Carlo Mamo - Academia.edu (original) (raw)
Papers by Carlo Mamo
International Journal of Public Health, Dec 17, 2023
Medicina Del Lavoro, Mar 1, 2007
PA ARGENTERO, CARLA MARIA ZOTTI*, FRANCESCA ABBONA*, C. MAMO**, ANNALISA CASTELLA*, ALESSANDRA VA... more PA ARGENTERO, CARLA MARIA ZOTTI*, FRANCESCA ABBONA*, C. MAMO**, ANNALISA CASTELLA*, ALESSANDRA VALLINO*, BEATRICE LUZZI*, GABRIELLA DE CARLI*** Ospedale di Rivoli ASL 5 Regione Piemonte * Dipartimento di Sanità Pubblica e Microbiologia ...
PubMed, 2009
Background: Occupational risks contribute to health inequalities, combined with psychosocial, beh... more Background: Occupational risks contribute to health inequalities, combined with psychosocial, behavioural, and environmental risk factors. Job Strain is a well-known risk factor for cardio-vascular and psychiatric diseases. Furthermore, stressful conditions at work promote unhealthy life styles. Among workers, sex (female), young age and migration are all causes of health inequalities. Conclusions: Although evidence on the effectiveness of workplace interventions for addressing inequalities is limited, equity audits to support decisions need to be implemented in conjunction with workability and health promotion programmes, and simultaneously with measures of an environmental and social nature.
Digestive and Liver Disease, Mar 1, 2011
PubMed, 2005
Background: Repetitive work injuries are a phenomenon that has not been sufficiently studied. Usi... more Background: Repetitive work injuries are a phenomenon that has not been sufficiently studied. Using data gathered by INAIL (National Institute for Insurance against Occupational Accidents and Diseases), it is possible to study the propensity of having a further injuries at the workplace after the first one. Objectives: To identify the risk of experiencing multiple injuries according to occupation, with discussion of how useful the available information systems are. Methods: The data base includes workplace injuries, as classified by INAIL in Italy between 1994 and 2000 in the industrial and artisan sectors (2,162,702 subjects, ages 25-55). Selecting data on accidents occurring among 107,082 subjects who had experienced the first accident in 1996-99, in this cohort we assessed the occurrence of further accidents within two years in the same occupation, taking into account job mobility and factors eventually influencing underreporting (geographic area, age, severity of first accident and size of the enterprise). The risk for each occupation was computed stratifying by gender. Results: There were significant differences between the first and successive accidents when examined by type, age group, severity of physical consequences and company size. Among men, the occupations showing higher risk were those already known to be at high risk for accidents: cleaning staff and refuse workers, foundry workers, masons, pilots, woodworkers, carpenters, transport workers, sailors, farmers, and miners. Among women the occupations most at risk were postwomen and messengers, cleaning staff and refuse workers, waitresses, cooks, bartenders, machine tool operators, woodworkers, and weavers in the textile industry. Conclusions: Among men, the risk of recurrent workplace accidents by occupation tends to reflect the frequency of the total accidents in each occupation. The results indicate that the study model employed is efficient and useful in providing risk profiles which allow identification of where to direct future studies, investigations, and preventive measures for each sex.
Human Pathology, Apr 1, 2006
The prognostic significance of microvessel density and proliferative activity of the neoplastic c... more The prognostic significance of microvessel density and proliferative activity of the neoplastic cells, evaluated respectively by CD31 and Ki-67 positivity, and immunohistochemical expression of vascular endothelial growth factor (VEGF) was retrospectively investigated in 105 cases of sinonasal carcinoma (80 surgical specimens and 25 biopsies). The most represented histologic types were intestinal-type adenocarcinoma found in 36 patients (34.3%), squamous cell carcinoma (SCC) in 34 (32.4%), mucinous adenocarcinoma (mainly made up of signet-ring cell patterns) in 15 (14.3%), and adenoid cystic carcinoma in 7 (6.7%). Microvessel density values (in vessels per square millimeter), VEGF, and Ki-67 were not dependent on histologic type but were rather correlated to the histologic grading in SCC. Clinical data were available for 92 (87.6%) of 105 patients, with minimum follow-up of 48 months. Most of the patients (81.5%) were at an advanced stage (T3-T4) at diagnosis. The values of all markers were correlated to tumor stage (P = .03). Multivariate analysis showed that both microvessel density and proliferative activity of the neoplastic cells were independent prognostic parameters (mortality hazard ratio, 1.33 and 1.60, respectively). Although VEGF expression was not correlated to prognosis on the whole series (P = .06), it was a powerful prognostic marker when the analysis was restricted to the group of SCCs (hazard ratio, 3.02; 90% confidence interval, 1.58-5.80). These results show that tumor neoangiogenesis, expressed by microvessel density, together with proliferative activity, is a pathologic marker with a strong prognostic impact in sinonasal carcinomas. Therefore, it may be a useful tool in this field so as to carry out therapeutic protocol planning, which may be further enhanced by the adoption of the more recent antiangiogenic molecules.
Assistenza Infermieristica E Ricerca, Jul 1, 2021
Bollettino epidemiologico nazionale, 2021
Medicina Del Lavoro, 2005
European Journal of Public Health, 2020
Background The Oncology Network of Piedmont and Aosta Valley (North-West Italy) was started in 20... more Background The Oncology Network of Piedmont and Aosta Valley (North-West Italy) was started in 2000 and fully established in 2010 as a regional organisational model offering multidisciplinary care by experienced reference centres for cancer diagnosis and surgical treatment. In particular, the San Giovanni Bosco Hospital in Turin is the regional reference centre for pancreatic cancer since 2015 (50-70 oncologic surgery operations performed annually). The aim of study is to assess the effectiveness of this model for pancreatic cancer surgery by comparing survival outcomes before and after the adoption of the Oncology Network model. Methods The study included 178 patients, aged 37-84, who underwent duodenocephalo- or total pancreatectomy for ductal cancer in the years 2007-2019. Clinical data were retrieved from surgical records, whereas the vital status was ascertained through an application connected to the Regional Registry Office. The Kaplan-Meier method was used to estimate surviv...
European Journal of Public Health, 2018
and efficiency of care. The Fondazione Policlinico Gemelli CCU 2.0-Rome-has recently been impleme... more and efficiency of care. The Fondazione Policlinico Gemelli CCU 2.0-Rome-has recently been implemented, according to the LHCM, to reduce the length of stay of frail and complex patients after their acute phase. A long hospitalization causes an increase in patient complications and costs for the healthcare facility. The early identification of the suitable patients (within 24-48h from the admission) and the multidimensional evaluation of their needs are strategic to offer the most appropriate care setting after the discharge. Problem: The CCU mission is to facilitate the take-charge of frail and complex patients, after hospital discharge, by community health facilities through an Individual Care Plan. The multidimensional evaluation using validated tools and the optimization of the patient flow result in a reduction in length of stay of these patients. Results: From December 2016 (starting date of CCU 2.0) to March 2018, a total of 1948 patients were taken in charge. The average length of stay was 28.8AE30.2 days. The average time from the CCU activation to the patient discharge was 12.0AE18.3 days. During the first 16 months of the Unit, our data show a significant reduction of the length of stay. A comparison between Dec 2016-Mar 2017 and Dec 2017-Mar 2018, the average length of stay was reduced by 7.9 days (t-test, p < 0.001), the average time between the admission and the activation of the Unit decreased by 2.3 days (t-test, p < 0.001), the average time between the activation and the discharge fell by 5.6 days (t-test, p < 0.001). Lessions: This reduction resulted in significant savings for the hospital in terms of costs derived from hospitalizations and treatments and also in care quality improvement for patients, as well as an advantage for their caregivers. Key messages: The Unit has shown an improvement in quality of care and containment of inefficiencies and costs by reducing length of stay. The Lean Health Care Methodology (LHCM) of applied to our CCU could be a study model for other hospitals.
Oncology, 2009
Background and objective: Acute myeloid leukemia (AML) is the most frequent type of acute leukemi... more Background and objective: Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukemia relapse occurs due to clonal evolution or clonal escape. In this study, we aimed to analyze the clinical and biological factors influencing outcomes in patients with AML relapse. Patients and methods: We included a total of 75 AML patients who experienced leukemia relapse after achieving complete remission. We performed complete immunophenotyping and conventional karyotyping in bone marrow aspirates obtained at diagnosis and at leukemia relapse. Results: Overall survival (OS) of the series was 3.7 ± 2.3%, leukemia progression being the most common cause of death. Patients relapsing before 12 months and those with adverse cytogenetic-molecular risk had statistically significant worse outcomes. A percentage of 52.5 of patients showed phenotypic changes and 50% cytogenetic changes at relapse. We did not find significant clinical factors predicting clonal evolution. The presence of clonal evolution at relapse did not have a significant impact on outcome. Conclusions: Patients with relapsed AML have a dismal prognosis, especially those with early relapse and adverse cytogenetic-molecular risk. Clonal evolution with phenotypic and cytogenetic changes occurred in half of the patients without predictive clinical factors or impact on outcome.
International Journal of Public Health, 2023
Objectives: Non-suicidal self-injury (NSSI) poses a threat in developmental ages, yet there is a ... more Objectives: Non-suicidal self-injury (NSSI) poses a threat in developmental ages, yet there is a scarcity of studies on NSSI trends, especially those in emergency departments (ED). Methods: The aim of this cross-sectional study is to describe trends in ED visits for NSSI among young people aged between 5 and 19 years in Italy from 2011 to 2021 in Piedmont. From the ministerial ED discharge information system, all occurring NSSIs were identified by medical report and/or ICD9CM code and reported as a population rate and a visit rate on all ED requests. Results: The general rate of ED visits remained stable, with around 210,000 (55% males) visits each year, along the whole period from 2011 to 2019, then halved during 2020 and 2021. The NSSI population and visits rates increased from 2013, peaking in 2019 at a rate of around 25 and 23 NSSI visits (girls) and 76 and 69 NSSI (boys) per 100,000 ED visits. In 2020 and 2021, the rate of NSSI visits increased, particularly in girls and among older adolescents. Conclusion: The gradual increase of NSSI over the last decade is a rising public health issue, which deserves wider attention to ensure early detection and prevention.
Tendenze nuove, 2007
... Tendenze nuove - 4-5/2007 nuova serie Filomena Bertone, Paola Serafini, Alba Baratta, Carlo M... more ... Tendenze nuove - 4-5/2007 nuova serie Filomena Bertone, Paola Serafini, Alba Baratta, Carlo Mamo e Andrea Chiecchio ... Condizione Assistenziale Bisogni non presenti o soddisfatti 0 6 5 4 3,3 1 Bisogno 1 20 16,5 4 3,3 2 Bisogni 2 24 19,8 18 14,9 2 1,7 ...
PubMed, Aug 8, 2007
Background: The prevalence of surgical cases of carpal tunnel syndrome (CTS) tends to increase in... more Background: The prevalence of surgical cases of carpal tunnel syndrome (CTS) tends to increase in the general population in Italy. Nevertheless, it is still unclear what percentage of CTS is attributable to occupational exposure, to ergonomic or psychosocial factors. Moreover, the problem of obtaining a reliable definition of occupational exposure in the absence of direct observation and measurement in the workplace remains unsolved. Piedmont (north-western Italy) is one of the Italian regions with the highest number of musculoskeletal disorders recognized and compensated as work-related. The aim of this study was to estimate the proportion of work-related CTS surgical cases, based on self-reported exposure data. Methods: An interview-based questionnaire included items on medical history, workplace exposures and non-occupational risk factors for CTS. The study was carried out between June 2003 and November 2004. A total of 260 adult patients (aged 18-65 years) were interviewed. An evaluation of the questionnaires was made by 3 occupational physicians, assigning every patient a probability score of occupational aetiology. Seventy-four per cent of the sample were female; the mean age was 48.4 years. Results: Seventy-one percent of the patients reported bilateral CTS. Occupational exposure preceded the onset of CTS symptoms for 184 patients. The probability that CTS was work-related was estimated as high for 66 patients (26% of the sample). Agreement among examiners, evaluated using the kappa statistic, was good. Conclusions: Despite the limitations of the study, the number of cases attributable to occupation was much higher than the number of diseases reported to INAIL (National Institute for the Insurance of Industrial Accidents), which suggests that there is substantial under-notification in Italy.
Medicina Del Lavoro, 2005
International Journal of Public Health, Dec 17, 2023
Medicina Del Lavoro, Mar 1, 2007
PA ARGENTERO, CARLA MARIA ZOTTI*, FRANCESCA ABBONA*, C. MAMO**, ANNALISA CASTELLA*, ALESSANDRA VA... more PA ARGENTERO, CARLA MARIA ZOTTI*, FRANCESCA ABBONA*, C. MAMO**, ANNALISA CASTELLA*, ALESSANDRA VALLINO*, BEATRICE LUZZI*, GABRIELLA DE CARLI*** Ospedale di Rivoli ASL 5 Regione Piemonte * Dipartimento di Sanità Pubblica e Microbiologia ...
PubMed, 2009
Background: Occupational risks contribute to health inequalities, combined with psychosocial, beh... more Background: Occupational risks contribute to health inequalities, combined with psychosocial, behavioural, and environmental risk factors. Job Strain is a well-known risk factor for cardio-vascular and psychiatric diseases. Furthermore, stressful conditions at work promote unhealthy life styles. Among workers, sex (female), young age and migration are all causes of health inequalities. Conclusions: Although evidence on the effectiveness of workplace interventions for addressing inequalities is limited, equity audits to support decisions need to be implemented in conjunction with workability and health promotion programmes, and simultaneously with measures of an environmental and social nature.
Digestive and Liver Disease, Mar 1, 2011
PubMed, 2005
Background: Repetitive work injuries are a phenomenon that has not been sufficiently studied. Usi... more Background: Repetitive work injuries are a phenomenon that has not been sufficiently studied. Using data gathered by INAIL (National Institute for Insurance against Occupational Accidents and Diseases), it is possible to study the propensity of having a further injuries at the workplace after the first one. Objectives: To identify the risk of experiencing multiple injuries according to occupation, with discussion of how useful the available information systems are. Methods: The data base includes workplace injuries, as classified by INAIL in Italy between 1994 and 2000 in the industrial and artisan sectors (2,162,702 subjects, ages 25-55). Selecting data on accidents occurring among 107,082 subjects who had experienced the first accident in 1996-99, in this cohort we assessed the occurrence of further accidents within two years in the same occupation, taking into account job mobility and factors eventually influencing underreporting (geographic area, age, severity of first accident and size of the enterprise). The risk for each occupation was computed stratifying by gender. Results: There were significant differences between the first and successive accidents when examined by type, age group, severity of physical consequences and company size. Among men, the occupations showing higher risk were those already known to be at high risk for accidents: cleaning staff and refuse workers, foundry workers, masons, pilots, woodworkers, carpenters, transport workers, sailors, farmers, and miners. Among women the occupations most at risk were postwomen and messengers, cleaning staff and refuse workers, waitresses, cooks, bartenders, machine tool operators, woodworkers, and weavers in the textile industry. Conclusions: Among men, the risk of recurrent workplace accidents by occupation tends to reflect the frequency of the total accidents in each occupation. The results indicate that the study model employed is efficient and useful in providing risk profiles which allow identification of where to direct future studies, investigations, and preventive measures for each sex.
Human Pathology, Apr 1, 2006
The prognostic significance of microvessel density and proliferative activity of the neoplastic c... more The prognostic significance of microvessel density and proliferative activity of the neoplastic cells, evaluated respectively by CD31 and Ki-67 positivity, and immunohistochemical expression of vascular endothelial growth factor (VEGF) was retrospectively investigated in 105 cases of sinonasal carcinoma (80 surgical specimens and 25 biopsies). The most represented histologic types were intestinal-type adenocarcinoma found in 36 patients (34.3%), squamous cell carcinoma (SCC) in 34 (32.4%), mucinous adenocarcinoma (mainly made up of signet-ring cell patterns) in 15 (14.3%), and adenoid cystic carcinoma in 7 (6.7%). Microvessel density values (in vessels per square millimeter), VEGF, and Ki-67 were not dependent on histologic type but were rather correlated to the histologic grading in SCC. Clinical data were available for 92 (87.6%) of 105 patients, with minimum follow-up of 48 months. Most of the patients (81.5%) were at an advanced stage (T3-T4) at diagnosis. The values of all markers were correlated to tumor stage (P = .03). Multivariate analysis showed that both microvessel density and proliferative activity of the neoplastic cells were independent prognostic parameters (mortality hazard ratio, 1.33 and 1.60, respectively). Although VEGF expression was not correlated to prognosis on the whole series (P = .06), it was a powerful prognostic marker when the analysis was restricted to the group of SCCs (hazard ratio, 3.02; 90% confidence interval, 1.58-5.80). These results show that tumor neoangiogenesis, expressed by microvessel density, together with proliferative activity, is a pathologic marker with a strong prognostic impact in sinonasal carcinomas. Therefore, it may be a useful tool in this field so as to carry out therapeutic protocol planning, which may be further enhanced by the adoption of the more recent antiangiogenic molecules.
Assistenza Infermieristica E Ricerca, Jul 1, 2021
Bollettino epidemiologico nazionale, 2021
Medicina Del Lavoro, 2005
European Journal of Public Health, 2020
Background The Oncology Network of Piedmont and Aosta Valley (North-West Italy) was started in 20... more Background The Oncology Network of Piedmont and Aosta Valley (North-West Italy) was started in 2000 and fully established in 2010 as a regional organisational model offering multidisciplinary care by experienced reference centres for cancer diagnosis and surgical treatment. In particular, the San Giovanni Bosco Hospital in Turin is the regional reference centre for pancreatic cancer since 2015 (50-70 oncologic surgery operations performed annually). The aim of study is to assess the effectiveness of this model for pancreatic cancer surgery by comparing survival outcomes before and after the adoption of the Oncology Network model. Methods The study included 178 patients, aged 37-84, who underwent duodenocephalo- or total pancreatectomy for ductal cancer in the years 2007-2019. Clinical data were retrieved from surgical records, whereas the vital status was ascertained through an application connected to the Regional Registry Office. The Kaplan-Meier method was used to estimate surviv...
European Journal of Public Health, 2018
and efficiency of care. The Fondazione Policlinico Gemelli CCU 2.0-Rome-has recently been impleme... more and efficiency of care. The Fondazione Policlinico Gemelli CCU 2.0-Rome-has recently been implemented, according to the LHCM, to reduce the length of stay of frail and complex patients after their acute phase. A long hospitalization causes an increase in patient complications and costs for the healthcare facility. The early identification of the suitable patients (within 24-48h from the admission) and the multidimensional evaluation of their needs are strategic to offer the most appropriate care setting after the discharge. Problem: The CCU mission is to facilitate the take-charge of frail and complex patients, after hospital discharge, by community health facilities through an Individual Care Plan. The multidimensional evaluation using validated tools and the optimization of the patient flow result in a reduction in length of stay of these patients. Results: From December 2016 (starting date of CCU 2.0) to March 2018, a total of 1948 patients were taken in charge. The average length of stay was 28.8AE30.2 days. The average time from the CCU activation to the patient discharge was 12.0AE18.3 days. During the first 16 months of the Unit, our data show a significant reduction of the length of stay. A comparison between Dec 2016-Mar 2017 and Dec 2017-Mar 2018, the average length of stay was reduced by 7.9 days (t-test, p < 0.001), the average time between the admission and the activation of the Unit decreased by 2.3 days (t-test, p < 0.001), the average time between the activation and the discharge fell by 5.6 days (t-test, p < 0.001). Lessions: This reduction resulted in significant savings for the hospital in terms of costs derived from hospitalizations and treatments and also in care quality improvement for patients, as well as an advantage for their caregivers. Key messages: The Unit has shown an improvement in quality of care and containment of inefficiencies and costs by reducing length of stay. The Lean Health Care Methodology (LHCM) of applied to our CCU could be a study model for other hospitals.
Oncology, 2009
Background and objective: Acute myeloid leukemia (AML) is the most frequent type of acute leukemi... more Background and objective: Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukemia relapse occurs due to clonal evolution or clonal escape. In this study, we aimed to analyze the clinical and biological factors influencing outcomes in patients with AML relapse. Patients and methods: We included a total of 75 AML patients who experienced leukemia relapse after achieving complete remission. We performed complete immunophenotyping and conventional karyotyping in bone marrow aspirates obtained at diagnosis and at leukemia relapse. Results: Overall survival (OS) of the series was 3.7 ± 2.3%, leukemia progression being the most common cause of death. Patients relapsing before 12 months and those with adverse cytogenetic-molecular risk had statistically significant worse outcomes. A percentage of 52.5 of patients showed phenotypic changes and 50% cytogenetic changes at relapse. We did not find significant clinical factors predicting clonal evolution. The presence of clonal evolution at relapse did not have a significant impact on outcome. Conclusions: Patients with relapsed AML have a dismal prognosis, especially those with early relapse and adverse cytogenetic-molecular risk. Clonal evolution with phenotypic and cytogenetic changes occurred in half of the patients without predictive clinical factors or impact on outcome.
International Journal of Public Health, 2023
Objectives: Non-suicidal self-injury (NSSI) poses a threat in developmental ages, yet there is a ... more Objectives: Non-suicidal self-injury (NSSI) poses a threat in developmental ages, yet there is a scarcity of studies on NSSI trends, especially those in emergency departments (ED). Methods: The aim of this cross-sectional study is to describe trends in ED visits for NSSI among young people aged between 5 and 19 years in Italy from 2011 to 2021 in Piedmont. From the ministerial ED discharge information system, all occurring NSSIs were identified by medical report and/or ICD9CM code and reported as a population rate and a visit rate on all ED requests. Results: The general rate of ED visits remained stable, with around 210,000 (55% males) visits each year, along the whole period from 2011 to 2019, then halved during 2020 and 2021. The NSSI population and visits rates increased from 2013, peaking in 2019 at a rate of around 25 and 23 NSSI visits (girls) and 76 and 69 NSSI (boys) per 100,000 ED visits. In 2020 and 2021, the rate of NSSI visits increased, particularly in girls and among older adolescents. Conclusion: The gradual increase of NSSI over the last decade is a rising public health issue, which deserves wider attention to ensure early detection and prevention.
Tendenze nuove, 2007
... Tendenze nuove - 4-5/2007 nuova serie Filomena Bertone, Paola Serafini, Alba Baratta, Carlo M... more ... Tendenze nuove - 4-5/2007 nuova serie Filomena Bertone, Paola Serafini, Alba Baratta, Carlo Mamo e Andrea Chiecchio ... Condizione Assistenziale Bisogni non presenti o soddisfatti 0 6 5 4 3,3 1 Bisogno 1 20 16,5 4 3,3 2 Bisogni 2 24 19,8 18 14,9 2 1,7 ...
PubMed, Aug 8, 2007
Background: The prevalence of surgical cases of carpal tunnel syndrome (CTS) tends to increase in... more Background: The prevalence of surgical cases of carpal tunnel syndrome (CTS) tends to increase in the general population in Italy. Nevertheless, it is still unclear what percentage of CTS is attributable to occupational exposure, to ergonomic or psychosocial factors. Moreover, the problem of obtaining a reliable definition of occupational exposure in the absence of direct observation and measurement in the workplace remains unsolved. Piedmont (north-western Italy) is one of the Italian regions with the highest number of musculoskeletal disorders recognized and compensated as work-related. The aim of this study was to estimate the proportion of work-related CTS surgical cases, based on self-reported exposure data. Methods: An interview-based questionnaire included items on medical history, workplace exposures and non-occupational risk factors for CTS. The study was carried out between June 2003 and November 2004. A total of 260 adult patients (aged 18-65 years) were interviewed. An evaluation of the questionnaires was made by 3 occupational physicians, assigning every patient a probability score of occupational aetiology. Seventy-four per cent of the sample were female; the mean age was 48.4 years. Results: Seventy-one percent of the patients reported bilateral CTS. Occupational exposure preceded the onset of CTS symptoms for 184 patients. The probability that CTS was work-related was estimated as high for 66 patients (26% of the sample). Agreement among examiners, evaluated using the kappa statistic, was good. Conclusions: Despite the limitations of the study, the number of cases attributable to occupation was much higher than the number of diseases reported to INAIL (National Institute for the Insurance of Industrial Accidents), which suggests that there is substantial under-notification in Italy.
Medicina Del Lavoro, 2005