Mahdieh Hasanalifard - Academia.edu (original) (raw)

Papers by Mahdieh Hasanalifard

Electrophysiological analysis of ENG signals in patients with Covid-19, 2023

Background: Currently, there is an increasing number of patients reporting dizziness, which has r... more Background: Currently, there is an increasing number of patients reporting dizziness, which has resulted in a positive COVID-19 PCR test. In this paper, we analyzed the ENG signals recorded from patients with a positive COVID-19 PCR test. Methods: In this paper, both linear and nonlinear analyses of time series were employed to determine the regularity and complexity of a recorded ENG signal. Results: The Wilcoxon rank-sum test indicated that the COVID-19 and non-COVID groups have significant differences based on different extracted features. Various machine learning methods including Linear Discriminant Analysis (LDA), Naïve Base (NB), K-nearest Neighbours (KNN), and Support Vector Machines (SVM) were used to classify COVID-19 and non-COVID groups. The best accuracy, precision and FCR achieved by SVM are 86%, 91% and 0.13. Conclusion: In this study, ENG signals were recorded from COVID-19 and control groups. Linear and non-linear features were extracted from the recorded signals to identify significantly different features. Subjects were classified based on SVM and different classifiers. The SVM (polynomial kernel) classifier showed the best result. The proposed method had not been used for the classification of COVID-19 and non-COVID-19 subjects before. This work helps other researchers conduct more research on the development of machine learning methods to diagnose the COVID-19 virus using ENG and other physiological signals.

International Journal of Pediatrics, Jul 1, 2021

Background Pragmatic skills of language are important for everyday life interactions. It has been... more Background Pragmatic skills of language are important for everyday life interactions. It has been proven that cochlear implantation age should be considered, as an important predictor of language skills in children with cochlear implantation (CI), but information about the benefits of early cochlear implantation on pragmatic language development in these children are very few. Thus, this study intends to compare pragmatic skills as well as speech intelligibility in prelingual deaf children who received cochlear implants before the age of 6 years and those who received cochlear implants after the age of 6 years with an 8-year follow-up. Materials and Methods: This Retrospective 8-year longitudinal study was conducted in a cochlear implant center in the city of Tehran, Iran, in 2021. Forty-five children were included in two groups: early cochlear implant (n = 17), and early cochlear implant (n = 28). The Persian version of the children's communication checklist (CCC) was used to assess the participants 'pragmatic skills and the Persian version of the Intelligibility Context Scale (ICS) was used to assess the participants' speech intelligibility. Results: The two study groups did not show a significant difference in terms of pragmatic scores (P>0.05) but had a significant difference in terms of ISC scores (P<0.001). Speech intelligibility had a significant negative relationship with the age of cochlear implantation (r =-0.5, P<0.001) but had no significant correlation with pragmatic skills (P>0.05). Conclusion The long-term results of early and late cochlear implants were similar in terms of the development of pragmatic skills but very different in terms of speech intelligibility. The age of cochlear implantation had no effect on the pragmatic of language.

International Journal of Pediatric Otorhinolaryngology, Jun 1, 2019

Objectives: Bimodal fitting (BF) allows children with cochlear implant to benefit from binaural h... more Objectives: Bimodal fitting (BF) allows children with cochlear implant to benefit from binaural hearing advantages. Three major binaural hearing advantages, which enhance hearing function of people with normal hearing, are head shadow effect (HSE), binaural squelch effect (BSQ) and binaural summation effect (BSU). This study in pediatric patients attempting to measure the auditory benefits of bimodal stimulation in children with long-standing use of a cochlear implant (CI), and residual hearing on the contralateral side. Methods: This cross-sectional study investigated binaural advantages in 24 children of 8-12 years who had undergone cochlear implantation in a cochlear implant center in Tehran and continuously used BF. Improved score of speech perception in noise (SPiN) under BF condition, as compared to the application of cochlear implant alone, was a binaural advantage found in this study. Each binaural advantage was measured by obtaining the SPiN score under different listening and noise conditions, using relevant formulas. The measured value of each advantage reflects the improved score of SPiN, caused by that certain advantage. Results: In this study, improved mean SPiN score caused by the HSE, BSQ and BSU was, respectively, 3.13, 1.42 and 2.04dB, indicating greater binaural advantages and hence improved SPiN, under BF condition in comparison with cochlear implant alone. Conclusion: Children with unilateral cochlear implant and measurable residual hearing in non-implanted ear can benefit from binaural advantages and better SPiN when hearing aid is used in the unaided ear.

International Journal of Pediatric Otorhinolaryngology, Apr 1, 2023

شنواییشناسی, Jun 27, 2021

Background and Aim: The COVID-19 has affected sensory organs in a different manner. This paper ai... more Background and Aim: The COVID-19 has affected sensory organs in a different manner. This paper aimed to review the auditory-vestibular symptoms associated with COVID-19 and it also investigated the impacts of this pandemic on hearing-impaired community. Recent Findings: The existing studies related to the effects of COVID-19 on the auditoryvestibular system were reviewed and discussed in order to achieve the overall image of COVID-19 on this system. Moreover, due to the adverse effects of using a mask on the communication function of hearing-impaired people, the effects of the mask on the communication process of hearing-impaired people were also reviewed. Conclusion: COVID-19 may be accompanying with some auditory and vestibular dysfunctions. Although there are few findings in this area, they showed that the induced hearing loss is often sudden in nature and it is unclear that this situation is because of the ototoxicity of virus treated drugs or not. The vertigo induced by COVID-19 can be a direct invasion of the virus or an invasion by the immune system and its association with hearing loss and tinnitus must be identified, and appropriate referrals should be considered. On the other hand, due to the adverse effects of using personal protective equipment such as masks on the communication performance of hearing-impaired people, the necessary advice and guidance in this field are provided to the medical staff.

PubMed, Jul 1, 2013

The use of rats in research academies to study deafness is widespread, meanwhile medicinal method... more The use of rats in research academies to study deafness is widespread, meanwhile medicinal methods to eliminate hair cells is also increasing. Thus, aminoglycosides and loop diuretics have grasped more attention. This study aimed at establishing an animal model in which a rapid distortion of the hair cell of cochlea administering amikacin and furosemide and using distortion product otoacoustic emission (DPOAE) the functioning of rat's ear would be assessed. Forty-eight male Sprague-Dawley rats (mean weight 200-250g) were randomly divided into six equal groups. Except the control group the rest received 0.5mg/g, 0.75mg/g, 1mg/g, 1.25mg/g, and 1.5mg/g, of subcutaneous amikacin respectively. 30 minutes later every rat received 0.1mg/g of furosemide intrapritoneally. DPOAE of rats was measured before these injections and 72 hours later. Then tissue sections of the rat's cochlea were prepared. All the cases had a significant decrease in their DPOAE with the frequencies 2KHz-8KHz (p<0.05). The most change in DPOAE was in rats which had received 1mg/g - 1.5mg/g amikacin. Histological studies approved distortion of hair cell even the apical turn. To establish a deafness model due losing hair cells, it is possible to use a combination of 1mg/g amikacin and 0.1mg/g furosemide. Besides, to approve deafness DPOAE resulted can be used.

Journal of Torbat Heydariyeh University of Medical Sciences, Jul 10, 2021

International Journal of Pediatric Otorhinolaryngology, Apr 1, 2013

To investigate efficacy of bone marrow stem cell implantation in rehabilitation of noise induced ... more To investigate efficacy of bone marrow stem cell implantation in rehabilitation of noise induced hearing loss in rats. Materials and methods: Hearing loss was induced in male rats by a continuous wide-band noise (8-16 kHz/120 dB/120 min). Ten microliter of stem cell containing solution was injected by a Hamilton syringe with 30G needle through the round window membrane. Hearing status was examined by, distortion product otoacoustic emissions using DP-OAE. Animals were studied in 4 different groups: (1) Normal hearing animals, undergoing sham surgery (no injection done, only round window membrane ruptured and sealed). (2) Deaf animals, undergoing sham surgery. (3) Deaf animals undergoing surgery and injection of solvent (artificial perilymph). (4) Deaf animals undergoing surgery and injection of artificial perilymph containing BMSCs. Results: DP-Gram in rat with normal hearing undergoing sham surgery show that procedure has neither negative impact on normal cochlear nor on deaf cochleas. No significant difference (p = 0.25) between ears excludes artificial perilymph as a confounding factor. There is no significant difference between ears in animals receiving BMSCs. Conclusions: Implanted cells with normal histologic structures have no physiologic function and hearing rehabilitation. Further studies by monitoring the survival of these cells with histologic and appropriate biomarkers will help to investigate differentiation process of these cells.

Iranian Red Crescent Medical Journal, Jan 5, 2013

International Journal of Pediatrics, Oct 1, 2021

Background: Hearing loss may affect many aspects of a person's life. The age of cochlear implanta... more Background: Hearing loss may affect many aspects of a person's life. The age of cochlear implantation (CI) is often considered an important predictor of language skills in children with CI, but little is known about the benefits of early CI on speech intelligibility development in these children. This study aimed to compare language skills as well as intelligibility of speech in prelingual deaf patients who received CI before the age of six years and those who received CI after the age of six years with an 8-year follow-up. Methods: This 8-year longitudinal, retrospective case-control study was conducted in 2021 at a cochlear implant center in Tehran, Iran. Thirty-one patients were included in two groups: late cochlear implant (n = 15), and early cochlear implant (n = 16). The Test of Language Development-Primary (TOLD-P3) was used to assess the participants' language skills. The intelligibility of the participants' speech was assessed through the Persian version of the Intelligibility Context Scale (ICS) and the speech intelligibility rating (SIR). Results: These two groups did not show a significant difference in terms of the language scores (P>0.05) but had a significant difference in terms of the SIR and the ICS scores (P<0.05). Speech intelligibility had a significantly negative correlation with the age of CI (r =-0.57, P<0.001), and a significant positive correlation with language skills (r = 0.75, P<0.001). Conclusion: The long-term outcomes of early and late CI were similar in terms of the development of language skills but too different in terms of the intelligibility of speech. The age of CI had no effect on language development but had a significant effect on speech intelligibility.

The Egyptian Journal of Otolaryngology, Apr 28, 2023

Background Tonsillectomy is a common surgery to treat tonsillitis. In addition to cold dissection... more Background Tonsillectomy is a common surgery to treat tonsillitis. In addition to cold dissection methods, other new methods are also used for tonsillectomy which has several advantages. We compared the cold dissection methods and the harmonic scalpel method and investigated the complications of both methods. Methods This is a descriptive analytical study on 50 patients in the population of 18 to 60 years who had tonsillectomy conditions based on the inclusion criteria. These patients were divided into two groups, harmonic scalpel method and cold dissection methods, and the duration of the operation, the amount of bleeding during the operation, the pain on the first, fourth, and seventh days after the operation, and the bleeding after the operation were measured in them. Results In this study, 36 men and 14 women were examined. The duration of surgery and the amount of bleeding during surgery were significantly less in the harmonic scalpel method group than in the cold dissection methods group (P = 0.000). Postoperative pain on days 1 and 4 after surgery was significantly less in the harmonic scalpel method group than in the cold dissection methods group (P = 0.047). Conclusion According to this study, the amount of bleeding and length of surgery were less in the harmonic scalpel method group. The pain on the first and fourth days after surgery was less in the harmonic group, but the pain on the seventh day was not significantly different from the cold dissection group.

شنواییشناسی, Jan 31, 2021

Background and Aim: In a bimodal fitting, one ear is stimulated acoustically with a hearing aid a... more Background and Aim: In a bimodal fitting, one ear is stimulated acoustically with a hearing aid and the other is stimulated electrically with a cochlear implant. This paper provides a brief summary of the concept of bimodal fitting, binaural hearing and its importance, the hearing benefits of binaural hearing in bimodal fitting, candidacy and hearing aid adjustment in bimodal fitting cases. Recent Findings: Researches have shown that bimodal fitting offers a wide range of hearing benefits over unilateral cochlear implants, such as better speech perception in noise, better musical perception, and a better understanding of pitch and tone perception and naturalness of sound perception. Conclusion: Considering the binaural hearing advantages in bimodal fitting users, it can be concluded that users of unilateral cochlear implants who have measurable residual hearing in their non-implanted ear can use a hearing aid in that ear and enjoy binaural hearing advantages. The hearing aid should be fitted in a way to complement the information obtained through cochlear implantation.

Purpose: the aim of thos survey is establishment of an animal model through which a rapid distort... more Purpose: the aim of thos survey is establishment of an animal model through which a rapid distortion of the hair cell of cochlea administering amikacin and furosemide and using distortion product otoacoustic emission (DPOAE) the functioning of rat's ear would be assessed. Materials and Methods: Forty-eight male Sprague dawley rats (with average of weight 200-250g, 12 weeks post natal) were randomly divided into six equal groups. Except the control group the rest received 0.5 mg/g, 0.75 mg/g, 1mg/g, 1.25 mg/g, and 1.5 mg/g, of ...

The Egyptian Journal of Otolaryngology, Jul 15, 2021

Background: The objective of this study was to evaluate the effect of "Spatially separated speech... more Background: The objective of this study was to evaluate the effect of "Spatially separated speech in noise" auditory training on the ability of speech perception in noise among bimodal fitting users. The assumption was that the rehabilitation can enhance spatial hearing and hence speech in noise perception. This study was an interventional study, with a pre/post-design. Speech recognition ability was assessed with the specific tests. After performing the rehabilitation stages in the intervention group, the speech tests were again implemented, and by comparing the pre-and post-intervention data, the effect of auditory training on the speech abilities was assessed. Twenty-four children of 8-12 years who had undergone cochlear implantation and continuously used bimodal fitting were investigated in two groups of control and intervention. Results: The results showed a significant difference between the groups in different speech tests after the intervention, which indicated that the intervention group have improved more than the control group. Conclusion: It can be concluded that "Spatially separated speech in noise" auditory training can improve the speech perception in noise in bimodal fitting users. In general, this rehabilitation method is useful for enhancing the speech in noise perception ability.

IBRO Neuroscience Reports

The Egyptian Journal of Otolaryngology

Background Tonsillectomy is a common surgery to treat tonsillitis. In addition to cold dissection... more Background Tonsillectomy is a common surgery to treat tonsillitis. In addition to cold dissection methods, other new methods are also used for tonsillectomy which has several advantages. We compared the cold dissection methods and the harmonic scalpel method and investigated the complications of both methods. Methods This is a descriptive analytical study on 50 patients in the population of 18 to 60 years who had tonsillectomy conditions based on the inclusion criteria. These patients were divided into two groups, harmonic scalpel method and cold dissection methods, and the duration of the operation, the amount of bleeding during the operation, the pain on the first, fourth, and seventh days after the operation, and the bleeding after the operation were measured in them. Results In this study, 36 men and 14 women were examined. The duration of surgery and the amount of bleeding during surgery were significantly less in the harmonic scalpel method group than in the cold dissection me...

Journal of Torbat Heydariyeh University of Medical Sciences, Jul 10, 2021

Iranian Red Crescent Medical Journal, 2013

International Journal of Pediatric Otorhinolaryngology

Kowsar Medical …, 2011

Aims: Hearing loss is the commonest type of sensory loss in children. Recent studies have confirm... more Aims: Hearing loss is the commonest type of sensory loss in children. Recent studies have confirmed the desirable effect of early cochlear implant on auditory and lingual skills. This study was performed in order to compare auditory and speech ability after cochlear implant surgery in <2 years old children and children aged between 2-4 years . Materials & Methods: This descriptive study was performed on 210 pre-lingually deaf children, including 85 under 2 years old children and 121 children aged between 2-4 in year 2009 in Baqiyatallah cochlear implant centre. All samples underwent surgery in the same center and were evaluated before implantation and 12 months after the device was switched on. Hearing ability was evaluated by means of Categories of Auditory Perception Scale (CAP) and speech ability was assessed by Speech Intelligibility Ratings (SIR). Data was analyzed using descriptive statistics and independent t-test by SPSS 16 software. Results: The mean CAP score after surgery for age group under 2 years was 5.14±0.38, and in age group 2< years old was 4.38±0.21, which was significantly higher in the first group (p=0.01). SIR results didn’t show significant difference between two groups. Conclusion: In consistence with other recent studies, this study demonstrates that better auditory outcome can be achieved when cochlear implantations is performed in younger age. Noticing that complications are rare and equal in both groups, performing cochlear implantation before 2 years of age is recommended.

Electrophysiological analysis of ENG signals in patients with Covid-19, 2023

Background: Currently, there is an increasing number of patients reporting dizziness, which has r... more Background: Currently, there is an increasing number of patients reporting dizziness, which has resulted in a positive COVID-19 PCR test. In this paper, we analyzed the ENG signals recorded from patients with a positive COVID-19 PCR test. Methods: In this paper, both linear and nonlinear analyses of time series were employed to determine the regularity and complexity of a recorded ENG signal. Results: The Wilcoxon rank-sum test indicated that the COVID-19 and non-COVID groups have significant differences based on different extracted features. Various machine learning methods including Linear Discriminant Analysis (LDA), Naïve Base (NB), K-nearest Neighbours (KNN), and Support Vector Machines (SVM) were used to classify COVID-19 and non-COVID groups. The best accuracy, precision and FCR achieved by SVM are 86%, 91% and 0.13. Conclusion: In this study, ENG signals were recorded from COVID-19 and control groups. Linear and non-linear features were extracted from the recorded signals to identify significantly different features. Subjects were classified based on SVM and different classifiers. The SVM (polynomial kernel) classifier showed the best result. The proposed method had not been used for the classification of COVID-19 and non-COVID-19 subjects before. This work helps other researchers conduct more research on the development of machine learning methods to diagnose the COVID-19 virus using ENG and other physiological signals.

International Journal of Pediatrics, Jul 1, 2021

Background Pragmatic skills of language are important for everyday life interactions. It has been... more Background Pragmatic skills of language are important for everyday life interactions. It has been proven that cochlear implantation age should be considered, as an important predictor of language skills in children with cochlear implantation (CI), but information about the benefits of early cochlear implantation on pragmatic language development in these children are very few. Thus, this study intends to compare pragmatic skills as well as speech intelligibility in prelingual deaf children who received cochlear implants before the age of 6 years and those who received cochlear implants after the age of 6 years with an 8-year follow-up. Materials and Methods: This Retrospective 8-year longitudinal study was conducted in a cochlear implant center in the city of Tehran, Iran, in 2021. Forty-five children were included in two groups: early cochlear implant (n = 17), and early cochlear implant (n = 28). The Persian version of the children's communication checklist (CCC) was used to assess the participants 'pragmatic skills and the Persian version of the Intelligibility Context Scale (ICS) was used to assess the participants' speech intelligibility. Results: The two study groups did not show a significant difference in terms of pragmatic scores (P>0.05) but had a significant difference in terms of ISC scores (P<0.001). Speech intelligibility had a significant negative relationship with the age of cochlear implantation (r =-0.5, P<0.001) but had no significant correlation with pragmatic skills (P>0.05). Conclusion The long-term results of early and late cochlear implants were similar in terms of the development of pragmatic skills but very different in terms of speech intelligibility. The age of cochlear implantation had no effect on the pragmatic of language.

International Journal of Pediatric Otorhinolaryngology, Jun 1, 2019

Objectives: Bimodal fitting (BF) allows children with cochlear implant to benefit from binaural h... more Objectives: Bimodal fitting (BF) allows children with cochlear implant to benefit from binaural hearing advantages. Three major binaural hearing advantages, which enhance hearing function of people with normal hearing, are head shadow effect (HSE), binaural squelch effect (BSQ) and binaural summation effect (BSU). This study in pediatric patients attempting to measure the auditory benefits of bimodal stimulation in children with long-standing use of a cochlear implant (CI), and residual hearing on the contralateral side. Methods: This cross-sectional study investigated binaural advantages in 24 children of 8-12 years who had undergone cochlear implantation in a cochlear implant center in Tehran and continuously used BF. Improved score of speech perception in noise (SPiN) under BF condition, as compared to the application of cochlear implant alone, was a binaural advantage found in this study. Each binaural advantage was measured by obtaining the SPiN score under different listening and noise conditions, using relevant formulas. The measured value of each advantage reflects the improved score of SPiN, caused by that certain advantage. Results: In this study, improved mean SPiN score caused by the HSE, BSQ and BSU was, respectively, 3.13, 1.42 and 2.04dB, indicating greater binaural advantages and hence improved SPiN, under BF condition in comparison with cochlear implant alone. Conclusion: Children with unilateral cochlear implant and measurable residual hearing in non-implanted ear can benefit from binaural advantages and better SPiN when hearing aid is used in the unaided ear.

International Journal of Pediatric Otorhinolaryngology, Apr 1, 2023

شنواییشناسی, Jun 27, 2021

Background and Aim: The COVID-19 has affected sensory organs in a different manner. This paper ai... more Background and Aim: The COVID-19 has affected sensory organs in a different manner. This paper aimed to review the auditory-vestibular symptoms associated with COVID-19 and it also investigated the impacts of this pandemic on hearing-impaired community. Recent Findings: The existing studies related to the effects of COVID-19 on the auditoryvestibular system were reviewed and discussed in order to achieve the overall image of COVID-19 on this system. Moreover, due to the adverse effects of using a mask on the communication function of hearing-impaired people, the effects of the mask on the communication process of hearing-impaired people were also reviewed. Conclusion: COVID-19 may be accompanying with some auditory and vestibular dysfunctions. Although there are few findings in this area, they showed that the induced hearing loss is often sudden in nature and it is unclear that this situation is because of the ototoxicity of virus treated drugs or not. The vertigo induced by COVID-19 can be a direct invasion of the virus or an invasion by the immune system and its association with hearing loss and tinnitus must be identified, and appropriate referrals should be considered. On the other hand, due to the adverse effects of using personal protective equipment such as masks on the communication performance of hearing-impaired people, the necessary advice and guidance in this field are provided to the medical staff.

PubMed, Jul 1, 2013

The use of rats in research academies to study deafness is widespread, meanwhile medicinal method... more The use of rats in research academies to study deafness is widespread, meanwhile medicinal methods to eliminate hair cells is also increasing. Thus, aminoglycosides and loop diuretics have grasped more attention. This study aimed at establishing an animal model in which a rapid distortion of the hair cell of cochlea administering amikacin and furosemide and using distortion product otoacoustic emission (DPOAE) the functioning of rat's ear would be assessed. Forty-eight male Sprague-Dawley rats (mean weight 200-250g) were randomly divided into six equal groups. Except the control group the rest received 0.5mg/g, 0.75mg/g, 1mg/g, 1.25mg/g, and 1.5mg/g, of subcutaneous amikacin respectively. 30 minutes later every rat received 0.1mg/g of furosemide intrapritoneally. DPOAE of rats was measured before these injections and 72 hours later. Then tissue sections of the rat's cochlea were prepared. All the cases had a significant decrease in their DPOAE with the frequencies 2KHz-8KHz (p<0.05). The most change in DPOAE was in rats which had received 1mg/g - 1.5mg/g amikacin. Histological studies approved distortion of hair cell even the apical turn. To establish a deafness model due losing hair cells, it is possible to use a combination of 1mg/g amikacin and 0.1mg/g furosemide. Besides, to approve deafness DPOAE resulted can be used.

Journal of Torbat Heydariyeh University of Medical Sciences, Jul 10, 2021

International Journal of Pediatric Otorhinolaryngology, Apr 1, 2013

To investigate efficacy of bone marrow stem cell implantation in rehabilitation of noise induced ... more To investigate efficacy of bone marrow stem cell implantation in rehabilitation of noise induced hearing loss in rats. Materials and methods: Hearing loss was induced in male rats by a continuous wide-band noise (8-16 kHz/120 dB/120 min). Ten microliter of stem cell containing solution was injected by a Hamilton syringe with 30G needle through the round window membrane. Hearing status was examined by, distortion product otoacoustic emissions using DP-OAE. Animals were studied in 4 different groups: (1) Normal hearing animals, undergoing sham surgery (no injection done, only round window membrane ruptured and sealed). (2) Deaf animals, undergoing sham surgery. (3) Deaf animals undergoing surgery and injection of solvent (artificial perilymph). (4) Deaf animals undergoing surgery and injection of artificial perilymph containing BMSCs. Results: DP-Gram in rat with normal hearing undergoing sham surgery show that procedure has neither negative impact on normal cochlear nor on deaf cochleas. No significant difference (p = 0.25) between ears excludes artificial perilymph as a confounding factor. There is no significant difference between ears in animals receiving BMSCs. Conclusions: Implanted cells with normal histologic structures have no physiologic function and hearing rehabilitation. Further studies by monitoring the survival of these cells with histologic and appropriate biomarkers will help to investigate differentiation process of these cells.

Iranian Red Crescent Medical Journal, Jan 5, 2013

International Journal of Pediatrics, Oct 1, 2021

Background: Hearing loss may affect many aspects of a person's life. The age of cochlear implanta... more Background: Hearing loss may affect many aspects of a person's life. The age of cochlear implantation (CI) is often considered an important predictor of language skills in children with CI, but little is known about the benefits of early CI on speech intelligibility development in these children. This study aimed to compare language skills as well as intelligibility of speech in prelingual deaf patients who received CI before the age of six years and those who received CI after the age of six years with an 8-year follow-up. Methods: This 8-year longitudinal, retrospective case-control study was conducted in 2021 at a cochlear implant center in Tehran, Iran. Thirty-one patients were included in two groups: late cochlear implant (n = 15), and early cochlear implant (n = 16). The Test of Language Development-Primary (TOLD-P3) was used to assess the participants' language skills. The intelligibility of the participants' speech was assessed through the Persian version of the Intelligibility Context Scale (ICS) and the speech intelligibility rating (SIR). Results: These two groups did not show a significant difference in terms of the language scores (P>0.05) but had a significant difference in terms of the SIR and the ICS scores (P<0.05). Speech intelligibility had a significantly negative correlation with the age of CI (r =-0.57, P<0.001), and a significant positive correlation with language skills (r = 0.75, P<0.001). Conclusion: The long-term outcomes of early and late CI were similar in terms of the development of language skills but too different in terms of the intelligibility of speech. The age of CI had no effect on language development but had a significant effect on speech intelligibility.

The Egyptian Journal of Otolaryngology, Apr 28, 2023

Background Tonsillectomy is a common surgery to treat tonsillitis. In addition to cold dissection... more Background Tonsillectomy is a common surgery to treat tonsillitis. In addition to cold dissection methods, other new methods are also used for tonsillectomy which has several advantages. We compared the cold dissection methods and the harmonic scalpel method and investigated the complications of both methods. Methods This is a descriptive analytical study on 50 patients in the population of 18 to 60 years who had tonsillectomy conditions based on the inclusion criteria. These patients were divided into two groups, harmonic scalpel method and cold dissection methods, and the duration of the operation, the amount of bleeding during the operation, the pain on the first, fourth, and seventh days after the operation, and the bleeding after the operation were measured in them. Results In this study, 36 men and 14 women were examined. The duration of surgery and the amount of bleeding during surgery were significantly less in the harmonic scalpel method group than in the cold dissection methods group (P = 0.000). Postoperative pain on days 1 and 4 after surgery was significantly less in the harmonic scalpel method group than in the cold dissection methods group (P = 0.047). Conclusion According to this study, the amount of bleeding and length of surgery were less in the harmonic scalpel method group. The pain on the first and fourth days after surgery was less in the harmonic group, but the pain on the seventh day was not significantly different from the cold dissection group.

شنواییشناسی, Jan 31, 2021

Background and Aim: In a bimodal fitting, one ear is stimulated acoustically with a hearing aid a... more Background and Aim: In a bimodal fitting, one ear is stimulated acoustically with a hearing aid and the other is stimulated electrically with a cochlear implant. This paper provides a brief summary of the concept of bimodal fitting, binaural hearing and its importance, the hearing benefits of binaural hearing in bimodal fitting, candidacy and hearing aid adjustment in bimodal fitting cases. Recent Findings: Researches have shown that bimodal fitting offers a wide range of hearing benefits over unilateral cochlear implants, such as better speech perception in noise, better musical perception, and a better understanding of pitch and tone perception and naturalness of sound perception. Conclusion: Considering the binaural hearing advantages in bimodal fitting users, it can be concluded that users of unilateral cochlear implants who have measurable residual hearing in their non-implanted ear can use a hearing aid in that ear and enjoy binaural hearing advantages. The hearing aid should be fitted in a way to complement the information obtained through cochlear implantation.

Purpose: the aim of thos survey is establishment of an animal model through which a rapid distort... more Purpose: the aim of thos survey is establishment of an animal model through which a rapid distortion of the hair cell of cochlea administering amikacin and furosemide and using distortion product otoacoustic emission (DPOAE) the functioning of rat's ear would be assessed. Materials and Methods: Forty-eight male Sprague dawley rats (with average of weight 200-250g, 12 weeks post natal) were randomly divided into six equal groups. Except the control group the rest received 0.5 mg/g, 0.75 mg/g, 1mg/g, 1.25 mg/g, and 1.5 mg/g, of ...

The Egyptian Journal of Otolaryngology, Jul 15, 2021

Background: The objective of this study was to evaluate the effect of "Spatially separated speech... more Background: The objective of this study was to evaluate the effect of "Spatially separated speech in noise" auditory training on the ability of speech perception in noise among bimodal fitting users. The assumption was that the rehabilitation can enhance spatial hearing and hence speech in noise perception. This study was an interventional study, with a pre/post-design. Speech recognition ability was assessed with the specific tests. After performing the rehabilitation stages in the intervention group, the speech tests were again implemented, and by comparing the pre-and post-intervention data, the effect of auditory training on the speech abilities was assessed. Twenty-four children of 8-12 years who had undergone cochlear implantation and continuously used bimodal fitting were investigated in two groups of control and intervention. Results: The results showed a significant difference between the groups in different speech tests after the intervention, which indicated that the intervention group have improved more than the control group. Conclusion: It can be concluded that "Spatially separated speech in noise" auditory training can improve the speech perception in noise in bimodal fitting users. In general, this rehabilitation method is useful for enhancing the speech in noise perception ability.

IBRO Neuroscience Reports

The Egyptian Journal of Otolaryngology

Background Tonsillectomy is a common surgery to treat tonsillitis. In addition to cold dissection... more Background Tonsillectomy is a common surgery to treat tonsillitis. In addition to cold dissection methods, other new methods are also used for tonsillectomy which has several advantages. We compared the cold dissection methods and the harmonic scalpel method and investigated the complications of both methods. Methods This is a descriptive analytical study on 50 patients in the population of 18 to 60 years who had tonsillectomy conditions based on the inclusion criteria. These patients were divided into two groups, harmonic scalpel method and cold dissection methods, and the duration of the operation, the amount of bleeding during the operation, the pain on the first, fourth, and seventh days after the operation, and the bleeding after the operation were measured in them. Results In this study, 36 men and 14 women were examined. The duration of surgery and the amount of bleeding during surgery were significantly less in the harmonic scalpel method group than in the cold dissection me...

Journal of Torbat Heydariyeh University of Medical Sciences, Jul 10, 2021

Iranian Red Crescent Medical Journal, 2013

International Journal of Pediatric Otorhinolaryngology

Kowsar Medical …, 2011

Aims: Hearing loss is the commonest type of sensory loss in children. Recent studies have confirm... more Aims: Hearing loss is the commonest type of sensory loss in children. Recent studies have confirmed the desirable effect of early cochlear implant on auditory and lingual skills. This study was performed in order to compare auditory and speech ability after cochlear implant surgery in <2 years old children and children aged between 2-4 years . Materials & Methods: This descriptive study was performed on 210 pre-lingually deaf children, including 85 under 2 years old children and 121 children aged between 2-4 in year 2009 in Baqiyatallah cochlear implant centre. All samples underwent surgery in the same center and were evaluated before implantation and 12 months after the device was switched on. Hearing ability was evaluated by means of Categories of Auditory Perception Scale (CAP) and speech ability was assessed by Speech Intelligibility Ratings (SIR). Data was analyzed using descriptive statistics and independent t-test by SPSS 16 software. Results: The mean CAP score after surgery for age group under 2 years was 5.14±0.38, and in age group 2< years old was 4.38±0.21, which was significantly higher in the first group (p=0.01). SIR results didn’t show significant difference between two groups. Conclusion: In consistence with other recent studies, this study demonstrates that better auditory outcome can be achieved when cochlear implantations is performed in younger age. Noticing that complications are rare and equal in both groups, performing cochlear implantation before 2 years of age is recommended.