Mahnoor Ali - Academia.edu (original) (raw)
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Papers by Mahnoor Ali
BENTHAM SCIENCE PUBLISHERS eBooks, Apr 18, 2024
Brazilian Journal of Pharmaceutical Sciences, 2020
There is emerging evidence for a dysregulation of insulin signaling in the brains of patients wit... more There is emerging evidence for a dysregulation of insulin signaling in the brains of patients with Alzheimer’s disease (AD) with overlapping molecular features to Type 2 Diabetes Mellitus (T2DM). In addition, T2DM is a known risk factor of AD. The goal of this study was to investigate the neurogenic and neuroprotective potential of rosmarinic acid (RA) in a streptozotocin (STZ)-induced combined with high fat diet (HFD) mouse model of diabetes. Animals were divided into four experimental groups (control, diabetic, diabetic + RA, RA only). Behavioral analysis was performed to assess spatial learning and anxiety levels of animals, whereas quantitative real time PCR was carried out to assess the gene expression levels of neuronal markers of neurogenesis (Ki67, DCX and NeuN). A significant decrease in memory and spatial learning was observed in the diabetic mice, which was substantially improved by RA treatment. RA also increased the gene expression of NeuN, DCX and Ki67, which were dysr...
Applied Nanoscience, 2019
Sial Journal of Medical Sciences
The aim of this comparative study was to evaluate the level of patient satisfaction of medical OP... more The aim of this comparative study was to evaluate the level of patient satisfaction of medical OPD services of different hospitals of Sialkot.
BENTHAM SCIENCE PUBLISHERS eBooks, Apr 18, 2024
Brazilian Journal of Pharmaceutical Sciences, 2020
There is emerging evidence for a dysregulation of insulin signaling in the brains of patients wit... more There is emerging evidence for a dysregulation of insulin signaling in the brains of patients with Alzheimer’s disease (AD) with overlapping molecular features to Type 2 Diabetes Mellitus (T2DM). In addition, T2DM is a known risk factor of AD. The goal of this study was to investigate the neurogenic and neuroprotective potential of rosmarinic acid (RA) in a streptozotocin (STZ)-induced combined with high fat diet (HFD) mouse model of diabetes. Animals were divided into four experimental groups (control, diabetic, diabetic + RA, RA only). Behavioral analysis was performed to assess spatial learning and anxiety levels of animals, whereas quantitative real time PCR was carried out to assess the gene expression levels of neuronal markers of neurogenesis (Ki67, DCX and NeuN). A significant decrease in memory and spatial learning was observed in the diabetic mice, which was substantially improved by RA treatment. RA also increased the gene expression of NeuN, DCX and Ki67, which were dysr...
Applied Nanoscience, 2019
Sial Journal of Medical Sciences
The aim of this comparative study was to evaluate the level of patient satisfaction of medical OP... more The aim of this comparative study was to evaluate the level of patient satisfaction of medical OPD services of different hospitals of Sialkot.