyskinesia (PCD). Although PCD is a rare disease with a prevalence of 1 in 20,000 it has a well recognized morbidity. It is believed that an accurate diagnosis and the application of appropriate management can significantly reduce this morbidity. The cilia themselves are highly complicated organelles that perform important functions, particularly in the respiratory and reproductive tracts, and they have been the focus of many years of research. Our current knowledge of ciliary function and mucociliary clearance is summarized, and the relationship with laterality defects is discussed. A phenotype resembling PCD is also seen in animal models, and some of these are described before reviewing the clinical aspects of PCD in humans and new developments in the field that may have implications for the future investigation and management of affected individuals.

Archives of Disease in Childhood, May 1, 2003

Current Paediatrics, Dec 1, 1998

Paediatric Respiratory Reviews, Mar 1, 2004

BMC Pediatrics, Aug 5, 2015

Background: Very low birth weight (less than 1500 g) is associated with increased morbidity and c... more Background: Very low birth weight (less than 1500 g) is associated with increased morbidity and costs of health care in childhood. Emerging evidence suggests these infants face a range of health and social problems as young adults. We studied all New Zealand very low birth weight infants born in 1986 (when 58 % were exposed to antenatal corticosteroids) in infancy, with later follow-up at 7 to 8 years and 23 to 24 years. We now aim to assess the cohort at 26-28 years compared with controls. Methods/design: The case sample will comprise a minimum of 250 members of the 1986 New Zealand national very low birth weight cohort (77 % of survivors). Outcomes will be compared with a control group of 100 young adults born at term in 1986. Following written informed consent, participants will travel to Christchurch for 2 days of assessments undertaken by experienced staff. Medical assessments include growth measures, vision, respiratory function, blood pressure and echocardiogram, renal function, dental examination and blood tests. Cognitive and neuropsychological functioning will be assessed with standard tests, and mental health and social functioning by participant interview. A telephone interview will be conducted with a parent or significant other person nominated by the respondent to gain a further perspective on the young person's health and functioning. All those born at less than 28 weeks' gestation, plus a random subset of the cohort to a total of 150 cases and 50 controls, will be offered cranial magnetic-resonance imaging. Statistical analysis will examine comparison with controls and long-term trajectories for the very low birth weight cohort. Discussion: The research will provide crucial New Zealand data on the young adult outcomes for very low birth weight infants and address gaps in the international literature, particularly regarding cardiovascular, respiratory, visual and neurocognitive outcomes. These data will inform future neonatal care, provide evidence-based guidelines for care of preterm graduates transitioning to adult care, and help shape health education and social policies for this high risk group.

Current Paediatrics, 1996

Genetics in Medicine, 2000

Current Paediatrics, 1996

Routledge eBooks, Nov 16, 2022

Australian and New Zealand Journal of Obstetrics and Gynaecology, 2021

BACKGROUND Severe maternal morbidity (SMM) occurs in 1-2% of pregnancies. Despite the knowledge t... more BACKGROUND Severe maternal morbidity (SMM) occurs in 1-2% of pregnancies. Despite the knowledge that a SMM event can contribute to poor fetal/neonatal outcomes, little is known about the preventability of these adverse outcomes. AIMS To examine adverse fetal/neonatal outcomes associated with SMM to determine if these outcomes were potentially preventable. MATERIALS AND METHODS A New Zealand national retrospective cohort study examining cases of SMM with an adverse fetal/neonatal outcome. Maternity and initial neonatal care were explored by multidisciplinary panels utilising a preventability tool to assess whether the fetal/neonatal harm was potentially preventable. Adverse fetal/neonatal outcomes were defined as fetal or early neonatal death, Apgar score <7 at five minutes, admission to neonatal intensive care unit or special care baby unit and neonatal encephalopathy. RESULTS Of 85 cases reviewed, adverse fetal/neonatal outcome was deemed potentially preventable in 55.3% of cases (n = 47/85). Preventability was related to maternal antenatal/peripartum care (in utero) in 39% (n = 33/85), to initial neonatal care (ex utero) in 36% (n = 29/80), and to both maternal and neonatal care in 20% (16/80) of cases. Main contributors to potential preventability were factors related to healthcare providers, particularly lack of recognition of high risk, delayed or failure to diagnose, and delayed or inappropriate treatment. CONCLUSIONS Multidisciplinary panels found that over half of adverse fetal/neonatal harm associated with SMM was potentially preventable. The novel approach of examining both maternal and neonatal care identifies opportunities to improve fetal/neonatal outcomes associated with SMM at multiple points on the perinatal continuum of care.

Telemedicine as emerged as a key response to the management of health delivery during Covid-19 lo... more Telemedicine as emerged as a key response to the management of health delivery during Covid-19 lockdown internationally. Telemedicine is becoming a part of the "new normal" in healthcare delivery. Compared to its rapid uptake during a time of public health emergency, the processes that can help best use of telemedicine and telehealth has lagged behind. A review of literature, websites, and guidelines indicates that at present, the focus on how to manage the technology and less to guide consultations. As the main application area of telemedicine/telehealth is on remote consultations, research on how it is used and how the features are utilised in synchronous/asynchronous consultations is in order. This exploratory project aims to fill in this gap and hence document the experiences and reflections of New Zealand-based health practitioners (e.g., Medical doctors, Nurses, Midwives, Allied Health practitioners such as physiotherapists, occupational therapists, speech-language t...

European Journal of Human Genetics, 2000

Primary ciliary dyskinesia (PCD), or immotile cilia syndrome (ICS), is an autosomal recessive dis... more Primary ciliary dyskinesia (PCD), or immotile cilia syndrome (ICS), is an autosomal recessive disorder affecting ciliary movement with an incidence of 1 in 20000-30000. Dysmotility to complete immotility of cilia results in a multisystem disease of variable severity with recurrent respiratory tract infections leading to bronchiectasis and male subfertility. Ultrastructural defects are present in ciliated mucosa and spermatozoa. Situs inversus (SI) is found in about half of the patients (Kartagener syndrome). We have collected samples from 61 European and North American families with PCD. A genome-wide linkage search was performed in 31 multiplex families (169 individuals including 70 affecteds) using 188 evenly spaced (19 cM average interval) polymorphic markers. Both parametric (recessive model) and non-parametric (identity by descent allele sharing) linkage analyses were used. No major locus for the majority of the families was identified, although the sample was powerful enough to detect linkage if 40% of the families were linked to one locus. These results strongly suggest extensive locus heterogeneity. Potential genomic regions harbouring PCD loci were localised on chromosomes 3p, 4q, 5p, 7p, 8q, 10p, 11q, 13q, 15q, 16p, 17q and 19q. Linkage analysis using PCD families with a dynein arm deficiency provided 'suggestive' evidence for linkage to chromosomal regions 8q, 16pter, while analyses using only PCD families with situs inversus resulted in 'suggestive' scores for chromosomes 8q, and 19q.

Nursing praxis in Aotearoa New Zealand, Oct 2, 2023

ngā māramatanga hē hei hīkoi tuatahi mō te akoranga whakawhiti mōhiotanga, me te whakapiki i te w... more ngā māramatanga hē hei hīkoi tuatahi mō te akoranga whakawhiti mōhiotanga, me te whakapiki i te whakawhitinga kōrero me te mahi hei tira. Ngā kupu matua: pāhekoheko, whakawhiti kōrero, akoranga whakawhiti umanga, ngā ākonga tākuta, ngā ākonga tapuhi, i mua o te rēhita, te whakahoahoa.

Journal of The American Dietetic Association, Sep 1, 2003

Berghahn Books, Dec 31, 2023

Berghahn Books, Jun 11, 2023

Doctoral thesis, UCL (University College London)., 2002

Establishing a Left-Right axis 2.1 Summary 2.2 Abnormalities of the left-right axis 2.3 Ciliary d... more Establishing a Left-Right axis 2.1 Summary 2.2 Abnormalities of the left-right axis 2.3 Ciliary defects and laterality 51 4 2.4 Situs ambiguous/isomerism sequence 53 2.5 Development of the left-right axis 55 2.6 Left-right signalling pathways 2.6.1 Left-right signalling in Chickens 60 2.6.2 Left-right signalling in Mice 63 2.6.3 Left-right signalling in Xenopus 66 2.6.4 Relevance to Human Laterality 68 Chapter 3 Primary Ciliary Dyskinesia 3.1 Summary 3.2 Historical background 3.3 Prevalence of PCD 3.4 Genetics 3.5 Clinical features and diagnostic criteria 3.6 Management, prognosis and complications 3.7 Animal Models 3.7.1 Dog, Pig and Cat 3.7.2 Rat and Mouse 3.7.3 Chlamydomonas.

Routledge eBooks, Nov 16, 2022

Pediatric Pulmonology, Apr 1, 2000

This article summarizes the current state of the scientific and clinical knowledge that relates t... more This article summarizes the current state of the scientific and clinical knowledge that relates to primary ciliary dyskinesia (PCD). Although PCD is a rare disease with a prevalence of 1 in 20,000 it has a well recognized morbidity. It is believed that an accurate diagnosis and the application of appropriate management can significantly reduce this morbidity. The cilia themselves are highly complicated organelles that perform important functions, particularly in the respiratory and reproductive tracts, and they have been the focus of many years of research. Our current knowledge of ciliary function and mucociliary clearance is summarized, and the relationship with laterality defects is discussed. A phenotype resembling PCD is also seen in animal models, and some of these are described before reviewing the clinical aspects of PCD in humans and new developments in the field that may have implications for the future investigation and management of affected individuals.

Archives of Disease in Childhood, May 1, 2003

Current Paediatrics, Dec 1, 1998

Paediatric Respiratory Reviews, Mar 1, 2004

BMC Pediatrics, Aug 5, 2015

Background: Very low birth weight (less than 1500 g) is associated with increased morbidity and c... more Background: Very low birth weight (less than 1500 g) is associated with increased morbidity and costs of health care in childhood. Emerging evidence suggests these infants face a range of health and social problems as young adults. We studied all New Zealand very low birth weight infants born in 1986 (when 58 % were exposed to antenatal corticosteroids) in infancy, with later follow-up at 7 to 8 years and 23 to 24 years. We now aim to assess the cohort at 26-28 years compared with controls. Methods/design: The case sample will comprise a minimum of 250 members of the 1986 New Zealand national very low birth weight cohort (77 % of survivors). Outcomes will be compared with a control group of 100 young adults born at term in 1986. Following written informed consent, participants will travel to Christchurch for 2 days of assessments undertaken by experienced staff. Medical assessments include growth measures, vision, respiratory function, blood pressure and echocardiogram, renal function, dental examination and blood tests. Cognitive and neuropsychological functioning will be assessed with standard tests, and mental health and social functioning by participant interview. A telephone interview will be conducted with a parent or significant other person nominated by the respondent to gain a further perspective on the young person's health and functioning. All those born at less than 28 weeks' gestation, plus a random subset of the cohort to a total of 150 cases and 50 controls, will be offered cranial magnetic-resonance imaging. Statistical analysis will examine comparison with controls and long-term trajectories for the very low birth weight cohort. Discussion: The research will provide crucial New Zealand data on the young adult outcomes for very low birth weight infants and address gaps in the international literature, particularly regarding cardiovascular, respiratory, visual and neurocognitive outcomes. These data will inform future neonatal care, provide evidence-based guidelines for care of preterm graduates transitioning to adult care, and help shape health education and social policies for this high risk group.

Current Paediatrics, 1996

Genetics in Medicine, 2000

Current Paediatrics, 1996

Routledge eBooks, Nov 16, 2022

Australian and New Zealand Journal of Obstetrics and Gynaecology, 2021

BACKGROUND Severe maternal morbidity (SMM) occurs in 1-2% of pregnancies. Despite the knowledge t... more BACKGROUND Severe maternal morbidity (SMM) occurs in 1-2% of pregnancies. Despite the knowledge that a SMM event can contribute to poor fetal/neonatal outcomes, little is known about the preventability of these adverse outcomes. AIMS To examine adverse fetal/neonatal outcomes associated with SMM to determine if these outcomes were potentially preventable. MATERIALS AND METHODS A New Zealand national retrospective cohort study examining cases of SMM with an adverse fetal/neonatal outcome. Maternity and initial neonatal care were explored by multidisciplinary panels utilising a preventability tool to assess whether the fetal/neonatal harm was potentially preventable. Adverse fetal/neonatal outcomes were defined as fetal or early neonatal death, Apgar score <7 at five minutes, admission to neonatal intensive care unit or special care baby unit and neonatal encephalopathy. RESULTS Of 85 cases reviewed, adverse fetal/neonatal outcome was deemed potentially preventable in 55.3% of cases (n = 47/85). Preventability was related to maternal antenatal/peripartum care (in utero) in 39% (n = 33/85), to initial neonatal care (ex utero) in 36% (n = 29/80), and to both maternal and neonatal care in 20% (16/80) of cases. Main contributors to potential preventability were factors related to healthcare providers, particularly lack of recognition of high risk, delayed or failure to diagnose, and delayed or inappropriate treatment. CONCLUSIONS Multidisciplinary panels found that over half of adverse fetal/neonatal harm associated with SMM was potentially preventable. The novel approach of examining both maternal and neonatal care identifies opportunities to improve fetal/neonatal outcomes associated with SMM at multiple points on the perinatal continuum of care.

Telemedicine as emerged as a key response to the management of health delivery during Covid-19 lo... more Telemedicine as emerged as a key response to the management of health delivery during Covid-19 lockdown internationally. Telemedicine is becoming a part of the "new normal" in healthcare delivery. Compared to its rapid uptake during a time of public health emergency, the processes that can help best use of telemedicine and telehealth has lagged behind. A review of literature, websites, and guidelines indicates that at present, the focus on how to manage the technology and less to guide consultations. As the main application area of telemedicine/telehealth is on remote consultations, research on how it is used and how the features are utilised in synchronous/asynchronous consultations is in order. This exploratory project aims to fill in this gap and hence document the experiences and reflections of New Zealand-based health practitioners (e.g., Medical doctors, Nurses, Midwives, Allied Health practitioners such as physiotherapists, occupational therapists, speech-language t...

European Journal of Human Genetics, 2000

Primary ciliary dyskinesia (PCD), or immotile cilia syndrome (ICS), is an autosomal recessive dis... more Primary ciliary dyskinesia (PCD), or immotile cilia syndrome (ICS), is an autosomal recessive disorder affecting ciliary movement with an incidence of 1 in 20000-30000. Dysmotility to complete immotility of cilia results in a multisystem disease of variable severity with recurrent respiratory tract infections leading to bronchiectasis and male subfertility. Ultrastructural defects are present in ciliated mucosa and spermatozoa. Situs inversus (SI) is found in about half of the patients (Kartagener syndrome). We have collected samples from 61 European and North American families with PCD. A genome-wide linkage search was performed in 31 multiplex families (169 individuals including 70 affecteds) using 188 evenly spaced (19 cM average interval) polymorphic markers. Both parametric (recessive model) and non-parametric (identity by descent allele sharing) linkage analyses were used. No major locus for the majority of the families was identified, although the sample was powerful enough to detect linkage if 40% of the families were linked to one locus. These results strongly suggest extensive locus heterogeneity. Potential genomic regions harbouring PCD loci were localised on chromosomes 3p, 4q, 5p, 7p, 8q, 10p, 11q, 13q, 15q, 16p, 17q and 19q. Linkage analysis using PCD families with a dynein arm deficiency provided 'suggestive' evidence for linkage to chromosomal regions 8q, 16pter, while analyses using only PCD families with situs inversus resulted in 'suggestive' scores for chromosomes 8q, and 19q.