Manoj Mandal - Academia.edu (original) (raw)

Papers by Manoj Mandal

Apple Academic Press eBooks, May 23, 2023

CRC Press eBooks, Aug 22, 2022

CRC Press eBooks, Aug 22, 2022

Journal of High Energy Physics

We propose a new method for the evaluation of intersection numbers for twisted meromorphic n-form... more We propose a new method for the evaluation of intersection numbers for twisted meromorphic n-forms, through Stokes’ theorem in n dimensions. It is based on the solution of an n-th order partial differential equation and on the evaluation of multivariate residues. We also present an algebraic expression for the contribution from each multivariate residue. We illustrate our approach with a number of simple examples from mathematics and physics.

Journal of High Energy Physics

We present the result of the spin-orbit interaction Hamiltonian for binary systems of rotating co... more We present the result of the spin-orbit interaction Hamiltonian for binary systems of rotating compact objects with generic spins, up to N3LO corrections within the post-Newtonian expansion. The calculation is performed by employing the effective field theory diagrammatic approach, and it involves Feynman integrals up to three loops, evaluated within the dimensional regularization scheme. We apply canonical transformations to eliminate the non-physical divergences and spurious logarithmic behaviours of the Hamiltonian, and use the latter to derive the gauge-invariant binding energy and the scattering angle, in special kinematic regimes.

Proceedings of MathemAmplitudes 2019: Intersection Theory & Feynman Integrals — PoS(MA2019)

arXiv (Cornell University), Sep 1, 2022

We present the result of the spin-orbit interaction Hamiltonian for binary systems of rotating co... more We present the result of the spin-orbit interaction Hamiltonian for binary systems of rotating compact objects with generic spins, up to N 3 LO corrections within the post-Newtonian expansion. The calculation is performed by employing the effective field theory diagrammatic approach, and it involves Feynman integrals up to three loops, evaluated within the dimensional regularization scheme. We apply canonical transformations to eliminate the non-physical divergences and spurious logarithmic behaviours of the Hamiltonian, and use the latter to derive the gauge-invariant binding energy and the scattering angle, in special kinematic regimes. 21 C.1 Non-spinning sector up to 3PN 21 C.2 Spin-orbit sector up to N 2 LO 22

We summarize the results of temporal and spectral analysis of the X-ray pulsar 2S 1553-542 using ... more We summarize the results of temporal and spectral analysis of the X-ray pulsar 2S 1553-542 using the Nuclear Spectroscopic Telescope Array (NuSTAR) and Swift during the outburst in January-February 2021. During the outburst, the spin period of the neutron star was P = 9.2822 ± 0.0001 s based on NuSTAR data. The temporal evolution of the spin period, pulse profile, and pulse fraction is studied during the outburst. The spectra of the source are studied for different days of the outburst and can be well described by a model consisting of – a black body emission or a power law. We have investigated the inter-day evolution of different timing and spectral parameters during the outburst. The energy dependence of the pulse profile was studied to investigate the evolution of the individual peaks and emission geometry of the pulsar with a different energy. The pulse profile of the source shows strong single peak nature with a humplike feature of relatively lower intensity and it evolves sig...

The matter presented in this dissertation has not been submitted by me for the award of any other... more The matter presented in this dissertation has not been submitted by me for the award of any other degree of this or any other institute.

Fertility and Sterility, 2005

transfer of embryos where oocytes were fertilized by ICSI vs. conventional insemination. DESIGN: ... more transfer of embryos where oocytes were fertilized by ICSI vs. conventional insemination. DESIGN: Retrospective review. MATERIALS AND METHODS: All frozen ET cycles over a 7 year period were retrospectively reviewed. Clinical and delivered PRs and implantation rates were compared according to whether ICSI was performed or not. Furthermore the data were analyzed according to 4 age groups: A-Յ35, B-36-39, C-40-42, and D-Ն43. The age was based on the age at the time of oocyte retrieval. RESULTS: The clinical PR for frozen ET with ICSI were group A-41.1% (335/816), B-30.8% (109/354), C-23.2% (32/138), and D-9.8% (6/61). The comparable rates for frozen ET without ICSI was A-44.2% (241/545), B-32.0% (74/231), C-24.8% (25/101), and D-23.9% (11/46). The delivered PRs with ICSI were: A-34.9%, B-25.1%, C-19.6%, and D-3.3 vs. for non-ICSI: A-40.0%, B-26.0%, C-18.8%, and D-15.2%. The implantation rates for frozen ET with ICSI were: A-19.3% (495/2560), B-13.0% (162/1245), C-8.4% (45/533), and D-3.2% (7/218). The comparable implantation rates for non-ICSI were: A-20.8% (369/1776), B-13.1% (107/816), C-10.3% (40/389), and D-9.0% (14/156). There were no significant differences in clinical and viable PRs and implantation rates in any age subgroup or in total comparisons. CONCLUSION: Fertilization by ICSI does not impair pregnancy outcome following frozen ET as determined by retrospective analysis of the largest study by far to date. This is important information for the clinician because if the clinician/patient thought the ICSI process could impair subsequent frozen ET success, some borderline cases of male factor or unexplained infertility might influence the choice for conventional insemination rather than ICSI. The possible trend for higher success in group D without ICSI could be explained by a younger median age (44 vs. 43).

Fertility and Sterility, 2005

Objective: Cryopreservation induces lethal and sub-lethal sperm damage that lead to loss of viabi... more Objective: Cryopreservation induces lethal and sub-lethal sperm damage that lead to loss of viability, acrosome loss, DNA fragmentation and poor fertilization. Reactive oxygen species, lipid peroxidation and loss of antioxidant activity such as reduced glutathione (GSH). are considered as mediators of sub-lethal cryodamage to human sperm during cryopreservation. Improvements in semen parameters have been reported by in vivo use of carnitine and acetyl-L-carnitine (ALC), possibly due to its key role in energy metabolism and antioxidant activity. The aim of this present study was to compare the effect of addition of GSH and ALC in freezing media on motility, DNA integrity and lipid peroxidation status of cryopreserved human spermatozoa. Design: Prospsective in vitro study. Materials and Methods: Normozoospermic samples (n=25) from healthy volunteers were included in the present study. Following liquefaction, each semen sample was divided into four equal parts. All aliquots were frozen, two using glycerol-based cryoprotectant with or without 5mM GSH and the other two aliquots with or without 175µM ALC as the final concentration. DNA integrity, both before and after cryopreservation, was assessed using acridine orange fluorescence. After thawing, sperm motility and lipid peroxidation (LPO) were assessed in both controls and test samples using phase contrast microscopy and malonaldehyde assay respectively. Results: Cryoprotectant supplemented with ALC was found to improve post-thaw progressive motility from 16.4 ± 11.9 (control) to 25.4 ± 17.8% (p < 0.05) and normal DNA integrity from 59.3 ± 20.5 (control) to 72.8 ± 15.2% (p = 0.007). No difference in % motility or progressive motility was observed between control and test samples frozen with or without GSH. However, GSH group showed 67.7 ± 20.9% normal DNA integrity compared to the control (p = 0.004). GSH or ALC fractions failed to reduce post thaw LPO rate (37.00 ± 5.9 in controls; 40.2 ± 3.8 for ALC samples, 37.9 ± 4.0 for GSH samples). Conclusion: Samples frozen as neat semen with protective environment of seminal plasma along with supplemented antioxidants such as GSH or ALC can withstand cryoinjuries, especially during post thaw processing which involves dilution and centrifugation steps.

Lecture notes in networks and systems, 2021

Wireless sensor network (WSN) is a part of wireless network which has flexible and dynamic nature... more Wireless sensor network (WSN) is a part of wireless network which has flexible and dynamic nature in context of real-life applications. It has several usages in terms of user requirements. It consists of several nodes having limited energy capacity. Energy capacity of the nodes does not completely fulfil the requirement of the services. During transaction or transmission, data is dropped and fails to reach the destination node or base station (BS). This BS also suffers several types of difficulties for sending or receiving data packets. So, there is need of some techniques or modelling that help to protect this issue. Apart from energy, distance is also one important parameter for transmitting data successfully. Although energy is the crucial parameter, but, combination of both energy and distance plays an important role for managing efficient route of the network. The proposed method is the combination of intelligent technique as well as mathematical modelling that uses fuzzy logic as an intelligent technique and quadratic programming as a mathematical modelling for solving the proposed goal. The combination of both provides a robustness technique that uses two basic parameters, energy and distance, for selecting optimal route of the WSN. The proposed method is validated in LINGO optimization software for formulating and validating the model efficiently.

CRC Press eBooks, Aug 22, 2022

International Journal of Molecular Sciences

Mycobacterium tuberculosis is able to establish a chronic colonization of lung macrophages in a c... more Mycobacterium tuberculosis is able to establish a chronic colonization of lung macrophages in a controlled replication manner, giving rise to a so-called latent infection. Conversely, when intracellular bacteria undergo actively uncontrolled replication rates, they provide the switch for the active infection called tuberculosis to occur. Our group found that the pathogen is able to manipulate the activity of endolysosomal enzymes, cathepsins, directly at the level of gene expression or indirectly by regulating their natural inhibitors, cystatins. To provide evidence for the crucial role of cathepsin manipulation for the success of tuberculosis bacilli in their intracellular survival, we used liposomal delivery of saquinavir. This protease inhibitor was previously found to be able to increase cathepsin proteolytic activity, overcoming the pathogen induced blockade. In this study, we demonstrate that incorporation in liposomes was able to increase the efficiency of saquinavir internal...

Journal of High Energy Physics, 2019

The computation of Feynman integrals is often the bottleneck of multi-loop calculations. We propo... more The computation of Feynman integrals is often the bottleneck of multi-loop calculations. We propose and implement a new method to efficiently evaluate such integrals in the physical region through the numerical integration of a suitable set of differential equations, where the initial conditions are provided in the unphysical region via the sector decomposition method. We present numerical results for a set of two-loop integrals, where the non-planar ones complete the master integrals forgg→γγandqoverlineqq\overline{q}qoverlineqqq¯→γγscattering mediated by the top quark.

Physical Chemistry Chemical Physics

Ca2+, which is a prerequisite for oxygen evolution at the catalytic Mn4CaO5 cluster in photosyste... more Ca2+, which is a prerequisite for oxygen evolution at the catalytic Mn4CaO5 cluster in photosystem II, is replaced with other alkaline earth metals to investigate its influence on the H-bond network.

CRC Press eBooks, Aug 22, 2022

Apple Academic Press eBooks, May 23, 2023

CRC Press eBooks, Aug 22, 2022

CRC Press eBooks, Aug 22, 2022

Journal of High Energy Physics

We propose a new method for the evaluation of intersection numbers for twisted meromorphic n-form... more We propose a new method for the evaluation of intersection numbers for twisted meromorphic n-forms, through Stokes’ theorem in n dimensions. It is based on the solution of an n-th order partial differential equation and on the evaluation of multivariate residues. We also present an algebraic expression for the contribution from each multivariate residue. We illustrate our approach with a number of simple examples from mathematics and physics.

Journal of High Energy Physics

We present the result of the spin-orbit interaction Hamiltonian for binary systems of rotating co... more We present the result of the spin-orbit interaction Hamiltonian for binary systems of rotating compact objects with generic spins, up to N3LO corrections within the post-Newtonian expansion. The calculation is performed by employing the effective field theory diagrammatic approach, and it involves Feynman integrals up to three loops, evaluated within the dimensional regularization scheme. We apply canonical transformations to eliminate the non-physical divergences and spurious logarithmic behaviours of the Hamiltonian, and use the latter to derive the gauge-invariant binding energy and the scattering angle, in special kinematic regimes.

Proceedings of MathemAmplitudes 2019: Intersection Theory & Feynman Integrals — PoS(MA2019)

arXiv (Cornell University), Sep 1, 2022

We present the result of the spin-orbit interaction Hamiltonian for binary systems of rotating co... more We present the result of the spin-orbit interaction Hamiltonian for binary systems of rotating compact objects with generic spins, up to N 3 LO corrections within the post-Newtonian expansion. The calculation is performed by employing the effective field theory diagrammatic approach, and it involves Feynman integrals up to three loops, evaluated within the dimensional regularization scheme. We apply canonical transformations to eliminate the non-physical divergences and spurious logarithmic behaviours of the Hamiltonian, and use the latter to derive the gauge-invariant binding energy and the scattering angle, in special kinematic regimes. 21 C.1 Non-spinning sector up to 3PN 21 C.2 Spin-orbit sector up to N 2 LO 22

We summarize the results of temporal and spectral analysis of the X-ray pulsar 2S 1553-542 using ... more We summarize the results of temporal and spectral analysis of the X-ray pulsar 2S 1553-542 using the Nuclear Spectroscopic Telescope Array (NuSTAR) and Swift during the outburst in January-February 2021. During the outburst, the spin period of the neutron star was P = 9.2822 ± 0.0001 s based on NuSTAR data. The temporal evolution of the spin period, pulse profile, and pulse fraction is studied during the outburst. The spectra of the source are studied for different days of the outburst and can be well described by a model consisting of – a black body emission or a power law. We have investigated the inter-day evolution of different timing and spectral parameters during the outburst. The energy dependence of the pulse profile was studied to investigate the evolution of the individual peaks and emission geometry of the pulsar with a different energy. The pulse profile of the source shows strong single peak nature with a humplike feature of relatively lower intensity and it evolves sig...

The matter presented in this dissertation has not been submitted by me for the award of any other... more The matter presented in this dissertation has not been submitted by me for the award of any other degree of this or any other institute.

Fertility and Sterility, 2005

transfer of embryos where oocytes were fertilized by ICSI vs. conventional insemination. DESIGN: ... more transfer of embryos where oocytes were fertilized by ICSI vs. conventional insemination. DESIGN: Retrospective review. MATERIALS AND METHODS: All frozen ET cycles over a 7 year period were retrospectively reviewed. Clinical and delivered PRs and implantation rates were compared according to whether ICSI was performed or not. Furthermore the data were analyzed according to 4 age groups: A-Յ35, B-36-39, C-40-42, and D-Ն43. The age was based on the age at the time of oocyte retrieval. RESULTS: The clinical PR for frozen ET with ICSI were group A-41.1% (335/816), B-30.8% (109/354), C-23.2% (32/138), and D-9.8% (6/61). The comparable rates for frozen ET without ICSI was A-44.2% (241/545), B-32.0% (74/231), C-24.8% (25/101), and D-23.9% (11/46). The delivered PRs with ICSI were: A-34.9%, B-25.1%, C-19.6%, and D-3.3 vs. for non-ICSI: A-40.0%, B-26.0%, C-18.8%, and D-15.2%. The implantation rates for frozen ET with ICSI were: A-19.3% (495/2560), B-13.0% (162/1245), C-8.4% (45/533), and D-3.2% (7/218). The comparable implantation rates for non-ICSI were: A-20.8% (369/1776), B-13.1% (107/816), C-10.3% (40/389), and D-9.0% (14/156). There were no significant differences in clinical and viable PRs and implantation rates in any age subgroup or in total comparisons. CONCLUSION: Fertilization by ICSI does not impair pregnancy outcome following frozen ET as determined by retrospective analysis of the largest study by far to date. This is important information for the clinician because if the clinician/patient thought the ICSI process could impair subsequent frozen ET success, some borderline cases of male factor or unexplained infertility might influence the choice for conventional insemination rather than ICSI. The possible trend for higher success in group D without ICSI could be explained by a younger median age (44 vs. 43).

Fertility and Sterility, 2005

Objective: Cryopreservation induces lethal and sub-lethal sperm damage that lead to loss of viabi... more Objective: Cryopreservation induces lethal and sub-lethal sperm damage that lead to loss of viability, acrosome loss, DNA fragmentation and poor fertilization. Reactive oxygen species, lipid peroxidation and loss of antioxidant activity such as reduced glutathione (GSH). are considered as mediators of sub-lethal cryodamage to human sperm during cryopreservation. Improvements in semen parameters have been reported by in vivo use of carnitine and acetyl-L-carnitine (ALC), possibly due to its key role in energy metabolism and antioxidant activity. The aim of this present study was to compare the effect of addition of GSH and ALC in freezing media on motility, DNA integrity and lipid peroxidation status of cryopreserved human spermatozoa. Design: Prospsective in vitro study. Materials and Methods: Normozoospermic samples (n=25) from healthy volunteers were included in the present study. Following liquefaction, each semen sample was divided into four equal parts. All aliquots were frozen, two using glycerol-based cryoprotectant with or without 5mM GSH and the other two aliquots with or without 175µM ALC as the final concentration. DNA integrity, both before and after cryopreservation, was assessed using acridine orange fluorescence. After thawing, sperm motility and lipid peroxidation (LPO) were assessed in both controls and test samples using phase contrast microscopy and malonaldehyde assay respectively. Results: Cryoprotectant supplemented with ALC was found to improve post-thaw progressive motility from 16.4 ± 11.9 (control) to 25.4 ± 17.8% (p < 0.05) and normal DNA integrity from 59.3 ± 20.5 (control) to 72.8 ± 15.2% (p = 0.007). No difference in % motility or progressive motility was observed between control and test samples frozen with or without GSH. However, GSH group showed 67.7 ± 20.9% normal DNA integrity compared to the control (p = 0.004). GSH or ALC fractions failed to reduce post thaw LPO rate (37.00 ± 5.9 in controls; 40.2 ± 3.8 for ALC samples, 37.9 ± 4.0 for GSH samples). Conclusion: Samples frozen as neat semen with protective environment of seminal plasma along with supplemented antioxidants such as GSH or ALC can withstand cryoinjuries, especially during post thaw processing which involves dilution and centrifugation steps.

Lecture notes in networks and systems, 2021

Wireless sensor network (WSN) is a part of wireless network which has flexible and dynamic nature... more Wireless sensor network (WSN) is a part of wireless network which has flexible and dynamic nature in context of real-life applications. It has several usages in terms of user requirements. It consists of several nodes having limited energy capacity. Energy capacity of the nodes does not completely fulfil the requirement of the services. During transaction or transmission, data is dropped and fails to reach the destination node or base station (BS). This BS also suffers several types of difficulties for sending or receiving data packets. So, there is need of some techniques or modelling that help to protect this issue. Apart from energy, distance is also one important parameter for transmitting data successfully. Although energy is the crucial parameter, but, combination of both energy and distance plays an important role for managing efficient route of the network. The proposed method is the combination of intelligent technique as well as mathematical modelling that uses fuzzy logic as an intelligent technique and quadratic programming as a mathematical modelling for solving the proposed goal. The combination of both provides a robustness technique that uses two basic parameters, energy and distance, for selecting optimal route of the WSN. The proposed method is validated in LINGO optimization software for formulating and validating the model efficiently.

CRC Press eBooks, Aug 22, 2022

International Journal of Molecular Sciences

Mycobacterium tuberculosis is able to establish a chronic colonization of lung macrophages in a c... more Mycobacterium tuberculosis is able to establish a chronic colonization of lung macrophages in a controlled replication manner, giving rise to a so-called latent infection. Conversely, when intracellular bacteria undergo actively uncontrolled replication rates, they provide the switch for the active infection called tuberculosis to occur. Our group found that the pathogen is able to manipulate the activity of endolysosomal enzymes, cathepsins, directly at the level of gene expression or indirectly by regulating their natural inhibitors, cystatins. To provide evidence for the crucial role of cathepsin manipulation for the success of tuberculosis bacilli in their intracellular survival, we used liposomal delivery of saquinavir. This protease inhibitor was previously found to be able to increase cathepsin proteolytic activity, overcoming the pathogen induced blockade. In this study, we demonstrate that incorporation in liposomes was able to increase the efficiency of saquinavir internal...

Journal of High Energy Physics, 2019

The computation of Feynman integrals is often the bottleneck of multi-loop calculations. We propo... more The computation of Feynman integrals is often the bottleneck of multi-loop calculations. We propose and implement a new method to efficiently evaluate such integrals in the physical region through the numerical integration of a suitable set of differential equations, where the initial conditions are provided in the unphysical region via the sector decomposition method. We present numerical results for a set of two-loop integrals, where the non-planar ones complete the master integrals forgg→γγandqoverlineqq\overline{q}qoverlineqqq¯→γγscattering mediated by the top quark.

Physical Chemistry Chemical Physics

Ca2+, which is a prerequisite for oxygen evolution at the catalytic Mn4CaO5 cluster in photosyste... more Ca2+, which is a prerequisite for oxygen evolution at the catalytic Mn4CaO5 cluster in photosystem II, is replaced with other alkaline earth metals to investigate its influence on the H-bond network.

CRC Press eBooks, Aug 22, 2022