Mahmud Baghbanian - Academia.edu (original) (raw)

Papers by Mahmud Baghbanian

Research paper thumbnail of A Patient with Congenital Generalized Lipodystrophy

World Journal of Peri & Neonatology

Background: Congenital generalized lipodystrophy (CGL) presents during the first two years of lif... more Background: Congenital generalized lipodystrophy (CGL) presents during the first two years of life. It is a rare autosomal recessive inherited disease with loss of cutaneous fat and various complaints and complications such as diabetes mellitus, hypertriglyceridaemia and hepatic steatosis. Case Report: A patient was hospitalized with abdominal distention, weight loss, irritability, and pruritus. Massive hepatomegaly, huge splenomegaly, multiple significant lymphadenopathies, hypertrichosis, generalized subcutaneous fat loss with bird-faced, increased musculature, and prominent superficial veins were detected on examination. In paraclinical evaluation, hyperlipidemia and severe liver fibrosis (grade 5) were diagnosed, and she was discharged as a case of congenital generalized lipodystrophy. Conclusion: In an approach to a child with hepatosplenomegaly, lipodystrophy should be in mind.

Research paper thumbnail of Su1424: EVALUATING SHORT DURATION OF NORTRIPTYLINE IN TREATING PREGNANT WOMEN WITH INTRACTABLE DYSPEPSIA

Research paper thumbnail of Photoclinic

Archives of Iranian medicine, 2014

Research paper thumbnail of Hepatitis B and Hepatitis C in large vehicle drivers in center of Iran (Yazd)

Occupational Medicine

Introduction: Hepatitis B and C are major health problems in many countries, especially developin... more Introduction: Hepatitis B and C are major health problems in many countries, especially developing areas. The frequency of hepatitis B is less than 0.8%, and chronic hepatitis C is less than 0.5% in the general population of Yazd in the center of Iran. Large vehicle drivers have some risk factors for acquiring hepatitis B and C infection. This is important because viral hepatitis complications, including cirrhosis and encephalopathy, may lead to road accidents. This study aims to determine the frequency of hepatitis B and C in large vehicle drivers. Material and Methods:In this cross-sectional descriptive study, 516 inter-province large vehicle drivers were tested for HBS Ag and HCV Ab in 2018. Liver function tests, physical examination, and abdominal sonography were done for all subjects with positive HBS Ag and/or anti- HCV. Results: Eight drivers (1.6%) had HBS Ag, and 7 cases (1.4%) had HCV Ab. There was a significant relation between hepatitis B and journey numbers in the month...

Research paper thumbnail of Photoclinic

Archives of Iranian medicine, 2012

Research paper thumbnail of Association between Gastric Pathology and Hepatitis B Virus Infection in Patients with or without Helicobacter Pylori

Asian Pacific Journal of Cancer Prevention, 2019

Background: In the recent years, hepatitis B virus (HBV) infection has been considered as a risk ... more Background: In the recent years, hepatitis B virus (HBV) infection has been considered as a risk factor for gastric cancer, but further studies are required to confirm these claim. The present study was aimed to evaluate the correlation between gastric pathology (precancerous and cancerous conditions) with HBV infection in Helicobacter pylori (H. pylori) positive or negative patients. Methods: In this cross-sectional study, 728 patients under endoscopy examination in Yazd Shaheed Sadoughi Hospital between 2017 and 2018 were participated. Histopathological analysis was performed on gastric specimens. Hepatitis B surface antigen (HBsAg) in sera was detected by the enzyme-linked immunosorbent assay (ELISA). The relationship between gastric pathology and HBV infection were explored by logistic regression analysis. Results: Of 728 patients, HBsAg and H. pylori infection were detected in 83 and 408 patients, respectively. Sixty nine patients were co-infected with H. pylori/HBV. H. pylori infection detected in patients with HbsAg positive significantly more than those were negative for HbsAg (p=0.029). None of HBV/H. pylori co-infected patients did not have normal gastric tissue. A significant difference was seen in histopathology of gastric tissue between HBsAg positive patients with and without H. pylori infection (p<0.0001). The HBsAg was associated with histopathology of gastric (OR=21.56, 95℅CI=7.070-65.741, p<0.001) and as a risk factor for gastritis (OR=12.457, 95℅CI= 3.007-51.614, P=0.001) but no cancer (OR=2.127, 95℅CI=0.242-18.704, P=0.496). Conclusion: The HBV infection alone is associated with some precancerous lesions but is not correlated with gastric cancer. It can increase development of premalignant conditions and carcinoma significantly in H. pylori positive patients.

Research paper thumbnail of Diagnostic and Epidemiologic Features of Hepatitis C among Hemodialysis Patients Living in Yazd Province of Iran

Iranian Journal of Virology, Feb 1, 2014

Research paper thumbnail of Etiology of lower gastrointestinal bleeding in Sulaimani governorate-Kurdistan region-Iraq

International Journal of Surgery Open, 2019

Abstract Background Acute lower gastrointestinal bleeding is arbitrarily defined as bleeding of l... more Abstract Background Acute lower gastrointestinal bleeding is arbitrarily defined as bleeding of less than 3 days in duration, while chronic lower gastrointestinal bleeding is the passage of blood from the rectum over a period of several days or longer and usually implies that blood loss is intermittent or slow. Objectives To find the causes of lower gastrointestinal bleeding and to find the commonest cause to raise awareness of the gastroenterologist personnel, surgeons and internists. Patients and methods The study was conducted as a retrospective cross-sectional study, 734 patients from a total number of 854 patients, underwent colonoscopy in Kurdistan Center for Gastroenterology and Hepatology in Sulaimani governorate, Kurdistan region-Iraq, were recruited, it took a period of 10 months; from 2nd January 2018 to 31st October in 2018. Clinical examination, digital rectal examination, and colonoscopy with biopsy were arranged for each patient. Results Bleeding due to hemorrhoid was the most frequent diagnosis (n = 211, 28.74%) which reported during colonoscopy, which was more common in males (n = 113, 15.3%) than females (n = 98, 13.3%) with female to male ratio of (0.86). Conclusion The most common cause of lower gastrointestinal bleeding in the area is hemorrhoid. Colonoscopy is superior to physical and digital rectal examination in detecting cause of bleeding in lower GIT bleeding.

Research paper thumbnail of Prevalence of Occult Hepatitis B Infection in Iranian Cancer Patients Before Chemotherapy Treatment

Arquivos de gastroenterologia

Occult hepatitis B infection is characterized by negative hepatitis B surface antigen (HBsAg) and... more Occult hepatitis B infection is characterized by negative hepatitis B surface antigen (HBsAg) and also detectable hepatitis B virus (HBV) -DNA, with or without hepatitis B core antibody (anti-HBc). HBV reactivation in individuals under immunosuppressive therapy is critical, occurring in occult HBV. In this study, we aimed to determine the prevalence of occult HBV infection among hepatitis B surface antigen negative in cancer patients before receiving chemotherapy. Sera from 204 cancer patients who were negative for HBsAg, were tested for anti-HBc antibodies. The samples that were negative for HBsAg but positive for anti-HBc also examined for HBV-DNA by polymerase chain reaction (PCR). Of the 204 HBsAg negative blood samples, 11 (5.4%) samples were positive for anti-HBc antibodies. HBV-DNA was detected in 9/11 (81%) of anti-HBc positive samples. Occult HBV infection in hematological cancers was more than solid cancers, 4.8% and 4.3% respectively. There was no significant difference i...

Research paper thumbnail of Giant fibrovascular polyp of the sigmoid colon

Journal of Case Reports in Practice, 2013

Research paper thumbnail of Etiology of Lower Gastrointestinal Bleeding in Patients Less than 40 Years Old, Yazd, Iran

Majallah-i Dānishgāh-i 'Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2018

Introduction: Most common causes of lower gastrointestinal bleeding (LGIB) in young patients are ... more Introduction: Most common causes of lower gastrointestinal bleeding (LGIB) in young patients are benign perianal lesions, but serious colorectal disease may be underlying etiology in this group. The aim of this study was identification of LGIB etiologies in the patients under 40 years old. Materials: In this retrospective descriptive study, which has been done during 2012-2013, 333 young patients (less than 40 years old) with lower GIB referred to Endoscopy Ward of Yazd Shahid Sadoughi Hospital assessed by colonoscopy with or without histopathology. Resultus: In this study, 57% of patients were males. Majority of them were between 30-40 years old. The most common presentation was hematochezia (49%) and the most common cause was internal hemorrhoid (17%). Other causes included: inflammatory bowel disease (15%), polyp (9%), infectious colitis (8%), anal fissure (6%), colon cancer (4%), solitary rectal ulcer (4%), vascular lesion (2%), aphtus lesion (1.1%), diverticulosis (0.6%) ,anal ...

Research paper thumbnail of CASE REPORT Giant fibrovascular polyp of the sigmoid colon

We present a patient with large fibrovascular polyp of the sigmoid; an extremely rare submucosal ... more We present a patient with large fibrovascular polyp of the sigmoid; an extremely rare submucosal tumor with only one case report in the literature. A 78-year-old woman presented with constipation and abdominal pain and intermittent maroon stool. Colonoscopic examination and other imaging revealed a large (6 centimeter), intralu-minal pedunculated polyp in the sigmoid that was removed as segmental colectomy. Histological diagnosis of the surgical specimen was fibrovascular polyp. Fibrovascular polyp of the colon is an extremely rare submucosal intraluminal tumor that can cause constipation, abdominal pain, obstruction, and or bleeding.

Research paper thumbnail of A Randomized Clinical Trial Comparing the Efficacy and Tolerability of Two Quadruple Regimens: Bismuth, Omeprazole, Metronidazole with Amoxicillin or Tetracycline as First-Line Treatment for Eradication of Helicobacter Pylori in Patients with Duodenal Ulce v1 (protocols.io.mdjc24n)

Aim: To evaluate the efficacy and tolerability of replacing tetracycline with high dose of amoxic... more Aim: To evaluate the efficacy and tolerability of replacing tetracycline with high dose of amoxicillin in bismuth-based quadruple therapy for H.pylori eradication. Methods: This randomized, open label clinical trial study was performed on 228 patients with H.pylori infection and duodenal ulcer without the history of previous H.pylori treatment. Patients were randomly divided into two groups. Group one received metronidazole 500mg, bismuth subcitrate 240mg and amoxicillin 1000mg, all three times a day and omeprazole 20 mg twice a day (amoxicillin group)for14 days. The second group received metronidazole 500mg three times a day and bismuth subcitrate240mg and tetracycline HCL 500mg both four times a day and omeprazole 20 mg twice a day (tetracycline group), for 14 days. Evaluation for compliance and drugs side effects were done after two weeks. Eight weeks after treatment, H.pylori eradication rate was assessed by c13-urease breath test. Results: Two hundred twenty-eight patients were enrolled. There was no statistically significant demographic difference between two groups. Amoxicillin containing regimen achieved higher Eradication rate: 105 of 110 ,95.51% (95%CI 91.5% to 99.3%) and 88 of 105, 83.8% (95% CI 76.7% to 90.8%) by per-protocol analysis (p-value=0.005) and 92.9%(95%CI 88.1% to 97.6%) and 76.5% (95% CI 68.7% to 84.2%) by intention-totreat (p-value=0.001) for amoxicillin and tetracycline groups, respectively. Adverse events were statistically more significant higher in Tetracycline group (65.2%) amoxicillin group (43.4%) (P value = 0.001). Conclusion: Bismuth based quadruple therapy included high dose of amoxicillin and metronidazole has an acceptable H. pylori infection eradication rate with good tolerance in patients with duodenal ulcer. This can overcome treatment resistance in areas with high prevalence of metronidazole and clarithromycin resistance DOI dx.

Research paper thumbnail of A 63 years old woman with progressive mechanical dysphagia and weight loss: a case presentation

Gastroenterology and hepatology from bed to bench, 2013

When considering a patient with dysphagia, an attempt should be made to determine whether the pat... more When considering a patient with dysphagia, an attempt should be made to determine whether the patient has difficulty only with solid boluses (suggestive of mechanical dysphagia) or with liquids and solids (suggestive of a motility dysphagia). Lesions such as an oesophageal tumor and external pressure effect from a lung tumor or aberrant vessel can lead to mechanical dysphagia. Endoscopy and / or a barium swallow are helpful in identifying the anatomical disarrangement. In this study a patient with progressive mechanical dysphagia is presented that finally diagnosed by as Lung Squamous Cell Carcinoma. There were no respiratory symptoms. Diagnosis was made by a computerized tomography scan of the thorax, bronchoscopy and bronchial biopsy.

Research paper thumbnail of Serum CA19-9 in patients with solid pancreatic mass

Gastroenterology and hepatology from bed to bench, 2013

This study evaluated the results and efficacy of serum CA 19-9 in determining the nature of a pan... more This study evaluated the results and efficacy of serum CA 19-9 in determining the nature of a pancreatic solid mass in patients referred for investigation of possible malignancy. A wide variety of tumor markers have been proposed for pancreatic cancer but currently the only one with any practical usefulness for diagnosis, prognosis, and monitoring of treatment is "CA 19-9". This present study is a single center 2 year descriptive, prospective and case series studying patients with a pancreatic solid mass. Serum CA 19-9 was checked in 159 patients. The majority of patients were male (68%) and 81% had mass in the head of pancreas. Pathologic assessment revealed 131 adenocarcinomas (82%), 10 other malignancies (6%), 7 benign lesion (4%) and was non-diagnostic in 11 cases (7%). Mean level of this tumor marker in patients with adenocarcinoma, non-adenocarcinoma malignancy, benign and non-diagnostic pathology was 1094, 1004, 120, 259 U/ML respectively. With regarding 58 U/ML as ...

Research paper thumbnail of Gastroenterol Hepatol Bed Bench 2013;6(1):32-35

Aim: This study evaluated the results and efficacy of serum CA 19-9 in determining the nature of ... more Aim: This study evaluated the results and efficacy of serum CA 19-9 in determining the nature of a pancreatic solid mass in patients referred for investigation of possible malignancy. Background: A wide variety of tumor markers have been proposed for pancreatic cancer but currently the only one with any practical usefulness for diagnosis, prognosis, and monitoring of treatment is “CA 19-9”. Patients and methods: This present study is a single center 2 year descriptive, prospective and case series studying patients with a pancreatic solid mass. Results: Serum CA 19-9 was checked in 159 patients.The majority of patients were male (68%) and 81 % had mass in the head of pancreas. Pathologic assessment revealed 131 adenocarcinomas (82%), 10 other malignancies (6%), 7 benign lesion (4%) and was non-diagnostic in 11 cases (7%). Mean level of this tumor marker in patients with adenocarcinoma, non-adenocarcinoma malignancy, benign and non-diagnostic pathology was 1094, 1004, 120, 259 U/ML re...

Research paper thumbnail of Gastroenterol Hepatol Bed Bench 2013;6(4):214-216 Gastroenterology and Hepatology From Bed to Bench

Early diagnosis and appropriate treatment of cholangiocarcinoma is problematic. Cross sectional i... more Early diagnosis and appropriate treatment of cholangiocarcinoma is problematic. Cross sectional imaging and tumor marker CA 19-9 are not absolutely reliable and tissue sampling is difficult. We present a patient with cholangitis and cystic dilation of intra-hepatic bile ducts that primarily diagnosed as Caroli's disease in imaging and needle biopsy but laparotomy and surgical biopsy revealed cholangiocarcinoma.

Research paper thumbnail of Result and Efficacy of Endoscopic Ultrasound Guided Fna in Patients with Solid Pancreatic Neoplasm

Research paper thumbnail of Pancreatic Tail Hydatid Cyst as a Rare Cause for Severe Acute Pancreatitis: A Case Report

  Iran is an endemic region for hydatid disease. Primary pancreatic hydatosis is a rare event... more   Iran is an endemic region for hydatid disease. Primary pancreatic hydatosis is a rare event; severe acute pancreatitis related to pancreatic hydatid cyst is extremely rare. We present the case of a patient with severe acute pancreatitis and hydatosis of the pancreas without liver or lung involvement. All etiologies for acute pancreatitis were excluded. The patient underwent a distal pancreatectomy which led to the diagnosis of pancreatic hydatosis. Since hydatid disease is endemic in some regions, it should be considered as one of the underlying etiologies for inflammation or infection of the pancreas (acute pancreatitis). Normal 0 false false false EN-US X-NONE FA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-ma...

Research paper thumbnail of Indications, One-Year Survival, and Complications of Percutaneous Endoscopic Gastrostomy: A Cross Sectional Study

Background: Providing ways for long-term feeding is essential for those who are not able to inges... more Background: Providing ways for long-term feeding is essential for those who are not able to ingest. Percutaneous endoscopic gastrostomy (PEG) is a type of enteral feeding methods. The aim of this study was to evaluate the complications, indications, and one-year survival of this method in patients who underwent PEG. Materials and Methods: The cross-sectional study was carried out on 97 patients (census sampling) who had referred to Shahid Sadoughi Hospital in Yazd (Iran) for PEG tube placement in the period of March 2014 to March 2016. Data were collected using a researcher-made questionnaire and were analyzed using SPSS software version 18. Results: Cerebrovascular accident (CVA) was the most reason to refer to the hospital (52 cases, [%53.6]) followed by head and neck trauma (32 cases [33%]), head and neck tumors (6 cases, [6.2%]), ischemic encephalopathy (5 cases, [5.2%]), and burning (head trauma) (2 cases [1.2%]). Wound infection was observed in eight cases (8.2%), aspiration i...

Research paper thumbnail of A Patient with Congenital Generalized Lipodystrophy

World Journal of Peri & Neonatology

Background: Congenital generalized lipodystrophy (CGL) presents during the first two years of lif... more Background: Congenital generalized lipodystrophy (CGL) presents during the first two years of life. It is a rare autosomal recessive inherited disease with loss of cutaneous fat and various complaints and complications such as diabetes mellitus, hypertriglyceridaemia and hepatic steatosis. Case Report: A patient was hospitalized with abdominal distention, weight loss, irritability, and pruritus. Massive hepatomegaly, huge splenomegaly, multiple significant lymphadenopathies, hypertrichosis, generalized subcutaneous fat loss with bird-faced, increased musculature, and prominent superficial veins were detected on examination. In paraclinical evaluation, hyperlipidemia and severe liver fibrosis (grade 5) were diagnosed, and she was discharged as a case of congenital generalized lipodystrophy. Conclusion: In an approach to a child with hepatosplenomegaly, lipodystrophy should be in mind.

Research paper thumbnail of Su1424: EVALUATING SHORT DURATION OF NORTRIPTYLINE IN TREATING PREGNANT WOMEN WITH INTRACTABLE DYSPEPSIA

Research paper thumbnail of Photoclinic

Archives of Iranian medicine, 2014

Research paper thumbnail of Hepatitis B and Hepatitis C in large vehicle drivers in center of Iran (Yazd)

Occupational Medicine

Introduction: Hepatitis B and C are major health problems in many countries, especially developin... more Introduction: Hepatitis B and C are major health problems in many countries, especially developing areas. The frequency of hepatitis B is less than 0.8%, and chronic hepatitis C is less than 0.5% in the general population of Yazd in the center of Iran. Large vehicle drivers have some risk factors for acquiring hepatitis B and C infection. This is important because viral hepatitis complications, including cirrhosis and encephalopathy, may lead to road accidents. This study aims to determine the frequency of hepatitis B and C in large vehicle drivers. Material and Methods:In this cross-sectional descriptive study, 516 inter-province large vehicle drivers were tested for HBS Ag and HCV Ab in 2018. Liver function tests, physical examination, and abdominal sonography were done for all subjects with positive HBS Ag and/or anti- HCV. Results: Eight drivers (1.6%) had HBS Ag, and 7 cases (1.4%) had HCV Ab. There was a significant relation between hepatitis B and journey numbers in the month...

Research paper thumbnail of Photoclinic

Archives of Iranian medicine, 2012

Research paper thumbnail of Association between Gastric Pathology and Hepatitis B Virus Infection in Patients with or without Helicobacter Pylori

Asian Pacific Journal of Cancer Prevention, 2019

Background: In the recent years, hepatitis B virus (HBV) infection has been considered as a risk ... more Background: In the recent years, hepatitis B virus (HBV) infection has been considered as a risk factor for gastric cancer, but further studies are required to confirm these claim. The present study was aimed to evaluate the correlation between gastric pathology (precancerous and cancerous conditions) with HBV infection in Helicobacter pylori (H. pylori) positive or negative patients. Methods: In this cross-sectional study, 728 patients under endoscopy examination in Yazd Shaheed Sadoughi Hospital between 2017 and 2018 were participated. Histopathological analysis was performed on gastric specimens. Hepatitis B surface antigen (HBsAg) in sera was detected by the enzyme-linked immunosorbent assay (ELISA). The relationship between gastric pathology and HBV infection were explored by logistic regression analysis. Results: Of 728 patients, HBsAg and H. pylori infection were detected in 83 and 408 patients, respectively. Sixty nine patients were co-infected with H. pylori/HBV. H. pylori infection detected in patients with HbsAg positive significantly more than those were negative for HbsAg (p=0.029). None of HBV/H. pylori co-infected patients did not have normal gastric tissue. A significant difference was seen in histopathology of gastric tissue between HBsAg positive patients with and without H. pylori infection (p<0.0001). The HBsAg was associated with histopathology of gastric (OR=21.56, 95℅CI=7.070-65.741, p<0.001) and as a risk factor for gastritis (OR=12.457, 95℅CI= 3.007-51.614, P=0.001) but no cancer (OR=2.127, 95℅CI=0.242-18.704, P=0.496). Conclusion: The HBV infection alone is associated with some precancerous lesions but is not correlated with gastric cancer. It can increase development of premalignant conditions and carcinoma significantly in H. pylori positive patients.

Research paper thumbnail of Diagnostic and Epidemiologic Features of Hepatitis C among Hemodialysis Patients Living in Yazd Province of Iran

Iranian Journal of Virology, Feb 1, 2014

Research paper thumbnail of Etiology of lower gastrointestinal bleeding in Sulaimani governorate-Kurdistan region-Iraq

International Journal of Surgery Open, 2019

Abstract Background Acute lower gastrointestinal bleeding is arbitrarily defined as bleeding of l... more Abstract Background Acute lower gastrointestinal bleeding is arbitrarily defined as bleeding of less than 3 days in duration, while chronic lower gastrointestinal bleeding is the passage of blood from the rectum over a period of several days or longer and usually implies that blood loss is intermittent or slow. Objectives To find the causes of lower gastrointestinal bleeding and to find the commonest cause to raise awareness of the gastroenterologist personnel, surgeons and internists. Patients and methods The study was conducted as a retrospective cross-sectional study, 734 patients from a total number of 854 patients, underwent colonoscopy in Kurdistan Center for Gastroenterology and Hepatology in Sulaimani governorate, Kurdistan region-Iraq, were recruited, it took a period of 10 months; from 2nd January 2018 to 31st October in 2018. Clinical examination, digital rectal examination, and colonoscopy with biopsy were arranged for each patient. Results Bleeding due to hemorrhoid was the most frequent diagnosis (n = 211, 28.74%) which reported during colonoscopy, which was more common in males (n = 113, 15.3%) than females (n = 98, 13.3%) with female to male ratio of (0.86). Conclusion The most common cause of lower gastrointestinal bleeding in the area is hemorrhoid. Colonoscopy is superior to physical and digital rectal examination in detecting cause of bleeding in lower GIT bleeding.

Research paper thumbnail of Prevalence of Occult Hepatitis B Infection in Iranian Cancer Patients Before Chemotherapy Treatment

Arquivos de gastroenterologia

Occult hepatitis B infection is characterized by negative hepatitis B surface antigen (HBsAg) and... more Occult hepatitis B infection is characterized by negative hepatitis B surface antigen (HBsAg) and also detectable hepatitis B virus (HBV) -DNA, with or without hepatitis B core antibody (anti-HBc). HBV reactivation in individuals under immunosuppressive therapy is critical, occurring in occult HBV. In this study, we aimed to determine the prevalence of occult HBV infection among hepatitis B surface antigen negative in cancer patients before receiving chemotherapy. Sera from 204 cancer patients who were negative for HBsAg, were tested for anti-HBc antibodies. The samples that were negative for HBsAg but positive for anti-HBc also examined for HBV-DNA by polymerase chain reaction (PCR). Of the 204 HBsAg negative blood samples, 11 (5.4%) samples were positive for anti-HBc antibodies. HBV-DNA was detected in 9/11 (81%) of anti-HBc positive samples. Occult HBV infection in hematological cancers was more than solid cancers, 4.8% and 4.3% respectively. There was no significant difference i...

Research paper thumbnail of Giant fibrovascular polyp of the sigmoid colon

Journal of Case Reports in Practice, 2013

Research paper thumbnail of Etiology of Lower Gastrointestinal Bleeding in Patients Less than 40 Years Old, Yazd, Iran

Majallah-i Dānishgāh-i 'Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2018

Introduction: Most common causes of lower gastrointestinal bleeding (LGIB) in young patients are ... more Introduction: Most common causes of lower gastrointestinal bleeding (LGIB) in young patients are benign perianal lesions, but serious colorectal disease may be underlying etiology in this group. The aim of this study was identification of LGIB etiologies in the patients under 40 years old. Materials: In this retrospective descriptive study, which has been done during 2012-2013, 333 young patients (less than 40 years old) with lower GIB referred to Endoscopy Ward of Yazd Shahid Sadoughi Hospital assessed by colonoscopy with or without histopathology. Resultus: In this study, 57% of patients were males. Majority of them were between 30-40 years old. The most common presentation was hematochezia (49%) and the most common cause was internal hemorrhoid (17%). Other causes included: inflammatory bowel disease (15%), polyp (9%), infectious colitis (8%), anal fissure (6%), colon cancer (4%), solitary rectal ulcer (4%), vascular lesion (2%), aphtus lesion (1.1%), diverticulosis (0.6%) ,anal ...

Research paper thumbnail of CASE REPORT Giant fibrovascular polyp of the sigmoid colon

We present a patient with large fibrovascular polyp of the sigmoid; an extremely rare submucosal ... more We present a patient with large fibrovascular polyp of the sigmoid; an extremely rare submucosal tumor with only one case report in the literature. A 78-year-old woman presented with constipation and abdominal pain and intermittent maroon stool. Colonoscopic examination and other imaging revealed a large (6 centimeter), intralu-minal pedunculated polyp in the sigmoid that was removed as segmental colectomy. Histological diagnosis of the surgical specimen was fibrovascular polyp. Fibrovascular polyp of the colon is an extremely rare submucosal intraluminal tumor that can cause constipation, abdominal pain, obstruction, and or bleeding.

Research paper thumbnail of A Randomized Clinical Trial Comparing the Efficacy and Tolerability of Two Quadruple Regimens: Bismuth, Omeprazole, Metronidazole with Amoxicillin or Tetracycline as First-Line Treatment for Eradication of Helicobacter Pylori in Patients with Duodenal Ulce v1 (protocols.io.mdjc24n)

Aim: To evaluate the efficacy and tolerability of replacing tetracycline with high dose of amoxic... more Aim: To evaluate the efficacy and tolerability of replacing tetracycline with high dose of amoxicillin in bismuth-based quadruple therapy for H.pylori eradication. Methods: This randomized, open label clinical trial study was performed on 228 patients with H.pylori infection and duodenal ulcer without the history of previous H.pylori treatment. Patients were randomly divided into two groups. Group one received metronidazole 500mg, bismuth subcitrate 240mg and amoxicillin 1000mg, all three times a day and omeprazole 20 mg twice a day (amoxicillin group)for14 days. The second group received metronidazole 500mg three times a day and bismuth subcitrate240mg and tetracycline HCL 500mg both four times a day and omeprazole 20 mg twice a day (tetracycline group), for 14 days. Evaluation for compliance and drugs side effects were done after two weeks. Eight weeks after treatment, H.pylori eradication rate was assessed by c13-urease breath test. Results: Two hundred twenty-eight patients were enrolled. There was no statistically significant demographic difference between two groups. Amoxicillin containing regimen achieved higher Eradication rate: 105 of 110 ,95.51% (95%CI 91.5% to 99.3%) and 88 of 105, 83.8% (95% CI 76.7% to 90.8%) by per-protocol analysis (p-value=0.005) and 92.9%(95%CI 88.1% to 97.6%) and 76.5% (95% CI 68.7% to 84.2%) by intention-totreat (p-value=0.001) for amoxicillin and tetracycline groups, respectively. Adverse events were statistically more significant higher in Tetracycline group (65.2%) amoxicillin group (43.4%) (P value = 0.001). Conclusion: Bismuth based quadruple therapy included high dose of amoxicillin and metronidazole has an acceptable H. pylori infection eradication rate with good tolerance in patients with duodenal ulcer. This can overcome treatment resistance in areas with high prevalence of metronidazole and clarithromycin resistance DOI dx.

Research paper thumbnail of A 63 years old woman with progressive mechanical dysphagia and weight loss: a case presentation

Gastroenterology and hepatology from bed to bench, 2013

When considering a patient with dysphagia, an attempt should be made to determine whether the pat... more When considering a patient with dysphagia, an attempt should be made to determine whether the patient has difficulty only with solid boluses (suggestive of mechanical dysphagia) or with liquids and solids (suggestive of a motility dysphagia). Lesions such as an oesophageal tumor and external pressure effect from a lung tumor or aberrant vessel can lead to mechanical dysphagia. Endoscopy and / or a barium swallow are helpful in identifying the anatomical disarrangement. In this study a patient with progressive mechanical dysphagia is presented that finally diagnosed by as Lung Squamous Cell Carcinoma. There were no respiratory symptoms. Diagnosis was made by a computerized tomography scan of the thorax, bronchoscopy and bronchial biopsy.

Research paper thumbnail of Serum CA19-9 in patients with solid pancreatic mass

Gastroenterology and hepatology from bed to bench, 2013

This study evaluated the results and efficacy of serum CA 19-9 in determining the nature of a pan... more This study evaluated the results and efficacy of serum CA 19-9 in determining the nature of a pancreatic solid mass in patients referred for investigation of possible malignancy. A wide variety of tumor markers have been proposed for pancreatic cancer but currently the only one with any practical usefulness for diagnosis, prognosis, and monitoring of treatment is "CA 19-9". This present study is a single center 2 year descriptive, prospective and case series studying patients with a pancreatic solid mass. Serum CA 19-9 was checked in 159 patients. The majority of patients were male (68%) and 81% had mass in the head of pancreas. Pathologic assessment revealed 131 adenocarcinomas (82%), 10 other malignancies (6%), 7 benign lesion (4%) and was non-diagnostic in 11 cases (7%). Mean level of this tumor marker in patients with adenocarcinoma, non-adenocarcinoma malignancy, benign and non-diagnostic pathology was 1094, 1004, 120, 259 U/ML respectively. With regarding 58 U/ML as ...

Research paper thumbnail of Gastroenterol Hepatol Bed Bench 2013;6(1):32-35

Aim: This study evaluated the results and efficacy of serum CA 19-9 in determining the nature of ... more Aim: This study evaluated the results and efficacy of serum CA 19-9 in determining the nature of a pancreatic solid mass in patients referred for investigation of possible malignancy. Background: A wide variety of tumor markers have been proposed for pancreatic cancer but currently the only one with any practical usefulness for diagnosis, prognosis, and monitoring of treatment is “CA 19-9”. Patients and methods: This present study is a single center 2 year descriptive, prospective and case series studying patients with a pancreatic solid mass. Results: Serum CA 19-9 was checked in 159 patients.The majority of patients were male (68%) and 81 % had mass in the head of pancreas. Pathologic assessment revealed 131 adenocarcinomas (82%), 10 other malignancies (6%), 7 benign lesion (4%) and was non-diagnostic in 11 cases (7%). Mean level of this tumor marker in patients with adenocarcinoma, non-adenocarcinoma malignancy, benign and non-diagnostic pathology was 1094, 1004, 120, 259 U/ML re...

Research paper thumbnail of Gastroenterol Hepatol Bed Bench 2013;6(4):214-216 Gastroenterology and Hepatology From Bed to Bench

Early diagnosis and appropriate treatment of cholangiocarcinoma is problematic. Cross sectional i... more Early diagnosis and appropriate treatment of cholangiocarcinoma is problematic. Cross sectional imaging and tumor marker CA 19-9 are not absolutely reliable and tissue sampling is difficult. We present a patient with cholangitis and cystic dilation of intra-hepatic bile ducts that primarily diagnosed as Caroli's disease in imaging and needle biopsy but laparotomy and surgical biopsy revealed cholangiocarcinoma.

Research paper thumbnail of Result and Efficacy of Endoscopic Ultrasound Guided Fna in Patients with Solid Pancreatic Neoplasm

Research paper thumbnail of Pancreatic Tail Hydatid Cyst as a Rare Cause for Severe Acute Pancreatitis: A Case Report

  Iran is an endemic region for hydatid disease. Primary pancreatic hydatosis is a rare event... more   Iran is an endemic region for hydatid disease. Primary pancreatic hydatosis is a rare event; severe acute pancreatitis related to pancreatic hydatid cyst is extremely rare. We present the case of a patient with severe acute pancreatitis and hydatosis of the pancreas without liver or lung involvement. All etiologies for acute pancreatitis were excluded. The patient underwent a distal pancreatectomy which led to the diagnosis of pancreatic hydatosis. Since hydatid disease is endemic in some regions, it should be considered as one of the underlying etiologies for inflammation or infection of the pancreas (acute pancreatitis). Normal 0 false false false EN-US X-NONE FA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-ma...

Research paper thumbnail of Indications, One-Year Survival, and Complications of Percutaneous Endoscopic Gastrostomy: A Cross Sectional Study

Background: Providing ways for long-term feeding is essential for those who are not able to inges... more Background: Providing ways for long-term feeding is essential for those who are not able to ingest. Percutaneous endoscopic gastrostomy (PEG) is a type of enteral feeding methods. The aim of this study was to evaluate the complications, indications, and one-year survival of this method in patients who underwent PEG. Materials and Methods: The cross-sectional study was carried out on 97 patients (census sampling) who had referred to Shahid Sadoughi Hospital in Yazd (Iran) for PEG tube placement in the period of March 2014 to March 2016. Data were collected using a researcher-made questionnaire and were analyzed using SPSS software version 18. Results: Cerebrovascular accident (CVA) was the most reason to refer to the hospital (52 cases, [%53.6]) followed by head and neck trauma (32 cases [33%]), head and neck tumors (6 cases, [6.2%]), ischemic encephalopathy (5 cases, [5.2%]), and burning (head trauma) (2 cases [1.2%]). Wound infection was observed in eight cases (8.2%), aspiration i...