Marcus Limones - Academia.edu (original) (raw)
Papers by Marcus Limones
RESUMO: O presente trabalho teve como objetivo, a partir do interesse de alunos da graduacao em B... more RESUMO: O presente trabalho teve como objetivo, a partir do interesse de alunos da graduacao em Biomedicina da Pontificia Universidade Catolica de Minas Gerais, fazer uma revisao bibliografica sobre Epilepsia Mioclonica com Fibras Vermelhas Rasgadas. Foi realizado uma revisao bibliografica, sistematica da literatura, entre o periodo de 15/08/ 2016 ate 10/10/2016, nos bancos de dados PubMed, Scielo, Bireme, Biblioteca Virtual de Saude alem de livros relacionados com o assunto. Epilepsia mioclonica associado com fibras vermelhas (MERRF) e um disturbio mitocondrial caracterizado por mioclonia, epilepsia, crises generalizadas, ataxia e miopatia (DI MAURO, et al , 2001). A MERRF ocorre principalmente devido a uma mutacao de A para G no mtDNA 8344 que interrompe o gene mitocondrial para tRNA(Lys) (LORENZONI, 2014). Sua patogenia esta associada com uma disfuncao causada no sistema de fosforilacao oxidativa da mitocondria, responsavel por fornecimento de energia celular. Essa disfuncao caus...
Journal of Stroke and Cerebrovascular Diseases, 2018
Background: Neuroinflammation is an important part of stroke pathophysiology and has both detrime... more Background: Neuroinflammation is an important part of stroke pathophysiology and has both detrimental and beneficial effects after stroke. Besides that the enhancement of neurotrophins seems to be related to improvements in stroke recovery. Evidences suggest that exercise plays a role in modulating anti-inflammatory and neurotrophic effects. However, little is known about its impact in stroke survivors, mainly in chronic stroke. The purpose of this study is to investigate the efficacy of moderate-intensity treadmill exercise in changing inflammatory mediators, interleukin-6 (IL-6), soluble tumor necrosis factor receptors I and II (sTNFRI, sTNFRII), interleukin-10 (IL-10), and brain-derived neurotrophic factor (BDNF) levels in chronic stroke patients. The secondary objective is to investigate the effects of training in improve mobility and exercise capacity. Methods: This is a randomized controlled trial. Chronic stroke patients will be randomized to an experimental or control group, and will receive group interventions three times per week, over 12 weeks. The experimental group will receive moderate-intensity (60%-80% of maximum heart rate reserve) treadmill exercise. Control group will perform walking training on the ground (<40% of maximum heart rate reserve). Primary outcomes include IL-6, sTNFRI, sTNFRII, IL-10, and BDNF levels. Secondary outcomes include mobility and exercise capacity. Outcomes will be measured at baseline, postintervention, and at the 4-week follow-up. Discussion: The findings of this trial have the potential to provide important insights regarding the effects of an aerobic physical program in the inflammatory process and in the neuronal plasticity in stroke persons and its impact on mobility and exercise capacity.
RESUMO: O presente trabalho teve como objetivo, a partir do interesse de alunos da graduacao em B... more RESUMO: O presente trabalho teve como objetivo, a partir do interesse de alunos da graduacao em Biomedicina da Pontificia Universidade Catolica de Minas Gerais, fazer uma revisao bibliografica sobre Epilepsia Mioclonica com Fibras Vermelhas Rasgadas. Foi realizado uma revisao bibliografica, sistematica da literatura, entre o periodo de 15/08/ 2016 ate 10/10/2016, nos bancos de dados PubMed, Scielo, Bireme, Biblioteca Virtual de Saude alem de livros relacionados com o assunto. Epilepsia mioclonica associado com fibras vermelhas (MERRF) e um disturbio mitocondrial caracterizado por mioclonia, epilepsia, crises generalizadas, ataxia e miopatia (DI MAURO, et al , 2001). A MERRF ocorre principalmente devido a uma mutacao de A para G no mtDNA 8344 que interrompe o gene mitocondrial para tRNA(Lys) (LORENZONI, 2014). Sua patogenia esta associada com uma disfuncao causada no sistema de fosforilacao oxidativa da mitocondria, responsavel por fornecimento de energia celular. Essa disfuncao caus...
Journal of Stroke and Cerebrovascular Diseases, 2018
Background: Neuroinflammation is an important part of stroke pathophysiology and has both detrime... more Background: Neuroinflammation is an important part of stroke pathophysiology and has both detrimental and beneficial effects after stroke. Besides that the enhancement of neurotrophins seems to be related to improvements in stroke recovery. Evidences suggest that exercise plays a role in modulating anti-inflammatory and neurotrophic effects. However, little is known about its impact in stroke survivors, mainly in chronic stroke. The purpose of this study is to investigate the efficacy of moderate-intensity treadmill exercise in changing inflammatory mediators, interleukin-6 (IL-6), soluble tumor necrosis factor receptors I and II (sTNFRI, sTNFRII), interleukin-10 (IL-10), and brain-derived neurotrophic factor (BDNF) levels in chronic stroke patients. The secondary objective is to investigate the effects of training in improve mobility and exercise capacity. Methods: This is a randomized controlled trial. Chronic stroke patients will be randomized to an experimental or control group, and will receive group interventions three times per week, over 12 weeks. The experimental group will receive moderate-intensity (60%-80% of maximum heart rate reserve) treadmill exercise. Control group will perform walking training on the ground (<40% of maximum heart rate reserve). Primary outcomes include IL-6, sTNFRI, sTNFRII, IL-10, and BDNF levels. Secondary outcomes include mobility and exercise capacity. Outcomes will be measured at baseline, postintervention, and at the 4-week follow-up. Discussion: The findings of this trial have the potential to provide important insights regarding the effects of an aerobic physical program in the inflammatory process and in the neuronal plasticity in stroke persons and its impact on mobility and exercise capacity.