María Laura Villalba - Academia.edu (original) (raw)
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Papers by María Laura Villalba
Proceedings of the 4th International ICST Conference on Pervasive Computing Technologies for Healthcare, 2010
... villalba,pedro.lara }@uem.es The actual trend is improving the quality of life of elder perso... more ... villalba,pedro.lara }@uem.es The actual trend is improving the quality of life of elder persons, not only extend its duration, the gerotechnology [1], is a very active application to improve the life of adult persons, considered a special users whose particular skills and needs on ...
The Journal of Emergency Medicine, 2002
e Abstract-Intravenous (IV) colchicine is occasionally prescribed for the treatment of acute gout... more e Abstract-Intravenous (IV) colchicine is occasionally prescribed for the treatment of acute gouty arthritis. The Food and Drug Administration (FDA) recently received a report of death in a patient that was associated with inappropriate IV dosing of colchicine. This report prompted further investigation of other deaths associated with IV colchicine use in the FDA Adverse Event Reporting System (AERS) and the medical literature. A total of 20 deaths were identified. Eight patients were females, 11 were males, and the gender was unknown in 1. In all cases, the recommended maximum cumulative dose of 2 to 4 mg during a course of therapy was exceeded. Dose reductions are recommended in patients with renal or hepatic disease and in the elderly. All reported adverse events were associated with colchicine toxicity, including thrombocytopenia, leukopenia, pancytopenia, agranulocytosis, aplastic anemia, acute renal failure, and disseminated intravascular coagulopathy. Death occurred within 1 to 40 days after drug administration. Therapeutic guidelines exist for use of IV colchicine and these guidelines should be followed to prevent serious toxicities and death.
Clinical Immunology, 1999
In an attempt to understand the mechanisms of cell injury in the inflammatory myopathies, we anal... more In an attempt to understand the mechanisms of cell injury in the inflammatory myopathies, we analyzed the expression of costimulatory molecules, CTLA4, CD28, CD86, CD40, and CD154 as well as HLA class I, HLA class II, and ICAM-I in normal muscle and in muscle biopsies from patients with polymyositis (PM) or dermatomyositis (DM). By immunohistochemical staining, DM and PM biopsies showed the presence of CTLA4, CD28, CD86, and CD40 on inflammatory cells. More strikingly, however, low levels of CTLA4 and CD28 were observed on muscle cells. The expression of CTLA4 and CD28 on nonlymphoid cells has not been previously reported. These unexpected findings were confirmed in cultured normal human myoblasts: various proinflammatory cytokines induced the expression of CTLA4 and CD28 on normal human muscle cells. The sequences of the cDNAs were found to be identical to the sequences for these molecules in T cells. The data suggest a novel complexity in the network of cellular interactions between the infiltrated immune cells and the muscle cells in which the normal relationship between infiltrating inflammatory cells and target tissue is under a previously unrecognized set of controls.
Arthritis Care & Research, 2010
Objective-To validate manual muscle testing (MMT) for strength assessment in juvenile and adult d... more Objective-To validate manual muscle testing (MMT) for strength assessment in juvenile and adult dermatomyositis (DM) and polymyositis (PM).
La presente investigación es el resultado de un trabajo de Seminario realizado en el marco de la ... more La presente investigación es el resultado de un trabajo de Seminario realizado en el marco de la carrera del Profesorado de Historia del ISPR N° 2 "Joaquín V. González" durante los años 1994 y 1995. Nuestro propósito es explicar cómo surgió y quiénes fueron los precursores de la industria metalúrgica en la región denominada Centro-Oeste santafesino, cristalizada en los talleres mecánicos y herrerías.
Proceedings of the 4th International ICST Conference on Pervasive Computing Technologies for Healthcare, 2010
... villalba,pedro.lara }@uem.es The actual trend is improving the quality of life of elder perso... more ... villalba,pedro.lara }@uem.es The actual trend is improving the quality of life of elder persons, not only extend its duration, the gerotechnology [1], is a very active application to improve the life of adult persons, considered a special users whose particular skills and needs on ...
The Journal of Emergency Medicine, 2002
e Abstract-Intravenous (IV) colchicine is occasionally prescribed for the treatment of acute gout... more e Abstract-Intravenous (IV) colchicine is occasionally prescribed for the treatment of acute gouty arthritis. The Food and Drug Administration (FDA) recently received a report of death in a patient that was associated with inappropriate IV dosing of colchicine. This report prompted further investigation of other deaths associated with IV colchicine use in the FDA Adverse Event Reporting System (AERS) and the medical literature. A total of 20 deaths were identified. Eight patients were females, 11 were males, and the gender was unknown in 1. In all cases, the recommended maximum cumulative dose of 2 to 4 mg during a course of therapy was exceeded. Dose reductions are recommended in patients with renal or hepatic disease and in the elderly. All reported adverse events were associated with colchicine toxicity, including thrombocytopenia, leukopenia, pancytopenia, agranulocytosis, aplastic anemia, acute renal failure, and disseminated intravascular coagulopathy. Death occurred within 1 to 40 days after drug administration. Therapeutic guidelines exist for use of IV colchicine and these guidelines should be followed to prevent serious toxicities and death.
Clinical Immunology, 1999
In an attempt to understand the mechanisms of cell injury in the inflammatory myopathies, we anal... more In an attempt to understand the mechanisms of cell injury in the inflammatory myopathies, we analyzed the expression of costimulatory molecules, CTLA4, CD28, CD86, CD40, and CD154 as well as HLA class I, HLA class II, and ICAM-I in normal muscle and in muscle biopsies from patients with polymyositis (PM) or dermatomyositis (DM). By immunohistochemical staining, DM and PM biopsies showed the presence of CTLA4, CD28, CD86, and CD40 on inflammatory cells. More strikingly, however, low levels of CTLA4 and CD28 were observed on muscle cells. The expression of CTLA4 and CD28 on nonlymphoid cells has not been previously reported. These unexpected findings were confirmed in cultured normal human myoblasts: various proinflammatory cytokines induced the expression of CTLA4 and CD28 on normal human muscle cells. The sequences of the cDNAs were found to be identical to the sequences for these molecules in T cells. The data suggest a novel complexity in the network of cellular interactions between the infiltrated immune cells and the muscle cells in which the normal relationship between infiltrating inflammatory cells and target tissue is under a previously unrecognized set of controls.
Arthritis Care & Research, 2010
Objective-To validate manual muscle testing (MMT) for strength assessment in juvenile and adult d... more Objective-To validate manual muscle testing (MMT) for strength assessment in juvenile and adult dermatomyositis (DM) and polymyositis (PM).
La presente investigación es el resultado de un trabajo de Seminario realizado en el marco de la ... more La presente investigación es el resultado de un trabajo de Seminario realizado en el marco de la carrera del Profesorado de Historia del ISPR N° 2 "Joaquín V. González" durante los años 1994 y 1995. Nuestro propósito es explicar cómo surgió y quiénes fueron los precursores de la industria metalúrgica en la región denominada Centro-Oeste santafesino, cristalizada en los talleres mecánicos y herrerías.