Manuel Higueras - Academia.edu (original) (raw)

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Papers by Manuel Higueras

Research paper thumbnail of Presence of elements associated with e-waste in teenagers living in Alcalá de Henares (Spain)

ISEE Conference Abstracts

Research paper thumbnail of Environmental presence of uranium and exposure to uranium and thorium in children living in Alcalá de Henares (Spain)

ISEE Conference Abstracts

Research paper thumbnail of Human health risks of gadolinium contamination in urban and rural soils across Leicestershire (UK)

ISEE Conference Abstracts

Research paper thumbnail of Assessing the environmental urban exposure to high tech-metals (Co, Li) in a healthy group of Spanish adolescents

ISEE Conference Abstracts

Research paper thumbnail of Biomonitoring cadmium and nickel using native mosses in Leicester, UK

ISEE Conference Abstracts

Research paper thumbnail of Lanthanum, cerium and praseodymium in urban topsoils, an emerging health concern?

ISEE Conference Abstracts

Research paper thumbnail of Children’s exposure and risks to the rare earth elements of gadolinium and yttrium in Alcalá de Henares (Spain)

ISEE Conference Abstracts

Research paper thumbnail of Assessing the environmental urban exposure to erbium and gadolinium in a healthy group of Spanish adolescents

ISEE Conference Abstracts, 2021

Research paper thumbnail of Environmental presence and exposure to platinum, palladium and rhodium by teenagers living in Alcalá de Henares (Spain)

Research paper thumbnail of Comparative study of micronucleus assays and dicentric plus ring chromosomes for dose assessment in particular cases of partial-body exposure

International Journal of Radiation Biology, 2019

Comparative study of Micronucleus assays and Dicentric plus ring chromosomes for dose assessment ... more Comparative study of Micronucleus assays and Dicentric plus ring chromosomes for dose assessment in particular cases of partial-body exposure ABSTRACT Purpose: The goal was to compare the micronucleus (MN) and dicentric plus ring chromosomes (D+R) assays for dose assessment in cases of partial body irradiations (PBI). Materials and methods: We constructed calibration curves for each assay at doses ranging from 0 to 5 Gy. In order to simulate partial-body exposures, blood samples from two donors were irradiated with 0.5, 1, 2 and 4 Gy and the ratios of irradiated to unirradiated blood were 25, 50, and 100%. Different tests were used to confirm if all samples were overdispersed or zero-inflated and for partial-body dose assessment we used the Qdr, Dolphin and Bayesian model. Results: In our samples for D+R calibration curve, practically all doses agreed with Poisson assumption, but MN exhibited cellular distributions that tend to be overdispersed and zero-inflated. The exact Poisson tests and zero-inflated tests demonstrate that virtually all samples of D+R from PBI simulation fit the Poisson distribution and were not zero-inflated, but almost all doses from MN samples were overdispersed and zero-inflated. In the partial-body estimation, when Qdr and Dolphin methods were used the results from dicentrics were better than MN, but in our samples from D+R and MN the dose estimation defined by the Bayesian methodology were more accurate than the classically methods used in biodosimetry. Conclusions: Dicentric chromosomes continue to prove to be the best biological marker for dose assessment. However exposure scenarios of partial-body estimation, overdispersion and zero-inflation may not occur, it being a critical point not only for dose assessment, but also to confirm partial-body exposure. MN could be used as alternative assays for partial-body dose estimation, but only in case when we have sure about the accident.

Research paper thumbnail of Presence of elements associated with e-waste in teenagers living in Alcalá de Henares (Spain)

ISEE Conference Abstracts

Research paper thumbnail of Environmental presence of uranium and exposure to uranium and thorium in children living in Alcalá de Henares (Spain)

ISEE Conference Abstracts

Research paper thumbnail of Human health risks of gadolinium contamination in urban and rural soils across Leicestershire (UK)

ISEE Conference Abstracts

Research paper thumbnail of Assessing the environmental urban exposure to high tech-metals (Co, Li) in a healthy group of Spanish adolescents

ISEE Conference Abstracts

Research paper thumbnail of Biomonitoring cadmium and nickel using native mosses in Leicester, UK

ISEE Conference Abstracts

Research paper thumbnail of Lanthanum, cerium and praseodymium in urban topsoils, an emerging health concern?

ISEE Conference Abstracts

Research paper thumbnail of Children’s exposure and risks to the rare earth elements of gadolinium and yttrium in Alcalá de Henares (Spain)

ISEE Conference Abstracts

Research paper thumbnail of Assessing the environmental urban exposure to erbium and gadolinium in a healthy group of Spanish adolescents

ISEE Conference Abstracts, 2021

Research paper thumbnail of Environmental presence and exposure to platinum, palladium and rhodium by teenagers living in Alcalá de Henares (Spain)

Research paper thumbnail of Comparative study of micronucleus assays and dicentric plus ring chromosomes for dose assessment in particular cases of partial-body exposure

International Journal of Radiation Biology, 2019

Comparative study of Micronucleus assays and Dicentric plus ring chromosomes for dose assessment ... more Comparative study of Micronucleus assays and Dicentric plus ring chromosomes for dose assessment in particular cases of partial-body exposure ABSTRACT Purpose: The goal was to compare the micronucleus (MN) and dicentric plus ring chromosomes (D+R) assays for dose assessment in cases of partial body irradiations (PBI). Materials and methods: We constructed calibration curves for each assay at doses ranging from 0 to 5 Gy. In order to simulate partial-body exposures, blood samples from two donors were irradiated with 0.5, 1, 2 and 4 Gy and the ratios of irradiated to unirradiated blood were 25, 50, and 100%. Different tests were used to confirm if all samples were overdispersed or zero-inflated and for partial-body dose assessment we used the Qdr, Dolphin and Bayesian model. Results: In our samples for D+R calibration curve, practically all doses agreed with Poisson assumption, but MN exhibited cellular distributions that tend to be overdispersed and zero-inflated. The exact Poisson tests and zero-inflated tests demonstrate that virtually all samples of D+R from PBI simulation fit the Poisson distribution and were not zero-inflated, but almost all doses from MN samples were overdispersed and zero-inflated. In the partial-body estimation, when Qdr and Dolphin methods were used the results from dicentrics were better than MN, but in our samples from D+R and MN the dose estimation defined by the Bayesian methodology were more accurate than the classically methods used in biodosimetry. Conclusions: Dicentric chromosomes continue to prove to be the best biological marker for dose assessment. However exposure scenarios of partial-body estimation, overdispersion and zero-inflation may not occur, it being a critical point not only for dose assessment, but also to confirm partial-body exposure. MN could be used as alternative assays for partial-body dose estimation, but only in case when we have sure about the accident.

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