Ardhendu Mandal - Academia.edu (original) (raw)

Papers by Ardhendu Mandal

Global journal of pharmacy & pharmaceutical sciences, Jul 9, 2023

Asian Journal of Biochemistry, Genetics and Molecular Biology, Nov 10, 2022

Challenges and Advances in Pharmaceutical Research Vol. 4

Journal of Biomaterials Applications

Mitochondrial dysfunction, characterized by the electron transport chain (ETC) leakage and reduce... more Mitochondrial dysfunction, characterized by the electron transport chain (ETC) leakage and reduced adenosine tri-phosphate synthesis, occurs primarily due to free radicals -induced mutations in either the mitochondrial deoxyribonucleic acid (mtDNA) or nuclear (n) DNA caused by pathogenic infections, toxicant exposures, adverse drug-effects, or other environmental exposures, leading to secondary dysfunction affecting ischemic, diabetic, cancerous, and degenerative diseases. In these concerns, mitochondria-targeted remedies may include a significant role in the protection and treatment of mitochondrial function to enhance its activity. Coenzyme Q10 pyridinol and pyrimidinol antioxidant analogues and other potent drug-compounds for their multifunctional radical quencher and other anti-toxic activities may take a significant therapeutic effectivity for ameliorating mitochondrial dysfunction. Moreover, the encapsulation of these bioactive ligands-attached potent compounds in vesicular sy...

INDIAN JOURNAL OF APPLIED RESEARCH

Conventional chemotherapy against various diseases causes severe side effects in the biological s... more Conventional chemotherapy against various diseases causes severe side effects in the biological system. To overcome drug toxicity, insolubility and resistance, and to get greater therapeutic efcacies, vesicular biodegradable and biocompatible polymeric nanoparticles have attracted attention as drug delivery vehicle. Polycaprolactone (PCL) nanoparticles owing to their nanosizes, spherical shapes and easy surface functionalization capability with drug encapsulation characteristics are utilized as drug carrier for targeted biomedical applications. This review is mainly focused on the preparation of polycaprolactone nanoparticles with their surface functionalization and their usages in different targeted drug delivery applications.

INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2020

The major problems in drug delivery to specific diseased sites possess drug-resistance, drug-toxi... more The major problems in drug delivery to specific diseased sites possess drug-resistance, drug-toxicity, biological barriers and non-specificity to the target-cells observed among patients worldwide. To overcome these barriers, the biodegradable poly alkyl cyanoacrylate (PACA) nanocarriers have been used, while a core made up of PACA is functionalized with biologically active ligands such as cargos, biotin and antibody for enabling specific targeting, and stabilized with outer polyethylene glycol or surfactants in combating cancer, neurodegenerative and infectious diseases. The review demonstrates mainly the synthesis, functionalizations and the biomedical applications of PACA nanoparticles against various diseases to consider them as potent delivery vehicle.

INDIAN JOURNAL OF APPLIED RESEARCH, 2020

As viruses, microbes, other pathogenic microorganisms and toxic agents are responsible for global... more As viruses, microbes, other pathogenic microorganisms and toxic agents are responsible for global broad spectrum diseases including cancer and malignant hypercalcemia, resulting significant mortality and morbidity, nanobiotechnology-based nanoparticles are being emerged as new nanomedicines for their biological applications owing to their unique shape, size and ease surface functionalizations. To overcome drug resistance and toxicity, gallium (Ga(III)) metal nanoparticles (GaNPs) have attracted attention for their requirements for prolonged treatments, especially, against human immunodeficiency virus, mycobacterium, hypercalcemia and cancer. These nanoparticles remain stable for the longer periods owing to the formation of native and passivating 2-3 nm oxide layer. Therefore, it is needed to encapsulate the NPs with bioactive compounds within vesicular system associated ligand-binding for specific delivery to target-sites for getting better efficacies. This review depicts especially...

Journal of experimental therapeutics & oncology, 2008

Reactive oxygen species (O2(*-), OH(-), H2O2) are known to play an important role in tumor initia... more Reactive oxygen species (O2(*-), OH(-), H2O2) are known to play an important role in tumor initiation in hepatocarcinoma. Hepatocarcinoma was developed in the Swiss Albino rats by administration three doses of diethylnitrosamine (DEN) (200 mg/kg b. wt.) (i.p.) at 15 days interval. Quercetin (QC), herbal polyphenolic compound, is a potent anticancer drug. Clinical trials are difficult for its hydrophobic nature. To overcome this problem, our study was aimed to formulate soluble liver specific, galactosylated liposomal QC and to investigate its efficacy against hepatocarcinoma in rat model. Galactosylated liposomal QC was formulated and the suspension was introduced intravenously to rats (8.98 microM/kg) once in a week for 16 weeks. Hepatocarcinoma in rat model and its pathological improvement were evaluated histopathologically, histochemically and electron microscopically. Severe oxidative damage was noticed in the whole liver and its microsomal fraction of DEN treated rats. Huge num...

Indian journal of applied research, 2018

Brain stroke is the main reasonforhealth disability and mortalityamong aged pupils worldwide. Mit... more Brain stroke is the main reasonforhealth disability and mortalityamong aged pupils worldwide. Mitochondrial dysfunction, due to oxidative stress during cerebral ischemia-reperfusion, exerts inflammations and damages to the neurones of the brain. Free form of antioxidant is basically inefficient for the treatment of cerebral ischemia as blood brain barrierremains in between systemic blood and brain interstitial fluid. Furthermore, the affectivity of antioxidant compounds may be hindered by their poor permeability, low solubility and enhanced rate of efflux from the effected cells. Therefore, different active compounds encapsulated in various vesicles have been investigated in vivo to prevent brain ischemia. Our review, on the methods applied for the preparation, characterization, and efficacy of vesicular active drug compounds -delivery, has demonstrated a promising aspect, especially for nanoencapsulation in the treatment of cerebral ischemia against oxidative cell death with higher...

Despite the advancement of medical and pharmaceutical chemistry, the chemotherapy is still a majo... more Despite the advancement of medical and pharmaceutical chemistry, the chemotherapy is still a major challenge for targeting drugs into liver to fight against life-threatening hepatocellular diseases. For many diseases e.g. viral hepatitis, arsenicosis, hepatocarcinogenesis, there are hundred of compounds that could be excellent drugs for the treatment of these various hepatic diseases. But the treatment of hepatocellular diseases with many drugs leads to several side effects thus reducing the quality of life. However, delivering these drugs to the target tissue has been a challenge for pharmaceutical area throughout history.

Current Science, 2001

Pentavalent antimonial Sb(V)-resistant Leishmania promastigotes isolated from Indian kala-azar pa... more Pentavalent antimonial Sb(V)-resistant Leishmania promastigotes isolated from Indian kala-azar patients were found to be cross-resistant to other heavy metal ions and two antileishmanial drugs, pentamidine isethionate andamphotericin B, used for treatment of Sb(V)-unresponsive patients. Results strongly suggest the presence of transport activities in resistant cells which are actively responsible for efflux of these drugs.

International Journal of Polymeric Materials and Polymeric Biomaterials

Journal of Applied Life Sciences International

Annual Research & Review in Biology

Toxicology and applied pharmacology, Jan 6, 2018

Environmental and occupational exposures to cadmium increase the risk of various cancers, includi... more Environmental and occupational exposures to cadmium increase the risk of various cancers, including lung cancer. The carcinogenic mechanism of cadmium, including its prevention remains to be investigated. Using fluorescence and electron spin resonance spin trapping, the present study shows that in immortalized lung cells (BEAS-2BR cells), exposure cadmium generated reactive oxygen species (ROS). Through ROS generation, cadmium increased the protein level of TNF-α, which activated NF-κB and its target protein COX-2, creating an inflammatory microenvironment. As measured by anchorage-independent colony formation assay, cadmium induced malignant cell transformation. Inhibition of ROS by antioxidants inhibited transformation, showing that ROS were important in the mechanism of this process. The inflammatory microenvironment created by cadmium may also contribute to the mechanism of the transformation. Using tandem fluorescence protein mCherry-GFP-LC3 construct, the present study shows t...

International Journal of Nanomedicine

The efficacy of mannosylated liposome formulations with Quercetin (QC, a flavonoid antioxidant is... more The efficacy of mannosylated liposome formulations with Quercetin (QC, a flavonoid antioxidant isolated from indigenous origin) has been tested in vivo against carbon tetrachloride(CCl(4))-induced liver oxidative damage in rats. Single subcutaneous injection of CCl(4) (40% v/v in olive oil; 1 ml/kg) induces the generation of toxic oxygen radicals and results in hepatocellular damage. The increased serum enzyme levels (glutamate pyruvate transaminase, alkaline phosphatase) and hepatocellular conjugated diene levels by CCl(4) induction were significantly lowered due to pretreatment with mannosylated liposomal QC (MLQ) (0.5 ml liposomal suspension containing 0.27 mg QC), whereas the same amount of free QC was found to be ineffective. In addition, the effectiveness of MLQ on CCl(4)-induced acute liver damage also was evaluated by tissue histopathological examination. Damage produced by CCl(4) in liver reverted to normal with pretreatment of MLQ.

The Journal of Pharmacology and Experimental Therapeutics, 2007