Maria Ferraz - Academia.edu (original) (raw)
Papers by Maria Ferraz
Arquivos De Gastroenterologia, Mar 1, 2006
Journal of Hepatology, Apr 1, 2012
Transplantation Proceedings, 2020
ABCD Express, Nov 11, 2017
PubMed, Mar 1, 1995
AFP is an oncofetal protein found in increased levels in hepatocellular carcinoma, liver metastas... more AFP is an oncofetal protein found in increased levels in hepatocellular carcinoma, liver metastasis and other benign liver diseases. PURPOSE--To know the behaviour of this protein in each of these clinical situations would undoubtedly help us to discriminate between hepatocellular carcinoma and benign diseases. PATIENTS--A hundred forty nine patients were divided into 4 groups: 1. acute hepatitis (AH) n = 24, 2. chronic liver disease, viral or alcoholic (CLD) n = 81, 3. hepatic metastasis (HM) n = 29, 4. hepatocellular carcinoma (HCC) n = 15. AFP assays were done by ELISA (Abbott Diagnostica, ref. value: 15ng/mL). RESULTS--The results observed were as follows: AFP < 15ng/mL: AH 75%, CLD 86.4%, HM 79.3%, HCC 6.6%, AFP > 15 e < 100ng/mL: AH 25%, CLD 8.6%, HM 20.6%, HCC 20%, AFP > 100ng/mL: AH zero, CLD 4.9%, HM zero, HCC 49%. It is clear that depending on the cut off level, there is a decrease of sensibility which is paralleled by an increase in specificity. CONCLUSIONS--AFP levels are increased in benign liver diseases (AH, CLD) and HM, how ever levels above 100ng/mL occur much more frequently in HCC. In our sample, 93.3% of the HCC showed high levels of AFP, probably because most of the patients had advanced clinical stages of the disease.
Infection and Drug Resistance, Oct 1, 2018
OBM Transplantation
Hepatitis B virus (HBV) infection is frequent among patients with chronic kidney disease (CKD). H... more Hepatitis B virus (HBV) infection is frequent among patients with chronic kidney disease (CKD). HBV reactivation after kidney transplant (KT) is more common in patients with HBsAg+; however, it can also occur in previously infected individuals, particularly those with HBsAg negative and total antiHBc positive (HBsAg-/antiHBcT+). However, reactivation in this population has scarce and conflicting data. This study aimed to assess the reactivation risk in KT recipients with previous HBV infection (antiHBcT+). A retrospective cohort study was conducted, including patients with KT between January 1993 and December 2012 with HBsAg+ (G1) and with previous HBV infection (antiHBcT+) (G2). A total of 10,493 transplants were performed in this period. A total of 203 patients were included (122 HBsAg+ and 81 HBsAg-/anti-HBcT+). The reactivation of infection occurred in 24.6% (30/38) patients and 9.8% (8/30) in G1 and G2, respectively. Detectable HCV RNA, indicating HCV coinfection, was the only ...
The Brazilian Journal of Infectious Diseases, 2021
Annals of Hepatology, 2021
Annals of Hepatology, 2021
Annals of Hepatology, 2019
Gastroenterology, Hepatology and Endoscopy, 2018
Journal of Hepatology, 2016
Univ Fed Sao Paulo, Gastroenterol, Sao Paulo, Brazil[Univ Fed Sao Paulo, Pathol, Sao Paulo, Brazi... more Univ Fed Sao Paulo, Gastroenterol, Sao Paulo, Brazil[Univ Fed Sao Paulo, Pathol, Sao Paulo, BrazilUniv Fed Sao Paulo, Gastroenterol, Sao Paulo, BrazilUniv Fed Sao Paulo, Pathol, Sao Paulo, BrazilWeb of Scienc
Annals of Hepatology, 2021
Arquivos Brasileiros de Cirurgia Digestiva Express, 2017
Arquivos De Gastroenterologia, 2006
Arquivos de gastroenterologia, 2015
Background - Different factors are responsible for the progression of hepatic fibrosis in chronic... more Background - Different factors are responsible for the progression of hepatic fibrosis in chronic infection with hepatitis C virus, but the role of nutritional factors in the progression of the disease is not clearly defined. This study aimed to evaluate the nutritional status and dietary profile among patients with chronic hepatitis C who were candidates for treatment and its association with histopathological features. Methods - A crossectional study was conducted on treatment-naïve patients with chronic hepatitis C genotype 1, between 2011 and 2013. The following assessments were performed before treatment: liver biopsy, anthropometric measurements and qualitative/quantitative analysis of food intake. Results - Seventy patients were studied. The majority of patients was classified as obese (34%) or overweight (20%) according to body mass index [BMI] and as at risk for cardiovascular diseases by waist circumference (79%). Unhealthy food intake was presented by 59% according to qua...
Revista da Sociedade Brasileira de Medicina Tropical, 2015
Introdução: Embora existam poucos dados a respeito da interação hepatite autoimune (HAI) e gravid... more Introdução: Embora existam poucos dados a respeito da interação hepatite autoimune (HAI) e gravidez, recentemente foram descritos casos de remissão da doença durante a gravidez, sugerindo que a tolerância imunológica que ocorre durante esse período pode normalizar a função hepática e resultar em uma boa evolução obstétrica. Entretanto, a reativação da doença pode ocorrer logo após o parto. Objetivo: Avaliar os efeitos da gravidez sobre a evolução da doença em pacientes com HAI. Método: Foram analisadas retrospectivamente todas as pacientes atendidas de 1985 a 2005, com diagnóstico de HAI, no Setor de Hepatites da UNIFESP-EPM. Resultados: Entre 71 mulheres, 6 delas ficaram grávidas (8 gestações) durante o acompanhamento. A maioria (71,4%) era da raça branca; 50% com diagnóstico provável e 50% definitivo de HAI pelo escore internacional. Três (50%) foram classificadas como HAI tipo1, 2 (33%) tipo 2 e 1 (17%) tipo 3. Todas foram tratadas com Azatioprina (AZA) e Prednisona (Pred). Foram...
Arquivos De Gastroenterologia, Mar 1, 2006
Journal of Hepatology, Apr 1, 2012
Transplantation Proceedings, 2020
ABCD Express, Nov 11, 2017
PubMed, Mar 1, 1995
AFP is an oncofetal protein found in increased levels in hepatocellular carcinoma, liver metastas... more AFP is an oncofetal protein found in increased levels in hepatocellular carcinoma, liver metastasis and other benign liver diseases. PURPOSE--To know the behaviour of this protein in each of these clinical situations would undoubtedly help us to discriminate between hepatocellular carcinoma and benign diseases. PATIENTS--A hundred forty nine patients were divided into 4 groups: 1. acute hepatitis (AH) n = 24, 2. chronic liver disease, viral or alcoholic (CLD) n = 81, 3. hepatic metastasis (HM) n = 29, 4. hepatocellular carcinoma (HCC) n = 15. AFP assays were done by ELISA (Abbott Diagnostica, ref. value: 15ng/mL). RESULTS--The results observed were as follows: AFP < 15ng/mL: AH 75%, CLD 86.4%, HM 79.3%, HCC 6.6%, AFP > 15 e < 100ng/mL: AH 25%, CLD 8.6%, HM 20.6%, HCC 20%, AFP > 100ng/mL: AH zero, CLD 4.9%, HM zero, HCC 49%. It is clear that depending on the cut off level, there is a decrease of sensibility which is paralleled by an increase in specificity. CONCLUSIONS--AFP levels are increased in benign liver diseases (AH, CLD) and HM, how ever levels above 100ng/mL occur much more frequently in HCC. In our sample, 93.3% of the HCC showed high levels of AFP, probably because most of the patients had advanced clinical stages of the disease.
Infection and Drug Resistance, Oct 1, 2018
OBM Transplantation
Hepatitis B virus (HBV) infection is frequent among patients with chronic kidney disease (CKD). H... more Hepatitis B virus (HBV) infection is frequent among patients with chronic kidney disease (CKD). HBV reactivation after kidney transplant (KT) is more common in patients with HBsAg+; however, it can also occur in previously infected individuals, particularly those with HBsAg negative and total antiHBc positive (HBsAg-/antiHBcT+). However, reactivation in this population has scarce and conflicting data. This study aimed to assess the reactivation risk in KT recipients with previous HBV infection (antiHBcT+). A retrospective cohort study was conducted, including patients with KT between January 1993 and December 2012 with HBsAg+ (G1) and with previous HBV infection (antiHBcT+) (G2). A total of 10,493 transplants were performed in this period. A total of 203 patients were included (122 HBsAg+ and 81 HBsAg-/anti-HBcT+). The reactivation of infection occurred in 24.6% (30/38) patients and 9.8% (8/30) in G1 and G2, respectively. Detectable HCV RNA, indicating HCV coinfection, was the only ...
The Brazilian Journal of Infectious Diseases, 2021
Annals of Hepatology, 2021
Annals of Hepatology, 2021
Annals of Hepatology, 2019
Gastroenterology, Hepatology and Endoscopy, 2018
Journal of Hepatology, 2016
Univ Fed Sao Paulo, Gastroenterol, Sao Paulo, Brazil[Univ Fed Sao Paulo, Pathol, Sao Paulo, Brazi... more Univ Fed Sao Paulo, Gastroenterol, Sao Paulo, Brazil[Univ Fed Sao Paulo, Pathol, Sao Paulo, BrazilUniv Fed Sao Paulo, Gastroenterol, Sao Paulo, BrazilUniv Fed Sao Paulo, Pathol, Sao Paulo, BrazilWeb of Scienc
Annals of Hepatology, 2021
Arquivos Brasileiros de Cirurgia Digestiva Express, 2017
Arquivos De Gastroenterologia, 2006
Arquivos de gastroenterologia, 2015
Background - Different factors are responsible for the progression of hepatic fibrosis in chronic... more Background - Different factors are responsible for the progression of hepatic fibrosis in chronic infection with hepatitis C virus, but the role of nutritional factors in the progression of the disease is not clearly defined. This study aimed to evaluate the nutritional status and dietary profile among patients with chronic hepatitis C who were candidates for treatment and its association with histopathological features. Methods - A crossectional study was conducted on treatment-naïve patients with chronic hepatitis C genotype 1, between 2011 and 2013. The following assessments were performed before treatment: liver biopsy, anthropometric measurements and qualitative/quantitative analysis of food intake. Results - Seventy patients were studied. The majority of patients was classified as obese (34%) or overweight (20%) according to body mass index [BMI] and as at risk for cardiovascular diseases by waist circumference (79%). Unhealthy food intake was presented by 59% according to qua...
Revista da Sociedade Brasileira de Medicina Tropical, 2015
Introdução: Embora existam poucos dados a respeito da interação hepatite autoimune (HAI) e gravid... more Introdução: Embora existam poucos dados a respeito da interação hepatite autoimune (HAI) e gravidez, recentemente foram descritos casos de remissão da doença durante a gravidez, sugerindo que a tolerância imunológica que ocorre durante esse período pode normalizar a função hepática e resultar em uma boa evolução obstétrica. Entretanto, a reativação da doença pode ocorrer logo após o parto. Objetivo: Avaliar os efeitos da gravidez sobre a evolução da doença em pacientes com HAI. Método: Foram analisadas retrospectivamente todas as pacientes atendidas de 1985 a 2005, com diagnóstico de HAI, no Setor de Hepatites da UNIFESP-EPM. Resultados: Entre 71 mulheres, 6 delas ficaram grávidas (8 gestações) durante o acompanhamento. A maioria (71,4%) era da raça branca; 50% com diagnóstico provável e 50% definitivo de HAI pelo escore internacional. Três (50%) foram classificadas como HAI tipo1, 2 (33%) tipo 2 e 1 (17%) tipo 3. Todas foram tratadas com Azatioprina (AZA) e Prednisona (Pred). Foram...