Mamta Bishnoi - Academia.edu (original) (raw)

Papers by Mamta Bishnoi

Perspectives in Clinical Research

Iranian Journal of Science

Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases, 2023

Healthline, 2021

Introduction: Social capital is defined as social cohesion among communities. This refers to proc... more Introduction: Social capital is defined as social cohesion among communities. This refers to processes between people which establish network, social trust and co-operation and mutual benefit. The present study was conducted to know the status of social capital among elderly population of Chandigarh city, India. Methods: The study was conducted from January to April 2017. The study was community based using convenience sampling. A total of 300 elderly subjects were selected for interview from the electoral rolls. The survey instrument was modified Onyx and Bullen scale consisting of 30 items with responses on likert scale from 1-4. Results: Mean age of respondents was 66.47 years. Male: Female ratio was 1.4:1. 45.7% owned their residence whereas 54.3% lived as tenants. Social capital score of majorities of elderly was good (63.7%) followed by average (19.3%).Highest mean scores were received for questions namely: would you help someone if their vehicle breaks down (3.03±0.69), do yo...

The Open COVID Journal

In 2019, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) was first reported in Wuh... more In 2019, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) was first reported in Wuhan, China, affecting the population all over the globe. This ongoing pandemic is creating major havoc and has already taken the lives of many people. It has become really difficult to control the spread of the virus because of its high rate of multiplication in the host and transmission. The virus spreads by the means of droplets or direct contact with the infected person, causing pneumonia-like symptoms, such as fever, dry cough, throat pain, and breathlessness. This review presents the indications, mechanism of action, administration, and adverse effects of some antiviral, antibiotic, and immunomodulatory drugs, that are currently employed in the treatment of SARS-CoV-2. It also presents the effects and benefits of drugs on an infected person, when co-administered together.

Nanotechnology for Biomedical Applications

Journal of Drug Targeting, 2014

Abstract Background: In intra-articular drug delivery, there are number of shortcomings such as l... more Abstract Background: In intra-articular drug delivery, there are number of shortcomings such as lymphatic drainage from the synovial cavity, frequent dosing, adverse side effects and patient discomfort in the management of osteoarthritis (OA). This research work reports the development and characterization of aceclofenac-loaded chondroitin sulfate (CS) conjugated (CS-SLN) and unconjugated solid lipid nanoparticles (SLN) for the effective management of OA. The SLNs were prepared using modified solvent injection method and coupled with CS. They were further characterized for size and size distribution, zeta potential, surface morphology, % entrapment efficiency and in vitro drug release profile. Anti-inflammatory activity and in vivo performance was also predicted. The particle size of the SLN and CS-SLN was found to be 143.4 ± 0.9 nm and 154.2 ± 1.1 nm, respectively. SLNs exhibited sustained drug release (SLN, 64.25 ± 0.75%; CS-SLN, 57.82 ± 0.62%) in vitro for more than 24 h. In vivo performance studies revealed the highest uptake of SLNs by the knee joint. SLNs enhanced accumulation at the knee joint due to specific interactions with CD44, annexin and leptin receptors attributed to CS coupling. CS-SLN could be potentially effective vector for the treatment or management of OA.

Glycoconjugate Journal, 2016

Chondroitin sulfate (CS) being a natural glycosaminoglycan is found in the cartilage and extracel... more Chondroitin sulfate (CS) being a natural glycosaminoglycan is found in the cartilage and extracellular matrix. It shows clinical benefits in symptomatic osteoarthritis (OA) of the finger, knee, hip joints, low back, facial joints and other diseases due to its anti-inflammatory activity. It also helps in OA by providing resistance to compression, maintaining the structural integrity, homeostasis, slows breakdown and reduces pain in sore muscles. It is most often used in combination with glucosamine to treat OA. CS is a key role player in the regulation of cell development, cell adhesion, proliferation, and differentiation. Its commercial applications have been continuously explored in the engineering of biological tissues and its combination with other biopolymers to formulate scaffolds which promote and accelerate the regeneration of damaged structure. It is approved in the USA as a dietary supplement for OA, while it is used as a symptomatic slow-acting drug (SYSADOA) in Europe and some other countries. Any significant side effects or overdoses of CS have not been reported in clinical trials suggesting its long-term safety. This review highlights the potential of CS, either alone or in combination with other drugs, to attract the scientists engaged in OA treatment and management across the world.

Journal of Liposome Research

Asian Journal of Pharmacy and Pharmacology

Background: Tapentadol hydrochloride (TAP) is a novel opioid that binds and activates opioid rece... more Background: Tapentadol hydrochloride (TAP) is a novel opioid that binds and activates opioid receptor in the central nervous system to modify the approach our body interprets pain. It hasdual mechanism of action (mu opioid-receptor agonist and noradrenaline reuptake inhibitor), this feature makes it an attractivemember of opioid class. The Objective: aim of the present study was to develop and validate a simple, rapid, selective, sensitive, accurate and precise High Performance Liquid Chromatography (HPLC) with UV detection method to quantify TAP in rat plasma. Material and methods: Different analytical parameters, such as linearity, accuracy, precision, specificity with intentional degradation, limit of detection and limit of quantification (LOQ), were determined according to the ICH guidelines. The chromatographic separation of tapentadol hydrochloride was achieved with LC-2010 HT column using a mobile phase, potassium phosphate buffer: acetonitrile (50:50 v/v) at flow rate 1.0 ml/min. using a UV detector set at 272 nm with a continuous run up to 5 min. Plasma samples were processed using acetonitrile as precipitating agent to extract drug. The linearity for tapentadol hydrochloride was found to be 100-1000 ng/ml with Results and conclusion: regression coefficient (r)> 0.9970. The recovery ranged from 98.9 to 100.8% for the drug with a relative standard 2 deviation (%RSD) of <2%. Stability analysis revealed that the drugs remained stable for sufficienttime. The limit of quantification in plasma for tapentadol hydrochloride was found to be 10ng/ml. The mean recovery was obtained at 98.96%. The chromatographic runs were specific with no interfering peaks at the retention times of the analytes confirmed by the experiments. The method can be used to perform pharmacokinetic and bioequivalence studies in rat blood/serum.