Manon Auger - Academia.edu (original) (raw)

Papers by Manon Auger

Research paper thumbnail of Breast implant–associated anaplastic large cell lymphoma and effusions: A review with emphasis on the role of cytopathology

Research paper thumbnail of Revitalising an academic pathology department: lessons learnt

Journal of Clinical Pathology

Pathology is a specialty that bridges basic medical science and clinical practice. In the era of ... more Pathology is a specialty that bridges basic medical science and clinical practice. In the era of personalised medicine, this specialty is facing unprecedented challenges. Some of these challenges are institution-specific, while many are shared worldwide at different magnitude. This review shares our team efforts in the past 5 years, 2012–2017, to revitalise a century-old academic pathology department in three aspects: administration, clinical service and academic development. The lessons learnt and insights gained from our experience may provide guidance to leaders in pathology or in other related specialties.

Research paper thumbnail of Implementing The Paris System for Reporting Urinary Cytology results in a decrease in the rate of the "atypical" category and an increase in its prediction of subsequent high-grade urothelial carcinoma

Cancer, Jan 26, 2017

In the current study, the authors evaluated the impact of implementing The Paris System for Repor... more In the current study, the authors evaluated the impact of implementing The Paris System for Reporting Urinary Cytology (PSRUC) on the prevalence of various cytological categories and their association with a subsequent diagnosis of high-grade urothelial carcinoma (HGUC). A comparative study was conducted over the 6-month period before PSRUC implementation (2013), including 1653 patients and 2371 specimens versus a 6-month period after implementation of the PSRUC (2016), including 1478 patients and 2392 specimens. The following cytological categories were correlated with the subsequent biopsy result when available (355 cases): negative for HGUC (NHGUC), atypical urothelial cells (AUC), suspicious for HGUC, and HGUC. Although 18.6% of specimens were diagnosed as AUC in 2013, the percentage was 14.4% in 2016 (P < .0001). Concurrently, the prevalence of the "benign" category increased from 2013 to 2016 (75.4% vs 80%; P < .0001). After implementation of the PSRUC, there w...

Research paper thumbnail of Off the beaten path: A case of mediastinal ectopic thyroid tissue

Research paper thumbnail of The EVVA cohort study

The Journal of Infectious Diseases

Background. The risk of anal cancer due to high-risk human papillomavirus (HR-HPV) is higher in w... more Background. The risk of anal cancer due to high-risk human papillomavirus (HR-HPV) is higher in women living with human immunodeficiency virus (HIV) than in the general population. We present findings of cervical and anal HPV and cytologic tests at baseline in the EVVA cohort study and HPV persistence data 6 months after baseline. Methods. Semiannual visits included questionnaires, chart reviews, cervical/anal cytologic and cervical/anal HPV testing for 2 years. Genotyping for 36 HPV genotypes was performed using the Roche Linear Array HPV genotyping test. Results. A total of 151 women living with HIV were recruited. At baseline, 75% had anal HPV, 51% had anal HR-HPV, 50% had cervical HPV, and 29% had cervical HR-HPV. Anal HPV-16 and HPV-51 were more frequent in women born in Canada (31% and 29%, respectively, compared with ≤16% for other women). Most anal HR-HPV types detected at 6 months (57%-93%) were persistent from baseline. Findings of anal cytologic tests were abnormal for 37% of women. Conclusions. Anal HPV is highly prevalent in women living with HIV, and type distribution varies by place of birth. Highresolution anoscopy was indicated in more than one third of results. As anal cancer is potentially preventable, these important findings need to be considered when selecting the best approach for anal cancer screening programs.

Research paper thumbnail of Update on the cytologic features of papillary thyroid carcinoma variants

Diagnostic cytopathology, 2017

Papillary thyroid cancer (PTC), which accounts for 85-90% of all thyroid cancers, is generally an... more Papillary thyroid cancer (PTC), which accounts for 85-90% of all thyroid cancers, is generally an indolent tumor with long term survival rates >95%. A reliable definitive diagnosis of PTC is usually straightforward in fine needle aspirates of conventional PTC whenever the characteristic papillary and/or flat honeycomb sheet-like architecture and the typical nuclear features of chromatin pallor, nuclear enlargement, crowding, grooves and pseudoinclusions are encountered. Conventional PTC, however, has diminished in relative frequency as compared to PTC variants, especially the noninvasive follicular variant of PTC, an indolent tumor which has recently been reclassified as "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP). These PTC variants are characterized by various architecture, cell type and shape, and stromal features, some of which can be recognized cytologically. Awareness of the cytomorphological spectrum and of the character...

Research paper thumbnail of Yield of EBUS-TBNA for the diagnosis of sarcoidosis: impact of operator and cytopathologist experience

BMJ open respiratory research, 2016

Studies have reported a high diagnostic yield of endobronchial ultrasound-guided transbronchial n... more Studies have reported a high diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the diagnosis of sarcoidosis. We sought to review the yield of EBUS-TBNA for the diagnosis of sarcoidosis at our institution over time, and examine factors that may influence this yield. Patients who underwent EBUS-TBNA for suspected sarcoidosis between December 2008 and November 2011 were identified. EBUS was performed without rapid on-site evaluation (ROSE) of samples. The final diagnosis was based on the results of all invasive diagnostic procedures and/or clinical follow-up. Logistic regression analysis was used to examine the effect of various factors on yield. 43 patients underwent 45 EBUS-TBNA procedures for suspected sarcoidosis. A total of 115 lymph nodes were sampled. The 21 G needle was used in 51% of procedures. The mean number of lymph node stations sampled was 2.6 (SD 0.7) and the mean number of needle passes per procedure was 7.8 (SD 2.0). ...

Research paper thumbnail of Impact of Implementing the Paris System for Reporting Urine Cytology in the Performance of Urine Cytology:  A Correlative Study of 124 Cases

American journal of clinical pathology, 2016

We assessed the performance of urine cytology using the Paris System for Reporting Urine Cytology... more We assessed the performance of urine cytology using the Paris System for Reporting Urine Cytology (PSRUC) in comparison to our current system. In total, 124 specimens with histologic correlation were reviewed and assigned to the PSRUC categories: benign, atypical urothelial cells (AUCs), suspicious for high-grade urothelial carcinoma (SHGUC), and high-grade urothelial carcinoma (HGUC). Original cytological diagnoses were recorded. Fewer cases were given an AUC diagnosis using the PSRUC in comparison to the original diagnoses (26% vs 39%), while the association of AUCs with subsequent HGUC increased from 33% to 53% with the PSRUC. Using the PSRUC resulted in a higher number of low-grade carcinomas assigned to the benign (40%) rather than the AUC (22%) category. The performance of SHGUC/HGUC diagnoses was similar in both systems (predictive value = 94%). The PSRUC seems to improve the performance of urine cytology by limiting the AUC category to cases that are more strongly associated...

Research paper thumbnail of Primary effusion lymphoma: A series of 4 cases and review of the literature with emphasis on cytomorphologic and immunocytochemical differential diagnosis

Cancer, Aug 25, 2007

BACKGROUND. Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV-8)-associated and very... more BACKGROUND. Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV-8)-associated and very rare type of lymphoma usually confined to the body cavities and commonly observed in human immunodeficiency virus (HIV)infected patients. A comparison was made between the cytologic and immunocytochemical features of 4 cases of PEL encountered in the authors' department with those reported to date in the literature. METHODS. A comprehensive comparison of the cytologic and immunocytochemical features of the 4 cases with those reported in the literature was conducted. RESULTS. Cytologically, the most consistent features of the 4 cases and those in the literature included large cell size, moderate to abundant cytoplasm, a single nucleus in most cells with occasional bi-or multinucleated giant cells, single to multiple prominent nucleoli, and coarse chromatin. Immunocytochemically, only 2 (50%) of the current cases were of the null-phenotype compared with 93% of cases in the literature; the other 2 cases had a T-cell phenotype. Activation markers were expressed in 50% and 78% of the current cases and the literature cases, respectively. Positivity for HHV-8 was proven in the 4 cases by immunocytochemistry. CONCLUSIONS. Cytomorphologically, PEL exhibits features bridging large cell immunoblastic and anaplastic large cell lymphoma. Although it is usually of null-phenotype, it may occasionally express B-cell or T-cell markers, rendering its distinction difficult from other lymphomatous effusions on a cytologic and immunocytochemical basis alone. Therefore, HHV-8 detection is an essential confirmatory ancillary test in suspected cases of PEL.

Research paper thumbnail of Dectection of metastatic vulvar and cervical squamous carcinoma in regional lymph nodes use of a plyclonal keratin antibody

International Journal of Gynecological Pathology, 1990

Research paper thumbnail of Cytopathology and Ultrastructure of Primary Rhabdoid Tumor of Lung

This case report presents the light microscopy, immunocytochemistry, and ultrastructure of the fi... more This case report presents the light microscopy, immunocytochemistry, and ultrastructure of the first unequivocal extrarenal rhabdoid tumor occurring in lung. Smears and cell blocks prepared from a fine-needle aspiration biopsy show the cytopathological features of this unusual neoplasm, in this case presenting in a 74-year-old male. Electron microscopy of the surgically resected circumscribed pulmonary mass assisted in establishing the diagnosis by demonstrating the considerable accumulation of cytoplasmic intermediate filaments that characterize cells in extrarenal rhabdoid tumor and account for the hyaline &quot;inclusion&quot; in this particular lesion.

Research paper thumbnail of Fine-needle aspiration cytology of ovarian cysts in in vitro fertilization patients: A study of 125 cases

Diagnostic Cytopathology, 1996

Fine-needle aspiration (FNA) cytology of ovarian cysts, especially in in vitro fertilization (IVF... more Fine-needle aspiration (FNA) cytology of ovarian cysts, especially in in vitro fertilization (IVF) patients, has been only rarely reported. The aim of this study was to describe the spectrum of cytological findings seen in FNA specimens of 125 ovarian cysts obtained from 84 IVF patients at our institution from 1989-1993. The Papanicolaou-stained slides made following cytocentrifuge or membrane-filter preparation were reviewed blindly by two independent pathologists, and the consensus diagnoses were compiled and correlated with clinical and radiological findings as well as surgical pathology when available. Eight aspirates derived from 4 different patients contained neoplastic cells and, of these, one patient was later found to have a serous cystadenocarcinoma of low malignant potential, while another had a serous cystadenoma. The other 2 patients with neoplastic cells in their ovarian aspirates have persistent ovarian cysts that are being followed clinically for preservation of fertility. The breakdown of the cytological diagnoses of the other aspirates is as follows: 30 follicular cysts, 5 corpus luteum cysts, and 16 endometriotic cysts. The exact underlying nature of 66 cysts could not be determined as the aspirates consisted of foamy macrophages only. This study demonstrates that the nature of ovarian cysts in IVF patients can be determined in many cases by their cytological features, information that may help in defining an unsuspected cause for infertility (such as endometriosis), and in choosing the most appropriate therapy. This study also illustrates that FNA cytology of ovarian cysts can play a role in the detection of occult ovarian neoplasms in the IVF patients population.

Research paper thumbnail of The atypical urothelial cell category in the Paris System: Strengthening the Achilles' heel

Cancer Cytopathology, 2015

Research paper thumbnail of Atypical squamous cells of undetermined significance. Stratification of the risk of association with, or progression to, squamous intraepithelial lesions based on morphologic subcategorization

Research paper thumbnail of Diagnosis of lymphoma in a continuous ambulatory peritoneal dialysis patient by peritoneal fluid cytology

American Journal of Kidney Diseases the Official Journal of the National Kidney Foundation, May 31, 1994

Research paper thumbnail of Pap smears with glandular cell abnormalities: Are they detected by rapid prescreening?

Cancer Cytopathology, 2015

Rapid prescreening (RPS) is one of the quality assurance (QA) methods used in gynecologic cytolog... more Rapid prescreening (RPS) is one of the quality assurance (QA) methods used in gynecologic cytology. The efficacy of RPS has been previously studied but mostly with respect to squamous lesions; in fact, there has been no study so far specifically looking at the sensitivity of RPS for detecting glandular cell abnormalities. A total of 80,565 Papanicolaou (Pap) smears underwent RPS during a 25-month period. A sample was designated as &amp;amp;amp;amp;amp;amp;quot;review for abnormality&amp;amp;amp;amp;amp;amp;quot; (R) if any abnormal cells (at the threshold of atypical squamous cells of undetermined significance/atypical glandular cells [AGC]) were thought to be present or was designated as negative (N) if none were detected. Each sample then underwent full screening (FS) and was designated as either R or N and also given a cytologic interpretation. The final cytologic interpretation was a glandular cell abnormality (≥AGC) in 107 samples (0.13%); 39 of these (36.4%) were flagged as R on RPS. Twenty-four patients (33.8%) out of 71 who had histologic follow-up were found to harbor a high-grade squamous intraepithelial lesion or carcinoma; 13 of those 24 Pap smears (54.2%) had been flagged as R on RPS. Notably, 11 AGC cases were picked up by RPS only and not by FS and represented false-negative cases; 2 of these showed endometrial adenocarcinoma on histologic follow-up. Pap smears with glandular cell abnormalities are often flagged as abnormal by RPS, and this results in a sensitivity of 36.4% (at the AGC threshold). Most importantly, some cases of AGC are detected on Pap smears by RPS only, and this demonstrates that RPS is a valuable QA method. Cancer (Cancer Cytopathol) 2015. © 2015 American Cancer Society.

Research paper thumbnail of Rapid prescreening in gynecologic cytology

Cancer Cytopathology, 2011

Research paper thumbnail of Granulomatous Thyroiditis Diagnosed by Fine-Needle Aspiration Cytology—A Case Report With Review of Other Benign Thyroid Entities

Pathology Case Reviews, 2015

Research paper thumbnail of Do liquid-based preparations of pulmonary bronchial brushing specimens perform differently from classically prepared cases for the diagnosis of malignancies? Observations from the College of American Pathologists interlaboratory comparison program in nongynecologic cytology

Archives of pathology & laboratory medicine, 2015

Pulmonary bronchial brushing specimens can be processed by liquid-based or conventional methods. ... more Pulmonary bronchial brushing specimens can be processed by liquid-based or conventional methods. The ability to accurately diagnose a pulmonary malignancy with a liquid-based preparation (LBP) versus a conventional preparation may differ. To compare the performance of LBPs of malignant pulmonary bronchial brushing specimens with the performance of conventional preparations. Participant responses from 553 malignant pulmonary bronchial brushing samples were evaluated for concordance with the general diagnosis. The performance of LBPs was compared with that of classic preparations. A nonlinear mixed model was used to analyze the performance by reference diagnosis, preparation type, program years, participant type, and the interaction terms between these 4 factors. Concordance with the general category of malignant disease was observed in 95.2% of conventional Papanicolaou-stained, 90.9% of modified Giemsa-stained, and 96.9% of LBP (P < .001) samples. The results were significantly d...

Research paper thumbnail of Reply to fine-needle cytology of Hürthle cell tumors and morphometry

Cancer cytopathology, 2014

Research paper thumbnail of Breast implant–associated anaplastic large cell lymphoma and effusions: A review with emphasis on the role of cytopathology

Research paper thumbnail of Revitalising an academic pathology department: lessons learnt

Journal of Clinical Pathology

Pathology is a specialty that bridges basic medical science and clinical practice. In the era of ... more Pathology is a specialty that bridges basic medical science and clinical practice. In the era of personalised medicine, this specialty is facing unprecedented challenges. Some of these challenges are institution-specific, while many are shared worldwide at different magnitude. This review shares our team efforts in the past 5 years, 2012–2017, to revitalise a century-old academic pathology department in three aspects: administration, clinical service and academic development. The lessons learnt and insights gained from our experience may provide guidance to leaders in pathology or in other related specialties.

Research paper thumbnail of Implementing The Paris System for Reporting Urinary Cytology results in a decrease in the rate of the "atypical" category and an increase in its prediction of subsequent high-grade urothelial carcinoma

Cancer, Jan 26, 2017

In the current study, the authors evaluated the impact of implementing The Paris System for Repor... more In the current study, the authors evaluated the impact of implementing The Paris System for Reporting Urinary Cytology (PSRUC) on the prevalence of various cytological categories and their association with a subsequent diagnosis of high-grade urothelial carcinoma (HGUC). A comparative study was conducted over the 6-month period before PSRUC implementation (2013), including 1653 patients and 2371 specimens versus a 6-month period after implementation of the PSRUC (2016), including 1478 patients and 2392 specimens. The following cytological categories were correlated with the subsequent biopsy result when available (355 cases): negative for HGUC (NHGUC), atypical urothelial cells (AUC), suspicious for HGUC, and HGUC. Although 18.6% of specimens were diagnosed as AUC in 2013, the percentage was 14.4% in 2016 (P < .0001). Concurrently, the prevalence of the "benign" category increased from 2013 to 2016 (75.4% vs 80%; P < .0001). After implementation of the PSRUC, there w...

Research paper thumbnail of Off the beaten path: A case of mediastinal ectopic thyroid tissue

Research paper thumbnail of The EVVA cohort study

The Journal of Infectious Diseases

Background. The risk of anal cancer due to high-risk human papillomavirus (HR-HPV) is higher in w... more Background. The risk of anal cancer due to high-risk human papillomavirus (HR-HPV) is higher in women living with human immunodeficiency virus (HIV) than in the general population. We present findings of cervical and anal HPV and cytologic tests at baseline in the EVVA cohort study and HPV persistence data 6 months after baseline. Methods. Semiannual visits included questionnaires, chart reviews, cervical/anal cytologic and cervical/anal HPV testing for 2 years. Genotyping for 36 HPV genotypes was performed using the Roche Linear Array HPV genotyping test. Results. A total of 151 women living with HIV were recruited. At baseline, 75% had anal HPV, 51% had anal HR-HPV, 50% had cervical HPV, and 29% had cervical HR-HPV. Anal HPV-16 and HPV-51 were more frequent in women born in Canada (31% and 29%, respectively, compared with ≤16% for other women). Most anal HR-HPV types detected at 6 months (57%-93%) were persistent from baseline. Findings of anal cytologic tests were abnormal for 37% of women. Conclusions. Anal HPV is highly prevalent in women living with HIV, and type distribution varies by place of birth. Highresolution anoscopy was indicated in more than one third of results. As anal cancer is potentially preventable, these important findings need to be considered when selecting the best approach for anal cancer screening programs.

Research paper thumbnail of Update on the cytologic features of papillary thyroid carcinoma variants

Diagnostic cytopathology, 2017

Papillary thyroid cancer (PTC), which accounts for 85-90% of all thyroid cancers, is generally an... more Papillary thyroid cancer (PTC), which accounts for 85-90% of all thyroid cancers, is generally an indolent tumor with long term survival rates >95%. A reliable definitive diagnosis of PTC is usually straightforward in fine needle aspirates of conventional PTC whenever the characteristic papillary and/or flat honeycomb sheet-like architecture and the typical nuclear features of chromatin pallor, nuclear enlargement, crowding, grooves and pseudoinclusions are encountered. Conventional PTC, however, has diminished in relative frequency as compared to PTC variants, especially the noninvasive follicular variant of PTC, an indolent tumor which has recently been reclassified as "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP). These PTC variants are characterized by various architecture, cell type and shape, and stromal features, some of which can be recognized cytologically. Awareness of the cytomorphological spectrum and of the character...

Research paper thumbnail of Yield of EBUS-TBNA for the diagnosis of sarcoidosis: impact of operator and cytopathologist experience

BMJ open respiratory research, 2016

Studies have reported a high diagnostic yield of endobronchial ultrasound-guided transbronchial n... more Studies have reported a high diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the diagnosis of sarcoidosis. We sought to review the yield of EBUS-TBNA for the diagnosis of sarcoidosis at our institution over time, and examine factors that may influence this yield. Patients who underwent EBUS-TBNA for suspected sarcoidosis between December 2008 and November 2011 were identified. EBUS was performed without rapid on-site evaluation (ROSE) of samples. The final diagnosis was based on the results of all invasive diagnostic procedures and/or clinical follow-up. Logistic regression analysis was used to examine the effect of various factors on yield. 43 patients underwent 45 EBUS-TBNA procedures for suspected sarcoidosis. A total of 115 lymph nodes were sampled. The 21 G needle was used in 51% of procedures. The mean number of lymph node stations sampled was 2.6 (SD 0.7) and the mean number of needle passes per procedure was 7.8 (SD 2.0). ...

Research paper thumbnail of Impact of Implementing the Paris System for Reporting Urine Cytology in the Performance of Urine Cytology:  A Correlative Study of 124 Cases

American journal of clinical pathology, 2016

We assessed the performance of urine cytology using the Paris System for Reporting Urine Cytology... more We assessed the performance of urine cytology using the Paris System for Reporting Urine Cytology (PSRUC) in comparison to our current system. In total, 124 specimens with histologic correlation were reviewed and assigned to the PSRUC categories: benign, atypical urothelial cells (AUCs), suspicious for high-grade urothelial carcinoma (SHGUC), and high-grade urothelial carcinoma (HGUC). Original cytological diagnoses were recorded. Fewer cases were given an AUC diagnosis using the PSRUC in comparison to the original diagnoses (26% vs 39%), while the association of AUCs with subsequent HGUC increased from 33% to 53% with the PSRUC. Using the PSRUC resulted in a higher number of low-grade carcinomas assigned to the benign (40%) rather than the AUC (22%) category. The performance of SHGUC/HGUC diagnoses was similar in both systems (predictive value = 94%). The PSRUC seems to improve the performance of urine cytology by limiting the AUC category to cases that are more strongly associated...

Research paper thumbnail of Primary effusion lymphoma: A series of 4 cases and review of the literature with emphasis on cytomorphologic and immunocytochemical differential diagnosis

Cancer, Aug 25, 2007

BACKGROUND. Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV-8)-associated and very... more BACKGROUND. Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV-8)-associated and very rare type of lymphoma usually confined to the body cavities and commonly observed in human immunodeficiency virus (HIV)infected patients. A comparison was made between the cytologic and immunocytochemical features of 4 cases of PEL encountered in the authors' department with those reported to date in the literature. METHODS. A comprehensive comparison of the cytologic and immunocytochemical features of the 4 cases with those reported in the literature was conducted. RESULTS. Cytologically, the most consistent features of the 4 cases and those in the literature included large cell size, moderate to abundant cytoplasm, a single nucleus in most cells with occasional bi-or multinucleated giant cells, single to multiple prominent nucleoli, and coarse chromatin. Immunocytochemically, only 2 (50%) of the current cases were of the null-phenotype compared with 93% of cases in the literature; the other 2 cases had a T-cell phenotype. Activation markers were expressed in 50% and 78% of the current cases and the literature cases, respectively. Positivity for HHV-8 was proven in the 4 cases by immunocytochemistry. CONCLUSIONS. Cytomorphologically, PEL exhibits features bridging large cell immunoblastic and anaplastic large cell lymphoma. Although it is usually of null-phenotype, it may occasionally express B-cell or T-cell markers, rendering its distinction difficult from other lymphomatous effusions on a cytologic and immunocytochemical basis alone. Therefore, HHV-8 detection is an essential confirmatory ancillary test in suspected cases of PEL.

Research paper thumbnail of Dectection of metastatic vulvar and cervical squamous carcinoma in regional lymph nodes use of a plyclonal keratin antibody

International Journal of Gynecological Pathology, 1990

Research paper thumbnail of Cytopathology and Ultrastructure of Primary Rhabdoid Tumor of Lung

This case report presents the light microscopy, immunocytochemistry, and ultrastructure of the fi... more This case report presents the light microscopy, immunocytochemistry, and ultrastructure of the first unequivocal extrarenal rhabdoid tumor occurring in lung. Smears and cell blocks prepared from a fine-needle aspiration biopsy show the cytopathological features of this unusual neoplasm, in this case presenting in a 74-year-old male. Electron microscopy of the surgically resected circumscribed pulmonary mass assisted in establishing the diagnosis by demonstrating the considerable accumulation of cytoplasmic intermediate filaments that characterize cells in extrarenal rhabdoid tumor and account for the hyaline &quot;inclusion&quot; in this particular lesion.

Research paper thumbnail of Fine-needle aspiration cytology of ovarian cysts in in vitro fertilization patients: A study of 125 cases

Diagnostic Cytopathology, 1996

Fine-needle aspiration (FNA) cytology of ovarian cysts, especially in in vitro fertilization (IVF... more Fine-needle aspiration (FNA) cytology of ovarian cysts, especially in in vitro fertilization (IVF) patients, has been only rarely reported. The aim of this study was to describe the spectrum of cytological findings seen in FNA specimens of 125 ovarian cysts obtained from 84 IVF patients at our institution from 1989-1993. The Papanicolaou-stained slides made following cytocentrifuge or membrane-filter preparation were reviewed blindly by two independent pathologists, and the consensus diagnoses were compiled and correlated with clinical and radiological findings as well as surgical pathology when available. Eight aspirates derived from 4 different patients contained neoplastic cells and, of these, one patient was later found to have a serous cystadenocarcinoma of low malignant potential, while another had a serous cystadenoma. The other 2 patients with neoplastic cells in their ovarian aspirates have persistent ovarian cysts that are being followed clinically for preservation of fertility. The breakdown of the cytological diagnoses of the other aspirates is as follows: 30 follicular cysts, 5 corpus luteum cysts, and 16 endometriotic cysts. The exact underlying nature of 66 cysts could not be determined as the aspirates consisted of foamy macrophages only. This study demonstrates that the nature of ovarian cysts in IVF patients can be determined in many cases by their cytological features, information that may help in defining an unsuspected cause for infertility (such as endometriosis), and in choosing the most appropriate therapy. This study also illustrates that FNA cytology of ovarian cysts can play a role in the detection of occult ovarian neoplasms in the IVF patients population.

Research paper thumbnail of The atypical urothelial cell category in the Paris System: Strengthening the Achilles' heel

Cancer Cytopathology, 2015

Research paper thumbnail of Atypical squamous cells of undetermined significance. Stratification of the risk of association with, or progression to, squamous intraepithelial lesions based on morphologic subcategorization

Research paper thumbnail of Diagnosis of lymphoma in a continuous ambulatory peritoneal dialysis patient by peritoneal fluid cytology

American Journal of Kidney Diseases the Official Journal of the National Kidney Foundation, May 31, 1994

Research paper thumbnail of Pap smears with glandular cell abnormalities: Are they detected by rapid prescreening?

Cancer Cytopathology, 2015

Rapid prescreening (RPS) is one of the quality assurance (QA) methods used in gynecologic cytolog... more Rapid prescreening (RPS) is one of the quality assurance (QA) methods used in gynecologic cytology. The efficacy of RPS has been previously studied but mostly with respect to squamous lesions; in fact, there has been no study so far specifically looking at the sensitivity of RPS for detecting glandular cell abnormalities. A total of 80,565 Papanicolaou (Pap) smears underwent RPS during a 25-month period. A sample was designated as &amp;amp;amp;amp;amp;amp;quot;review for abnormality&amp;amp;amp;amp;amp;amp;quot; (R) if any abnormal cells (at the threshold of atypical squamous cells of undetermined significance/atypical glandular cells [AGC]) were thought to be present or was designated as negative (N) if none were detected. Each sample then underwent full screening (FS) and was designated as either R or N and also given a cytologic interpretation. The final cytologic interpretation was a glandular cell abnormality (≥AGC) in 107 samples (0.13%); 39 of these (36.4%) were flagged as R on RPS. Twenty-four patients (33.8%) out of 71 who had histologic follow-up were found to harbor a high-grade squamous intraepithelial lesion or carcinoma; 13 of those 24 Pap smears (54.2%) had been flagged as R on RPS. Notably, 11 AGC cases were picked up by RPS only and not by FS and represented false-negative cases; 2 of these showed endometrial adenocarcinoma on histologic follow-up. Pap smears with glandular cell abnormalities are often flagged as abnormal by RPS, and this results in a sensitivity of 36.4% (at the AGC threshold). Most importantly, some cases of AGC are detected on Pap smears by RPS only, and this demonstrates that RPS is a valuable QA method. Cancer (Cancer Cytopathol) 2015. © 2015 American Cancer Society.

Research paper thumbnail of Rapid prescreening in gynecologic cytology

Cancer Cytopathology, 2011

Research paper thumbnail of Granulomatous Thyroiditis Diagnosed by Fine-Needle Aspiration Cytology—A Case Report With Review of Other Benign Thyroid Entities

Pathology Case Reviews, 2015

Research paper thumbnail of Do liquid-based preparations of pulmonary bronchial brushing specimens perform differently from classically prepared cases for the diagnosis of malignancies? Observations from the College of American Pathologists interlaboratory comparison program in nongynecologic cytology

Archives of pathology & laboratory medicine, 2015

Pulmonary bronchial brushing specimens can be processed by liquid-based or conventional methods. ... more Pulmonary bronchial brushing specimens can be processed by liquid-based or conventional methods. The ability to accurately diagnose a pulmonary malignancy with a liquid-based preparation (LBP) versus a conventional preparation may differ. To compare the performance of LBPs of malignant pulmonary bronchial brushing specimens with the performance of conventional preparations. Participant responses from 553 malignant pulmonary bronchial brushing samples were evaluated for concordance with the general diagnosis. The performance of LBPs was compared with that of classic preparations. A nonlinear mixed model was used to analyze the performance by reference diagnosis, preparation type, program years, participant type, and the interaction terms between these 4 factors. Concordance with the general category of malignant disease was observed in 95.2% of conventional Papanicolaou-stained, 90.9% of modified Giemsa-stained, and 96.9% of LBP (P < .001) samples. The results were significantly d...

Research paper thumbnail of Reply to fine-needle cytology of Hürthle cell tumors and morphometry

Cancer cytopathology, 2014