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Papers by Mahmoud Ragab

Research paper thumbnail of Acute Postdialysis Changes in Plasma ICAM-1 and IL1 Levels in Hemodialysis Patients

Hemodialysis International, 2003

Fifty subjects: 20 controls and 30 hemodialysis patients were included in the study. The acute ch... more Fifty subjects: 20 controls and 30 hemodialysis patients were included in the study. The acute changes in plasma ICAM-1 and IL-1β levels immediately after dialysis were evaluated using two types of membranes and two types of dialysate.The predialysis ICAM-1 level in the whole patients was significantly higher than controls, while that of IL-1β was significantly lower. The postdialysis ICAM-1 showed insignificant higher level than the predialysis one, while that of IL-1β showed significant higher level than both the predialysis and control levels.Both postdialysis ICAM-1 and IL-1β levels in patients using cuprophane membrane (bioincompatible) showed insignificant higher levels than in those using polysulfone one (biocompatible). The percent increase in ICAM-1 level did not significantly differ in these two subgroups, while the percent increase in IL-1β level showed significantly higher value in those using bioincompatible membrane (108%) than that in those using biocompatible membrane (44%).No significant difference in the levels of either ICAM-1 or IL-1β were found between patients using acetate and bicarbonate dialysate.Conclusion: the bioincompatibility of the membrane is the important factor in the occurrence of the acute reaction during hemodialysis.

Research paper thumbnail of Changes in pTau in CSF and brain relating to chronic hydrocephalus

Cerebrospinal Fluid Research, 2004

Research paper thumbnail of Treatment of third ventriculostomy failure: re-fenestration or shunt

Cerebrospinal Fluid Research, 2004

Though endoscopic third ventriculostomy (ETV) has proven to be a valid alternative to shunting fo... more Though endoscopic third ventriculostomy (ETV) has proven to be a valid alternative to shunting for some hydrocephalic patients, the decision to re-fenestrate or shunt after ETV failure is less clear. The aim of this retrospective study was to evaluate the clinical outcome and complications for patients who required re-fenestration or shunting compared to initial ETV cases.

Research paper thumbnail of 184 TOLTERODINE EXTENDED RELEASE IMPROVES OVERACTIVE BLADDER SYMPTOMS IN MEN TREATED WITH α-BLOCKERS IRRESPECTIVE OF BASELINE SERUM PROSTATE-SPECIFIC ANTIGEN LEVEL

European Urology Supplements, 2009

Research paper thumbnail of Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects

A Ab bs st tr ra ac ct t This study aimed to evaluate the plasma homocysteine (tHcy) and folate l... more A Ab bs st tr ra ac ct t This study aimed to evaluate the plasma homocysteine (tHcy) and folate levels as well as the methylenetetrahydrofolate reductase (MTHFR) C677T mutation in Egyptian subjects. Fasting total homocysteine (tHcy) and the (MTHFR) C677T mutation were evaluated in 50 healthy young control males (age 35-50 years, Gp1), 50 elderly males age ranged between 50-75 years without any cardiovascular diseases (Gp2) and 50 age matched elderly male patients (Gp3) with myocardial infarction. There was a significant elevation of plasma tHcy in the patients group and Gp2 compared to the young control group (Gp1). The total plasma homocysteine (tHcy) in the control group, Gp2 and the patients group were 17.99 ± 9.76, 39.9 ± 20.06 and 43.8 ± 13.13 µmol/L respectively. The frequency of the TT genotype was 12% in the patient group compared with 8 % in the young healthy controls and elderly subjects (Gp2). The CT genotype constituted 36%, 48% and 44% in the control group, Gp2 and the patients group respectively. There was no significant difference in the occurrence of the TT genotype between the studied groups. Plasma tHcy correlated positively with age, total cholesterol, urea, creatinine, glucose levels and carotid intimal thickness (CIT). Conclusion: The MTHFR mutation does not seem to be associated with either high tHcy or the occurrence of cardiovascular diseases in the studied patients. However, elevated plasma tHcy level positively correlates with age in the studied subjects.

Research paper thumbnail of Acute Postdialysis Changes in Plasma ICAM-1 and IL1 Levels in Hemodialysis Patients

Hemodialysis International, 2003

Fifty subjects: 20 controls and 30 hemodialysis patients were included in the study. The acute ch... more Fifty subjects: 20 controls and 30 hemodialysis patients were included in the study. The acute changes in plasma ICAM-1 and IL-1β levels immediately after dialysis were evaluated using two types of membranes and two types of dialysate.The predialysis ICAM-1 level in the whole patients was significantly higher than controls, while that of IL-1β was significantly lower. The postdialysis ICAM-1 showed insignificant higher level than the predialysis one, while that of IL-1β showed significant higher level than both the predialysis and control levels.Both postdialysis ICAM-1 and IL-1β levels in patients using cuprophane membrane (bioincompatible) showed insignificant higher levels than in those using polysulfone one (biocompatible). The percent increase in ICAM-1 level did not significantly differ in these two subgroups, while the percent increase in IL-1β level showed significantly higher value in those using bioincompatible membrane (108%) than that in those using biocompatible membrane (44%).No significant difference in the levels of either ICAM-1 or IL-1β were found between patients using acetate and bicarbonate dialysate.Conclusion: the bioincompatibility of the membrane is the important factor in the occurrence of the acute reaction during hemodialysis.

Research paper thumbnail of Changes in pTau in CSF and brain relating to chronic hydrocephalus

Cerebrospinal Fluid Research, 2004

Research paper thumbnail of Treatment of third ventriculostomy failure: re-fenestration or shunt

Cerebrospinal Fluid Research, 2004

Though endoscopic third ventriculostomy (ETV) has proven to be a valid alternative to shunting fo... more Though endoscopic third ventriculostomy (ETV) has proven to be a valid alternative to shunting for some hydrocephalic patients, the decision to re-fenestrate or shunt after ETV failure is less clear. The aim of this retrospective study was to evaluate the clinical outcome and complications for patients who required re-fenestration or shunting compared to initial ETV cases.

Research paper thumbnail of 184 TOLTERODINE EXTENDED RELEASE IMPROVES OVERACTIVE BLADDER SYMPTOMS IN MEN TREATED WITH α-BLOCKERS IRRESPECTIVE OF BASELINE SERUM PROSTATE-SPECIFIC ANTIGEN LEVEL

European Urology Supplements, 2009

Research paper thumbnail of Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects

A Ab bs st tr ra ac ct t This study aimed to evaluate the plasma homocysteine (tHcy) and folate l... more A Ab bs st tr ra ac ct t This study aimed to evaluate the plasma homocysteine (tHcy) and folate levels as well as the methylenetetrahydrofolate reductase (MTHFR) C677T mutation in Egyptian subjects. Fasting total homocysteine (tHcy) and the (MTHFR) C677T mutation were evaluated in 50 healthy young control males (age 35-50 years, Gp1), 50 elderly males age ranged between 50-75 years without any cardiovascular diseases (Gp2) and 50 age matched elderly male patients (Gp3) with myocardial infarction. There was a significant elevation of plasma tHcy in the patients group and Gp2 compared to the young control group (Gp1). The total plasma homocysteine (tHcy) in the control group, Gp2 and the patients group were 17.99 ± 9.76, 39.9 ± 20.06 and 43.8 ± 13.13 µmol/L respectively. The frequency of the TT genotype was 12% in the patient group compared with 8 % in the young healthy controls and elderly subjects (Gp2). The CT genotype constituted 36%, 48% and 44% in the control group, Gp2 and the patients group respectively. There was no significant difference in the occurrence of the TT genotype between the studied groups. Plasma tHcy correlated positively with age, total cholesterol, urea, creatinine, glucose levels and carotid intimal thickness (CIT). Conclusion: The MTHFR mutation does not seem to be associated with either high tHcy or the occurrence of cardiovascular diseases in the studied patients. However, elevated plasma tHcy level positively correlates with age in the studied subjects.

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