Marianne Goodman - Academia.edu (original) (raw)
Papers by Marianne Goodman
Psychiatric Rehabilitation Journal, 1998
Biological Psychiatry, 2012
Background-Borderline personality disorder (BPD) is characterized by an inability to regulate emo... more Background-Borderline personality disorder (BPD) is characterized by an inability to regulate emotional responses. The amygdala is important in learning about the valence (goodness and badness) of stimuli and has been reported to function abnormally in BPD. Methods-Event-related functional MRI (fMRI) was employed in three groups: unmedicated BPD (n=33) and schizotypal personality disorder (SPD;n=28) participants and healthy controls (n=32) during a task involving an intermixed series of unpleasant, neutral, and pleasant pictures each presented twice within their respective trial block/run. The amygdala was hand-traced on each participant's structural-MRI scan which was co-registered to their BOLD-scan. Amygdala responses were examined with a mixed-model MANOVA with repeated measures. Results-Compared with both control groups, BPD patients showed greater amygdala activation, particularly to the repeated emotional but not neutral pictures and a prolonged return to baseline for the overall BOLD response averaged across all pictures. Despite amygdala overactivation, BPD patients showed a blunted response on the self-report ratings of emotional but not neutral pictures. Fewer dissociative symptoms in both patient groups were associated with greater amygdala activation to repeated unpleasant pictures. Conclusions-The increased amygdala response to the repeated emotional pictures observed in BPD was not observed in SPD patients suggesting diagnostic specificity. This BPD-related abnormality is consistent with the well-documented clinical feature of high sensitivity to emotional stimuli with unusually strong and long-lasting reactions. The finding of a mismatch between physiological and self-report measures of emotion reactivity in BPD patients suggests they may benefit from treatments which help them recognize emotions.
Psychiatry Research: Neuroimaging, 2009
Emotional instability is a hallmark feature of borderline personality disorder (BPD), yet its bio... more Emotional instability is a hallmark feature of borderline personality disorder (BPD), yet its biological underpinnings are poorly understood. We employed functional MRI to compare patterns of regional brain activation in BPD patients and healthy volunteers as they process positive and negative social emotional stimuli. fMRI images were acquired while 19 BPD patients and 17 healthy controls (HC) viewed emotion-inducing pictures from the IAPS set. Activation data were analyzed with SPM5 ANCOVA models to derive the effects of diagnosis and stimulus type. BPD patients demonstrated greater differences in activation than controls, when viewing negative pictures compared to rest, in the amygdala, fusiform gyrus, primary visual areas, superior temporal gyrus (STG), and premotor areas, while healthy controls showed greater differences than BPD's in the insula, middle temporal gyrus and dorsolateral prefrontal cortex (BA46). When viewing positive pictures compared to rest, BPD patients showed greater differences in the STG, premotor cortex, and ventrolateral prefrontal cortex. These findings suggest that BPD patients show greater amygdala activity and heightened activity of visual processing regions than HC's, when processing negative social emotional pictures compared to rest. They activate neural networks in emotion processing that are phylogenetically older and more reflexive than healthy controls.
The goal of this study was to examine the effects of personality traits as measured by the NEO-PI... more The goal of this study was to examine the effects of personality traits as measured by the NEO-PI on the quality of life (QOL) of persons with schizoaffective disorder and schizophrenia. The premise of this research is that personality traits may be important in shaping one's outlook and satisfaction with life. In a prior pilot study, personality traits were measured in persons with schizoaffective disorder and schizophrenia. In this study, the relationship between QOL and specific personality domains as assessed by the NEO-PI were studied in 21 patients. Global QOL as measured by the Lehman QOL instrument was positively correlated with Extroversion (E) and Agreeableness (A), and negatively correlated with the domain of Neuroticism (N). Global satisfaction scores were not correlated with ratings of psychoticism, paranoia or depression. These data suggest that even in psychotic conditions such as schizoaffective disorder or schizophrenia, intrapsychic factors influence one's sense of QOL. In addition, these data suggest that personality variables may differentially affect patients' satisfaction and QOL with different treatment settings.
Psychiatry Research, 1997
A cohort of acutely ill, hospitalized patients with chronic psychotic disorders participated in a... more A cohort of acutely ill, hospitalized patients with chronic psychotic disorders participated in a study of a manualized community reintegration skills training program. Initial data analyses revealed that skill levels improved significantly over the course of treatment, and that higher post-training skill levels were associated with better post-discharge functioning for the group as a whole. Post-discharge treatment adherence rates were dramatically better in females, and analyses were conducted to determine the role of gender. Males and females had different predictors of post-training skill level and post-discharge treatment adherence. In males, who as a group were at higher risk for poor post-discharge outcome, there was a positive association between post-training skill level and post-discharge treatment adherence. Females, on the other hand, showed good post-discharge treatment adherence regardless of post-training skill or symptom levels. This report is consistent with prior studies suggesting that male and female individuals with schizophrenia show differential patterns of social skill, skill improvement, and social adjustment.
Schizophrenia Research, 1997
Using a naturalistic studies design, our group recently reported data on the effectiveness of the... more Using a naturalistic studies design, our group recently reported data on the effectiveness of the Community Re-Entry Program, a brief, time-limited skills training module that teaches acutely ill inpatients skills for engagement with community-based treatment programs. Data from a cohort of 44 subjects showed that while positive and negative symptoms diminished over the course of an inpatient hospitalization,
Schizophrenia Research, 1997
Ratings (RRA) as a predictor of successful rehabilitation outcome in subjects with chronic schizo... more Ratings (RRA) as a predictor of successful rehabilitation outcome in subjects with chronic schizophrenia. Methods: As part of their clinical treatment, 32 schizophrenic patients attending a continuing day treatment program participated in a Rehabilitation Assessment Group for eight one hour sessions in which each subject's readiness to set a goal in the environments of living, learning, working and socializing was assessed. Six months later, each subject was interviewed to determine the degree to which changes had been accomplished in these four environments. Results: There was a statistically significant positive correlation between the degree of expressed rehabilitation readiness with a particular environment in patients ' lives and their ability to effect a change. There was no correlation between age, or length of treatment and the degree to which they made a change in that particular environment. Conclusion: These data suggest that a patient's expressed readiness for rehabilitative change is the best predictor of making change. Also, that satisfaction and dissatisfaction is not limited to a single domain but seems to be generalized across the four environments.
Psychiatric Rehabilitation Journal, 1997
ABSTRACT
Evaluation and Program Planning, 1997
... Diamond, Sainfort, 1993; Bigelow, Brodsky, Steward, Olson, 1982; Heinrichs, Hanlon, Carpenter... more ... Diamond, Sainfort, 1993; Bigelow, Brodsky, Steward, Olson, 1982; Heinrichs, Hanlon, Carpenter, 1984; Lehman, 1988; Malm, May, Dencker, 1981; Stein ... asks patient's opinions regarding factual matters and subjective attitudes in a highly structured interview for mat and ratings ...
Journal of Psychiatric Research, 2010
Background-There is decreased serotonergic function in impulsive aggression and borderline person... more Background-There is decreased serotonergic function in impulsive aggression and borderline personality disorder (BPD), and genetic association studies suggest a role of serotonergic genes in impulsive aggression and BPD. Only one study has analyzed the association between the tryptophanhydroxylase 2 (TPH2) gene and BPD. A TPH2 "risk" haplotype has been described that is associated with anxiety, depression and suicidal behavior.
Schizophrenia …, 1997
Recent studies suggest that schizophrenic symptoms can be categorized into three domains: Positiv... more Recent studies suggest that schizophrenic symptoms can be categorized into three domains: Positive, Negative, and Disorganized (eg Andreasen et al, 1995). In an effort to further validate this notion, these symptom areas were tracked longitudinally in 26 schizophrenic ...
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 1997
The goal of this study was to examine the effects of personality traits as measured by the NEO-PI... more The goal of this study was to examine the effects of personality traits as measured by the NEO-PI on the quality of life (QOL) of persons with schizoaffective disorder and schizophrenia. The premise of this research is that personality traits may be important in shaping one's outlook and satisfaction with life. In a prior pilot study, personality traits were measured in persons with schizoaffective disorder and schizophrenia. In this study, the relationship between QOL and specific personality domains as assessed by the NEO-PI were studied in 21 patients. Global QOL as measured by the Lehman QOL instrument was positively correlated with Extroversion (E) and Agreeableness (A), and negatively correlated with the domain of Neuroticism (N). Global satisfaction scores were not correlated with ratings of psychoticism, paranoia or depression. These data suggest that even in psychotic conditions such as schizoaffective disorder or schizophrenia, intrapsychic factors influence one's ...
Psychiatric Rehabilitation Journal, 1998
Biological Psychiatry, 2012
Background-Borderline personality disorder (BPD) is characterized by an inability to regulate emo... more Background-Borderline personality disorder (BPD) is characterized by an inability to regulate emotional responses. The amygdala is important in learning about the valence (goodness and badness) of stimuli and has been reported to function abnormally in BPD. Methods-Event-related functional MRI (fMRI) was employed in three groups: unmedicated BPD (n=33) and schizotypal personality disorder (SPD;n=28) participants and healthy controls (n=32) during a task involving an intermixed series of unpleasant, neutral, and pleasant pictures each presented twice within their respective trial block/run. The amygdala was hand-traced on each participant's structural-MRI scan which was co-registered to their BOLD-scan. Amygdala responses were examined with a mixed-model MANOVA with repeated measures. Results-Compared with both control groups, BPD patients showed greater amygdala activation, particularly to the repeated emotional but not neutral pictures and a prolonged return to baseline for the overall BOLD response averaged across all pictures. Despite amygdala overactivation, BPD patients showed a blunted response on the self-report ratings of emotional but not neutral pictures. Fewer dissociative symptoms in both patient groups were associated with greater amygdala activation to repeated unpleasant pictures. Conclusions-The increased amygdala response to the repeated emotional pictures observed in BPD was not observed in SPD patients suggesting diagnostic specificity. This BPD-related abnormality is consistent with the well-documented clinical feature of high sensitivity to emotional stimuli with unusually strong and long-lasting reactions. The finding of a mismatch between physiological and self-report measures of emotion reactivity in BPD patients suggests they may benefit from treatments which help them recognize emotions.
Psychiatry Research: Neuroimaging, 2009
Emotional instability is a hallmark feature of borderline personality disorder (BPD), yet its bio... more Emotional instability is a hallmark feature of borderline personality disorder (BPD), yet its biological underpinnings are poorly understood. We employed functional MRI to compare patterns of regional brain activation in BPD patients and healthy volunteers as they process positive and negative social emotional stimuli. fMRI images were acquired while 19 BPD patients and 17 healthy controls (HC) viewed emotion-inducing pictures from the IAPS set. Activation data were analyzed with SPM5 ANCOVA models to derive the effects of diagnosis and stimulus type. BPD patients demonstrated greater differences in activation than controls, when viewing negative pictures compared to rest, in the amygdala, fusiform gyrus, primary visual areas, superior temporal gyrus (STG), and premotor areas, while healthy controls showed greater differences than BPD's in the insula, middle temporal gyrus and dorsolateral prefrontal cortex (BA46). When viewing positive pictures compared to rest, BPD patients showed greater differences in the STG, premotor cortex, and ventrolateral prefrontal cortex. These findings suggest that BPD patients show greater amygdala activity and heightened activity of visual processing regions than HC's, when processing negative social emotional pictures compared to rest. They activate neural networks in emotion processing that are phylogenetically older and more reflexive than healthy controls.
The goal of this study was to examine the effects of personality traits as measured by the NEO-PI... more The goal of this study was to examine the effects of personality traits as measured by the NEO-PI on the quality of life (QOL) of persons with schizoaffective disorder and schizophrenia. The premise of this research is that personality traits may be important in shaping one's outlook and satisfaction with life. In a prior pilot study, personality traits were measured in persons with schizoaffective disorder and schizophrenia. In this study, the relationship between QOL and specific personality domains as assessed by the NEO-PI were studied in 21 patients. Global QOL as measured by the Lehman QOL instrument was positively correlated with Extroversion (E) and Agreeableness (A), and negatively correlated with the domain of Neuroticism (N). Global satisfaction scores were not correlated with ratings of psychoticism, paranoia or depression. These data suggest that even in psychotic conditions such as schizoaffective disorder or schizophrenia, intrapsychic factors influence one's sense of QOL. In addition, these data suggest that personality variables may differentially affect patients' satisfaction and QOL with different treatment settings.
Psychiatry Research, 1997
A cohort of acutely ill, hospitalized patients with chronic psychotic disorders participated in a... more A cohort of acutely ill, hospitalized patients with chronic psychotic disorders participated in a study of a manualized community reintegration skills training program. Initial data analyses revealed that skill levels improved significantly over the course of treatment, and that higher post-training skill levels were associated with better post-discharge functioning for the group as a whole. Post-discharge treatment adherence rates were dramatically better in females, and analyses were conducted to determine the role of gender. Males and females had different predictors of post-training skill level and post-discharge treatment adherence. In males, who as a group were at higher risk for poor post-discharge outcome, there was a positive association between post-training skill level and post-discharge treatment adherence. Females, on the other hand, showed good post-discharge treatment adherence regardless of post-training skill or symptom levels. This report is consistent with prior studies suggesting that male and female individuals with schizophrenia show differential patterns of social skill, skill improvement, and social adjustment.
Schizophrenia Research, 1997
Using a naturalistic studies design, our group recently reported data on the effectiveness of the... more Using a naturalistic studies design, our group recently reported data on the effectiveness of the Community Re-Entry Program, a brief, time-limited skills training module that teaches acutely ill inpatients skills for engagement with community-based treatment programs. Data from a cohort of 44 subjects showed that while positive and negative symptoms diminished over the course of an inpatient hospitalization,
Schizophrenia Research, 1997
Ratings (RRA) as a predictor of successful rehabilitation outcome in subjects with chronic schizo... more Ratings (RRA) as a predictor of successful rehabilitation outcome in subjects with chronic schizophrenia. Methods: As part of their clinical treatment, 32 schizophrenic patients attending a continuing day treatment program participated in a Rehabilitation Assessment Group for eight one hour sessions in which each subject's readiness to set a goal in the environments of living, learning, working and socializing was assessed. Six months later, each subject was interviewed to determine the degree to which changes had been accomplished in these four environments. Results: There was a statistically significant positive correlation between the degree of expressed rehabilitation readiness with a particular environment in patients ' lives and their ability to effect a change. There was no correlation between age, or length of treatment and the degree to which they made a change in that particular environment. Conclusion: These data suggest that a patient's expressed readiness for rehabilitative change is the best predictor of making change. Also, that satisfaction and dissatisfaction is not limited to a single domain but seems to be generalized across the four environments.
Psychiatric Rehabilitation Journal, 1997
ABSTRACT
Evaluation and Program Planning, 1997
... Diamond, Sainfort, 1993; Bigelow, Brodsky, Steward, Olson, 1982; Heinrichs, Hanlon, Carpenter... more ... Diamond, Sainfort, 1993; Bigelow, Brodsky, Steward, Olson, 1982; Heinrichs, Hanlon, Carpenter, 1984; Lehman, 1988; Malm, May, Dencker, 1981; Stein ... asks patient's opinions regarding factual matters and subjective attitudes in a highly structured interview for mat and ratings ...
Journal of Psychiatric Research, 2010
Background-There is decreased serotonergic function in impulsive aggression and borderline person... more Background-There is decreased serotonergic function in impulsive aggression and borderline personality disorder (BPD), and genetic association studies suggest a role of serotonergic genes in impulsive aggression and BPD. Only one study has analyzed the association between the tryptophanhydroxylase 2 (TPH2) gene and BPD. A TPH2 "risk" haplotype has been described that is associated with anxiety, depression and suicidal behavior.
Schizophrenia …, 1997
Recent studies suggest that schizophrenic symptoms can be categorized into three domains: Positiv... more Recent studies suggest that schizophrenic symptoms can be categorized into three domains: Positive, Negative, and Disorganized (eg Andreasen et al, 1995). In an effort to further validate this notion, these symptom areas were tracked longitudinally in 26 schizophrenic ...
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 1997
The goal of this study was to examine the effects of personality traits as measured by the NEO-PI... more The goal of this study was to examine the effects of personality traits as measured by the NEO-PI on the quality of life (QOL) of persons with schizoaffective disorder and schizophrenia. The premise of this research is that personality traits may be important in shaping one's outlook and satisfaction with life. In a prior pilot study, personality traits were measured in persons with schizoaffective disorder and schizophrenia. In this study, the relationship between QOL and specific personality domains as assessed by the NEO-PI were studied in 21 patients. Global QOL as measured by the Lehman QOL instrument was positively correlated with Extroversion (E) and Agreeableness (A), and negatively correlated with the domain of Neuroticism (N). Global satisfaction scores were not correlated with ratings of psychoticism, paranoia or depression. These data suggest that even in psychotic conditions such as schizoaffective disorder or schizophrenia, intrapsychic factors influence one's ...