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articles by Marcelle Alves

Research paper thumbnail of Chronic slowly progressive monoarthritis tuberculosis of the hip without systemic symptoms mimicking osteoarthritis: a case report.

The authors report and discuss the clinical and radiological features of a immunocompetent patien... more The authors report and discuss the clinical and radiological features of a immunocompetent patient with chronic progressive monoarthritis tuberculosis of the hip without systemic symptoms such as fever, and weight loss presenting as caseating abscess and severe destruction of the hip joint, treated with resection arthroplasty.

Papers by Marcelle Alves

Research paper thumbnail of Avaliação da dosagem de cefepima na mortalidade de pacientes hospitalizados com bacteremia por bacilos Gram negativos

Research paper thumbnail of Rhizobium radiobacter recovered from blood of a pediatric patient with stem cell transplantation: a case report and characterization of antimicrobial susceptibility profile

Clinical Biomedical Research, Oct 20, 2014

Research paper thumbnail of Avaliação da concentração inibitória mínima de antimicrobianos em bacilos Gram-negativos isolados de hemoculturas no Hospital de Clínicas de Porto Alegre

Research paper thumbnail of Nephrotic syndrome caused by membranous glomerulonephritis associated with chronic myeloid leukemia

AMB; revista da Associação Médica Brasileira

A patient developed nephrotic syndrome four years after diagnosed chronic myelogenous leukemia. R... more A patient developed nephrotic syndrome four years after diagnosed chronic myelogenous leukemia. Renal histology showed characteristic changes of membranous glomerulopathy. To our knowledge, this is the first reported case of membranous glomerulopathy associated with chronic myelogenous leukemia.

Research paper thumbnail of Glucose and lactate utilization by the amygdala of male and female rats

Neurochemical research, 2002

Gonadal hormones appear to modulate brain energy metabolism, and morphological and functional sex... more Gonadal hormones appear to modulate brain energy metabolism, and morphological and functional sexual differences are found in the amygdaloid complex (AC) of rats. Our aim was to study the CO2 production and lipid synthesis, measured by the rate of L-[U-14C]lactate or D-[U-14C]glucose utilization (in pmol x hr(-1) x mg(-1)), by AC slices in vitro of male and female rats. Lactate was more used than glucose as energy substrate (p < 0.01) but no sex-related difference was observed in glucose or lactate oxidation to CO2 (p > 0.05) or on lipid synthesis obtained from both substrates (p > 0.05). In addition, there was no effect of the estrous cycle on lactate oxidation to CO2 by the AC of females (p > 0.05). Based on the present data, it appears that the endogenous normal levels of gonadal hormones are not able to promote sex-related differences in the in vitro glucose or lactate utilization by the AC of rats.

Research paper thumbnail of HIV-associated lipodystrophy: a review from a Brazilian perspective

Therapeutics and Clinical Risk Management, 2014

The prognosis of human immunodeficiency virus (HIV)-infected individuals has dramatically improve... more The prognosis of human immunodeficiency virus (HIV)-infected individuals has dramatically improved worldwide since the introduction of highly antiretroviral therapy. Nevertheless, along with the decrease in mortality, several body modifications not initially related to HIV infection have been reported. Disorders in lipid and glucose metabolism, accompanied by body shape abnormalities and alterations in fat distribution, began to be described. A syndrome, named "HIV-associated lipodystrophy syndrome", was coined to classify these clinical spectrum aspects. This syndrome involves not only metabolic alterations but also fat redistribution, with lipoatrophy due to subcutaneous fat loss (predominantly in the face and lower limbs) and lipohypertrophy related to central fat gain. These changes in body shape are very important to be recognized, as they are associated with worse morbidity and mortality. Selfesteem difficulties related to body alterations might lead to treatment failures due to medication adherence problems. Moreover, these alterations have been associated with an increased risk of cardiovascular events. Therefore, it is extremely important to identify this syndrome early in order to provide an even better quality of life for this population, as the clinical approach is not easy. Treatment change, medications to treat dyslipidemia, and surgical intervention are instruments to be used to try to correct these abnormalities. The aim of this study is to review clinical presentation, diagnosis, and management of body shape and metabolic complications of HIV infection from a Brazilian perspective, a medium income country with a large number of patients on antiretroviral therapy.

Research paper thumbnail of IL-2 antibody induction and the outcome of pediatric renal trasplants

Transplantation Proceedings, 2002

Research paper thumbnail of Histoplasma capsulatum Sinusitis: Case Report and Review

Mycopathologia, 2011

Histoplasma capsulatum has not typically been associated with sinusitis in either immunocompetent... more Histoplasma capsulatum has not typically been associated with sinusitis in either immunocompetent or immunocompromised hosts. We report a case of sinusitis caused by H. capsulatum in a patient with chronic lymphocytic leukemia and discuss the reported cases of this rare clinical manifestation of histoplasmosis in the medical literature.

Research paper thumbnail of Effect of cefepime dose on mortality of patients with Gram-negative bacterial bloodstream infections: a prospective cohort study

Journal of Antimicrobial Chemotherapy, 2014

Objectives: There are controversies regarding the association of cefepime therapy with increased ... more Objectives: There are controversies regarding the association of cefepime therapy with increased mortality among patients with infections caused by Gram-negative bacteria (GNB). We evaluated the effect of cefepime on the mortality of patients with GNB bloodstream infections (BSIs).

Research paper thumbnail of Chronic slowly progressive monoarthritis tuberculosis of the hip without systemic symptoms mimicking osteoarthritis: a case report.

The authors report and discuss the clinical and radiological features of a immunocompetent patien... more The authors report and discuss the clinical and radiological features of a immunocompetent patient with chronic progressive monoarthritis tuberculosis of the hip without systemic symptoms such as fever, and weight loss presenting as caseating abscess and severe destruction of the hip joint, treated with resection arthroplasty.

Research paper thumbnail of Avaliação da dosagem de cefepima na mortalidade de pacientes hospitalizados com bacteremia por bacilos Gram negativos

Research paper thumbnail of Rhizobium radiobacter recovered from blood of a pediatric patient with stem cell transplantation: a case report and characterization of antimicrobial susceptibility profile

Clinical Biomedical Research, Oct 20, 2014

Research paper thumbnail of Avaliação da concentração inibitória mínima de antimicrobianos em bacilos Gram-negativos isolados de hemoculturas no Hospital de Clínicas de Porto Alegre

Research paper thumbnail of Nephrotic syndrome caused by membranous glomerulonephritis associated with chronic myeloid leukemia

AMB; revista da Associação Médica Brasileira

A patient developed nephrotic syndrome four years after diagnosed chronic myelogenous leukemia. R... more A patient developed nephrotic syndrome four years after diagnosed chronic myelogenous leukemia. Renal histology showed characteristic changes of membranous glomerulopathy. To our knowledge, this is the first reported case of membranous glomerulopathy associated with chronic myelogenous leukemia.

Research paper thumbnail of Glucose and lactate utilization by the amygdala of male and female rats

Neurochemical research, 2002

Gonadal hormones appear to modulate brain energy metabolism, and morphological and functional sex... more Gonadal hormones appear to modulate brain energy metabolism, and morphological and functional sexual differences are found in the amygdaloid complex (AC) of rats. Our aim was to study the CO2 production and lipid synthesis, measured by the rate of L-[U-14C]lactate or D-[U-14C]glucose utilization (in pmol x hr(-1) x mg(-1)), by AC slices in vitro of male and female rats. Lactate was more used than glucose as energy substrate (p < 0.01) but no sex-related difference was observed in glucose or lactate oxidation to CO2 (p > 0.05) or on lipid synthesis obtained from both substrates (p > 0.05). In addition, there was no effect of the estrous cycle on lactate oxidation to CO2 by the AC of females (p > 0.05). Based on the present data, it appears that the endogenous normal levels of gonadal hormones are not able to promote sex-related differences in the in vitro glucose or lactate utilization by the AC of rats.

Research paper thumbnail of HIV-associated lipodystrophy: a review from a Brazilian perspective

Therapeutics and Clinical Risk Management, 2014

The prognosis of human immunodeficiency virus (HIV)-infected individuals has dramatically improve... more The prognosis of human immunodeficiency virus (HIV)-infected individuals has dramatically improved worldwide since the introduction of highly antiretroviral therapy. Nevertheless, along with the decrease in mortality, several body modifications not initially related to HIV infection have been reported. Disorders in lipid and glucose metabolism, accompanied by body shape abnormalities and alterations in fat distribution, began to be described. A syndrome, named "HIV-associated lipodystrophy syndrome", was coined to classify these clinical spectrum aspects. This syndrome involves not only metabolic alterations but also fat redistribution, with lipoatrophy due to subcutaneous fat loss (predominantly in the face and lower limbs) and lipohypertrophy related to central fat gain. These changes in body shape are very important to be recognized, as they are associated with worse morbidity and mortality. Selfesteem difficulties related to body alterations might lead to treatment failures due to medication adherence problems. Moreover, these alterations have been associated with an increased risk of cardiovascular events. Therefore, it is extremely important to identify this syndrome early in order to provide an even better quality of life for this population, as the clinical approach is not easy. Treatment change, medications to treat dyslipidemia, and surgical intervention are instruments to be used to try to correct these abnormalities. The aim of this study is to review clinical presentation, diagnosis, and management of body shape and metabolic complications of HIV infection from a Brazilian perspective, a medium income country with a large number of patients on antiretroviral therapy.

Research paper thumbnail of IL-2 antibody induction and the outcome of pediatric renal trasplants

Transplantation Proceedings, 2002

Research paper thumbnail of Histoplasma capsulatum Sinusitis: Case Report and Review

Mycopathologia, 2011

Histoplasma capsulatum has not typically been associated with sinusitis in either immunocompetent... more Histoplasma capsulatum has not typically been associated with sinusitis in either immunocompetent or immunocompromised hosts. We report a case of sinusitis caused by H. capsulatum in a patient with chronic lymphocytic leukemia and discuss the reported cases of this rare clinical manifestation of histoplasmosis in the medical literature.

Research paper thumbnail of Effect of cefepime dose on mortality of patients with Gram-negative bacterial bloodstream infections: a prospective cohort study

Journal of Antimicrobial Chemotherapy, 2014

Objectives: There are controversies regarding the association of cefepime therapy with increased ... more Objectives: There are controversies regarding the association of cefepime therapy with increased mortality among patients with infections caused by Gram-negative bacteria (GNB). We evaluated the effect of cefepime on the mortality of patients with GNB bloodstream infections (BSIs).