Marco Antonio Eleno - Academia.edu (original) (raw)
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Papers by Marco Antonio Eleno
A novel series of 4-(1,2,3-triazol-1-yl) salicylic acid derivatives was synthesized from 4-azidos... more A novel series of 4-(1,2,3-triazol-1-yl) salicylic acid derivatives was synthesized from 4-azidosalicylic acid and diverse alkynes using copper catalyzed azide-alkyne cycloaddition as key process and fully characterized by using different analytical techniques. The in vitro antiproliferative activity of these new compounds was explored against a series of tumoral cell lines which included U251 (human glioblastoma), PC-3 (human prostate cancer cell line), K562 (human leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma) and SKLU (human lung adenocarcinoma), showing selective activity in some compounds. Moreover, molecular docking studies suggest a strong interaction between ARG-154 in STAT3 and the triazole fragment which can explain the inhibitory activity observed in these compounds.
Organic Preparations and Procedures International
![Research paper thumbnail of Synthesis, characterization and cytotoxic activity of diorganotin (IV) complexes with 4H-pyrido[1,2-a]pyrimidin-4-one derivatives](https://attachments.academia-assets.com/67899875/thumbnails/1.jpg)
](The synthesis and characterization of ruthenium complexes (Ru1-Ru8) of the type [Ru(S) 2 (K)], (w... more The synthesis and characterization of ruthenium complexes (Ru1-Ru8) of the type [Ru(S) 2 (K)], (where S = 1,10-phenanthroline/ 2,2'-bipyridine and K = iinh, inhba, na, mitsz) are described. These ligands form bidentate octahedral ruthenium complexes. The title compounds were subjected to in vitro cytostatic activity measurements against the human cancer T-lymphocyte cell lines Molt 4/C8 and CEM, and the murine tumor leukemia cell line L1210. In vitro evaluation of these ruthenium compounds revealed cytotoxic activity from 0.84 to 119 µg/mL against CEM, 3.7 to 158 µg/mL against Molt and 15 to ≥200 µg/mL against L1210 cell proliferation, depending the nature of the compound.
![Research paper thumbnail of Synthesis, characterization and cytotoxic activity of diorganotin (IV) complexes with 4H-pyrido[1,2-a]pyrimidin-4-one derivatives](https://attachments.academia-assets.com/67899873/thumbnails/1.jpg)
](The synthesis and characterization of ruthenium complexes (Ru1-Ru8) of the type [Ru(S) 2 (K)], (w... more The synthesis and characterization of ruthenium complexes (Ru1-Ru8) of the type [Ru(S) 2 (K)], (where S = 1,10-phenanthroline/ 2,2'-bipyridine and K = iinh, inhba, na, mitsz) are described. These ligands form bidentate octahedral ruthenium complexes. The title compounds were subjected to in vitro cytostatic activity measurements against the human cancer T-lymphocyte cell lines Molt 4/C8 and CEM, and the murine tumor leukemia cell line L1210. In vitro evaluation of these ruthenium compounds revealed cytotoxic activity from 0.84 to 119 µg/mL against CEM, 3.7 to 158 µg/mL against Molt and 15 to ≥200 µg/mL against L1210 cell proliferation, depending the nature of the compound.
A novel series of 4-(1,2,3-triazol-1-yl) salicylic acid derivatives was synthesized from 4-azidos... more A novel series of 4-(1,2,3-triazol-1-yl) salicylic acid derivatives was synthesized from 4-azidosalicylic acid and diverse alkynes using copper catalyzed azide-alkyne cycloaddition as key process and fully characterized by using different analytical techniques. The in vitro antiproliferative activity of these new compounds was explored against a series of tumoral cell lines which included U251 (human glioblastoma), PC-3 (human prostate cancer cell line), K562 (human leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma) and SKLU (human lung adenocarcinoma), showing selective activity in some compounds. Moreover, molecular docking studies suggest a strong interaction between ARG-154 in STAT3 and the triazole fragment which can explain the inhibitory activity observed in these compounds.
Organic Preparations and Procedures International
The synthesis and characterization of ruthenium complexes (Ru1-Ru8) of the type [Ru(S) 2 (K)], (w... more The synthesis and characterization of ruthenium complexes (Ru1-Ru8) of the type [Ru(S) 2 (K)], (where S = 1,10-phenanthroline/ 2,2'-bipyridine and K = iinh, inhba, na, mitsz) are described. These ligands form bidentate octahedral ruthenium complexes. The title compounds were subjected to in vitro cytostatic activity measurements against the human cancer T-lymphocyte cell lines Molt 4/C8 and CEM, and the murine tumor leukemia cell line L1210. In vitro evaluation of these ruthenium compounds revealed cytotoxic activity from 0.84 to 119 µg/mL against CEM, 3.7 to 158 µg/mL against Molt and 15 to ≥200 µg/mL against L1210 cell proliferation, depending the nature of the compound.
The synthesis and characterization of ruthenium complexes (Ru1-Ru8) of the type [Ru(S) 2 (K)], (w... more The synthesis and characterization of ruthenium complexes (Ru1-Ru8) of the type [Ru(S) 2 (K)], (where S = 1,10-phenanthroline/ 2,2'-bipyridine and K = iinh, inhba, na, mitsz) are described. These ligands form bidentate octahedral ruthenium complexes. The title compounds were subjected to in vitro cytostatic activity measurements against the human cancer T-lymphocyte cell lines Molt 4/C8 and CEM, and the murine tumor leukemia cell line L1210. In vitro evaluation of these ruthenium compounds revealed cytotoxic activity from 0.84 to 119 µg/mL against CEM, 3.7 to 158 µg/mL against Molt and 15 to ≥200 µg/mL against L1210 cell proliferation, depending the nature of the compound.