Maira Kaleem - Academia.edu (original) (raw)
Papers by Maira Kaleem
Migraine is a common neurological disorder, prevalent in almost all over the world population and... more Migraine is a common neurological disorder, prevalent in almost all over the world population and being considered as the 13 th major medical disorder among other major disorders across the globe, generally characterized with unilateral or bilateral headache, nausea and vomiting. In developing world, countries like Pakistan, most of the patients are not well aware of migraine headaches, as usually taken for simple headache due to no proper awareness. Usually it is not a contagious condition and most of the time it is recoded as episodic in nature. To assess the migraine, its frequency, symptoms, usual triggers and patients' perceptions, the present study was conducted. For this purpose a prospective study was carried out based on properly designed questionnaire. The data were collected from 7 educational institutes, including students of
Optics & Laser Technology, 2013
Large bandgap blueshifts in III-V quantum semiconductor microstructures are achievable with UV-la... more Large bandgap blueshifts in III-V quantum semiconductor microstructures are achievable with UV-laser induced quantum well intermixing (QWI). We report on the application of the UV-laser QWI technique to investigate bandgap engineering of a compressively strained InGaAsP/InP quantum well laser microstructure. The attractive performance of the technique, determined by the ability of a laser to generate point defects, has been demonstrated with bandgap blueshifts reaching 142 nm, with enhancement of photoluminescence intensity. We have also investigated this technique for post-growth wafer level processing designed for the fabrication of laser diodes.
Journal of Materials Science: …, 2012
Effect of variation in filler particle size, morphology and wet conditioning on the viscoelastic ... more Effect of variation in filler particle size, morphology and wet conditioning on the viscoelastic stability of resin-composites under dynamic loading was investigated. Eight experimental light cured resin-composites were selected. For each of the eight resin-...
Internal Medicine Journal, 2008
Dental Materials Journal, 2013
The purpose of this study was to investigate the reinforcing effect of short E-glass fiber filler... more The purpose of this study was to investigate the reinforcing effect of short E-glass fiber fillers oriented in different directions on composite resin under static and dynamic loading. Experimental short fiber-reinforced composite resin (FC) was prepared by mixing 22.5 wt% of short E-glass fibers, 22.5 wt% of resin, and 55 wt% of silane-treated silica fillers. Three groups of specimens (n=5) were tested: FC with isotropic fiber orientation, FC with anisotropic fiber orientation, and particulate-filled composite resin (PFC) as a control. Time-dependent creep and recovery were recorded. ANOVA revealed that after secondary curing in a vacuum oven and after storage in dry condition for 30 days, FC with isotropic fiber orientation (1.73%) exhibited significantly lower static creep value (p<0.05) than PFC (2.54%). For the different curing methods and storage conditions evaluated in this study, FC achieved acceptable static and dynamic creep values when compared to PFC.
European …, 2012
... 2 Awamy League led by Mujeeb-ur-Rehman bagged 160 out of 300 seats, while the PPP emerged as ... more ... 2 Awamy League led by Mujeeb-ur-Rehman bagged 160 out of 300 seats, while the PPP emerged as the second large part by ... and PPP was able to form the government at center, Sind and Khyber Pakhtunkhawa, while IJI formed government in Punjab, Bugti in Baluchistan. ...
Journal of …, 1989
1. J Chemother. 1989 Jul;1(4 Suppl):383-5. Ofloxacin--a possible breakthrough in the treatment of... more 1. J Chemother. 1989 Jul;1(4 Suppl):383-5. Ofloxacin--a possible breakthrough in the treatment of typhoid fever caused by chloramphenicol resistant Salmonella typhi. Hannan A, Ahmed SA, Akhtar MA, Anwar CM, Mahmood S, Kaleem M, Iqbal M. ...
Clinical and Experimental Dermatology, 2009
Indian journal of …, 2006
Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptoz... more Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxidant enzymes like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase in liver and kidney. The results confirm the antidiabetic activity of N. sativa seeds extract and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic rats.
International Journal of Education and Social Sciences …, 2011
This study is part of my PhD dissertation titled ―Assessing the Relevance of Public Sector Manage... more This study is part of my PhD dissertation titled ―Assessing the Relevance of Public Sector Management Training to Workplace: Case Study of National Institutes of Management in Pakistan‖. The undercurrent of the study is to provide a baseline to analyze ...
Mineralogical and petrological study of ultramafic rocks of Bela Ophiolite of Cretaceous age reve... more Mineralogical and petrological study of ultramafic rocks of Bela Ophiolite of Cretaceous age revealed serpentinization after harzburgite. It is further evident on SiO 2 /MgO vs. Al 2 O 3 , molar ratio Si/Mg+Fe vs. LOI and MgO-SiO 2-LOI diagrams. The XRD analysis also showed occurrence of olivine, different members of pyroxene and serpentine groups. The three polymorphous of serpentines can be distinguished on (Fe 2+ + Mg 2+)/(Fe 3+ +A1 3+) vs. H 2 O diagram, reflecting thermal regime in the study area. The analyzed samples of the study area showed relevance with Alpine peridotites. The plots MgO versus CaO and Ni show relation with average primitive mantle. The high amount of Ni and low content of Al 2 O 3 in the study area indicates depleted-mantle peridotite. The parent rock is classified on the basis of Al/Si (av. 0.031) and Mg/Si (av. 1.05) ratios as harzburgite. The altered harzburgites displayed as serpentines on SiO 2 vs. LOI plot and SiO 2-(Al 2 O 3 +Fe 2 O 3)-MgO triangular diagram.
… University Journal of …, 2008
Abstract: The cryptocrystalline magnesite deposits of Khuzdar region are Kraubath-type and are ho... more Abstract: The cryptocrystalline magnesite deposits of Khuzdar region are Kraubath-type and are hosted within serpentinized harzburgites. Mineralogical studies (XRD) revealed high magnesite in association of dolomite, calcite, Mg-calcite, artinite, huntite, brucite and Fe-magnesite ...
Indian Journal of Clinical Biochemistry, 2005
The present study is related to the comparative effects of fish oil and olive oil supplementation... more The present study is related to the comparative effects of fish oil and olive oil supplementation on gentamicin induced nephrotoxicity in rats. Three treatment groups (Pretrement, Co-treatment and post treatment) were chosen for the study. Nephrotoxicity in rats was induced by intrapedtonial administration of gentamicin (80 mg/kg/d) for 3, 5,7,10, & 12 consecutive days. The animals were sacrificed 12 hrs after last treatment in each group. The maximum nephrotoxicity was developed on 10 days treatment of gentamicin. For each group a control group was taken without any oil or gentamicin treatment. Beneficial effects of oils were evidenced by reduced serum urea and creatinine concentrations in the group receiving oils compared to the non oil treatment animals receiving gentamicin only. Further, the changed values of alkaline phosphatase and acid phosphatase activity retumed to normal in kidney and liver tissue homogenates after fish and olive oil treatment. In this study, it was found that co-treatment of fish and olive oil is more effective antagonist of gentamicin induced nephrotoxicity. However fish oil was found to be more effective. Hypercholesteromia associated with gentamicin induced nephrotoxicity is also lowered by oil supplementations. The beneficial effects of these oils are due to counteracting effect of the biochemical alterations induced by the drug.
Indian J Physiol Pharmacol, 2005
In the present study aqueous extract of Piper nigrum seeds and Vinca rosea flowers were administe... more In the present study aqueous extract of Piper nigrum seeds and Vinca rosea flowers were administered orally to alloxan induced diabetic rats once a day for 4 weeks. These treatments lead to significant lowering of blood sugar level and reduction in serum lipids. The levels of antioxidant enzymes, catalase and glutathione peroxidase decreased in alloxan induced diabetic rats however these levels returned to normal in insulin, P. nigrum and V. rosea treated rats. There was no significant difference in superoxide dismutase activity in all groups compared to controls. Lipid peroxidation levels were significantly higher in diabetic rats and it was slightly increased in insulin, P. nigrum and V. rosea treated rats as compared to control rat. These results suggest that oxidative stress plays a key role in diabetes, and treatment with P. nigrum and V. rosea are useful in controlling not only the glucose and lipid levels but these components may also be helpful in strengthening the antioxidants potential.
Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's di... more Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's disease (AD) pathology, it has not been clear whether it is involved genetically. We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the welldescribed H1 clade is associated with PSP. Here we report that the same haplotype is associated with the risk of AD in two autopsy confirmed series of cases with ages at death >65 years.
Background: The haplotype H1 of the tau gene, MAPT, is highly associated with progressive supranu... more Background: The haplotype H1 of the tau gene, MAPT, is highly associated with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Objective: To investigate the pathogenic basis of this association. Methods: Detailed linkage disequilibrium and common haplotype structure of MAPT were examined in 27 CEPH trios using validated HapMap genotype data for 24 single nucleotide polymorphisms (SNPs) spanning MAPT. Results: Multiple variants of the H1 haplotype were resolved, reflecting a far greater diversity of MAPT than can be explained by the H1 and H2 clades alone. Based on this, six haplotype tagging SNPs (htSNPs) that capture 95% of the common haplotype diversity were used to genotype well characterised PSP and CBD case-control cohorts. In addition to strong association with PSP and CBD of individual SNPs, two common haplotypes derived from these htSNPs were identified that are highly associated with PSP: the sole H2 derived haplotype was underrepresented and one of the common H1 derived haplotypes was highly associated, with a similar trend observed in CBD. There were powerful and highly significant associations with PSP and CBD of haplotypes formed by three H1 specific SNPs. This made it possible to define a candidate region of at least ,56 kb, spanning sequences from upstream of MAPT exon 1 to intron 9. On the H1 haplotype background, these could harbour the pathogenic variants. Conclusions: The findings support the pathological evidence that underlying variations in MAPT could contribute to disease pathogenesis by subtle effects on gene expression and/or splicing. They also form the basis for the investigation of the possible genetic role of MAPT in Parkinson's disease and other tauopathies, including Alzheimer's disease.
![Research paper thumbnail of Synthesis, Spectroscopic, and Biological Studies of Tris [(dimethylethylsilyl) methylene] tin Mono (or di) thiophosphates](https://attachments.academia-assets.com/79567245/thumbnails/1.jpg)
](Heteroatom Chemistry, 1998
Ortho amino hydrazobenzene (L) has been prepared from the reaction of ortho amino phenyl thiol wi... more Ortho amino hydrazobenzene (L) has been prepared from the reaction of ortho amino phenyl thiol with phenyl hyrazan in mole ratio(1:1). It has been characterized by elemental analysis (C, H, N), IR, UV-Vis. The complexes of the bivalent ions (Co, Ni, Cu, Zn, Pd, Cd, Hg and Pb) and the trivalent (Cr) have been prepared and characterized too. The structural have been established by elemental analysis(C,H,N), IR , UV-Vis spectra , conductivity measurements , atomic absorption and magnetic susceptibility. The complexes showed characteristic behaviour of octahedral geometry around the metal ion and the(N,N) ligand coordinated in bidentate modeexcept with pd showed square planer. α ,kf , Єmax for the complexes were estimated too. β for Cocomplex was calculated. The study of biological activity of the ligand (L) and its complexes showed various activity toward Streptococcus pyogenes Staphylococcus aureus , Pseudomonas aeruginosa , E. coli and Candida albicans .
The American Journal of Human Genetics, 2006
Acta Crystallographica Section E Structure Reports Online, 2006
Migraine is a common neurological disorder, prevalent in almost all over the world population and... more Migraine is a common neurological disorder, prevalent in almost all over the world population and being considered as the 13 th major medical disorder among other major disorders across the globe, generally characterized with unilateral or bilateral headache, nausea and vomiting. In developing world, countries like Pakistan, most of the patients are not well aware of migraine headaches, as usually taken for simple headache due to no proper awareness. Usually it is not a contagious condition and most of the time it is recoded as episodic in nature. To assess the migraine, its frequency, symptoms, usual triggers and patients' perceptions, the present study was conducted. For this purpose a prospective study was carried out based on properly designed questionnaire. The data were collected from 7 educational institutes, including students of
Optics & Laser Technology, 2013
Large bandgap blueshifts in III-V quantum semiconductor microstructures are achievable with UV-la... more Large bandgap blueshifts in III-V quantum semiconductor microstructures are achievable with UV-laser induced quantum well intermixing (QWI). We report on the application of the UV-laser QWI technique to investigate bandgap engineering of a compressively strained InGaAsP/InP quantum well laser microstructure. The attractive performance of the technique, determined by the ability of a laser to generate point defects, has been demonstrated with bandgap blueshifts reaching 142 nm, with enhancement of photoluminescence intensity. We have also investigated this technique for post-growth wafer level processing designed for the fabrication of laser diodes.
Journal of Materials Science: …, 2012
Effect of variation in filler particle size, morphology and wet conditioning on the viscoelastic ... more Effect of variation in filler particle size, morphology and wet conditioning on the viscoelastic stability of resin-composites under dynamic loading was investigated. Eight experimental light cured resin-composites were selected. For each of the eight resin-...
Internal Medicine Journal, 2008
Dental Materials Journal, 2013
The purpose of this study was to investigate the reinforcing effect of short E-glass fiber filler... more The purpose of this study was to investigate the reinforcing effect of short E-glass fiber fillers oriented in different directions on composite resin under static and dynamic loading. Experimental short fiber-reinforced composite resin (FC) was prepared by mixing 22.5 wt% of short E-glass fibers, 22.5 wt% of resin, and 55 wt% of silane-treated silica fillers. Three groups of specimens (n=5) were tested: FC with isotropic fiber orientation, FC with anisotropic fiber orientation, and particulate-filled composite resin (PFC) as a control. Time-dependent creep and recovery were recorded. ANOVA revealed that after secondary curing in a vacuum oven and after storage in dry condition for 30 days, FC with isotropic fiber orientation (1.73%) exhibited significantly lower static creep value (p<0.05) than PFC (2.54%). For the different curing methods and storage conditions evaluated in this study, FC achieved acceptable static and dynamic creep values when compared to PFC.
European …, 2012
... 2 Awamy League led by Mujeeb-ur-Rehman bagged 160 out of 300 seats, while the PPP emerged as ... more ... 2 Awamy League led by Mujeeb-ur-Rehman bagged 160 out of 300 seats, while the PPP emerged as the second large part by ... and PPP was able to form the government at center, Sind and Khyber Pakhtunkhawa, while IJI formed government in Punjab, Bugti in Baluchistan. ...
Journal of …, 1989
1. J Chemother. 1989 Jul;1(4 Suppl):383-5. Ofloxacin--a possible breakthrough in the treatment of... more 1. J Chemother. 1989 Jul;1(4 Suppl):383-5. Ofloxacin--a possible breakthrough in the treatment of typhoid fever caused by chloramphenicol resistant Salmonella typhi. Hannan A, Ahmed SA, Akhtar MA, Anwar CM, Mahmood S, Kaleem M, Iqbal M. ...
Clinical and Experimental Dermatology, 2009
Indian journal of …, 2006
Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptoz... more Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxidant enzymes like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase in liver and kidney. The results confirm the antidiabetic activity of N. sativa seeds extract and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic rats.
International Journal of Education and Social Sciences …, 2011
This study is part of my PhD dissertation titled ―Assessing the Relevance of Public Sector Manage... more This study is part of my PhD dissertation titled ―Assessing the Relevance of Public Sector Management Training to Workplace: Case Study of National Institutes of Management in Pakistan‖. The undercurrent of the study is to provide a baseline to analyze ...
Mineralogical and petrological study of ultramafic rocks of Bela Ophiolite of Cretaceous age reve... more Mineralogical and petrological study of ultramafic rocks of Bela Ophiolite of Cretaceous age revealed serpentinization after harzburgite. It is further evident on SiO 2 /MgO vs. Al 2 O 3 , molar ratio Si/Mg+Fe vs. LOI and MgO-SiO 2-LOI diagrams. The XRD analysis also showed occurrence of olivine, different members of pyroxene and serpentine groups. The three polymorphous of serpentines can be distinguished on (Fe 2+ + Mg 2+)/(Fe 3+ +A1 3+) vs. H 2 O diagram, reflecting thermal regime in the study area. The analyzed samples of the study area showed relevance with Alpine peridotites. The plots MgO versus CaO and Ni show relation with average primitive mantle. The high amount of Ni and low content of Al 2 O 3 in the study area indicates depleted-mantle peridotite. The parent rock is classified on the basis of Al/Si (av. 0.031) and Mg/Si (av. 1.05) ratios as harzburgite. The altered harzburgites displayed as serpentines on SiO 2 vs. LOI plot and SiO 2-(Al 2 O 3 +Fe 2 O 3)-MgO triangular diagram.
… University Journal of …, 2008
Abstract: The cryptocrystalline magnesite deposits of Khuzdar region are Kraubath-type and are ho... more Abstract: The cryptocrystalline magnesite deposits of Khuzdar region are Kraubath-type and are hosted within serpentinized harzburgites. Mineralogical studies (XRD) revealed high magnesite in association of dolomite, calcite, Mg-calcite, artinite, huntite, brucite and Fe-magnesite ...
Indian Journal of Clinical Biochemistry, 2005
The present study is related to the comparative effects of fish oil and olive oil supplementation... more The present study is related to the comparative effects of fish oil and olive oil supplementation on gentamicin induced nephrotoxicity in rats. Three treatment groups (Pretrement, Co-treatment and post treatment) were chosen for the study. Nephrotoxicity in rats was induced by intrapedtonial administration of gentamicin (80 mg/kg/d) for 3, 5,7,10, & 12 consecutive days. The animals were sacrificed 12 hrs after last treatment in each group. The maximum nephrotoxicity was developed on 10 days treatment of gentamicin. For each group a control group was taken without any oil or gentamicin treatment. Beneficial effects of oils were evidenced by reduced serum urea and creatinine concentrations in the group receiving oils compared to the non oil treatment animals receiving gentamicin only. Further, the changed values of alkaline phosphatase and acid phosphatase activity retumed to normal in kidney and liver tissue homogenates after fish and olive oil treatment. In this study, it was found that co-treatment of fish and olive oil is more effective antagonist of gentamicin induced nephrotoxicity. However fish oil was found to be more effective. Hypercholesteromia associated with gentamicin induced nephrotoxicity is also lowered by oil supplementations. The beneficial effects of these oils are due to counteracting effect of the biochemical alterations induced by the drug.
Indian J Physiol Pharmacol, 2005
In the present study aqueous extract of Piper nigrum seeds and Vinca rosea flowers were administe... more In the present study aqueous extract of Piper nigrum seeds and Vinca rosea flowers were administered orally to alloxan induced diabetic rats once a day for 4 weeks. These treatments lead to significant lowering of blood sugar level and reduction in serum lipids. The levels of antioxidant enzymes, catalase and glutathione peroxidase decreased in alloxan induced diabetic rats however these levels returned to normal in insulin, P. nigrum and V. rosea treated rats. There was no significant difference in superoxide dismutase activity in all groups compared to controls. Lipid peroxidation levels were significantly higher in diabetic rats and it was slightly increased in insulin, P. nigrum and V. rosea treated rats as compared to control rat. These results suggest that oxidative stress plays a key role in diabetes, and treatment with P. nigrum and V. rosea are useful in controlling not only the glucose and lipid levels but these components may also be helpful in strengthening the antioxidants potential.
Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's di... more Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's disease (AD) pathology, it has not been clear whether it is involved genetically. We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the welldescribed H1 clade is associated with PSP. Here we report that the same haplotype is associated with the risk of AD in two autopsy confirmed series of cases with ages at death >65 years.
Background: The haplotype H1 of the tau gene, MAPT, is highly associated with progressive supranu... more Background: The haplotype H1 of the tau gene, MAPT, is highly associated with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Objective: To investigate the pathogenic basis of this association. Methods: Detailed linkage disequilibrium and common haplotype structure of MAPT were examined in 27 CEPH trios using validated HapMap genotype data for 24 single nucleotide polymorphisms (SNPs) spanning MAPT. Results: Multiple variants of the H1 haplotype were resolved, reflecting a far greater diversity of MAPT than can be explained by the H1 and H2 clades alone. Based on this, six haplotype tagging SNPs (htSNPs) that capture 95% of the common haplotype diversity were used to genotype well characterised PSP and CBD case-control cohorts. In addition to strong association with PSP and CBD of individual SNPs, two common haplotypes derived from these htSNPs were identified that are highly associated with PSP: the sole H2 derived haplotype was underrepresented and one of the common H1 derived haplotypes was highly associated, with a similar trend observed in CBD. There were powerful and highly significant associations with PSP and CBD of haplotypes formed by three H1 specific SNPs. This made it possible to define a candidate region of at least ,56 kb, spanning sequences from upstream of MAPT exon 1 to intron 9. On the H1 haplotype background, these could harbour the pathogenic variants. Conclusions: The findings support the pathological evidence that underlying variations in MAPT could contribute to disease pathogenesis by subtle effects on gene expression and/or splicing. They also form the basis for the investigation of the possible genetic role of MAPT in Parkinson's disease and other tauopathies, including Alzheimer's disease.
Heteroatom Chemistry, 1998
Ortho amino hydrazobenzene (L) has been prepared from the reaction of ortho amino phenyl thiol wi... more Ortho amino hydrazobenzene (L) has been prepared from the reaction of ortho amino phenyl thiol with phenyl hyrazan in mole ratio(1:1). It has been characterized by elemental analysis (C, H, N), IR, UV-Vis. The complexes of the bivalent ions (Co, Ni, Cu, Zn, Pd, Cd, Hg and Pb) and the trivalent (Cr) have been prepared and characterized too. The structural have been established by elemental analysis(C,H,N), IR , UV-Vis spectra , conductivity measurements , atomic absorption and magnetic susceptibility. The complexes showed characteristic behaviour of octahedral geometry around the metal ion and the(N,N) ligand coordinated in bidentate modeexcept with pd showed square planer. α ,kf , Єmax for the complexes were estimated too. β for Cocomplex was calculated. The study of biological activity of the ligand (L) and its complexes showed various activity toward Streptococcus pyogenes Staphylococcus aureus , Pseudomonas aeruginosa , E. coli and Candida albicans .
The American Journal of Human Genetics, 2006
Acta Crystallographica Section E Structure Reports Online, 2006