C. Mangas - Academia.edu (original) (raw)
Papers by C. Mangas
Immuno-Oncology and Technology
Actas Dermo-Sifiliográficas, 2010
Initial evaluation, diagnosis, staging, treatment, and follow-up of patients with primary cutaneo... more Initial evaluation, diagnosis, staging, treatment, and follow-up of patients with primary cutaneous malignant melanoma. Consensus statement of the network of Catalan and Balearic Melanoma Centers
Cancer Immunology, Immunotherapy, 2020
European Journal of Cancer, 2019
We present four patients aff ected by a lymphomatous proliferation of the skin with cutaneous and... more We present four patients aff ected by a lymphomatous proliferation of the skin with cutaneous and systemic involvement to discuss diagnostic and management options. They all had a complete diff erent clinical presentation and evolution but all of them were extensively positive to CD30, a marker which emerge as "a clue for four" Case 1. A 48-year-old man with recurrent papules and nodules on four extremities from last 2 years. Case 2. A 72-year-old man recently diagnosed by a lung tumor treated by surgery. Some weeks after he developed cutaneous ulcerated plaques with rapid evolution. A PET scan showed multiple lymphadenopathies. Case 3. A 66-year-old man aff ected by a persistent infi ltrated erythe matous plaque on the ocular conjunctiva. The patient was known for a longtime story of cutaneous lesions. Case 4. A 56-year-old aff ected by a mycosis fungoides stage IIB treated by allogenic transplantation developed multiple ulcerated nodules responsive to radiotherapy Histological analysis from the four cases showed similar aspects in spite to a clinical spectrum so variable. A discussion about the role of the marker CD30 for diff erential diagnosis of cutaneous lymphoproliferative disorders and the fi nal outcome of these four interesting cases will be guaranteed.
Journal of Clinical & Experimental Dermatology Research, 2017
elsevier.es
... Molecular. Hospital Universitario Virgen Macarena. Sevilla. ... hepático. 8REACCIONES AL COLO... more ... Molecular. Hospital Universitario Virgen Macarena. Sevilla. ... hepático. 8REACCIONES AL COLOR ROJO DE LOS TATUAJES R. Rivera, A. Miguélez, N. Barrientos, C. Postigo, P. Ortiz, J. Ortiz, L. Iglesias Hospital 12 de Octubre. Madrid. ...
British Journal of Dermatology, 2016
Nearly 10% of all cases of cutaneous melanoma (CM) occur in patients with a personal or family hi... more Nearly 10% of all cases of cutaneous melanoma (CM) occur in patients with a personal or family history of the disease.
Journal of the European Academy of Dermatology and Venereology
Yu X, Zhang J, Gu Y et al. CHILD syndrome mimicking verrucous nevus in a Chinese patient responde... more Yu X, Zhang J, Gu Y et al. CHILD syndrome mimicking verrucous nevus in a Chinese patient responded well to the topical therapy of a compound of simvastatin and cholesterol.
Actas Dermo-Sifiliográficas (English Edition), 2010
The consensus statement on the management of primary cutaneous melanoma that we present here was ... more The consensus statement on the management of primary cutaneous melanoma that we present here was based on selection, discussion, review, and comparison of recent literature (including national and international guidelines). The protocols for the diagnosis, treatment, and follow-up used in the hospital centers throughout Catalonia and the Balearic Isles belonging to the Network of Catalan and Balearic Melanoma Centers were also considered. The main objective of this statement was to present the overall management of melanoma patients typically used in our region at the present time. As such, the statement was not designed to be an obligatory protocol for health professionals caring for this group of patients, and neither can it nor should it be used for this purpose. Professionals reading the statement should not therefore consider it binding on their practice, and in no case can this text be used to guarantee or seek responsibility for a given medical opinion. The group of dermatologists who have signed this statement was created 3 years ago with the aim of making our authorities aware of the importance of this complex tumor, which, in comparison with other types of cancer, we believe does not receive sufficient attention in Spain. In addition, the regular meetings of the group have produced interesting proposals for collaboration in various epidemiological, clinical, and basic applied research projects on the subject of malignant melanoma in our society.
![Research paper thumbnail of [Evaluation of dermatological services implemented in the primary care setting]](https://attachments.academia-assets.com/47964460/thumbnails/1.jpg)
](Actas dermo-sifiliográficas, 2007
Actas Dermo-Sifiliográficas (English Edition), 2008
Actas Dermo-Sifiliográficas (English Edition), 2010
The consensus statement on the management of primary cutaneous melanoma that we present here was ... more The consensus statement on the management of primary cutaneous melanoma that we present here was based on selection, discussion, review, and comparison of recent literature (including national and international guidelines). The protocols for the diagnosis, treatment, and follow-up used in the hospital centers throughout Catalonia and the Balearic Isles belonging to the Network of Catalan and Balearic Melanoma Centers were also considered. The main objective of this statement was to present the overall management of melanoma patients typically used in our region at the present time. As such, the statement was not designed to be an obligatory protocol for health professionals caring for this group of patients, and neither can it nor should it be used for this purpose. Professionals reading the statement should not therefore consider it binding on their practice, and in no case can this text be used to guarantee or seek responsibility for a given medical opinion. The group of dermatologists who have signed this statement was created 3 years ago with the aim of making our authorities aware of the importance of this complex tumor, which, in comparison with other types of cancer, we believe does not receive sufficient attention in Spain. In addition, the regular meetings of the group have produced interesting proposals for collaboration in various epidemiological, clinical, and basic applied research projects on the subject of malignant melanoma in our society.
Journal of the European Academy of Dermatology and Venereology, 2006
computerized tomography with contrast or magnetic resonance in cases that neurological tumour or ... more computerized tomography with contrast or magnetic resonance in cases that neurological tumour or intracranial extension is suspected is needed.
Journal of Cutaneous Pathology, 2006
Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology in which skin involvemen... more Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology in which skin involvement is frequent. To review histological characteristics of biopsies of specific cutaneous lesions of sarcoidosis and their relationship with clinical course. Biopsies from 32 patients with specific cutaneous sarcoidosis were reviewed. Histological findings and clinical characteristics of these patients were analysed. The initial clinical lesions of the patients were ten infiltrated nodule-plaques, eight papules, four maculopapular eruptions, five scar sarcoidosis, four subcutaneous nodules and one lupus pernio. Sarcoidal granulomas were located at dermis in 31 cases (74%) and at subcutaneous fat in 12 (28%) but only four were subcutaneous exclusively. Perivascular or periannexial distribution of granulomas was observed in eight cases (19%) and they had coalescence in 29 samples. The presence of foreign material was demonstrated in 11 cases (26%). Clinical spectrum of specific lesions of cutaneous sarcoidosis showed a good correlation with granulomas localization in the biopsies. However, traditional classification of specific cutaneous sarcoidosis is often overlapping. On the other hand, foreign bodies and other atypical histological findings were more common than initially expected.
Dermatologic Surgery, 2007
... CRISTINA MANGAS MD 1 ,; MARIA TERESA FERNÁNDEZ-FIGUERAS PhD 2 ,; JOSE MANUEL CARRASCOSA PhD 3... more ... CRISTINA MANGAS MD 1 ,; MARIA TERESA FERNÁNDEZ-FIGUERAS PhD 2 ,; JOSE MANUEL CARRASCOSA PhD 3,4 ,; XAVIER SORIA MD 3,4 ,; CRISTINA PARADELO MD 3,4 ,; CARLOS FERRANDIZ PhD 3,4 ,; MIQUEL JUST PhD 5. Article first published online: 5 JUN 2007 ...
Annals of Surgical Oncology, 2009
The aim of this study was to evaluate the prognostic potential of quantitative reverse-transcript... more The aim of this study was to evaluate the prognostic potential of quantitative reverse-transcription, polymerase chain reaction (qRT-PCR) in melanoma patients with pathologically negative sentinel lymph nodes (SLN). Our study included 195 node-negative melanoma patients with a Breslow thickness greater than 0.76 mm (n = 158), or less than 0.76 mm but who had Clark level IV-V, microscopic ulceration, or pathological signs of regression (n = 32), and five patients with melanoma of unknown thickness. SLNs were examined by serial-section histopathology. A portion of each SLN was frozen for qRT-PCR analysis using markers Tyrosinase, MART1, SSX2, MAGEA3, PAX3, and GalNAc-T. In addition, two other markers (PLAB and L1CAM) were evaluated for melanoma specificity but not for SLN analysis. Median follow-up was 64 months, during which time there were 15 (7.7%) recurrences. A total of 370 lymph nodes were analyzed by qRT-PCR. No association was found between quantitative expression level of any marker and disease recurrence. Previously published primer designs were tested for PAX3 and GalNAc-T and revealed that alternative PAX3 transcripts are differentially expressed in melanoma and benign lymph nodes. No associations with recurrence were found regardless of the transcripts amplified by different primer sets. PLAB and L1CAM did not appear to differentiate between malignant melanoma and benign melanocytes or lymph nodes in our analysis. We conclude that, in this large cohort of patients, multimarker qRT-PCR analysis of SLNs did not correlate with disease recurrence. Our data support specific PAX3 splice variants but not GalNAc-T, PLAB or L1CAM as possible markers for melanoma metastasis to SLNs.
Actas Dermo-Sifiliográficas, 2008
Sentinel lymph node biopsy was introduced into the management of cancer patients 20 years ago. Mo... more Sentinel lymph node biopsy was introduced into the management of cancer patients 20 years ago. Most hospitals now currently use the technique as a routine diagnostic tool in patients with localized malignant melanoma. However, the technique is complex and numerous details need to be determined and assessed to provide reliable diagnostic and prognostic information. In addition, the introduction of immunohistochemical
Actas Dermo-Sifiliográficas, 2007
Actas Dermo-Sifiliográficas, 2010
En la versión impresa del artículo )Valoración inicial, diagnóstico, estadificación, tratamiento ... more En la versión impresa del artículo )Valoración inicial, diagnóstico, estadificación, tratamiento y seguimiento de los pacientes con melanoma maligno primario de la piel. Documento de consenso de la Xarxa de Centres de Melanoma de Catalunya i Balears* (Actas Dermosifiliogr. 2010; 101: 129-42) se ha publicado por error una versión del artículo en la que no se han incorporado las correcciones enviadas por los autores durante las pruebas de imprenta.
Immuno-Oncology and Technology
Actas Dermo-Sifiliográficas, 2010
Initial evaluation, diagnosis, staging, treatment, and follow-up of patients with primary cutaneo... more Initial evaluation, diagnosis, staging, treatment, and follow-up of patients with primary cutaneous malignant melanoma. Consensus statement of the network of Catalan and Balearic Melanoma Centers
Cancer Immunology, Immunotherapy, 2020
European Journal of Cancer, 2019
We present four patients aff ected by a lymphomatous proliferation of the skin with cutaneous and... more We present four patients aff ected by a lymphomatous proliferation of the skin with cutaneous and systemic involvement to discuss diagnostic and management options. They all had a complete diff erent clinical presentation and evolution but all of them were extensively positive to CD30, a marker which emerge as "a clue for four" Case 1. A 48-year-old man with recurrent papules and nodules on four extremities from last 2 years. Case 2. A 72-year-old man recently diagnosed by a lung tumor treated by surgery. Some weeks after he developed cutaneous ulcerated plaques with rapid evolution. A PET scan showed multiple lymphadenopathies. Case 3. A 66-year-old man aff ected by a persistent infi ltrated erythe matous plaque on the ocular conjunctiva. The patient was known for a longtime story of cutaneous lesions. Case 4. A 56-year-old aff ected by a mycosis fungoides stage IIB treated by allogenic transplantation developed multiple ulcerated nodules responsive to radiotherapy Histological analysis from the four cases showed similar aspects in spite to a clinical spectrum so variable. A discussion about the role of the marker CD30 for diff erential diagnosis of cutaneous lymphoproliferative disorders and the fi nal outcome of these four interesting cases will be guaranteed.
Journal of Clinical & Experimental Dermatology Research, 2017
elsevier.es
... Molecular. Hospital Universitario Virgen Macarena. Sevilla. ... hepático. 8REACCIONES AL COLO... more ... Molecular. Hospital Universitario Virgen Macarena. Sevilla. ... hepático. 8REACCIONES AL COLOR ROJO DE LOS TATUAJES R. Rivera, A. Miguélez, N. Barrientos, C. Postigo, P. Ortiz, J. Ortiz, L. Iglesias Hospital 12 de Octubre. Madrid. ...
British Journal of Dermatology, 2016
Nearly 10% of all cases of cutaneous melanoma (CM) occur in patients with a personal or family hi... more Nearly 10% of all cases of cutaneous melanoma (CM) occur in patients with a personal or family history of the disease.
Journal of the European Academy of Dermatology and Venereology
Yu X, Zhang J, Gu Y et al. CHILD syndrome mimicking verrucous nevus in a Chinese patient responde... more Yu X, Zhang J, Gu Y et al. CHILD syndrome mimicking verrucous nevus in a Chinese patient responded well to the topical therapy of a compound of simvastatin and cholesterol.
Actas Dermo-Sifiliográficas (English Edition), 2010
The consensus statement on the management of primary cutaneous melanoma that we present here was ... more The consensus statement on the management of primary cutaneous melanoma that we present here was based on selection, discussion, review, and comparison of recent literature (including national and international guidelines). The protocols for the diagnosis, treatment, and follow-up used in the hospital centers throughout Catalonia and the Balearic Isles belonging to the Network of Catalan and Balearic Melanoma Centers were also considered. The main objective of this statement was to present the overall management of melanoma patients typically used in our region at the present time. As such, the statement was not designed to be an obligatory protocol for health professionals caring for this group of patients, and neither can it nor should it be used for this purpose. Professionals reading the statement should not therefore consider it binding on their practice, and in no case can this text be used to guarantee or seek responsibility for a given medical opinion. The group of dermatologists who have signed this statement was created 3 years ago with the aim of making our authorities aware of the importance of this complex tumor, which, in comparison with other types of cancer, we believe does not receive sufficient attention in Spain. In addition, the regular meetings of the group have produced interesting proposals for collaboration in various epidemiological, clinical, and basic applied research projects on the subject of malignant melanoma in our society.
Actas dermo-sifiliográficas, 2007
Actas Dermo-Sifiliográficas (English Edition), 2008
Actas Dermo-Sifiliográficas (English Edition), 2010
The consensus statement on the management of primary cutaneous melanoma that we present here was ... more The consensus statement on the management of primary cutaneous melanoma that we present here was based on selection, discussion, review, and comparison of recent literature (including national and international guidelines). The protocols for the diagnosis, treatment, and follow-up used in the hospital centers throughout Catalonia and the Balearic Isles belonging to the Network of Catalan and Balearic Melanoma Centers were also considered. The main objective of this statement was to present the overall management of melanoma patients typically used in our region at the present time. As such, the statement was not designed to be an obligatory protocol for health professionals caring for this group of patients, and neither can it nor should it be used for this purpose. Professionals reading the statement should not therefore consider it binding on their practice, and in no case can this text be used to guarantee or seek responsibility for a given medical opinion. The group of dermatologists who have signed this statement was created 3 years ago with the aim of making our authorities aware of the importance of this complex tumor, which, in comparison with other types of cancer, we believe does not receive sufficient attention in Spain. In addition, the regular meetings of the group have produced interesting proposals for collaboration in various epidemiological, clinical, and basic applied research projects on the subject of malignant melanoma in our society.
Journal of the European Academy of Dermatology and Venereology, 2006
computerized tomography with contrast or magnetic resonance in cases that neurological tumour or ... more computerized tomography with contrast or magnetic resonance in cases that neurological tumour or intracranial extension is suspected is needed.
Journal of Cutaneous Pathology, 2006
Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology in which skin involvemen... more Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology in which skin involvement is frequent. To review histological characteristics of biopsies of specific cutaneous lesions of sarcoidosis and their relationship with clinical course. Biopsies from 32 patients with specific cutaneous sarcoidosis were reviewed. Histological findings and clinical characteristics of these patients were analysed. The initial clinical lesions of the patients were ten infiltrated nodule-plaques, eight papules, four maculopapular eruptions, five scar sarcoidosis, four subcutaneous nodules and one lupus pernio. Sarcoidal granulomas were located at dermis in 31 cases (74%) and at subcutaneous fat in 12 (28%) but only four were subcutaneous exclusively. Perivascular or periannexial distribution of granulomas was observed in eight cases (19%) and they had coalescence in 29 samples. The presence of foreign material was demonstrated in 11 cases (26%). Clinical spectrum of specific lesions of cutaneous sarcoidosis showed a good correlation with granulomas localization in the biopsies. However, traditional classification of specific cutaneous sarcoidosis is often overlapping. On the other hand, foreign bodies and other atypical histological findings were more common than initially expected.
Dermatologic Surgery, 2007
... CRISTINA MANGAS MD 1 ,; MARIA TERESA FERNÁNDEZ-FIGUERAS PhD 2 ,; JOSE MANUEL CARRASCOSA PhD 3... more ... CRISTINA MANGAS MD 1 ,; MARIA TERESA FERNÁNDEZ-FIGUERAS PhD 2 ,; JOSE MANUEL CARRASCOSA PhD 3,4 ,; XAVIER SORIA MD 3,4 ,; CRISTINA PARADELO MD 3,4 ,; CARLOS FERRANDIZ PhD 3,4 ,; MIQUEL JUST PhD 5. Article first published online: 5 JUN 2007 ...
Annals of Surgical Oncology, 2009
The aim of this study was to evaluate the prognostic potential of quantitative reverse-transcript... more The aim of this study was to evaluate the prognostic potential of quantitative reverse-transcription, polymerase chain reaction (qRT-PCR) in melanoma patients with pathologically negative sentinel lymph nodes (SLN). Our study included 195 node-negative melanoma patients with a Breslow thickness greater than 0.76 mm (n = 158), or less than 0.76 mm but who had Clark level IV-V, microscopic ulceration, or pathological signs of regression (n = 32), and five patients with melanoma of unknown thickness. SLNs were examined by serial-section histopathology. A portion of each SLN was frozen for qRT-PCR analysis using markers Tyrosinase, MART1, SSX2, MAGEA3, PAX3, and GalNAc-T. In addition, two other markers (PLAB and L1CAM) were evaluated for melanoma specificity but not for SLN analysis. Median follow-up was 64 months, during which time there were 15 (7.7%) recurrences. A total of 370 lymph nodes were analyzed by qRT-PCR. No association was found between quantitative expression level of any marker and disease recurrence. Previously published primer designs were tested for PAX3 and GalNAc-T and revealed that alternative PAX3 transcripts are differentially expressed in melanoma and benign lymph nodes. No associations with recurrence were found regardless of the transcripts amplified by different primer sets. PLAB and L1CAM did not appear to differentiate between malignant melanoma and benign melanocytes or lymph nodes in our analysis. We conclude that, in this large cohort of patients, multimarker qRT-PCR analysis of SLNs did not correlate with disease recurrence. Our data support specific PAX3 splice variants but not GalNAc-T, PLAB or L1CAM as possible markers for melanoma metastasis to SLNs.
Actas Dermo-Sifiliográficas, 2008
Sentinel lymph node biopsy was introduced into the management of cancer patients 20 years ago. Mo... more Sentinel lymph node biopsy was introduced into the management of cancer patients 20 years ago. Most hospitals now currently use the technique as a routine diagnostic tool in patients with localized malignant melanoma. However, the technique is complex and numerous details need to be determined and assessed to provide reliable diagnostic and prognostic information. In addition, the introduction of immunohistochemical
Actas Dermo-Sifiliográficas, 2007
Actas Dermo-Sifiliográficas, 2010
En la versión impresa del artículo )Valoración inicial, diagnóstico, estadificación, tratamiento ... more En la versión impresa del artículo )Valoración inicial, diagnóstico, estadificación, tratamiento y seguimiento de los pacientes con melanoma maligno primario de la piel. Documento de consenso de la Xarxa de Centres de Melanoma de Catalunya i Balears* (Actas Dermosifiliogr. 2010; 101: 129-42) se ha publicado por error una versión del artículo en la que no se han incorporado las correcciones enviadas por los autores durante las pruebas de imprenta.