Margaret Eastman - Academia.edu (original) (raw)
Papers by Margaret Eastman
Accurately measuring the bioavailability of organic contaminants associated with complex environm... more Accurately measuring the bioavailability of organic contaminants associated with complex environmental matrices is necessary for assessing contaminant risk, as well as for evaluating the effectiveness of proposed and in-place remediation strategies. Due to its importance, the bioavailability of organic contaminants associated with soils and sediments has been widely examined at the macroscopic or bulk-scale and found to be highly controlled
Journal of The American Chemical Society, 2002
The origin of the unusual regioselectivity of heme oxygenation, ie the oxidation of heme to δ-bil... more The origin of the unusual regioselectivity of heme oxygenation, ie the oxidation of heme to δ-biliverdin (70%) and β-biliverdin (30%), that is exhibited by heme oxygenase from Pseudomonas aeruginosa (pa-HO) has been studied by 1 H NMR, 13 C NMR, and resonance Raman ...
The Open Medicinal Chemistry Journal, 2007
The Flex-Het compound 10a (SHetA2-NSC 721689) {[4-nitrophenylamino][(2,2,4,4-tetramethylthiochrom... more The Flex-Het compound 10a (SHetA2-NSC 721689) {[4-nitrophenylamino][(2,2,4,4-tetramethylthiochroman-6-yl)amino]methane-1-thione]} has shown promise in preclinical testing as an anti-cancer agent without evidence of toxicity, skin irritancy, or teratogenicity. One objective of this study was to synthesize a series of heteroarotinoids structurally related to SHetA2 and to measure the effect of structural alterations on the cytotoxicity activities of the compounds on A2780 ovarian cancer cells. Alterations included comparisons of activity of an NO2 end group versus a CO2Et end group, a thiourea linker versus a urea linker, and a distorted, thiochroman ring unit versus a planar quinoline ring unit. Cytotoxicity assays demonstrated the thiourea linker compounds to be similar in potency to the urea linker counterparts, the NO2 substitutions were slightly more potent than the CO2Et substitutions, and replacement of the thiochroman group with a planar quinoline fused ring system markedly reduced activity. The mechanism of cytotoxicity through apoptosis was confirmed for the compounds. The optimal combination of structural features for enhancing potency consisted of a urea linker, a NO2 substitution, and a flexible thiochroman unit. Extensive H-bonding in the more active urea derivative was confirmed by X-ray and NMR analyses. This is the first example in which the biological activity of flexible, thiochroman units is compared to that of fused aryl units in a heteroarotinoid molecule.
Materials science & engineering. C, Materials for biological applications, 2014
With the aim of developing appropriate scaffolds for tissue engineering to suppress the formation... more With the aim of developing appropriate scaffolds for tissue engineering to suppress the formation of biofilms, an effective one-pot process was applied in this study to produce scaffolds with inherent antibacterial activity. A new method to synthesize genipin-crosslinked gelatin/nanosilver scaffolds with "green" in situ formation of silver nanoparticles by heat treatment is presented in this paper. In this procedure, toxic solvents, reducing agents, and stabilizing agents are avoided. UV-visible absorption spectra of the synthesized gelatin/nanosilver solutions were obtained immediately and three months after the synthesis revealing the presence and high stability of the silver nanoparticles. The TEM of gelatin/nanosilver solutions showed silver particles with spherical shapes that were less than 5 nm in size. Interestingly, contact angle was found to increase from 80°to 125°with the increase in concentration of nanosilver in gelatin. All gelatin/nanosilver solutions showed antimicrobial activity against Staphylococcus aureus and Escherichia coli. However, only the highest concentration showed antifungal effects against Candida albicans pathogens. Scaffolds were prepared by a lyophilization technique from this solution and their antimicrobial activities were examined. Introducing this facile green one-pot process of synthesizing scaffolds with antimicrobial and anti-biofilm properties may lead to key applications in tissue engineering techniques.
International Journal of Nanomedicine, 2013
Instruments, Methods, and Missions for Astrobiology XI, 2008
Numerous chemical additives lower the freezing point of water, but life at sub-zero temperatures ... more Numerous chemical additives lower the freezing point of water, but life at sub-zero temperatures is sustained by a limited number of biological cryoprotectants. Antifreeze proteins in fish, plants, and insects provide protection to a few degrees below freezing. Microbes have been found to survive at even lower temperatures, although, with a few exceptions, antifreeze proteins are missing. Survival has been attributed to external factors, such as high salt concentration (brine veins) and adhesion to particulates or ice crystal defects. Teichoic acid is a phosphodiester polymer ubiquitous in Gram positive bacteria, composing 50% of the mass of the bacterial cell wall and excreted into the extracellular space of biofilm communities. We have found that when bound to the peptidoglycan cell wall (wall teichoic acid) or as a free molecule (lipoteichoic acid), teichoic acid is surrounded by liquid water at temperatures significantly below freezing. Using solid-state NMR, we are unable to collect 31 P CPMAS spectra for frozen solutions of lipoteichoic acid at temperatures above -60 °C. For wall teichoic acid in D 2 O, signals are not seen above -30 °C. These results can be explained by the presence of liquid water, which permits rapid molecular motion to remove 1 H/ 31 P dipolar coupling. 2 H quadrupole echo NMR spectroscopy reveals that both liquid and solid water are present. We suggest that teichoic acids could provide a shell of liquid water around biofilms and planktonic bacteria, removing the need for brine veins to prevent bacterial freezing.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2007
A systematic study of 1,2-additions to 3,7-diheterabicyclo[3.3.1]nonan-9-ones (3,7-DHBCN-9-ONES) ... more A systematic study of 1,2-additions to 3,7-diheterabicyclo[3.3.1]nonan-9-ones (3,7-DHBCN-9-ONES) by symmetrically substituted aryl Grignard reagents in anhydrous THF or ether has been conducted. 1,2-Additions of aryl Grignard reagents to the carbonyl group at C-9 in 7-benzyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-one and 7-benzyl-3-thia-7-azabicyclo[3.3.1]nonan-9-one resulted in the formation of tertiary alcohols with the aryl group “syn” to the oxygen or sulfur atoms in the respective rings. The X-ray analyses demonstrated that the solid, bicyclic, oxygen-containing alcohol was in chair–chair form while the solid, bicyclic, sulfur-containing alcohol existed in chair–boat form. A tentative mechanism is that the Grignard reagent may coordinate with the oxygen atom and / or sulfur atom in a boat conformer of the bicyclic system prior to the attack from the “oxygen or sulfur sides.”
Phosphorus, Sulfur, and Silicon and the Related Elements, 2005
A series of derivatives of tetrahydro-4 H-pyran-4-one and tetrahydrothiopyran-4-one have been pre... more A series of derivatives of tetrahydro-4 H-pyran-4-one and tetrahydrothiopyran-4-one have been prepared by condensation with aryl Grignard reagents. IR spectra, 1 H and 13 C NMR spectral analyses, and elemental analyses support the structures. A single-crystal X-ray diffraction ...
The Journal of Chemical Physics, 1992
We describe here a new solid-state nuclear-magnetic-resonance (NMR) experiment for correlating an... more We describe here a new solid-state nuclear-magnetic-resonance (NMR) experiment for correlating anisotropic and isotropic chemical shifts of inequivalent nuclei in powdered samples. Spectra are obtained by processing signals arising from a spinning sample, acquired in independent experiments as a function of the angle between the axis of macroscopic rotation and the external magnetic field. This is in contrast to previously proposed techniques, which were based on sudden mechanical flippings or multiple-pulse sequences. We show that the time evolution of variable-angle-spinning signals is determined by a distribution relating the isotropic frequencies of the spins with their corresponding chemical shift anisotropies. Fourier transformation of these data therefore affords a twodimensional NMR spectrum, in which line shapes of isotropic and anisotropic interactions are correlated. Theoretical and experimental considerations involved in the extraction of this spectral information are discussed, and the technique is illustrated by an analysis of 13C NMR anisotropy in glycine, cysteine, and p-anisic acid. 4800
Israel Journal of Chemistry, 1992
Chemistry of Materials, 2003
A novel material, amorphous nanostructured HAlO, has been synthesized by the reaction of various ... more A novel material, amorphous nanostructured HAlO, has been synthesized by the reaction of various methylsiloxanes [e.g., (Me 2 HSi) 2 O] with the aluminum hydride H 3 Al‚NMe 3 in ether or aromatic solvents under mild conditions. Its high surface area of ca. 250 m 2 /g is due to both its small particle size of approximately 5 nm and its amorphous nanostructure. Its amorphous nature was demonstrated by TEM and XRD studies, and its composition was determined by elemental analysis, 1 H and 27 Al MAS solid-state NMR spectroscopies, and FT-IR spectroscopy. HAlO is an oxidic material that still contains a reactive aluminum hydride functional group. Prolonged heating at 200-250°C causes it to slowly decompose to aluminum metal and amorphous Al 2 O 3 without significantly changing the particle size or the BET surface area. This decomposition is accompanied by the loss of hydride and a decrease of the aluminum coordination number from five to four. HAlO reacts readily with protic reagents such as water or alcohols to give bayerite, Al(OH) 3 , or alkoxy alumoxanes (ROAlO) n . Annealing below its decomposition temperature led not to crystallization but rather to a dramatic decrease in reactivity. No reaction was observed between n-octanol and HAlO that had been annealed at 200°C even after 17 h at 90°C. HAlO cleanly reduces 2-cyclohexene-1-one to the corresponding alcohol, 2-cyclohexene-1-ol, and it converts Me 3 -SiCl to Me 3 SiH, although with a yield of only 24% for the latter. Corriu, R. J. P.; Leclercq, D.; Lefevre, P.; Mutin, P.
Biochemistry, 2005
Native-state hydrogen-deuterium exchange (HDX) monitored by NMR spectroscopy has been used to com... more Native-state hydrogen-deuterium exchange (HDX) monitored by NMR spectroscopy has been used to compare conformational plasticity in ferric rat liver outer mitochondrial membrane cytochrome b5 (rOM b5) and ferric bovine liver microsomal cytochrome b5 (bMc b5). Analysis of the data indicated that rOM b5 is the less conformationally flexible protein on the time scale probed by the HDX experiments. The data also suggest a likely contributor to the much higher kinetic barrier for the release of hemin from OM b5s in comparison to Mc b5s, a characteristic that may be to a large extent the source of their divergent functional properties. Specifically, the data indicate that conformational mobility within helices alpha4 and alpha5, which flank the loop harboring axial ligand His63, is considerably more restricted in rOM b5 than in bMc b5. The lower conformational flexibility of alpha4 and alpha5 in rOM b5 can reasonably be attributed to more extensive hydrophobic packing in that region of the protein, arising from two conserved side chain packing motifs in OM cytochrome b5s [Altuve, A., Wang, L., Benson, D. R., and Rivera, M. (2004) Biochem. Biophys. Res. Commun. 314, 602-609].
A new design for a double-tuned dynamic-angle-spinning (DAS) probe that employs a RF coil wrapped... more A new design for a double-tuned dynamic-angle-spinning (DAS) probe that employs a RF coil wrapped directly around the stator is presented. The increased filling factor of this design and the smaller RF coil result in improved sensitivity and facilitate the incorporation of 'H decoupling capabilities. Since the RF coil is reoriented with the spinning sample, the pulse lengths and sensitivity vary as the cosecant of the angle between the RF coil and the external magnetic field. However, this was not found to be a significant impediment to the usage of the probe. As a demonstration of the probes performance a 'H-decoupled "B DAS spectrum of boric acid is presented. o
Stable aqueous colloids of 2-3 nm In2S3 nanocrystals have been prepared by using the classical me... more Stable aqueous colloids of 2-3 nm In2S3 nanocrystals have been prepared by using the classical method of nanoparticle stabilization by low molecular weight thiols. TEM crystal lattice spacing, X-ray diffraction, EDAX data, and electron diffraction indicate that the nanoparticles are predominantly in In2S3 form. They exhibit relatively strong excitonic emission at 360-380 nm with a quantum yield of 1.5%. The excitonic radiative lifetime is 350 ns, which indicates that a direct allowed electronic transition is responsible for this emission. The NMR lines of the stabilizer are strongly broadened and shifted as a result of deshielding induced by electron withdrawing by positively charged metal ions. This effect quickly wears off as the carbon chain becomes longer and the separation between the hydrogen atoms of the stabilizer and the semiconductor surface increases. The broadening is attributed to the reduced mobility of the stabilizer in the nanoparticle shell. For CdS nanoparticles of the same size, this effect was found to be substantially stronger than for In2S3. The lower density of metal centers in In2S3than in CdS, which serve as anchor points for the stabilizer, promotes greater mobility of the stabilizer moieties.
Accurately measuring the bioavailability of organic contaminants associated with complex environm... more Accurately measuring the bioavailability of organic contaminants associated with complex environmental matrices is necessary for assessing contaminant risk, as well as for evaluating the effectiveness of proposed and in-place remediation strategies. Due to its importance, the bioavailability of organic contaminants associated with soils and sediments has been widely examined at the macroscopic or bulk-scale and found to be highly controlled
Journal of The American Chemical Society, 2002
The origin of the unusual regioselectivity of heme oxygenation, ie the oxidation of heme to δ-bil... more The origin of the unusual regioselectivity of heme oxygenation, ie the oxidation of heme to δ-biliverdin (70%) and β-biliverdin (30%), that is exhibited by heme oxygenase from Pseudomonas aeruginosa (pa-HO) has been studied by 1 H NMR, 13 C NMR, and resonance Raman ...
The Open Medicinal Chemistry Journal, 2007
The Flex-Het compound 10a (SHetA2-NSC 721689) {[4-nitrophenylamino][(2,2,4,4-tetramethylthiochrom... more The Flex-Het compound 10a (SHetA2-NSC 721689) {[4-nitrophenylamino][(2,2,4,4-tetramethylthiochroman-6-yl)amino]methane-1-thione]} has shown promise in preclinical testing as an anti-cancer agent without evidence of toxicity, skin irritancy, or teratogenicity. One objective of this study was to synthesize a series of heteroarotinoids structurally related to SHetA2 and to measure the effect of structural alterations on the cytotoxicity activities of the compounds on A2780 ovarian cancer cells. Alterations included comparisons of activity of an NO2 end group versus a CO2Et end group, a thiourea linker versus a urea linker, and a distorted, thiochroman ring unit versus a planar quinoline ring unit. Cytotoxicity assays demonstrated the thiourea linker compounds to be similar in potency to the urea linker counterparts, the NO2 substitutions were slightly more potent than the CO2Et substitutions, and replacement of the thiochroman group with a planar quinoline fused ring system markedly reduced activity. The mechanism of cytotoxicity through apoptosis was confirmed for the compounds. The optimal combination of structural features for enhancing potency consisted of a urea linker, a NO2 substitution, and a flexible thiochroman unit. Extensive H-bonding in the more active urea derivative was confirmed by X-ray and NMR analyses. This is the first example in which the biological activity of flexible, thiochroman units is compared to that of fused aryl units in a heteroarotinoid molecule.
Materials science & engineering. C, Materials for biological applications, 2014
With the aim of developing appropriate scaffolds for tissue engineering to suppress the formation... more With the aim of developing appropriate scaffolds for tissue engineering to suppress the formation of biofilms, an effective one-pot process was applied in this study to produce scaffolds with inherent antibacterial activity. A new method to synthesize genipin-crosslinked gelatin/nanosilver scaffolds with "green" in situ formation of silver nanoparticles by heat treatment is presented in this paper. In this procedure, toxic solvents, reducing agents, and stabilizing agents are avoided. UV-visible absorption spectra of the synthesized gelatin/nanosilver solutions were obtained immediately and three months after the synthesis revealing the presence and high stability of the silver nanoparticles. The TEM of gelatin/nanosilver solutions showed silver particles with spherical shapes that were less than 5 nm in size. Interestingly, contact angle was found to increase from 80°to 125°with the increase in concentration of nanosilver in gelatin. All gelatin/nanosilver solutions showed antimicrobial activity against Staphylococcus aureus and Escherichia coli. However, only the highest concentration showed antifungal effects against Candida albicans pathogens. Scaffolds were prepared by a lyophilization technique from this solution and their antimicrobial activities were examined. Introducing this facile green one-pot process of synthesizing scaffolds with antimicrobial and anti-biofilm properties may lead to key applications in tissue engineering techniques.
International Journal of Nanomedicine, 2013
Instruments, Methods, and Missions for Astrobiology XI, 2008
Numerous chemical additives lower the freezing point of water, but life at sub-zero temperatures ... more Numerous chemical additives lower the freezing point of water, but life at sub-zero temperatures is sustained by a limited number of biological cryoprotectants. Antifreeze proteins in fish, plants, and insects provide protection to a few degrees below freezing. Microbes have been found to survive at even lower temperatures, although, with a few exceptions, antifreeze proteins are missing. Survival has been attributed to external factors, such as high salt concentration (brine veins) and adhesion to particulates or ice crystal defects. Teichoic acid is a phosphodiester polymer ubiquitous in Gram positive bacteria, composing 50% of the mass of the bacterial cell wall and excreted into the extracellular space of biofilm communities. We have found that when bound to the peptidoglycan cell wall (wall teichoic acid) or as a free molecule (lipoteichoic acid), teichoic acid is surrounded by liquid water at temperatures significantly below freezing. Using solid-state NMR, we are unable to collect 31 P CPMAS spectra for frozen solutions of lipoteichoic acid at temperatures above -60 °C. For wall teichoic acid in D 2 O, signals are not seen above -30 °C. These results can be explained by the presence of liquid water, which permits rapid molecular motion to remove 1 H/ 31 P dipolar coupling. 2 H quadrupole echo NMR spectroscopy reveals that both liquid and solid water are present. We suggest that teichoic acids could provide a shell of liquid water around biofilms and planktonic bacteria, removing the need for brine veins to prevent bacterial freezing.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2007
A systematic study of 1,2-additions to 3,7-diheterabicyclo[3.3.1]nonan-9-ones (3,7-DHBCN-9-ONES) ... more A systematic study of 1,2-additions to 3,7-diheterabicyclo[3.3.1]nonan-9-ones (3,7-DHBCN-9-ONES) by symmetrically substituted aryl Grignard reagents in anhydrous THF or ether has been conducted. 1,2-Additions of aryl Grignard reagents to the carbonyl group at C-9 in 7-benzyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-one and 7-benzyl-3-thia-7-azabicyclo[3.3.1]nonan-9-one resulted in the formation of tertiary alcohols with the aryl group “syn” to the oxygen or sulfur atoms in the respective rings. The X-ray analyses demonstrated that the solid, bicyclic, oxygen-containing alcohol was in chair–chair form while the solid, bicyclic, sulfur-containing alcohol existed in chair–boat form. A tentative mechanism is that the Grignard reagent may coordinate with the oxygen atom and / or sulfur atom in a boat conformer of the bicyclic system prior to the attack from the “oxygen or sulfur sides.”
Phosphorus, Sulfur, and Silicon and the Related Elements, 2005
A series of derivatives of tetrahydro-4 H-pyran-4-one and tetrahydrothiopyran-4-one have been pre... more A series of derivatives of tetrahydro-4 H-pyran-4-one and tetrahydrothiopyran-4-one have been prepared by condensation with aryl Grignard reagents. IR spectra, 1 H and 13 C NMR spectral analyses, and elemental analyses support the structures. A single-crystal X-ray diffraction ...
The Journal of Chemical Physics, 1992
We describe here a new solid-state nuclear-magnetic-resonance (NMR) experiment for correlating an... more We describe here a new solid-state nuclear-magnetic-resonance (NMR) experiment for correlating anisotropic and isotropic chemical shifts of inequivalent nuclei in powdered samples. Spectra are obtained by processing signals arising from a spinning sample, acquired in independent experiments as a function of the angle between the axis of macroscopic rotation and the external magnetic field. This is in contrast to previously proposed techniques, which were based on sudden mechanical flippings or multiple-pulse sequences. We show that the time evolution of variable-angle-spinning signals is determined by a distribution relating the isotropic frequencies of the spins with their corresponding chemical shift anisotropies. Fourier transformation of these data therefore affords a twodimensional NMR spectrum, in which line shapes of isotropic and anisotropic interactions are correlated. Theoretical and experimental considerations involved in the extraction of this spectral information are discussed, and the technique is illustrated by an analysis of 13C NMR anisotropy in glycine, cysteine, and p-anisic acid. 4800
Israel Journal of Chemistry, 1992
Chemistry of Materials, 2003
A novel material, amorphous nanostructured HAlO, has been synthesized by the reaction of various ... more A novel material, amorphous nanostructured HAlO, has been synthesized by the reaction of various methylsiloxanes [e.g., (Me 2 HSi) 2 O] with the aluminum hydride H 3 Al‚NMe 3 in ether or aromatic solvents under mild conditions. Its high surface area of ca. 250 m 2 /g is due to both its small particle size of approximately 5 nm and its amorphous nanostructure. Its amorphous nature was demonstrated by TEM and XRD studies, and its composition was determined by elemental analysis, 1 H and 27 Al MAS solid-state NMR spectroscopies, and FT-IR spectroscopy. HAlO is an oxidic material that still contains a reactive aluminum hydride functional group. Prolonged heating at 200-250°C causes it to slowly decompose to aluminum metal and amorphous Al 2 O 3 without significantly changing the particle size or the BET surface area. This decomposition is accompanied by the loss of hydride and a decrease of the aluminum coordination number from five to four. HAlO reacts readily with protic reagents such as water or alcohols to give bayerite, Al(OH) 3 , or alkoxy alumoxanes (ROAlO) n . Annealing below its decomposition temperature led not to crystallization but rather to a dramatic decrease in reactivity. No reaction was observed between n-octanol and HAlO that had been annealed at 200°C even after 17 h at 90°C. HAlO cleanly reduces 2-cyclohexene-1-one to the corresponding alcohol, 2-cyclohexene-1-ol, and it converts Me 3 -SiCl to Me 3 SiH, although with a yield of only 24% for the latter. Corriu, R. J. P.; Leclercq, D.; Lefevre, P.; Mutin, P.
Biochemistry, 2005
Native-state hydrogen-deuterium exchange (HDX) monitored by NMR spectroscopy has been used to com... more Native-state hydrogen-deuterium exchange (HDX) monitored by NMR spectroscopy has been used to compare conformational plasticity in ferric rat liver outer mitochondrial membrane cytochrome b5 (rOM b5) and ferric bovine liver microsomal cytochrome b5 (bMc b5). Analysis of the data indicated that rOM b5 is the less conformationally flexible protein on the time scale probed by the HDX experiments. The data also suggest a likely contributor to the much higher kinetic barrier for the release of hemin from OM b5s in comparison to Mc b5s, a characteristic that may be to a large extent the source of their divergent functional properties. Specifically, the data indicate that conformational mobility within helices alpha4 and alpha5, which flank the loop harboring axial ligand His63, is considerably more restricted in rOM b5 than in bMc b5. The lower conformational flexibility of alpha4 and alpha5 in rOM b5 can reasonably be attributed to more extensive hydrophobic packing in that region of the protein, arising from two conserved side chain packing motifs in OM cytochrome b5s [Altuve, A., Wang, L., Benson, D. R., and Rivera, M. (2004) Biochem. Biophys. Res. Commun. 314, 602-609].
A new design for a double-tuned dynamic-angle-spinning (DAS) probe that employs a RF coil wrapped... more A new design for a double-tuned dynamic-angle-spinning (DAS) probe that employs a RF coil wrapped directly around the stator is presented. The increased filling factor of this design and the smaller RF coil result in improved sensitivity and facilitate the incorporation of 'H decoupling capabilities. Since the RF coil is reoriented with the spinning sample, the pulse lengths and sensitivity vary as the cosecant of the angle between the RF coil and the external magnetic field. However, this was not found to be a significant impediment to the usage of the probe. As a demonstration of the probes performance a 'H-decoupled "B DAS spectrum of boric acid is presented. o
Stable aqueous colloids of 2-3 nm In2S3 nanocrystals have been prepared by using the classical me... more Stable aqueous colloids of 2-3 nm In2S3 nanocrystals have been prepared by using the classical method of nanoparticle stabilization by low molecular weight thiols. TEM crystal lattice spacing, X-ray diffraction, EDAX data, and electron diffraction indicate that the nanoparticles are predominantly in In2S3 form. They exhibit relatively strong excitonic emission at 360-380 nm with a quantum yield of 1.5%. The excitonic radiative lifetime is 350 ns, which indicates that a direct allowed electronic transition is responsible for this emission. The NMR lines of the stabilizer are strongly broadened and shifted as a result of deshielding induced by electron withdrawing by positively charged metal ions. This effect quickly wears off as the carbon chain becomes longer and the separation between the hydrogen atoms of the stabilizer and the semiconductor surface increases. The broadening is attributed to the reduced mobility of the stabilizer in the nanoparticle shell. For CdS nanoparticles of the same size, this effect was found to be substantially stronger than for In2S3. The lower density of metal centers in In2S3than in CdS, which serve as anchor points for the stabilizer, promotes greater mobility of the stabilizer moieties.