Marco Marcolin - Academia.edu (original) (raw)

Papers by Marco Marcolin

Rev Bras …, 2007

... Maria Inês Lobato Post-Graduate Program in Medical Sciences, Universidade Federal do Rio Gran... more ... Maria Inês Lobato Post-Graduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre (RS ... to contribute to such debate, approaching the genetic participation and its interaction with environmental factors in the manifestation of this ...

European Journal of Neurology, 2010

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Alzheimer's & Dementia, 2012

Background:Normal aging is associated with cognitive impairments, often overlooked in medical pra... more Background:Normal aging is associated with cognitive impairments, often overlooked in medical practice, especially in milder forms, with significant impact on quality of life. Such cognitive decline has not, up to date, specific treatment approach, leaving a gap in the therapeutic arsenal of both specialist and general practitioner. Repetitive transcranial magnetic stimulation (rTMS) is a promising noninvasive and painless technique. It has the potential to improve cognition in elderly activating neural networks, and provides an attractive option as strategy to enhance cognitive abilities, especially memory, in older subjects. The objective of this study is to assess the effects of high frequency rTMS to the dorsolateral prefrontal cortex (DLPFC) on global cognition of functionally independent elderly with subjective complaints of memory impairment. Methods: Clinical trial. Nineteen (8 male and 11 female) elderly, aged between 60 and 74 years old (mean age 1⁄4 64.5 6 3.8), independent for instrumental activities of daily living (IADL) with subjective memory complaints and evidence of some impairment in neuropsychological assessment, characterizing cognitive impairment no-dementia. The MoCA test was used for screening. For each patient, a brain magnetic resonance Table 2 Reversal of scopolamine induced amnesia by Ageratum conyzoides of EPM model in young mice

The Journal of Pain Official Journal of the American Pain Society, Nov 1, 2010

Neurology

Objective To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) ... more Objective To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study. Methods Participants were randomly allocated into the active PSI-rTMS, ACC-rTMS, sham-PSI-rTMS, or sham-ACC-rTMS arms. Stimulations were performed for 12 weeks, and a comprehensive clinical and pain assessment, psychophysics, and cortical excitability measurements were performed at baseline and during treatment. The main outcome of the study was pain intensity (numeric rating scale [NRS]) after the last stimulation session. Results Ninety-eight patients (age 55.02 ± 12.13 years) completed the study. NRS score was not significantly different between groups at the end of the study. Active rTMS treatments had no significant effects on pain interference with daily activities, pain dimensions, neuropathic pain symptoms, mood, medication use, cortical excitability measurements, or quality of life. Heat pain threshold was significantly increased after treatment in the PSI-dTMS group from baseline (1.58, 95% confidence interval [CI] 0.09-3.06]) compared to sham-dTMS (−1.02, 95% CI −2.10 to 0.04, p = 0.014), and ACC-dTMS caused a significant decrease in anxiety scores (−2.96, 95% CI −4.1 to −1.7]) compared to sham-dTMS (−0.78, 95% CI −1.9 to 0.3; p = 0.018). Conclusions ACC-and PSI-dTMS were not different from sham-dTMS for pain relief in CNP despite a significant antinociceptive effect after insular stimulation and anxiolytic effects of ACC-dTMS. These results showed that the different dimensions of pain can be modulated in humans noninvasively by directly stimulating deeper SNC cortical structures without necessarily affecting clinical pain per se. ClinicalTrials.gov identifier: NCT01932905.

Neurology

Objective To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) ... more Objective To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study. Methods Participants were randomly allocated into the active PSI-rTMS, ACC-rTMS, sham-PSI-rTMS, or sham-ACC-rTMS arms. Stimulations were performed for 12 weeks, and a comprehensive clinical and pain assessment, psychophysics, and cortical excitability measurements were performed at baseline and during treatment. The main outcome of the study was pain intensity (numeric rating scale [NRS]) after the last stimulation session. Results Ninety-eight patients (age 55.02 ± 12.13 years) completed the study. NRS score was not significantly different between groups at the end of the study. Active rTMS treatments had no significant effects on pain interference with daily activities, pain dimensions, neuropathic pain symptoms, mood, medication use, cortical excitability measurements, or quality of life. Heat pain threshold was significantly increased after treatment in the PSI-dTMS group from baseline (1.58, 95% confidence interval [CI] 0.09-3.06]) compared to sham-dTMS (−1.02, 95% CI −2.10 to 0.04, p = 0.014), and ACC-dTMS caused a significant decrease in anxiety scores (−2.96, 95% CI −4.1 to −1.7]) compared to sham-dTMS (−0.78, 95% CI −1.9 to 0.3; p = 0.018). Conclusions ACC-and PSI-dTMS were not different from sham-dTMS for pain relief in CNP despite a significant antinociceptive effect after insular stimulation and anxiolytic effects of ACC-dTMS. These results showed that the different dimensions of pain can be modulated in humans noninvasively by directly stimulating deeper SNC cortical structures without necessarily affecting clinical pain per se. ClinicalTrials.gov identifier: NCT01932905.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017

Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H... more Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H1-coil) transcranial magnetic stimulation (dTMS) is a novel TMS modality with established efficacy for unipolar depression. We conducted a randomized sham-controlled trial to evaluate the efficacy and safety of dTMS in treatment-resistant BD patients. Patients received 20 sessions of active or sham dTMS over the left dorsolateral prefrontal cortex (H1-coil, 55 18 Hz 2-sec 120% MT trains). The primary outcome was changes in the 17-item Hamilton Depression Rating Scale (HDRS-17) from baseline to endpoint (week 4). Secondary outcomes were changes from baseline to the end of the follow-up phase (week 8), and response and remission rates. Safety was assessed using a dTMS adverse effects questionnaire and the Young Mania Rating Scale to assess treatment-emergent mania switch (TEMS). Out of 50 patients, 43 finished the trial. There were 2 and 5 dropouts in the sham and active groups, respective...

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017

Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H... more Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H1-coil) transcranial magnetic stimulation (dTMS) is a novel TMS modality with established efficacy for unipolar depression. We conducted a randomized sham-controlled trial to evaluate the efficacy and safety of dTMS in treatment-resistant BD patients. Patients received 20 sessions of active or sham dTMS over the left dorsolateral prefrontal cortex (H1-coil, 55 18 Hz 2-sec 120% MT trains). The primary outcome was changes in the 17-item Hamilton Depression Rating Scale (HDRS-17) from baseline to endpoint (week 4). Secondary outcomes were changes from baseline to the end of the follow-up phase (week 8), and response and remission rates. Safety was assessed using a dTMS adverse effects questionnaire and the Young Mania Rating Scale to assess treatment-emergent mania switch (TEMS). Out of 50 patients, 43 finished the trial. There were 2 and 5 dropouts in the sham and active groups, respective...

Archives of Physical Medicine and Rehabilitation, Apr 30, 2015

Archives of Physical Medicine and Rehabilitation, Apr 30, 2015

To examine evidence suggesting a potential role for transcranial magnetic stimulation (TMS) in th... more To examine evidence suggesting a potential role for transcranial magnetic stimulation (TMS) in the treatment of chronic pain. Conclusion: Chronic pain is characterized by brain changes that can reasonably be presumed to be associated with hyperalgesia, as occurs with neuropathic changes in the periphery. TMS has the ability to induce plastic changes in the cortex at the site of stimulation and at connected sites, including the spinal cord. It also has the ability to influence the experience of experimental/acute pain. In studies of TMS in chronic pain, there is some evidence that temporary relief can be achieved in a proportion of sufferers. Chronic pain is common. Current treatments are often ineffective and complicated by side-effects. Work to this point is encouraging, but systematic assessment of stimulation parameters is necessary if TMS is to achieve a role in the treatment of chronic pain. Maintenance TMS is currently provided in relapsing major depression and may be a useful model in chronic pain management.

Arch Clin Psychiatry, Aug 1, 2000

... Erfurth, A.; Kammer, C.; Grunze, H.; Normann, C. & Walden, J. _ An open label study of ga... more ... Erfurth, A.; Kammer, C.; Grunze, H.; Normann, C. & Walden, J. _ An open label study of gabapentin in the treatment of acute mania _ J Psych Res 32: 261-4, 1998. ... Mariana Tatsch R. Ovídio Pires de Campos, s/n _ CEP 05403-0110 _ São Paulo _ SP. voltar ao início. Revista de. ...

Rev Bras …, 2007

... Maria Inês Lobato Post-Graduate Program in Medical Sciences, Universidade Federal do Rio Gran... more ... Maria Inês Lobato Post-Graduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre (RS ... to contribute to such debate, approaching the genetic participation and its interaction with environmental factors in the manifestation of this ...

European Journal of Neurology, 2010

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Alzheimer's & Dementia, 2012

Background:Normal aging is associated with cognitive impairments, often overlooked in medical pra... more Background:Normal aging is associated with cognitive impairments, often overlooked in medical practice, especially in milder forms, with significant impact on quality of life. Such cognitive decline has not, up to date, specific treatment approach, leaving a gap in the therapeutic arsenal of both specialist and general practitioner. Repetitive transcranial magnetic stimulation (rTMS) is a promising noninvasive and painless technique. It has the potential to improve cognition in elderly activating neural networks, and provides an attractive option as strategy to enhance cognitive abilities, especially memory, in older subjects. The objective of this study is to assess the effects of high frequency rTMS to the dorsolateral prefrontal cortex (DLPFC) on global cognition of functionally independent elderly with subjective complaints of memory impairment. Methods: Clinical trial. Nineteen (8 male and 11 female) elderly, aged between 60 and 74 years old (mean age 1⁄4 64.5 6 3.8), independent for instrumental activities of daily living (IADL) with subjective memory complaints and evidence of some impairment in neuropsychological assessment, characterizing cognitive impairment no-dementia. The MoCA test was used for screening. For each patient, a brain magnetic resonance Table 2 Reversal of scopolamine induced amnesia by Ageratum conyzoides of EPM model in young mice

The Journal of Pain Official Journal of the American Pain Society, Nov 1, 2010

Neurology

Objective To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) ... more Objective To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study. Methods Participants were randomly allocated into the active PSI-rTMS, ACC-rTMS, sham-PSI-rTMS, or sham-ACC-rTMS arms. Stimulations were performed for 12 weeks, and a comprehensive clinical and pain assessment, psychophysics, and cortical excitability measurements were performed at baseline and during treatment. The main outcome of the study was pain intensity (numeric rating scale [NRS]) after the last stimulation session. Results Ninety-eight patients (age 55.02 ± 12.13 years) completed the study. NRS score was not significantly different between groups at the end of the study. Active rTMS treatments had no significant effects on pain interference with daily activities, pain dimensions, neuropathic pain symptoms, mood, medication use, cortical excitability measurements, or quality of life. Heat pain threshold was significantly increased after treatment in the PSI-dTMS group from baseline (1.58, 95% confidence interval [CI] 0.09-3.06]) compared to sham-dTMS (−1.02, 95% CI −2.10 to 0.04, p = 0.014), and ACC-dTMS caused a significant decrease in anxiety scores (−2.96, 95% CI −4.1 to −1.7]) compared to sham-dTMS (−0.78, 95% CI −1.9 to 0.3; p = 0.018). Conclusions ACC-and PSI-dTMS were not different from sham-dTMS for pain relief in CNP despite a significant antinociceptive effect after insular stimulation and anxiolytic effects of ACC-dTMS. These results showed that the different dimensions of pain can be modulated in humans noninvasively by directly stimulating deeper SNC cortical structures without necessarily affecting clinical pain per se. ClinicalTrials.gov identifier: NCT01932905.

Neurology

Objective To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) ... more Objective To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study. Methods Participants were randomly allocated into the active PSI-rTMS, ACC-rTMS, sham-PSI-rTMS, or sham-ACC-rTMS arms. Stimulations were performed for 12 weeks, and a comprehensive clinical and pain assessment, psychophysics, and cortical excitability measurements were performed at baseline and during treatment. The main outcome of the study was pain intensity (numeric rating scale [NRS]) after the last stimulation session. Results Ninety-eight patients (age 55.02 ± 12.13 years) completed the study. NRS score was not significantly different between groups at the end of the study. Active rTMS treatments had no significant effects on pain interference with daily activities, pain dimensions, neuropathic pain symptoms, mood, medication use, cortical excitability measurements, or quality of life. Heat pain threshold was significantly increased after treatment in the PSI-dTMS group from baseline (1.58, 95% confidence interval [CI] 0.09-3.06]) compared to sham-dTMS (−1.02, 95% CI −2.10 to 0.04, p = 0.014), and ACC-dTMS caused a significant decrease in anxiety scores (−2.96, 95% CI −4.1 to −1.7]) compared to sham-dTMS (−0.78, 95% CI −1.9 to 0.3; p = 0.018). Conclusions ACC-and PSI-dTMS were not different from sham-dTMS for pain relief in CNP despite a significant antinociceptive effect after insular stimulation and anxiolytic effects of ACC-dTMS. These results showed that the different dimensions of pain can be modulated in humans noninvasively by directly stimulating deeper SNC cortical structures without necessarily affecting clinical pain per se. ClinicalTrials.gov identifier: NCT01932905.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017

Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H... more Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H1-coil) transcranial magnetic stimulation (dTMS) is a novel TMS modality with established efficacy for unipolar depression. We conducted a randomized sham-controlled trial to evaluate the efficacy and safety of dTMS in treatment-resistant BD patients. Patients received 20 sessions of active or sham dTMS over the left dorsolateral prefrontal cortex (H1-coil, 55 18 Hz 2-sec 120% MT trains). The primary outcome was changes in the 17-item Hamilton Depression Rating Scale (HDRS-17) from baseline to endpoint (week 4). Secondary outcomes were changes from baseline to the end of the follow-up phase (week 8), and response and remission rates. Safety was assessed using a dTMS adverse effects questionnaire and the Young Mania Rating Scale to assess treatment-emergent mania switch (TEMS). Out of 50 patients, 43 finished the trial. There were 2 and 5 dropouts in the sham and active groups, respective...

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017

Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H... more Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H1-coil) transcranial magnetic stimulation (dTMS) is a novel TMS modality with established efficacy for unipolar depression. We conducted a randomized sham-controlled trial to evaluate the efficacy and safety of dTMS in treatment-resistant BD patients. Patients received 20 sessions of active or sham dTMS over the left dorsolateral prefrontal cortex (H1-coil, 55 18 Hz 2-sec 120% MT trains). The primary outcome was changes in the 17-item Hamilton Depression Rating Scale (HDRS-17) from baseline to endpoint (week 4). Secondary outcomes were changes from baseline to the end of the follow-up phase (week 8), and response and remission rates. Safety was assessed using a dTMS adverse effects questionnaire and the Young Mania Rating Scale to assess treatment-emergent mania switch (TEMS). Out of 50 patients, 43 finished the trial. There were 2 and 5 dropouts in the sham and active groups, respective...

Archives of Physical Medicine and Rehabilitation, Apr 30, 2015

Archives of Physical Medicine and Rehabilitation, Apr 30, 2015

To examine evidence suggesting a potential role for transcranial magnetic stimulation (TMS) in th... more To examine evidence suggesting a potential role for transcranial magnetic stimulation (TMS) in the treatment of chronic pain. Conclusion: Chronic pain is characterized by brain changes that can reasonably be presumed to be associated with hyperalgesia, as occurs with neuropathic changes in the periphery. TMS has the ability to induce plastic changes in the cortex at the site of stimulation and at connected sites, including the spinal cord. It also has the ability to influence the experience of experimental/acute pain. In studies of TMS in chronic pain, there is some evidence that temporary relief can be achieved in a proportion of sufferers. Chronic pain is common. Current treatments are often ineffective and complicated by side-effects. Work to this point is encouraging, but systematic assessment of stimulation parameters is necessary if TMS is to achieve a role in the treatment of chronic pain. Maintenance TMS is currently provided in relapsing major depression and may be a useful model in chronic pain management.

Arch Clin Psychiatry, Aug 1, 2000

... Erfurth, A.; Kammer, C.; Grunze, H.; Normann, C. & Walden, J. _ An open label study of ga... more ... Erfurth, A.; Kammer, C.; Grunze, H.; Normann, C. & Walden, J. _ An open label study of gabapentin in the treatment of acute mania _ J Psych Res 32: 261-4, 1998. ... Mariana Tatsch R. Ovídio Pires de Campos, s/n _ CEP 05403-0110 _ São Paulo _ SP. voltar ao início. Revista de. ...