Mahendra Rana - Academia.edu (original) (raw)
Papers by Mahendra Rana
Critical-sized bone defects (CSDs) have a multi-factorial etiology including high-energy trauma, ... more Critical-sized bone defects (CSDs) have a multi-factorial etiology including high-energy trauma, infection, and revision surgery. CSDs are a major clinical dilemma, as reliable, evidenced-based solutions do not exist. The purpose of this study is to develop a healing patch for the CSDs, investigating the best outcome of formulation developed from Cissus qudrangularis and to reduce the side effects of corticosteroids, chemotherapeutic agents, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, and anticoagulants in the patient suffering from CSDs. The primary objective of the study was to estimate the potential of Cissus qudrangularis for fracture healing. The transdermal patch containing ethanolic extract of Cissus qudrangularis was developed by solvent casting method. The formulated patch was further studied for thickness of the patch, moisture content, moisture re-absorption, SEM analysis, drug content, In-vitro drug-release and in-vivo animal activity. Male Wister rats w...
Agroforestry and Climate Change, 2019
Journal of Drug Delivery and Therapeutics, 2019
Streptococcus mutans is the most common cause of tooth decay. Parabens and other commonly used as... more Streptococcus mutans is the most common cause of tooth decay. Parabens and other commonly used as anti-Streptococcus agents in toothpaste industry have numerous side effects such as discoloration of teeth. The herbal extract of all three plants gives antimicrobial and anti-inflammatory activity and prevent and reducing the tooth decay, dental caries and given to freshness of mouth. The aim of present work was development and evaluation of herbal antimicrobial toothpaste containing Bark of Acacia nilotica, Acacia catechu and flower buds of syzygium aromaticum as herbal ingredients. Different types of formulations (F1-F6) were formulated using calcium carbonate as abrasive and Glycerine as humectant in varied concentrations. All the formulations were evaluated for various parameters like dryness, color, appearance, consistency, washability, pH, spreadability and foaming power. Polyherbal toothpaste containing hydroalcoholic extract of plants was tested for antimicrobial activity again...
Asian Pacific Journal of Health Sciences
Plagiochasma appendiculatum, a flavonoid rich liverwort, is reported to be used in the treatment ... more Plagiochasma appendiculatum, a flavonoid rich liverwort, is reported to be used in the treatment of cuts, burns, outside wounds, bacteriostatic, pulmonary tuberculosis, neurasthenia, fractures, convulsions, scalds, uropathy, and inflammation by tribal communities. In the present study, flavonoid luteolin, reported to possess anti-inflammatory potential, is isolated from P. appendiculatum methanol extract and extract is evaluated for anti-inflammatory effect. Anti-inflammatory potential was studied by protein denaturation assay and carrageenan-induced rat paw edema method. Plant flavonoid is isolated from methanol extract by column chromatography, using petroleum ether and ethyl acetate in various proportion, as mobile phase. Further identified by spectroscopic analysis. In vitro studies, at a concentration of 800 μg/ml, P. appendiculatum methanolic extract (PAME) exhibited 74% inhibition while indomethacin showed 79% inhibition at the same concentration. The extract exhibits a decre...
Journal of Pharmacognosy and Phytochemistry, 2014
Air dried leaves essential oil was extracted by hydrodistillation. Quantitative Phytochemical ana... more Air dried leaves essential oil was extracted by hydrodistillation. Quantitative Phytochemical analysis of volatile compounds viz. Limonin, Citronellol, linalool and terpineol was done by Gas chromatography, Limonin, linalool, terpineol (36.9%, 2.12%, 4.19%) was found higher extent in Citrus limettioides as compared to Citrus pseudo limon (10.6%,1.7%, 2.59%). Citronellol content was found higher extent in Citrus pseudo limon (62.30%) than Citrus limettioides (5.11%). Antioxidant activity of leaves essential oil was done by using 1, 1, Diphenyl 2Picryl Hydrazine (DPPH) free radical scavenging assay. IC50 of both plants leaves essential oil was calculated. Comparative study shows that Citrus limettioides shows higher antioxidant potential (IC50= 15.35 ul) as compared to Citrus pseudo limon (IC50= 18.43 ul) against DPPH free radicals.
Industrial Crops and Products, 2009
The chemical composition of essential oils isolated from aerial parts of native populations of Or... more The chemical composition of essential oils isolated from aerial parts of native populations of Origanum vulgare L. from northwestern Himalaya was investigated by enantioselective gas chromatography (enantio-GC), capillary-gas chromatography (capillary-GC) and GC-MS. Seventy compounds, which accounted for 84.9-97% of the oil composition, have been identified. The oils were allotted to two main groups; the first group had a high percentage of components belonging to the thymol/carvacrol biosynthetic pathway and the second was characterized by a different sesquiterpene composition and a high linalool and bornyl acetate percentage. Essential oils of O. vulgare populations from Rilkot and Dhanachuli areas in northwestern Himalaya were characterized by high monoterpenoids proportions as compared to Nainital and Bhowali populations, which were dominated by sesquiterpenoids. High proportions of thymol (29.2-82%) were found only in two populations. Composition of the samples collected from Dhanachuli area differed from Nainital and Bhowali collections by a unique presence of carvacrol. Notably, there were significant differences in the concentration of rest of the terpenes in all the collections. On enantio-GC, enantiomeric excess for (3R) (−)-and (3S) (+)-linalool, (S) (+)-and (R) (−)-terpinen-4-ol, (S) (−)-and (R) (+)-˛-terpineol, (1S) (−)-bornyl acetate and (1S) (−)-borneol were established in populations from Bhowali and Dhanachuli area. Moreover, linalool type oregano may be useful in promoting wider commercial utilization of the biodiversity of this species.
Naturally Occurring Chemicals Against Alzheimer's Disease, 2021
Abstract Many herbal plant extracts as well as their bio-active compound are considered to be saf... more Abstract Many herbal plant extracts as well as their bio-active compound are considered to be safer and their use is widely acceptable. It was found that many herbs with anti-inflammatory potential may reduce inflammation of brain tissues. Several steroids, terpenoids (di and tri), long chain aliphatic tetrols and esters found in the plant Guggulu (Commiphora wightii) possess anti-oxidant as well as anti-inflammatory properties. Guggulu in India, has been used in traditional system of medicines from the past several years in the treatment of hypercholesterolemia, atherosclerosis, arthritis, gout, rheumatism, inflammation and obesity. Alzheimer diseases is a neurodegenerative disorder caused by oxidative stress and inflammation of neurons. This chapter investigates the therapeutic role of various bio-active compounds present in Guggulu (Commiphora wightii) in the treatment of Alzheimer disease.
Urological Science, 2019
Background: Pesticide exposure has the potential for causing acute or chronic health effects at c... more Background: Pesticide exposure has the potential for causing acute or chronic health effects at certain developmental stages of life. It can result in irreversible damage to structure and function of an organ. The exposure of females to pesticides before or after pregnancy is a matter of concern because of the possibility of having a child born with congenital disorders and developmental defects. Prenatal exposure of any toxicants can program the developing foetus to develop diseases that manifest in later life. Very few reports are available related to the pesticide exposure induced morphological changes in kidney which has prompted us to undertake this research study. Aim: The aim of this study is to evaluate the effect of pesticide, chlorpyrifos on the kidney development of rat neonates after being exposed prenatally to pesticides throughout their gestational period. Materials and Methods: Virgin female wistar rats weighing 200-250 gms were mated with adult males. It consisted of twelve, divided into two sub groups six rats per each were treated with selected pesticides, chlorpyrifos (insecticide) readily available commercially for various agricultural and non-agricultural settings. Insecticide chlorpyrifos was given at a dose of 10mg/kg per orally to the female rats throughout their gestation period. After gestation period rat neonates were sacrificed and their kidney section was processed for histopathological analysis. The SEM study of chlorpyrifos exposed kidney section of rat neonates was performed, investigating changes in morphometric and ultra-structural features of kidney in rat neonates. Results: The histopathological analysis shows morphological changes in the kidneys of prenatally pesticides exposed rat neonates markedly different from control group. Chlorpyrifos exposed neonates kidney shows damaged kidney corpuscles and glomeruli. Conclusion: This study concluded that pesticide exposure during gestation period to pregnant rats causes significant renal toxicity in their neonates.
Bryophytes are the second largest group of plants in the plant kingdom containing about 24000 spe... more Bryophytes are the second largest group of plants in the plant kingdom containing about 24000 species; they are well known to create an incredible range of biologically active compounds Marchantia is a dioecious liverwort found all over the world. It belongs to family Marchantiaceae. Marchantia has been mentioned in ancient Greek medical texts as a very useful plant, used in the prevention of infection and inflammation on open wounds. It has been used as a model system for investigating biological processes. Marchantia and liverworts are rich in flavonoid, tannins and phenolic compounds, the main constituent being Marchantian A which is an anticancer agent. This review article is an attempt to explore the pharmacological aspects of this miracle bryophyte. Context: This review focuses on the study and compilation of pharmacological and therapeutic activities of genus Marchantia. Aims: It was noted that pharmacological details related to genus Marchantia is not well documented. The pr...
Birth disorders defined as any abnormality in the newborn during fetal development. These disorde... more Birth disorders defined as any abnormality in the newborn during fetal development. These disorders are burden to the family and associated with substantial morbidity and mortality. In developing countries the data on the incidences of congenital disorders is very limited. The main objective of this study is to determine the incidence and profile of the congenital disorders present at birth in the newborn. This is a prospective, observational study conducted in government and private nursing home of Pithoragarh District, Uttarakhand. The information objectives of the survey were reflected in the content of the survey questionnaire included child age, gender, disorders at the time of birth. The data shows 200 cases of child birth disorders and intrauterine foetal death observed during five month period. A total of 144 cases of by birth disorders were reported and 56 cases of child death due to disorders and intrauterine foetal death were observed. 144 cases of child birth disorder in...
New and Future Developments in Microbial Biotechnology and Bioengineering, 2018
Abstract Actinobacteria is one of the most widely studied taxa of prokaryotes due to its signific... more Abstract Actinobacteria is one of the most widely studied taxa of prokaryotes due to its significance in biotechnology, medical science, ecology, and other branches of biology, found ubiquitously in soil, freshwater, and marine ecosystems. Although various reports are available on the ecology of Actinobacteria, information is scant on actinobacterial diversity inhabiting hot springs. Recent advances in genome sequencing technology and multiomics approaches have significantly increased the understanding of actinobacterial diversity from various ecosystems. The present chapter highlights the diversity and biotechnological potential of actinobacteria isolated from various hot springs, with special reference to actinobacterial metabolites, i.e., antibiotics, anticancer compounds, enzymes, and enzyme inhibitors, etc.
Pesticides in Crop Production, 2020
Role of Novel Drug Delivery Vehicles in Nanobiomedicine, 2020
Novel drug delivery is a great tool to deliver the drug at a specific site of action by the means... more Novel drug delivery is a great tool to deliver the drug at a specific site of action by the means of specific drug carrier like Solid-lipid Nanoparticles, Nanostructured lipid carriers, lipid vesicles, liposomes, phytosomes and ethosomes. Every carrier used in novel drug delivery system to deliver the drug at targeted site requires some special formulation techniques. These techniques help the drug carrier to deliver the active drug at targeted site, by reducing the side-effect, minimizing the dose, increasing the absorption and increasing the efficacy of the drug. There is a recent upsurge to move "back to nature" for healing body ailments because the report states that conventional treatment cause various side effects to the human body after prolonged used. Various novel drug delivery vesicles/'somes' are being used for the delivery of phytoconstitutents to the targeted site of action. Phytosome is one of the more reliable and best option for the delivery of herbal constituent to the targeted site. The combination of Novel drug delivery with the transdermal route may be a good idea having fast and targeted delivery of drug. Many health challenges like skin diseases, skin burns, migraine, allergies, cardiac problems, diabetes and trauma like bone fracture could be easily managed by the combination of novel drug delivery and the transdermal route in future.
International Journal of Nutrition, Pharmacology, Neurological Diseases, 2017
The most common physical disability in childhood is cerebral palsy (CP). It is difficult to asses... more The most common physical disability in childhood is cerebral palsy (CP). It is difficult to assess and clarify the risk factors associated with this disorder. The aim of this article is to review the recent literature relating to etiology, epidemiology, and advances in the treatment of CP. A systematic search for peer-reviewed articles with keywords “cerebral palsy” and “neurodisability” since 1980 was performed. An investigational research on CP offers an excellent opportunity in understanding the risk factors associated with this disorder as well as its incidences and prevalence. Various new techniques have evolved in the management of CP, such as traditional physiotherapy, occupational therapy, selective dorsal rhizotomy, sensory integration, botulinum toxin injection, and intrathecal baclofen. The care and management of CP in an individual is a very complex process. Although a number of therapeutic interventions have been used by healthcare professionals, but the efficacy of only few has been established by scientific research. To prevent the chances of CP, we need to understand the causes as well as risk factors associated with this disorder.
JOURNAL OF INDIAN COLLEGE OF CARDIOLOGY, 2019
Performance is a person's achievement with regard to all tasks assigned to him. Patient satisfact... more Performance is a person's achievement with regard to all tasks assigned to him. Patient satisfaction can be influenced by factors such as, not in line with expectations and reality, service and personnel behavior is unsatisfactory, the physical condition of the environment, the cost is too high, and the promotion is not in accordance with reality. The purpose of this research is to identify The Correlation between nurse's performances and patient's satisfaction in Emergency Room of RSU GMIM Pancaran Kasih Manado. This research used cross sectional approach. The respondents are consisted of 94 patients and the sampling technique used purposive sampling. Questionnaires were used as the measuring instrument. The result of this research was analyzed by statistical analysis used chi square. The result indicates value (p=0,000) which means the Ha was accepted or there is correlation between nurse's performance and patient's satisfaction in Emergency Room of RSU GMIM Pancaran Kasih Manado. In conclusion this study shows that there are relations between the nurse performance and the patient's satisfaction in Emergency Room of GMIM Pancaran Kasih Public Hospital.
Critical-sized bone defects (CSDs) have a multi-factorial etiology including high-energy trauma, ... more Critical-sized bone defects (CSDs) have a multi-factorial etiology including high-energy trauma, infection, and revision surgery. CSDs are a major clinical dilemma, as reliable, evidenced-based solutions do not exist. The purpose of this study is to develop a healing patch for the CSDs, investigating the best outcome of formulation developed from Cissus qudrangularis and to reduce the side effects of corticosteroids, chemotherapeutic agents, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, and anticoagulants in the patient suffering from CSDs. The primary objective of the study was to estimate the potential of Cissus qudrangularis for fracture healing. The transdermal patch containing ethanolic extract of Cissus qudrangularis was developed by solvent casting method. The formulated patch was further studied for thickness of the patch, moisture content, moisture re-absorption, SEM analysis, drug content, In-vitro drug-release and in-vivo animal activity. Male Wister rats w...
Agroforestry and Climate Change, 2019
Journal of Drug Delivery and Therapeutics, 2019
Streptococcus mutans is the most common cause of tooth decay. Parabens and other commonly used as... more Streptococcus mutans is the most common cause of tooth decay. Parabens and other commonly used as anti-Streptococcus agents in toothpaste industry have numerous side effects such as discoloration of teeth. The herbal extract of all three plants gives antimicrobial and anti-inflammatory activity and prevent and reducing the tooth decay, dental caries and given to freshness of mouth. The aim of present work was development and evaluation of herbal antimicrobial toothpaste containing Bark of Acacia nilotica, Acacia catechu and flower buds of syzygium aromaticum as herbal ingredients. Different types of formulations (F1-F6) were formulated using calcium carbonate as abrasive and Glycerine as humectant in varied concentrations. All the formulations were evaluated for various parameters like dryness, color, appearance, consistency, washability, pH, spreadability and foaming power. Polyherbal toothpaste containing hydroalcoholic extract of plants was tested for antimicrobial activity again...
Asian Pacific Journal of Health Sciences
Plagiochasma appendiculatum, a flavonoid rich liverwort, is reported to be used in the treatment ... more Plagiochasma appendiculatum, a flavonoid rich liverwort, is reported to be used in the treatment of cuts, burns, outside wounds, bacteriostatic, pulmonary tuberculosis, neurasthenia, fractures, convulsions, scalds, uropathy, and inflammation by tribal communities. In the present study, flavonoid luteolin, reported to possess anti-inflammatory potential, is isolated from P. appendiculatum methanol extract and extract is evaluated for anti-inflammatory effect. Anti-inflammatory potential was studied by protein denaturation assay and carrageenan-induced rat paw edema method. Plant flavonoid is isolated from methanol extract by column chromatography, using petroleum ether and ethyl acetate in various proportion, as mobile phase. Further identified by spectroscopic analysis. In vitro studies, at a concentration of 800 μg/ml, P. appendiculatum methanolic extract (PAME) exhibited 74% inhibition while indomethacin showed 79% inhibition at the same concentration. The extract exhibits a decre...
Journal of Pharmacognosy and Phytochemistry, 2014
Air dried leaves essential oil was extracted by hydrodistillation. Quantitative Phytochemical ana... more Air dried leaves essential oil was extracted by hydrodistillation. Quantitative Phytochemical analysis of volatile compounds viz. Limonin, Citronellol, linalool and terpineol was done by Gas chromatography, Limonin, linalool, terpineol (36.9%, 2.12%, 4.19%) was found higher extent in Citrus limettioides as compared to Citrus pseudo limon (10.6%,1.7%, 2.59%). Citronellol content was found higher extent in Citrus pseudo limon (62.30%) than Citrus limettioides (5.11%). Antioxidant activity of leaves essential oil was done by using 1, 1, Diphenyl 2Picryl Hydrazine (DPPH) free radical scavenging assay. IC50 of both plants leaves essential oil was calculated. Comparative study shows that Citrus limettioides shows higher antioxidant potential (IC50= 15.35 ul) as compared to Citrus pseudo limon (IC50= 18.43 ul) against DPPH free radicals.
Industrial Crops and Products, 2009
The chemical composition of essential oils isolated from aerial parts of native populations of Or... more The chemical composition of essential oils isolated from aerial parts of native populations of Origanum vulgare L. from northwestern Himalaya was investigated by enantioselective gas chromatography (enantio-GC), capillary-gas chromatography (capillary-GC) and GC-MS. Seventy compounds, which accounted for 84.9-97% of the oil composition, have been identified. The oils were allotted to two main groups; the first group had a high percentage of components belonging to the thymol/carvacrol biosynthetic pathway and the second was characterized by a different sesquiterpene composition and a high linalool and bornyl acetate percentage. Essential oils of O. vulgare populations from Rilkot and Dhanachuli areas in northwestern Himalaya were characterized by high monoterpenoids proportions as compared to Nainital and Bhowali populations, which were dominated by sesquiterpenoids. High proportions of thymol (29.2-82%) were found only in two populations. Composition of the samples collected from Dhanachuli area differed from Nainital and Bhowali collections by a unique presence of carvacrol. Notably, there were significant differences in the concentration of rest of the terpenes in all the collections. On enantio-GC, enantiomeric excess for (3R) (−)-and (3S) (+)-linalool, (S) (+)-and (R) (−)-terpinen-4-ol, (S) (−)-and (R) (+)-˛-terpineol, (1S) (−)-bornyl acetate and (1S) (−)-borneol were established in populations from Bhowali and Dhanachuli area. Moreover, linalool type oregano may be useful in promoting wider commercial utilization of the biodiversity of this species.
Naturally Occurring Chemicals Against Alzheimer's Disease, 2021
Abstract Many herbal plant extracts as well as their bio-active compound are considered to be saf... more Abstract Many herbal plant extracts as well as their bio-active compound are considered to be safer and their use is widely acceptable. It was found that many herbs with anti-inflammatory potential may reduce inflammation of brain tissues. Several steroids, terpenoids (di and tri), long chain aliphatic tetrols and esters found in the plant Guggulu (Commiphora wightii) possess anti-oxidant as well as anti-inflammatory properties. Guggulu in India, has been used in traditional system of medicines from the past several years in the treatment of hypercholesterolemia, atherosclerosis, arthritis, gout, rheumatism, inflammation and obesity. Alzheimer diseases is a neurodegenerative disorder caused by oxidative stress and inflammation of neurons. This chapter investigates the therapeutic role of various bio-active compounds present in Guggulu (Commiphora wightii) in the treatment of Alzheimer disease.
Urological Science, 2019
Background: Pesticide exposure has the potential for causing acute or chronic health effects at c... more Background: Pesticide exposure has the potential for causing acute or chronic health effects at certain developmental stages of life. It can result in irreversible damage to structure and function of an organ. The exposure of females to pesticides before or after pregnancy is a matter of concern because of the possibility of having a child born with congenital disorders and developmental defects. Prenatal exposure of any toxicants can program the developing foetus to develop diseases that manifest in later life. Very few reports are available related to the pesticide exposure induced morphological changes in kidney which has prompted us to undertake this research study. Aim: The aim of this study is to evaluate the effect of pesticide, chlorpyrifos on the kidney development of rat neonates after being exposed prenatally to pesticides throughout their gestational period. Materials and Methods: Virgin female wistar rats weighing 200-250 gms were mated with adult males. It consisted of twelve, divided into two sub groups six rats per each were treated with selected pesticides, chlorpyrifos (insecticide) readily available commercially for various agricultural and non-agricultural settings. Insecticide chlorpyrifos was given at a dose of 10mg/kg per orally to the female rats throughout their gestation period. After gestation period rat neonates were sacrificed and their kidney section was processed for histopathological analysis. The SEM study of chlorpyrifos exposed kidney section of rat neonates was performed, investigating changes in morphometric and ultra-structural features of kidney in rat neonates. Results: The histopathological analysis shows morphological changes in the kidneys of prenatally pesticides exposed rat neonates markedly different from control group. Chlorpyrifos exposed neonates kidney shows damaged kidney corpuscles and glomeruli. Conclusion: This study concluded that pesticide exposure during gestation period to pregnant rats causes significant renal toxicity in their neonates.
Bryophytes are the second largest group of plants in the plant kingdom containing about 24000 spe... more Bryophytes are the second largest group of plants in the plant kingdom containing about 24000 species; they are well known to create an incredible range of biologically active compounds Marchantia is a dioecious liverwort found all over the world. It belongs to family Marchantiaceae. Marchantia has been mentioned in ancient Greek medical texts as a very useful plant, used in the prevention of infection and inflammation on open wounds. It has been used as a model system for investigating biological processes. Marchantia and liverworts are rich in flavonoid, tannins and phenolic compounds, the main constituent being Marchantian A which is an anticancer agent. This review article is an attempt to explore the pharmacological aspects of this miracle bryophyte. Context: This review focuses on the study and compilation of pharmacological and therapeutic activities of genus Marchantia. Aims: It was noted that pharmacological details related to genus Marchantia is not well documented. The pr...
Birth disorders defined as any abnormality in the newborn during fetal development. These disorde... more Birth disorders defined as any abnormality in the newborn during fetal development. These disorders are burden to the family and associated with substantial morbidity and mortality. In developing countries the data on the incidences of congenital disorders is very limited. The main objective of this study is to determine the incidence and profile of the congenital disorders present at birth in the newborn. This is a prospective, observational study conducted in government and private nursing home of Pithoragarh District, Uttarakhand. The information objectives of the survey were reflected in the content of the survey questionnaire included child age, gender, disorders at the time of birth. The data shows 200 cases of child birth disorders and intrauterine foetal death observed during five month period. A total of 144 cases of by birth disorders were reported and 56 cases of child death due to disorders and intrauterine foetal death were observed. 144 cases of child birth disorder in...
New and Future Developments in Microbial Biotechnology and Bioengineering, 2018
Abstract Actinobacteria is one of the most widely studied taxa of prokaryotes due to its signific... more Abstract Actinobacteria is one of the most widely studied taxa of prokaryotes due to its significance in biotechnology, medical science, ecology, and other branches of biology, found ubiquitously in soil, freshwater, and marine ecosystems. Although various reports are available on the ecology of Actinobacteria, information is scant on actinobacterial diversity inhabiting hot springs. Recent advances in genome sequencing technology and multiomics approaches have significantly increased the understanding of actinobacterial diversity from various ecosystems. The present chapter highlights the diversity and biotechnological potential of actinobacteria isolated from various hot springs, with special reference to actinobacterial metabolites, i.e., antibiotics, anticancer compounds, enzymes, and enzyme inhibitors, etc.
Pesticides in Crop Production, 2020
Role of Novel Drug Delivery Vehicles in Nanobiomedicine, 2020
Novel drug delivery is a great tool to deliver the drug at a specific site of action by the means... more Novel drug delivery is a great tool to deliver the drug at a specific site of action by the means of specific drug carrier like Solid-lipid Nanoparticles, Nanostructured lipid carriers, lipid vesicles, liposomes, phytosomes and ethosomes. Every carrier used in novel drug delivery system to deliver the drug at targeted site requires some special formulation techniques. These techniques help the drug carrier to deliver the active drug at targeted site, by reducing the side-effect, minimizing the dose, increasing the absorption and increasing the efficacy of the drug. There is a recent upsurge to move "back to nature" for healing body ailments because the report states that conventional treatment cause various side effects to the human body after prolonged used. Various novel drug delivery vesicles/'somes' are being used for the delivery of phytoconstitutents to the targeted site of action. Phytosome is one of the more reliable and best option for the delivery of herbal constituent to the targeted site. The combination of Novel drug delivery with the transdermal route may be a good idea having fast and targeted delivery of drug. Many health challenges like skin diseases, skin burns, migraine, allergies, cardiac problems, diabetes and trauma like bone fracture could be easily managed by the combination of novel drug delivery and the transdermal route in future.
International Journal of Nutrition, Pharmacology, Neurological Diseases, 2017
The most common physical disability in childhood is cerebral palsy (CP). It is difficult to asses... more The most common physical disability in childhood is cerebral palsy (CP). It is difficult to assess and clarify the risk factors associated with this disorder. The aim of this article is to review the recent literature relating to etiology, epidemiology, and advances in the treatment of CP. A systematic search for peer-reviewed articles with keywords “cerebral palsy” and “neurodisability” since 1980 was performed. An investigational research on CP offers an excellent opportunity in understanding the risk factors associated with this disorder as well as its incidences and prevalence. Various new techniques have evolved in the management of CP, such as traditional physiotherapy, occupational therapy, selective dorsal rhizotomy, sensory integration, botulinum toxin injection, and intrathecal baclofen. The care and management of CP in an individual is a very complex process. Although a number of therapeutic interventions have been used by healthcare professionals, but the efficacy of only few has been established by scientific research. To prevent the chances of CP, we need to understand the causes as well as risk factors associated with this disorder.
JOURNAL OF INDIAN COLLEGE OF CARDIOLOGY, 2019
Performance is a person's achievement with regard to all tasks assigned to him. Patient satisfact... more Performance is a person's achievement with regard to all tasks assigned to him. Patient satisfaction can be influenced by factors such as, not in line with expectations and reality, service and personnel behavior is unsatisfactory, the physical condition of the environment, the cost is too high, and the promotion is not in accordance with reality. The purpose of this research is to identify The Correlation between nurse's performances and patient's satisfaction in Emergency Room of RSU GMIM Pancaran Kasih Manado. This research used cross sectional approach. The respondents are consisted of 94 patients and the sampling technique used purposive sampling. Questionnaires were used as the measuring instrument. The result of this research was analyzed by statistical analysis used chi square. The result indicates value (p=0,000) which means the Ha was accepted or there is correlation between nurse's performance and patient's satisfaction in Emergency Room of RSU GMIM Pancaran Kasih Manado. In conclusion this study shows that there are relations between the nurse performance and the patient's satisfaction in Emergency Room of GMIM Pancaran Kasih Public Hospital.