Marianna Vitaloni - Academia.edu (original) (raw)

Papers by Marianna Vitaloni

Annals of the Rheumatic Diseases, May 19, 2021

Conclusion: The majority of activity limitations reported by patients receiving a structured OA c... more Conclusion: The majority of activity limitations reported by patients receiving a structured OA care model in primary care were within the ICF Mobility domain. The most common third-level ICF domains were Changing body positions, Walking and Moving around. After participating in OA patient education and structured 8-12 weeks of exercise, the patients reported a statistically significant and clinically important improvement in the difficulty of performing their individual activities. REFERENCES: [1] Allen KD, Choong PF, Davis AM, et al. Osteoarthritis: Models for appropriate care across the disease continuum.

BMC Musculoskeletal Disorders, Nov 7, 2020

Background: Globally, osteoarthritis (OA) is the third condition associated with disability. Ther... more Background: Globally, osteoarthritis (OA) is the third condition associated with disability. There is still poor treatment in OA but science holds the key to finding better treatments and a cure. It is essential to learn what's important to patients from them to implement the most effective OA management. The OA Patients Task Force, conducted the Global OA Patient Perception Survey (GOAPPS)-the first global survey made by patients to analize the quality of life (QoL) & patient perceptions of care. The goal was to collect data on OA patients' perception of OA to understand patients' needs and expectations to improve OA management. Methods: Observational, cross-sectional study by online survey data collection from six countries, translated into three languages. The questionnaire was comprised of 3 sections: patient demographics and clinical symptomology characteristics; relationship with physicians: perception of attention, treatment, and information provided; and OA impact on daily activity and QoL. The results of the survey were evaluated using the Limited Data Set. The survey results were analyzed using descriptive statistics to characterize the patients' answers. Additionally, Cronbach's alpha was calculated to determine internal consistency validity. Results: A total of 1512 surveys were completed in 6 countries. 84.2% of respondents reported pain/tenderness and 91.1% experienced limitations to physical activities. 42.3% of patients were not satisfied with their current OA treatment. 86% had comorbidities, especially hypertension, and obesity. 51.3 and 78% would like access to additional drug or additional non-drug/non-surgical treatments respectively. 48.2% of patients perceived their QoL to be affected by OA. The Cronbach's alpha was 0.61. Conclusions: OA has a significant impact on patients' daily activities and their desire to play an active role in managing this disease. Patients are seeking additional treatments, especially no pharmacological/no surgical treatments stressing the need for investing in clinical research, implementing OA preventive measures, and managing interventions to improve the healthcare value chain in OA.

Stem Cells, Jul 24, 2012

The efficiency of somatic cell reprogramming to pluripotency using defined factors is dramaticall... more The efficiency of somatic cell reprogramming to pluripotency using defined factors is dramatically affected by the cell type of origin. Here, we show that human keratinocytes, which can be reprogrammed at a higher efficiency than fibroblast [Nat Biotechnol 2008;26:1276-1284], share more genes hypermethylated at CpGs with human embryonic stem cells (ESCs) than other somatic cells frequently used for reprogramming. Moreover, pluripotent cells reprogrammed from keratinocytes (KiPS) are more similar to ESCs than those reprogrammed from fibroblasts (FiPS) in regard to DNA methylation levels, mostly due to the presence of genes that fail to acquire high levels of DNA methylation in FiPS cells. We propose that higher reprogramming efficiency correlates with the hypermethylation of tissuespecific genes rather than with a more permissive pluripotency gene network.

Therapeutic Advances in Musculoskeletal Disease

Background: Several studies have reported that the use of chondroitin sulphate (CS) and glucosami... more Background: Several studies have reported that the use of chondroitin sulphate (CS) and glucosamine may reduce the risk of acute myocardial infarction. Although it is thought that this potential benefit could be extended to ischaemic stroke (IS), the evidence is scarce. Objective: To test the hypothesis that the use of prescription glucosamine or CS reduces the risk of IS. Design: Case–control study nested in an open cohort. Methods: Patients aged 40–99 years registered in a Spanish primary healthcare database (BIFAP) during the 2002–2015 study period. From this cohort, we identified incident cases of IS, applying a case-finding algorithm and specific validation procedures, and randomly sampled five controls per case, individually matched with cases by exact age, gender and index date. Adjusted odds ratios (AORs) and 95% confidence interval (CI) were computed through a conditional logistic regression. Only new users of glucosamine or CS were considered. Results: A total of 13,952 in...

Journal of Patient Experience

Pancreatic cancer is a disease requiring urgent attention from governments and policymakers. Rece... more Pancreatic cancer is a disease requiring urgent attention from governments and policymakers. Recently, a state of emergency has been declared for this cancer—being the fourth most common cause of cancer deaths in the European Union, it has the lowest survival rate of all common cancers. One of the major reasons pancreatic cancer is associated with such poor outcomes is because it is usually diagnosed at a late stage. Also, investment in research for effective targeted therapies is lacking. This is the perspective of a white paper developed by Digestive Cancers Europe, an umbrella organisation representing European patient organisations. It has been developed after consultation with pancreatic cancer patients, representatives of cancer patient organisations and leading pancreatic cancer healthcare professionals. The purpose of the paper is to highlight the key urgent unmet needs in pancreatic cancer from the patient perspective, ultimately with a view to improve patient care and outc...

Supportive Care in Cancer

Nutritional intervention is an essential part of cancer treatments. Research and clinical evidenc... more Nutritional intervention is an essential part of cancer treatments. Research and clinical evidence in cancer have shown that nutritional support can reduce length of hospitalisation, diminish treatment-related toxicity, and improve nutrient intake, quality of life, and physical function. Nutritional intervention can improve outcomes and help patients in the successful completion of oncological treatments by preventing malnutrition. Malnutrition is a very common hallmark in patients with cancers. Almost one-fourth of cancer patients are at risk of dying because of the consequences of malnutrition, rather than cancer itself. Patients with digestive cancers are at higher risk of suffering malnutrition due to the gastrointestinal impairment caused by their disease. They are at high nutritional risk by definition, yet the majority of them have insufficient or null access to nutritional intervention.Inadequate resources are dedicated to implementing nutritional services in Europe. Univers...

Additional file 4. Table showing participants' responses to questions related to the causes o... more Additional file 4. Table showing participants' responses to questions related to the causes of OA and their relationship with their doctor.

Additional file 5. Table reporting the limitations experienced due by OA as reported.

Additional file 3. Figure showing the joints reported by participants in the category "other... more Additional file 3. Figure showing the joints reported by participants in the category "other". Patients could report OA in joints other than the options offered as an answer (knee, hip, spine, hand). Each column represents the localization(s) of OA as diagnosed by their medical doctor.

Additional file 3: Table S1. Quality of life of KOA patients vs. reference population by instrume... more Additional file 3: Table S1. Quality of life of KOA patients vs. reference population by instrument used. Table comparing the variable values in KOA patientâ s population with reference populations and statistical significance analysis. The data are organized by article.

Additional file 2. Quality appraisal report results obtained after the evaluation of articles qua... more Additional file 2. Quality appraisal report results obtained after the evaluation of articles quality based on the Cochrane modified instrument rated by three independent reviewers and the mean value of the three scores.

Additional file 1: Figure S1. Flowchart used in the selection of the articles included in the stu... more Additional file 1: Figure S1. Flowchart used in the selection of the articles included in the study. The flowchart shows the sequence of criteria followed for the selection of the articles included in the study.

Additional file 1. Global Osteoarthritis Patient Perception Survey (GOAPPS) questionnaire. Englis... more Additional file 1. Global Osteoarthritis Patient Perception Survey (GOAPPS) questionnaire. English version.

Patient information and education, 2019

Abstracts Accepted for Publication, 2019

Conclusion: Although both treatment groups present the same OA radiologic grade, ART group presen... more Conclusion: Although both treatment groups present the same OA radiologic grade, ART group presents significant higher stiffness and functional disability. That may affect to the gait of these ART patients, altering the forces distribution and torques between both legs. Although no differences in knee pain in life situation (Wp) between treatment group are reported, ART group present more painful sites in the knee with pressure stimuli. Emotional component may be playing a role in the pain and illness perception, influencing the patient decision to undergo ART surgery

Osteoarthritis and Cartilage, 2019

vs. high HRQoL (score 50, above the population norm). Logistic regression investigated the relati... more vs. high HRQoL (score 50, above the population norm). Logistic regression investigated the relationship between joint pain, physical activity and HRQoL. Unadjusted and adjusted odds ratios (95% confidence intervals) were calculated. Odds ratios were adjusted for age, body mass index, and the presence of comorbidities. All assumptions for logistic regression were evaluated and satisfied. Results: A total of 570 former cricketers, aged 58 (SD 13) years, BMI of 28.2 (SD 5.4) kg/m 2 , who had played on average 29 (SD 14) cricket seasons, were included in the analyses. 83 (15%) former cricketers had only upper-limb pain, 170 (30%) had only lower-limb pain, and 317 (55%) had no joint pain. 79 (16%) former cricketers did not meet the physical activity guidelines, 190 (36%) reported PCS scores worse than the population norm and 134 (25%) reported MCS scores worse than the population norm. Upper-limb pain was not associated with meeting the physical activity guidelines (OR 2.3; 95% CI 0.9 to 5.8). Former cricketers with lower-limb pain had a 2.9 (95% CI 1.0 to 3.6) times greater odds of not meeting the physical activity guidelines compared to those with no pain (Table 1). The MCS means per group were: upper-limb pain: 48.75 (SD 7.79); lower-limb pain: 45.99 (SD 8.12); no pain: 52.52 (SD 6.79). The PCS mean scores were: upper limb pain: 53.44 (SD 7.76); lowerlimb pain: 53.37 (SD 7.46); no pain: 52.29 (SD 8.05). Former cricketers with upper-limb pain had a 2.5 (95% CI 1.4 to 4.3) times greater odds of reporting a PCS score worse than the population norm, compared to those with no pain. Former cricketers with lower-limb pain had a 4.4 (95% CI 2.8 to 6.9) times greater odds of reporting a PCS score worse than the population norm, compared to those with no pain (Table 2). Joint pain was not associated with MCS scores (Upper-Limb: 0.7; 95% CI 0.4 to 1.4); Lower-Limb: 0.9; 95% CI 0.6 to 1.5) (Table 3). Conclusions: Individuals with lower-limb joint pain were more likely to have reduced physical activity levels compared to those with no joint pain, however this relationship was not observed for individuals with upper-limb joint pain. Both upper-limb and lower-limb joint pain was associated with worse physical components of HRQoL compared with no joint pain. In contrast, mental components of HRQoL were not associated with joint pain. Further research is needed to better understand physical activity impairments and factors influencing HRQoL in former sport participants with upper-limb and lower-limb OA.

Cell Reports, 2016

Highlights d A defined set of six factors directly converts fibroblasts to megakaryocyte progenit... more Highlights d A defined set of six factors directly converts fibroblasts to megakaryocyte progenitors d Transdifferentiated cells engraft and differentiate upon transplantation in NSG mice d Megakaryocytes and platelets can be generated from fibroblasts of Fanconi anemia patients

Stem Cells, 2014

Reprogramming technologies have emerged as a promising approach for future regenerative medicine.... more Reprogramming technologies have emerged as a promising approach for future regenerative medicine. Here, we report on the establishment of a novel methodology allowing for the conversion of human fibroblasts into hematopoietic progenitor-like cells with macrophage differentiation potential. SOX2 overexpression in human fibroblasts, a gene found to be upregulated during hematopoietic reconstitution in mice, induced the rapid appearance of CD34+ cells with a concomitant upregulation of mesoderm-related markers. Profiling of cord blood hematopoietic progenitor cell populations identified miR-125b as a factor facilitating commitment of SOX2-generated CD34+ cells to immature hematopoietic-like progenitor cells with grafting potential. Further differentiation toward the monocytic lineage resulted in the appearance of CD14+ cells with functional phagocytic capacity. In vivo transplantation of SOX2/miR-125b-generated CD34+ cells facilitated the maturation of the engrafted cells toward CD45+ ...

STEM CELLS, 2012