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Papers by Maria Longu

Research paper thumbnail of Gotta secondaria ad adenocarcinoma del retto: case-report

Research paper thumbnail of Asymmetric dimethylarginine and arterial stiffness in patients with rheumatoid arthritis: A case-control study

Journal of International Medical Research, 2016

Objective: To investigate whether levels of asymmetric dimethylarginine (ADMA), as a measure of e... more Objective: To investigate whether levels of asymmetric dimethylarginine (ADMA), as a measure of endothelial dysfunction, are higher in patients with rheumatoid arthritis compared with healthy control subjects. The relationships between ADMA and surrogate measures of arterial stiffness were evaluated. Methods: Patients with rheumatoid arthritis and healthy control subjects were recruited. ADMA was quantified via enzyme-linked immunosorbent assay. Arterial stiffness was evaluated using pulse wave analysis. Results: There was no significant difference in plasma ADMA concentration between patients with rheumatoid arthritis (n ¼ 30) and healthy controls (n ¼ 30). Aortic augmentation pressure was significantly higher in patients than in controls. C-reactive protein and Health Assessment Questionnaire score were independent predictors of arterial stiffness in patients. There was no relationship between ADMA concentration and aortic augmentation pressure in the study population as a whole. Conclusions: Arterial stiffness appears to be increased in rheumatoid arthritis and independently associated with systemic inflammation and physical disability. ADMA concentration was not increased in this small group of patients with rheumatoid arthritis compared with healthy controls; nor was it associated with arterial stiffness.

Research paper thumbnail of P112. Effetto di Rituximab sulle manifestazioni clinico-sierologiche della sindrome da anticorpi antifosfolipidi: report di un caso clinico

Research paper thumbnail of Squamous-cell carcinoma of the tongue following therapy of rheumatoid arthritis with abatacept

Clinical Case Reports, 2014

A patient affected by rheumatoid arthritis developed a squamous-cell carcinoma probably due to ab... more A patient affected by rheumatoid arthritis developed a squamous-cell carcinoma probably due to abatacept, according to Naranjo algorithm. The case describes this adverse reaction for the first time and highlights the need for additional studies to establish the long-term risk profile of abatacept.

Research paper thumbnail of Antiphospholipid syndrome nephropathy (APSN) in patients with lupus nephritis: a retrospective clinical and renal pathology study

Rheumatology international, 2014

Data about clinical-laboratory features and outcome of antiphospholipid syndrome nephropathy (APS... more Data about clinical-laboratory features and outcome of antiphospholipid syndrome nephropathy (APSN) in the course of lupus nephritis (LN) are scarce. To determine prevalence, clinical correlations and outcome of APSN in patients with LN, retrospective analysis of renal specimens and review of medical records from 48 LN patients were performed. APSN was found in 12/48 (25 %) of LN. Positivity for lupus anticoagulant (LAC) and double antiphospholipids positivity [LAC plus anticardiolipin (aCL)] were significantly more frequent in APSN-LN (p = 0.02 and p = 0.01, respectively) than in LN, while single aCL positivity was not. Overt antiphospholipid syndrome appeared more frequent in patients with APSN-LN (p = 0.05). There were no statistically significant differences between APSN-LN and LN in the proportion of each World Health Organization class of LN (with the exception of a trend toward fewer Class III LN in APS-LN) and in the systemic lupus erythematosus (SLE) disease duration and se...

Research paper thumbnail of Gotta secondaria ad adenocarcinoma del retto: case-report

Research paper thumbnail of Asymmetric dimethylarginine and arterial stiffness in patients with rheumatoid arthritis: A case-control study

Journal of International Medical Research, 2016

Objective: To investigate whether levels of asymmetric dimethylarginine (ADMA), as a measure of e... more Objective: To investigate whether levels of asymmetric dimethylarginine (ADMA), as a measure of endothelial dysfunction, are higher in patients with rheumatoid arthritis compared with healthy control subjects. The relationships between ADMA and surrogate measures of arterial stiffness were evaluated. Methods: Patients with rheumatoid arthritis and healthy control subjects were recruited. ADMA was quantified via enzyme-linked immunosorbent assay. Arterial stiffness was evaluated using pulse wave analysis. Results: There was no significant difference in plasma ADMA concentration between patients with rheumatoid arthritis (n ¼ 30) and healthy controls (n ¼ 30). Aortic augmentation pressure was significantly higher in patients than in controls. C-reactive protein and Health Assessment Questionnaire score were independent predictors of arterial stiffness in patients. There was no relationship between ADMA concentration and aortic augmentation pressure in the study population as a whole. Conclusions: Arterial stiffness appears to be increased in rheumatoid arthritis and independently associated with systemic inflammation and physical disability. ADMA concentration was not increased in this small group of patients with rheumatoid arthritis compared with healthy controls; nor was it associated with arterial stiffness.

Research paper thumbnail of P112. Effetto di Rituximab sulle manifestazioni clinico-sierologiche della sindrome da anticorpi antifosfolipidi: report di un caso clinico

Research paper thumbnail of Squamous-cell carcinoma of the tongue following therapy of rheumatoid arthritis with abatacept

Clinical Case Reports, 2014

A patient affected by rheumatoid arthritis developed a squamous-cell carcinoma probably due to ab... more A patient affected by rheumatoid arthritis developed a squamous-cell carcinoma probably due to abatacept, according to Naranjo algorithm. The case describes this adverse reaction for the first time and highlights the need for additional studies to establish the long-term risk profile of abatacept.

Research paper thumbnail of Antiphospholipid syndrome nephropathy (APSN) in patients with lupus nephritis: a retrospective clinical and renal pathology study

Rheumatology international, 2014

Data about clinical-laboratory features and outcome of antiphospholipid syndrome nephropathy (APS... more Data about clinical-laboratory features and outcome of antiphospholipid syndrome nephropathy (APSN) in the course of lupus nephritis (LN) are scarce. To determine prevalence, clinical correlations and outcome of APSN in patients with LN, retrospective analysis of renal specimens and review of medical records from 48 LN patients were performed. APSN was found in 12/48 (25 %) of LN. Positivity for lupus anticoagulant (LAC) and double antiphospholipids positivity [LAC plus anticardiolipin (aCL)] were significantly more frequent in APSN-LN (p = 0.02 and p = 0.01, respectively) than in LN, while single aCL positivity was not. Overt antiphospholipid syndrome appeared more frequent in patients with APSN-LN (p = 0.05). There were no statistically significant differences between APSN-LN and LN in the proportion of each World Health Organization class of LN (with the exception of a trend toward fewer Class III LN in APS-LN) and in the systemic lupus erythematosus (SLE) disease duration and se...

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