Marco M Lizzio - Academia.edu (original) (raw)

Papers by Marco M Lizzio

Research paper thumbnail of Manganese superoxide dismutase, glutathione peroxidase, and total radical trapping antioxidant capacity in active rheumatoid arthritis

The Journal of rheumatology, 2002

Research paper thumbnail of Sarilumab use in severe SARS-CoV-2 pneumonia

Importance: Interleukin-6 signal blockade has shown preliminary beneficial effects in treating ab... more Importance: Interleukin-6 signal blockade has shown preliminary beneficial effects in treating aberrant host inflammatory response against SARS-CoV-2 leading to severe respiratory distress. Objective: to describe the effect of off-label intravenous use of Sarilumab in patients with severe SARS-CoV-2-related pneumonia. Design: Observational clinical cohort study. Setting: Fondazione Policlinico Universitario A. Gemelli IRCCS as Italian Covid reference center. Participants: Patients with laboratory-confirmed SARS-CoV-2 infection and respiratory distress with PaO2/FiO2 ratio<300 treated with Sarilumab between March 23rd − April 4th, 2020. Date of final follow-up was April 18, 2020. Main outcomes and measures: We describe the clinical outcomes of 53 patients with SARS−CoV−2 severe pneumonia treated with intravenous Sarilumab in terms of pulmonary function improvement or Intensive Care Unit (ICU) admission rate in medical wards setting and of live discharge rate in ICU treated patient...

Research paper thumbnail of Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury

Renal Failure, 2016

Introduction The aim of this study was to evaluate the potential association of single gene polym... more Introduction The aim of this study was to evaluate the potential association of single gene polymorphisms of manganese superoxide dismutase (MnSOD), glutathione peroxidase 1 (GPX1) and catalase (CAT) with clinical outcomes of acute kidney injury (AKI). Materials and methods Ninety AKI patients and 101 healthy volunteers were included in the study. Determination of MnSOD rs4880, GPX1 rs1050450 and CAT rs769217 polymorphisms was performed using real-time polymerase chain reaction amplification. The duration of hospitalization of AKI patients, dialysis and intensive care requirements, sepsis, oliguria and in-hospital mortality rates were assessed. Results The MnSOD, GPX1 and CAT genotypes and allele frequencies of AKI patients did not differ significantly from those of healthy controls. In patients with a T allele in the ninth exon of the CAT gene, intensive care requirements were greater than those of patients with the CC genotype (p = 0.04). In addition, sepsis and in-hospital mortality were observed significantly more frequently in patients with a T allele in the ninth exon of the CAT gene (p = 0.03). Logistic regression analysis determined that bearing a T allele was the primary determinant of intensive care requirements and in-hospital mortality, independent of patient age, gender, presence of diabetes and dialysis requirements (OR 6.10, 95% CI 1.34-27.81, p = 0.02 and OR 10.25, 95% CI 1.13-92.80, p = 0.04, respectively). Conclusion Among AKI patients in the Turkish population, hospital morbidity and mortality were found to be more frequent in patients bearing a T allele of the rs769217 polymorphism of the CAT gene.

Research paper thumbnail of Osteoporosis and bone metabolism in postmenopausal women with osteoarthritis of the hand

Menopause, 2006

Osteoarthritis and osteoporosis are two major health problems affecting postmenopausal women. Epi... more Osteoarthritis and osteoporosis are two major health problems affecting postmenopausal women. Epidemiological observations seem to demonstrate a possible inverse relationship between osteoarthritis and osteoporosis. Erosive osteoarthritis (EOA) of the hand is a destructive form of primary osteoarthritis. This study evaluated bone mineral density and bone metabolism changes in erosive and nonerosive hand osteoarthritis women. Fifty-five women (mean age, 59 years; body mass index, 23 +/- 1.4 kg/m) who had been postmenopausal for an average of 9 years and who presented with hand osteoarthritis according to American College of Rheumatology criteria were enrolled in the study; 15 women showed clinical and radiological evidence of hand EOA. Twenty women matched for age, age at menopause, and body mass index formed the control group. Bone mineral density (g/cm) was measured at the hip and lumbar spine using dual-energy x-ray absorptiometry. Serum and urinary calcium and phosphate, serum 25-hydroxyvitamin D, parathyroid hormone, osteocalcin, and urinary breakdown products of bone matrix (CrossLaps) were analyzed. Women with hand EOA had a statistically significant lower T- and Z-score L2-L4 value than non-hand EOA women and controls (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). Moreover, postmenopausal women with hand EOA had higher significant percentage of osteoporosis at lumbar spine when compared with non-hand EOA postmenopausal women and controls. Any statistically significant difference in osteocalcin and CrossLaps serum levels was noted among women with hand EOA, hand osteoarthritis, and controls. Our data suggest that postmenopausal women with clinical and radiological EOA are at risk for development of osteoporosis.

Research paper thumbnail of Prolactin/Cortisol Ratio in Rheumatoid Arthritis

Annals of the New York Academy of Sciences, 2002

Research paper thumbnail of Predicting In‐Hospital Mortality in COVID ‐19 Older Patients with Specifically Developed Scores

Journal of the American Geriatrics Society, 2020

Research paper thumbnail of Analysis of response to infliximab in ankylosing spondylitis according to the axial and/or peripheral involvement: autoantibodies and drop outs are more frequent in the peripheral subset

Annals of the Rheumatic Diseases, 2007

The response rate for participation in the study was 61%. Because the analysis of the influence o... more The response rate for participation in the study was 61%. Because the analysis of the influence of weight, BMI and lifestyle factors was based on an internal comparison of responders, non-participation is unlikely to have had a major effect on the observed results. Intraobserver agreement levels for assessment of the radiographic features were good (k = 0.7-0.8), and it seems unlikely that random error in scoring the films importantly attenuated the associations. Finally, the results were derived from a predominantly Caucasian population in northeastern Scotland, and the data should be extrapolated beyond this population with caution. Previous population-based studies examining the effect of regular levels of physical activity and smoking provide somewhat conflicting results. 5 7-9 Our data suggest no important influence of these factors on the occurrence of the individual radiographic features of lumbar disc degeneration. By contrast, increased weight was associated with an increased risk of osteophytes. ACKNOWLEDGEMENTS We thank the Arthritis Research Campaign for support.

Research paper thumbnail of Manganese superoxide dismutase, glutathione peroxidase, and total radical trapping antioxidant capacity in active rheumatoid arthritis

The Journal of rheumatology, 2002

Research paper thumbnail of Sarilumab use in severe SARS-CoV-2 pneumonia

Importance: Interleukin-6 signal blockade has shown preliminary beneficial effects in treating ab... more Importance: Interleukin-6 signal blockade has shown preliminary beneficial effects in treating aberrant host inflammatory response against SARS-CoV-2 leading to severe respiratory distress. Objective: to describe the effect of off-label intravenous use of Sarilumab in patients with severe SARS-CoV-2-related pneumonia. Design: Observational clinical cohort study. Setting: Fondazione Policlinico Universitario A. Gemelli IRCCS as Italian Covid reference center. Participants: Patients with laboratory-confirmed SARS-CoV-2 infection and respiratory distress with PaO2/FiO2 ratio<300 treated with Sarilumab between March 23rd − April 4th, 2020. Date of final follow-up was April 18, 2020. Main outcomes and measures: We describe the clinical outcomes of 53 patients with SARS−CoV−2 severe pneumonia treated with intravenous Sarilumab in terms of pulmonary function improvement or Intensive Care Unit (ICU) admission rate in medical wards setting and of live discharge rate in ICU treated patient...

Research paper thumbnail of Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury

Renal Failure, 2016

Introduction The aim of this study was to evaluate the potential association of single gene polym... more Introduction The aim of this study was to evaluate the potential association of single gene polymorphisms of manganese superoxide dismutase (MnSOD), glutathione peroxidase 1 (GPX1) and catalase (CAT) with clinical outcomes of acute kidney injury (AKI). Materials and methods Ninety AKI patients and 101 healthy volunteers were included in the study. Determination of MnSOD rs4880, GPX1 rs1050450 and CAT rs769217 polymorphisms was performed using real-time polymerase chain reaction amplification. The duration of hospitalization of AKI patients, dialysis and intensive care requirements, sepsis, oliguria and in-hospital mortality rates were assessed. Results The MnSOD, GPX1 and CAT genotypes and allele frequencies of AKI patients did not differ significantly from those of healthy controls. In patients with a T allele in the ninth exon of the CAT gene, intensive care requirements were greater than those of patients with the CC genotype (p = 0.04). In addition, sepsis and in-hospital mortality were observed significantly more frequently in patients with a T allele in the ninth exon of the CAT gene (p = 0.03). Logistic regression analysis determined that bearing a T allele was the primary determinant of intensive care requirements and in-hospital mortality, independent of patient age, gender, presence of diabetes and dialysis requirements (OR 6.10, 95% CI 1.34-27.81, p = 0.02 and OR 10.25, 95% CI 1.13-92.80, p = 0.04, respectively). Conclusion Among AKI patients in the Turkish population, hospital morbidity and mortality were found to be more frequent in patients bearing a T allele of the rs769217 polymorphism of the CAT gene.

Research paper thumbnail of Osteoporosis and bone metabolism in postmenopausal women with osteoarthritis of the hand

Menopause, 2006

Osteoarthritis and osteoporosis are two major health problems affecting postmenopausal women. Epi... more Osteoarthritis and osteoporosis are two major health problems affecting postmenopausal women. Epidemiological observations seem to demonstrate a possible inverse relationship between osteoarthritis and osteoporosis. Erosive osteoarthritis (EOA) of the hand is a destructive form of primary osteoarthritis. This study evaluated bone mineral density and bone metabolism changes in erosive and nonerosive hand osteoarthritis women. Fifty-five women (mean age, 59 years; body mass index, 23 +/- 1.4 kg/m) who had been postmenopausal for an average of 9 years and who presented with hand osteoarthritis according to American College of Rheumatology criteria were enrolled in the study; 15 women showed clinical and radiological evidence of hand EOA. Twenty women matched for age, age at menopause, and body mass index formed the control group. Bone mineral density (g/cm) was measured at the hip and lumbar spine using dual-energy x-ray absorptiometry. Serum and urinary calcium and phosphate, serum 25-hydroxyvitamin D, parathyroid hormone, osteocalcin, and urinary breakdown products of bone matrix (CrossLaps) were analyzed. Women with hand EOA had a statistically significant lower T- and Z-score L2-L4 value than non-hand EOA women and controls (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). Moreover, postmenopausal women with hand EOA had higher significant percentage of osteoporosis at lumbar spine when compared with non-hand EOA postmenopausal women and controls. Any statistically significant difference in osteocalcin and CrossLaps serum levels was noted among women with hand EOA, hand osteoarthritis, and controls. Our data suggest that postmenopausal women with clinical and radiological EOA are at risk for development of osteoporosis.

Research paper thumbnail of Prolactin/Cortisol Ratio in Rheumatoid Arthritis

Annals of the New York Academy of Sciences, 2002

Research paper thumbnail of Predicting In‐Hospital Mortality in COVID ‐19 Older Patients with Specifically Developed Scores

Journal of the American Geriatrics Society, 2020

Research paper thumbnail of Analysis of response to infliximab in ankylosing spondylitis according to the axial and/or peripheral involvement: autoantibodies and drop outs are more frequent in the peripheral subset

Annals of the Rheumatic Diseases, 2007

The response rate for participation in the study was 61%. Because the analysis of the influence o... more The response rate for participation in the study was 61%. Because the analysis of the influence of weight, BMI and lifestyle factors was based on an internal comparison of responders, non-participation is unlikely to have had a major effect on the observed results. Intraobserver agreement levels for assessment of the radiographic features were good (k = 0.7-0.8), and it seems unlikely that random error in scoring the films importantly attenuated the associations. Finally, the results were derived from a predominantly Caucasian population in northeastern Scotland, and the data should be extrapolated beyond this population with caution. Previous population-based studies examining the effect of regular levels of physical activity and smoking provide somewhat conflicting results. 5 7-9 Our data suggest no important influence of these factors on the occurrence of the individual radiographic features of lumbar disc degeneration. By contrast, increased weight was associated with an increased risk of osteophytes. ACKNOWLEDGEMENTS We thank the Arthritis Research Campaign for support.