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Papers by Maitane Oscoz Irurozqui

Research paper thumbnail of Nrn1 Epistasis With Bdnf and Cacna1c: Mediation Effects on Symptom Severity Through Neuroanatomical Changes in Schizophrenia

Research Square (Research Square), Dec 31, 2023

Research paper thumbnail of Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis

International Journal of Molecular Sciences

The role of both cannabis use and genetic background has been shown in the risk for psychosis. Ho... more The role of both cannabis use and genetic background has been shown in the risk for psychosis. However, the effect of the interplay between cannabis and variability at the endocannabinoid receptor genes on the neurobiological underpinnings of psychosis remains inconclusive. Through a case-only design, including patients with a first-episode of psychosis (n = 40) classified as cannabis users (50%) and non-users (50%), we aimed to evaluate the interaction between cannabis use and common genetic variants at the endocannabinoid receptor genes on brain activity. Genetic variability was assessed by genotyping two Single Nucleotide Polymorphisms (SNP) at the cannabinoid receptor type 1 gene (CNR1; rs1049353) and cannabinoid receptor type 2 gene (CNR2; rs2501431). Functional Magnetic Resonance Imaging (fMRI) data were obtained while performing the n-back task. Gene × cannabis interaction models evidenced a combined effect of CNR1 and CNR2 genotypes and cannabis use on brain activity in diff...

Research paper thumbnail of P.0173 Cannabinoid receptor genes, cannabis use and brain activity in first-episode psychosis

European Neuropsychopharmacology, 2021

Research paper thumbnail of Demographic and Clinical Characteristics of Alcohol Use Disorder in Patients Undergoing Bariatric Surgery

Research paper thumbnail of Cannabis use and genes of endocannabinoid system: their role in psychotic symptoms and cognition in first-episode psychosis

Objectives. To evaluate the association of cannabis use, genes of the endocannabinoid system and ... more Objectives. To evaluate the association of cannabis use, genes of the endocannabinoid system and their interaction on clinical symptoms and cognitive performance in patients with a first-episode of pyschosis. Background. The role of both cannabis use and individual genetic background has been shown in the risk for psychosis. However, the influence of cannabis and variability at endocannabinoid genes on the psychosis outcome still remains inconclusive. Materials and Methods. The sample comprised 43 Caucasian individuals with a first-episode of psychosis (mean age(sd)=25.80(6.39) years, 76.7% males, 51.2% cannabis users).There were no differences in age and sex between cannabis users and non-users. Genetic variability was assessed by genotyping one Single Nucleotide Polymorphism (SNP) in each gene (CNR1-rs1049353 and CNR2-rs2501431). Clinical (PANSS, GAF) and neuropsychological (WAIS, WMS, BADS) scales were administered. Results and conclusions. Genotypic frequencies did not differ be...

Research paper thumbnail of CNR2 Gene and Cannabis Use Interplay Modulates Manipulative Abilities in First-Episode of Psychosis

LIBRO COMUNICACIONES

1. Objectives: While endocannabinoid system seems to be involved in processes underlying psychosi... more 1. Objectives: While endocannabinoid system seems to be involved in processes underlying psychosis, research about Cannabinoid Receptor 2 gene (CNR2) is scarce and inconclusive. Some few reports indicate that CNR2 plays a role in psychiatric conditions, including depression or drug addiction (Onaivi et al., 2009). We aimed to evaluate the role of CNR2 and its interplay with cannabis on cognition and clinical symptoms in patients with a first-episode of psychosis (FEP). 2. Materials and Methods: the sample comprised 50 Caucasian individuals with a FEP (mean age(sd)=26.14(6.55) years, 76% males, 58% cannabis users). There were no differences in age, sex, premorbid IQ and antipsychotic dose between cannabis users (CU) and non-users (CNU). Neuropsychological (premorbid IQ - TAP-E, current IQ - WAIS, memory - WMS, executive function - BADS) and clinical (psychotic symptoms - PANSS, general functioning - GAF) scales were administered. Genetic variability was assessed by genotyping one Sin...

Research paper thumbnail of TU75. Cannabis Use and CNR1 Gene: Effects on Psychotic Symptoms and Cognition in First-Episode Psychosis

European Neuropsychopharmacology

Research paper thumbnail of 15 - Brain activity linked to auditory verbal hallucinations in fMRI

Research paper thumbnail of Cannabis Use and Genes of Dopaminergic and Endocannabinoid Systems: Their Role in Psychotic Symptoms and Cognition in First-Episode Psychosis

Research paper thumbnail of Etomidate Improves Seizure Adequacy During Electroconvulsive Therapy

Research paper thumbnail of Etomidate Improves Seizure Adequacy During Electroconvulsive Therapy

Research paper thumbnail of Geniuses of medical science: friendly, open and responsible, not mad

Medical Hypotheses, 2016

Recent studies based on biography analysis provide support for the notion that the prevalence of ... more Recent studies based on biography analysis provide support for the notion that the prevalence of mental illness in the creative geniuses of art, literature and science is higher than it is in more ordinary folk. However, this relationship between madness and genius, which was also addressed by the classical philosophers, has been generalized to all branches of professional endeavour. Whilst it may hold true for illustrious personalities of the fine arts, we found that the relationship proves inappropriate to the biographies of ten individuals renowned in history for their innovative contributions to medical science. Furthermore, examination of these ten biographies invites the hypothesis that certain personality traits -especially, agreeableness, conscientiousness and openness to new experience-can act to enhance creativity and protect against mental illness.

Research paper thumbnail of Geniuses of medical science: friendly, open and responsible, not mad

Medical Hypotheses, 2016

Recent studies based on biography analysis provide support for the notion that the prevalence of ... more Recent studies based on biography analysis provide support for the notion that the prevalence of mental illness in the creative geniuses of art, literature and science is higher than it is in more ordinary folk. However, this relationship between madness and genius, which was also addressed by the classical philosophers, has been generalized to all branches of professional endeavour. Whilst it may hold true for illustrious personalities of the fine arts, we found that the relationship proves inappropriate to the biographies of ten individuals renowned in history for their innovative contributions to medical science. Furthermore, examination of these ten biographies invites the hypothesis that certain personality traits -especially, agreeableness, conscientiousness and openness to new experience-can act to enhance creativity and protect against mental illness.

Research paper thumbnail of Nrn1 Epistasis With Bdnf and Cacna1c: Mediation Effects on Symptom Severity Through Neuroanatomical Changes in Schizophrenia

Research Square (Research Square), Dec 31, 2023

Research paper thumbnail of Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis

International Journal of Molecular Sciences

The role of both cannabis use and genetic background has been shown in the risk for psychosis. Ho... more The role of both cannabis use and genetic background has been shown in the risk for psychosis. However, the effect of the interplay between cannabis and variability at the endocannabinoid receptor genes on the neurobiological underpinnings of psychosis remains inconclusive. Through a case-only design, including patients with a first-episode of psychosis (n = 40) classified as cannabis users (50%) and non-users (50%), we aimed to evaluate the interaction between cannabis use and common genetic variants at the endocannabinoid receptor genes on brain activity. Genetic variability was assessed by genotyping two Single Nucleotide Polymorphisms (SNP) at the cannabinoid receptor type 1 gene (CNR1; rs1049353) and cannabinoid receptor type 2 gene (CNR2; rs2501431). Functional Magnetic Resonance Imaging (fMRI) data were obtained while performing the n-back task. Gene × cannabis interaction models evidenced a combined effect of CNR1 and CNR2 genotypes and cannabis use on brain activity in diff...

Research paper thumbnail of P.0173 Cannabinoid receptor genes, cannabis use and brain activity in first-episode psychosis

European Neuropsychopharmacology, 2021

Research paper thumbnail of Demographic and Clinical Characteristics of Alcohol Use Disorder in Patients Undergoing Bariatric Surgery

Research paper thumbnail of Cannabis use and genes of endocannabinoid system: their role in psychotic symptoms and cognition in first-episode psychosis

Objectives. To evaluate the association of cannabis use, genes of the endocannabinoid system and ... more Objectives. To evaluate the association of cannabis use, genes of the endocannabinoid system and their interaction on clinical symptoms and cognitive performance in patients with a first-episode of pyschosis. Background. The role of both cannabis use and individual genetic background has been shown in the risk for psychosis. However, the influence of cannabis and variability at endocannabinoid genes on the psychosis outcome still remains inconclusive. Materials and Methods. The sample comprised 43 Caucasian individuals with a first-episode of psychosis (mean age(sd)=25.80(6.39) years, 76.7% males, 51.2% cannabis users).There were no differences in age and sex between cannabis users and non-users. Genetic variability was assessed by genotyping one Single Nucleotide Polymorphism (SNP) in each gene (CNR1-rs1049353 and CNR2-rs2501431). Clinical (PANSS, GAF) and neuropsychological (WAIS, WMS, BADS) scales were administered. Results and conclusions. Genotypic frequencies did not differ be...

Research paper thumbnail of CNR2 Gene and Cannabis Use Interplay Modulates Manipulative Abilities in First-Episode of Psychosis

LIBRO COMUNICACIONES

1. Objectives: While endocannabinoid system seems to be involved in processes underlying psychosi... more 1. Objectives: While endocannabinoid system seems to be involved in processes underlying psychosis, research about Cannabinoid Receptor 2 gene (CNR2) is scarce and inconclusive. Some few reports indicate that CNR2 plays a role in psychiatric conditions, including depression or drug addiction (Onaivi et al., 2009). We aimed to evaluate the role of CNR2 and its interplay with cannabis on cognition and clinical symptoms in patients with a first-episode of psychosis (FEP). 2. Materials and Methods: the sample comprised 50 Caucasian individuals with a FEP (mean age(sd)=26.14(6.55) years, 76% males, 58% cannabis users). There were no differences in age, sex, premorbid IQ and antipsychotic dose between cannabis users (CU) and non-users (CNU). Neuropsychological (premorbid IQ - TAP-E, current IQ - WAIS, memory - WMS, executive function - BADS) and clinical (psychotic symptoms - PANSS, general functioning - GAF) scales were administered. Genetic variability was assessed by genotyping one Sin...

Research paper thumbnail of TU75. Cannabis Use and CNR1 Gene: Effects on Psychotic Symptoms and Cognition in First-Episode Psychosis

European Neuropsychopharmacology

Research paper thumbnail of 15 - Brain activity linked to auditory verbal hallucinations in fMRI

Research paper thumbnail of Cannabis Use and Genes of Dopaminergic and Endocannabinoid Systems: Their Role in Psychotic Symptoms and Cognition in First-Episode Psychosis

Research paper thumbnail of Etomidate Improves Seizure Adequacy During Electroconvulsive Therapy

Research paper thumbnail of Etomidate Improves Seizure Adequacy During Electroconvulsive Therapy

Research paper thumbnail of Geniuses of medical science: friendly, open and responsible, not mad

Medical Hypotheses, 2016

Recent studies based on biography analysis provide support for the notion that the prevalence of ... more Recent studies based on biography analysis provide support for the notion that the prevalence of mental illness in the creative geniuses of art, literature and science is higher than it is in more ordinary folk. However, this relationship between madness and genius, which was also addressed by the classical philosophers, has been generalized to all branches of professional endeavour. Whilst it may hold true for illustrious personalities of the fine arts, we found that the relationship proves inappropriate to the biographies of ten individuals renowned in history for their innovative contributions to medical science. Furthermore, examination of these ten biographies invites the hypothesis that certain personality traits -especially, agreeableness, conscientiousness and openness to new experience-can act to enhance creativity and protect against mental illness.

Research paper thumbnail of Geniuses of medical science: friendly, open and responsible, not mad

Medical Hypotheses, 2016

Recent studies based on biography analysis provide support for the notion that the prevalence of ... more Recent studies based on biography analysis provide support for the notion that the prevalence of mental illness in the creative geniuses of art, literature and science is higher than it is in more ordinary folk. However, this relationship between madness and genius, which was also addressed by the classical philosophers, has been generalized to all branches of professional endeavour. Whilst it may hold true for illustrious personalities of the fine arts, we found that the relationship proves inappropriate to the biographies of ten individuals renowned in history for their innovative contributions to medical science. Furthermore, examination of these ten biographies invites the hypothesis that certain personality traits -especially, agreeableness, conscientiousness and openness to new experience-can act to enhance creativity and protect against mental illness.