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Research paper thumbnail of Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes

International journal of obesity (2005), Jan 17, 2018

The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic ... more The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic disease prevalence and outcomes after bariatric surgery are not well-defined. Associations between pre- and post-operative serum levels of four biomarkers (C-reactive protein (CRP), cystatin C (CC), leptin, and ghrelin) with baseline measures of adiposity and metabolic disease prevalence (asthma, diabetes, sleep apnea), and weight loss and metabolic disease remission after bariatric surgery were studied in the Longitudinal Assessment of Bariatric Surgery (LABS) cohort. Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. Increased weight loss was associate...

Research paper thumbnail of Effect of Bariatric Surgery on CKD Risk

Journal of the American Society of Nephrology : JASN, Jan 15, 2018

Obesity is linked to the development and progression of CKD, but whether bariatric surgery protec... more Obesity is linked to the development and progression of CKD, but whether bariatric surgery protects against CKD is poorly understood. We, therefore, examined whether bariatric surgery influences CKD risk. The study included 2144 adults who underwent bariatric surgery from March of 2006 to April of 2009 and participated in the Longitudinal Assessment of Bariatric Surgery-2 Study cohort. The primary outcome was CKD risk categories as assessed by the Kidney Disease Improving Global Outcomes (KDIGO) consortium criteria using a combination of eGFR and albuminuria. Patients were 79% women and 87% white, with a median age of 46 years old. Improvements were observed in CKD risk at 1 and 7 years after surgery in patients with moderate baseline CKD risk (63% and 53%, respectively), high baseline risk (78% and 56%, respectively), and very high baseline risk (59% and 23%, respectively). The proportion of patients whose CKD risk worsened was ≤10%; five patients developed ESRD. Sensitivity analys...

Research paper thumbnail of A Prospective, Longitudinal Examination of Suicidal Ideation among Bariatric Surgery Patients

Surgery for Obesity and Related Diseases, 2016

Research paper thumbnail of Alcohol and other substance use after bariatric surgery: prospective evidence from a U.S. multicenter cohort study

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, Jan 31, 2017

Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol ... more Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol use disorder (AUD). However, prospective assessment of substance use disorders (SUD) after bariatric surgery is limited. To report SUD-related outcomes after RYGB and laparoscopic adjustable gastric banding (LAGB). To identify factors associated with incident SUD-related outcomes. 10 U.S. hospitals METHODS: The Longitudinal Assessment of Bariatric Surgery-2 is a prospective cohort study. Participants self-reported past-year AUD symptoms (determined by the Alcohol Use Disorders Identification Test), illicit drug use (cocaine, hallucinogens, inhalants, phencyclidine, amphetamines, or marijuana), and SUD treatment (counseling or hospitalization for alcohol or drugs) presurgery and annually postsurgery for up to 7 years through January 2015. Of 2348 participants who underwent RYGB or LAGB, 2003 completed baseline and follow-up assessments (79.2% women, baseline median age: 47 years, median b...

Research paper thumbnail of Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, Jan 7, 2017

Limited evidence suggests bariatric surgery may not reduce opioid analgesic use, despite improvem... more Limited evidence suggests bariatric surgery may not reduce opioid analgesic use, despite improvements in pain. To determine if use of prescribed opioid analgesics changes in the short and long term after bariatric surgery and to identify factors associated with continued and postsurgery initiated use. Ten U.S. hospitals. The Longitudinal Assessment of Bariatric Surgery-2 is an observational cohort study. Assessments were conducted presurgery, 6 months postsurgery, and annually postsurgery for up to 7 years until January 2015. Opioid use was defined as self-reported daily, weekly, or "as needed" use of a prescribed medication classified as an opioid analgesic. Of 2258 participants with baseline data, 2218 completed follow-up assessment(s) (78.7% were female, median body mass index: 46; 70.6% underwent Roux-en-Y gastric bypass). Prevalence of opioid use decreased after surgery from 14.7% (95% CI: 13.3-16.2) at baseline to 12.9% (95% CI: 11.5-14.4) at month 6 but then increas...

Research paper thumbnail of Prescribed Opioid and Non-Opioid Analgesic Medication Use Before and After Bariatric Surgery: 7 Year Follow-up

Surgery for Obesity and Related Diseases, 2016

Research paper thumbnail of Change in Pain and Physical Function Following Bariatric Surgery for Severe Obesity

Research paper thumbnail of Factors Related to Improvement In Joint Pain and Physical Function Following Bariatric Surgery

Surgery for Obesity and Related Diseases, 2015

Research paper thumbnail of Longitudinal Assessment of Substance use and Misuse among Adults following Roux-en Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding: 7 Year Follow-up

Surgery for Obesity and Related Diseases, 2015

This is an open access article distributed under the terms of the Creative Commons Attribution-No... more This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Research paper thumbnail of Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes

International journal of obesity (2005), Jan 17, 2018

The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic ... more The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic disease prevalence and outcomes after bariatric surgery are not well-defined. Associations between pre- and post-operative serum levels of four biomarkers (C-reactive protein (CRP), cystatin C (CC), leptin, and ghrelin) with baseline measures of adiposity and metabolic disease prevalence (asthma, diabetes, sleep apnea), and weight loss and metabolic disease remission after bariatric surgery were studied in the Longitudinal Assessment of Bariatric Surgery (LABS) cohort. Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. Increased weight loss was associate...

Research paper thumbnail of Effect of Bariatric Surgery on CKD Risk

Journal of the American Society of Nephrology : JASN, Jan 15, 2018

Obesity is linked to the development and progression of CKD, but whether bariatric surgery protec... more Obesity is linked to the development and progression of CKD, but whether bariatric surgery protects against CKD is poorly understood. We, therefore, examined whether bariatric surgery influences CKD risk. The study included 2144 adults who underwent bariatric surgery from March of 2006 to April of 2009 and participated in the Longitudinal Assessment of Bariatric Surgery-2 Study cohort. The primary outcome was CKD risk categories as assessed by the Kidney Disease Improving Global Outcomes (KDIGO) consortium criteria using a combination of eGFR and albuminuria. Patients were 79% women and 87% white, with a median age of 46 years old. Improvements were observed in CKD risk at 1 and 7 years after surgery in patients with moderate baseline CKD risk (63% and 53%, respectively), high baseline risk (78% and 56%, respectively), and very high baseline risk (59% and 23%, respectively). The proportion of patients whose CKD risk worsened was ≤10%; five patients developed ESRD. Sensitivity analys...

Research paper thumbnail of A Prospective, Longitudinal Examination of Suicidal Ideation among Bariatric Surgery Patients

Surgery for Obesity and Related Diseases, 2016

Research paper thumbnail of Alcohol and other substance use after bariatric surgery: prospective evidence from a U.S. multicenter cohort study

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, Jan 31, 2017

Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol ... more Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol use disorder (AUD). However, prospective assessment of substance use disorders (SUD) after bariatric surgery is limited. To report SUD-related outcomes after RYGB and laparoscopic adjustable gastric banding (LAGB). To identify factors associated with incident SUD-related outcomes. 10 U.S. hospitals METHODS: The Longitudinal Assessment of Bariatric Surgery-2 is a prospective cohort study. Participants self-reported past-year AUD symptoms (determined by the Alcohol Use Disorders Identification Test), illicit drug use (cocaine, hallucinogens, inhalants, phencyclidine, amphetamines, or marijuana), and SUD treatment (counseling or hospitalization for alcohol or drugs) presurgery and annually postsurgery for up to 7 years through January 2015. Of 2348 participants who underwent RYGB or LAGB, 2003 completed baseline and follow-up assessments (79.2% women, baseline median age: 47 years, median b...

Research paper thumbnail of Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, Jan 7, 2017

Limited evidence suggests bariatric surgery may not reduce opioid analgesic use, despite improvem... more Limited evidence suggests bariatric surgery may not reduce opioid analgesic use, despite improvements in pain. To determine if use of prescribed opioid analgesics changes in the short and long term after bariatric surgery and to identify factors associated with continued and postsurgery initiated use. Ten U.S. hospitals. The Longitudinal Assessment of Bariatric Surgery-2 is an observational cohort study. Assessments were conducted presurgery, 6 months postsurgery, and annually postsurgery for up to 7 years until January 2015. Opioid use was defined as self-reported daily, weekly, or "as needed" use of a prescribed medication classified as an opioid analgesic. Of 2258 participants with baseline data, 2218 completed follow-up assessment(s) (78.7% were female, median body mass index: 46; 70.6% underwent Roux-en-Y gastric bypass). Prevalence of opioid use decreased after surgery from 14.7% (95% CI: 13.3-16.2) at baseline to 12.9% (95% CI: 11.5-14.4) at month 6 but then increas...

Research paper thumbnail of Prescribed Opioid and Non-Opioid Analgesic Medication Use Before and After Bariatric Surgery: 7 Year Follow-up

Surgery for Obesity and Related Diseases, 2016

Research paper thumbnail of Change in Pain and Physical Function Following Bariatric Surgery for Severe Obesity

Research paper thumbnail of Factors Related to Improvement In Joint Pain and Physical Function Following Bariatric Surgery

Surgery for Obesity and Related Diseases, 2015

Research paper thumbnail of Longitudinal Assessment of Substance use and Misuse among Adults following Roux-en Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding: 7 Year Follow-up

Surgery for Obesity and Related Diseases, 2015

This is an open access article distributed under the terms of the Creative Commons Attribution-No... more This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.