Marie Grassia - Academia.edu (original) (raw)

Papers by Marie Grassia

Research paper thumbnail of A prospective test of rumination as a moderator of the link between negative events and depressive symptoms

Research paper thumbnail of Children's Attentional Biases and 5-HTTLPR Genotype: Potential Mechanisms Linking Mother and Child Depression

Journal of Clinical Child & Adolescent Psychology, 2009

In this study, we examined the roles of specific cognitive (attentional bias) and genetic (5-HTTL... more In this study, we examined the roles of specific cognitive (attentional bias) and genetic (5-HTTLPR) risk factors in the intergenerational transmission of depression. Focusing first on the link between maternal history of major depressive disorder (MDD) and children's attentional biases, we found that children of mothers with a history of MDD during their children's lives, compared to children of mothers with no depression history, exhibited greater attentional avoidance of sad faces. This attention bias was specific to sad, rather than happy or angry, faces. There was also preliminary evidence that this relation is stronger among children carrying the 5-HTTLPR S or L G allele than among those homozygous for the L A allele. Next, conceptualizing mothers' levels of depressive symptoms during the multi-wave prospective follow-up within a vulnerability-stress framework, we found evidence for a three-way child 5-HTTLPR  attentional bias  mother depressive symptom interaction predicting children's depressive symptoms. Specifically, the relation between mother and child depressive symptom levels over time was strongest among children carrying the 5-HTTLR S or L G allele who also exhibited attentional avoidance of sad faces. These findings provide initial support for role of children's 5-HTTLPR genotype and attentional biases for sad faces in the intergenerational transmission of depression.

Research paper thumbnail of Children’s inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: An integrated model for the intergenerational transmission of depression

Journal of Abnormal Psychology, 2009

The authors tested a model for the intergenerational transmission of depression integrating speci... more The authors tested a model for the intergenerational transmission of depression integrating specific genetic (5-HTTLPR), cognitive (inferential style), and environmental (mother depressive symptoms and expressed-emotion criticism [EE-Crit]) risk factors. Supporting the hypothesis that maternal depression is associated with elevated levels of stress in children's lives, mothers with a history of major depressive disorder (MDD) exhibited higher depressive symptoms across a 6-month multiwave follow-up than mothers with no depression history. In addition, partially supporting our hypothesis, levels of maternal criticism during the follow-up were significantly related to mothers' current depressive symptoms but not to history of MDD. Finally, the authors found support for an integrated Gene ϫ Cognition ϫ Environment model of risk. Specifically, among children with negative inferential styles regarding their self-characteristics, there was a clear dose response of 5-HTTLPR genotype moderating the relation between maternal criticism and children's depressive symptoms, with the highest depressive symptoms during the follow-up observed among children carrying 2 copies of the 5-HTTLPR lower expressing alleles (short [S] or long [L G ]) who also exhibited negative inferential styles for self-characteristics and who experienced high levels of EE-Crit. In contrast, children with positive inferential styles exhibited low depressive symptoms regardless of 5-HTTLPR genotype or level of maternal criticism.

Research paper thumbnail of Rumination and Prospective Changes in Depressive Symptoms

Journal of Social and Clinical Psychology, 2008

according to the response styles theory , rumination contributes to both the development and main... more according to the response styles theory , rumination contributes to both the development and maintenance of depressive symptoms. in this study, we examined the vulnerability and maintenance hypotheses in a multi-wave prospective study of young adults with levels of negative events and depressive symptoms assessed every week for 7 weeks. We found no support for the vulnerability hypothesis. Specifically, levels of rumination (brooding or reflective rumination) did not moderate the link between weekly negative events and weekly changes in depressive symptoms. in contrast, we did find support for the maintenance hypothesis. Specifically, levels of brooding and reflective rumination were related to elevated depressive symptom levels across the follow-up. Consistent with previous research, the magnitude of the effect for brooding was stronger than that for reflective rumination.

Research paper thumbnail of Brooding Rumination and Risk for Depressive Disorders in Children of Depressed Mothers

Journal of Abnormal Child Psychology, 2012

The goal of the current study was to examine the role of brooding rumination in children at risk ... more The goal of the current study was to examine the role of brooding rumination in children at risk for depression. We found that children of mothers with a history of major depression exhibited higher levels of brooding rumination than did children of mothers with no depression history. Examining potential mechanisms of this risk, we found no evidence for shared genetic influences (BDNF or 5-HTTLPR) or modeling of mothers' rumination. However, we did find that children with a history of prior depressive disorders exhibited higher current levels of brooding rumination than children with no depression history. Importantly, children's brooding predicted prospective onsets of new depressive episodes over a 20-month follow-up even when we statistically controlled for depressive symptom levels at the initial assessment, suggesting that the predictive effect of brooding rumination in children was not due simply to co-occurring depressive symptoms.

Research paper thumbnail of Rumination and Lifetime History of Suicide Attempts

International Journal of Cognitive Therapy, 2009

The primary goal of the current study was to examine the link between rumination (brooding and re... more The primary goal of the current study was to examine the link between rumination (brooding and reflective rumination) and the history of suicide attempts in adult psychiatric inpatients. As predicted, psychiatric inpatients reporting histories of suicide attempts exhibited higher current levels of brooding, but not reflective, rumination than did those with no prior suicide attempts. These results were maintained even after statistically controlling for patients' current depressive symptom levels. These results support the hypothesis that rumination, particularly brooding rumination, may be a risk factor for suicide attempts.

Research paper thumbnail of A prospective test of rumination as a moderator of the link between negative events and depressive symptoms

Research paper thumbnail of Children's Attentional Biases and 5-HTTLPR Genotype: Potential Mechanisms Linking Mother and Child Depression

Journal of Clinical Child & Adolescent Psychology, 2009

In this study, we examined the roles of specific cognitive (attentional bias) and genetic (5-HTTL... more In this study, we examined the roles of specific cognitive (attentional bias) and genetic (5-HTTLPR) risk factors in the intergenerational transmission of depression. Focusing first on the link between maternal history of major depressive disorder (MDD) and children's attentional biases, we found that children of mothers with a history of MDD during their children's lives, compared to children of mothers with no depression history, exhibited greater attentional avoidance of sad faces. This attention bias was specific to sad, rather than happy or angry, faces. There was also preliminary evidence that this relation is stronger among children carrying the 5-HTTLPR S or L G allele than among those homozygous for the L A allele. Next, conceptualizing mothers' levels of depressive symptoms during the multi-wave prospective follow-up within a vulnerability-stress framework, we found evidence for a three-way child 5-HTTLPR  attentional bias  mother depressive symptom interaction predicting children's depressive symptoms. Specifically, the relation between mother and child depressive symptom levels over time was strongest among children carrying the 5-HTTLR S or L G allele who also exhibited attentional avoidance of sad faces. These findings provide initial support for role of children's 5-HTTLPR genotype and attentional biases for sad faces in the intergenerational transmission of depression.

Research paper thumbnail of Children’s inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: An integrated model for the intergenerational transmission of depression

Journal of Abnormal Psychology, 2009

The authors tested a model for the intergenerational transmission of depression integrating speci... more The authors tested a model for the intergenerational transmission of depression integrating specific genetic (5-HTTLPR), cognitive (inferential style), and environmental (mother depressive symptoms and expressed-emotion criticism [EE-Crit]) risk factors. Supporting the hypothesis that maternal depression is associated with elevated levels of stress in children's lives, mothers with a history of major depressive disorder (MDD) exhibited higher depressive symptoms across a 6-month multiwave follow-up than mothers with no depression history. In addition, partially supporting our hypothesis, levels of maternal criticism during the follow-up were significantly related to mothers' current depressive symptoms but not to history of MDD. Finally, the authors found support for an integrated Gene ϫ Cognition ϫ Environment model of risk. Specifically, among children with negative inferential styles regarding their self-characteristics, there was a clear dose response of 5-HTTLPR genotype moderating the relation between maternal criticism and children's depressive symptoms, with the highest depressive symptoms during the follow-up observed among children carrying 2 copies of the 5-HTTLPR lower expressing alleles (short [S] or long [L G ]) who also exhibited negative inferential styles for self-characteristics and who experienced high levels of EE-Crit. In contrast, children with positive inferential styles exhibited low depressive symptoms regardless of 5-HTTLPR genotype or level of maternal criticism.

Research paper thumbnail of Rumination and Prospective Changes in Depressive Symptoms

Journal of Social and Clinical Psychology, 2008

according to the response styles theory , rumination contributes to both the development and main... more according to the response styles theory , rumination contributes to both the development and maintenance of depressive symptoms. in this study, we examined the vulnerability and maintenance hypotheses in a multi-wave prospective study of young adults with levels of negative events and depressive symptoms assessed every week for 7 weeks. We found no support for the vulnerability hypothesis. Specifically, levels of rumination (brooding or reflective rumination) did not moderate the link between weekly negative events and weekly changes in depressive symptoms. in contrast, we did find support for the maintenance hypothesis. Specifically, levels of brooding and reflective rumination were related to elevated depressive symptom levels across the follow-up. Consistent with previous research, the magnitude of the effect for brooding was stronger than that for reflective rumination.

Research paper thumbnail of Brooding Rumination and Risk for Depressive Disorders in Children of Depressed Mothers

Journal of Abnormal Child Psychology, 2012

The goal of the current study was to examine the role of brooding rumination in children at risk ... more The goal of the current study was to examine the role of brooding rumination in children at risk for depression. We found that children of mothers with a history of major depression exhibited higher levels of brooding rumination than did children of mothers with no depression history. Examining potential mechanisms of this risk, we found no evidence for shared genetic influences (BDNF or 5-HTTLPR) or modeling of mothers' rumination. However, we did find that children with a history of prior depressive disorders exhibited higher current levels of brooding rumination than children with no depression history. Importantly, children's brooding predicted prospective onsets of new depressive episodes over a 20-month follow-up even when we statistically controlled for depressive symptom levels at the initial assessment, suggesting that the predictive effect of brooding rumination in children was not due simply to co-occurring depressive symptoms.

Research paper thumbnail of Rumination and Lifetime History of Suicide Attempts

International Journal of Cognitive Therapy, 2009

The primary goal of the current study was to examine the link between rumination (brooding and re... more The primary goal of the current study was to examine the link between rumination (brooding and reflective rumination) and the history of suicide attempts in adult psychiatric inpatients. As predicted, psychiatric inpatients reporting histories of suicide attempts exhibited higher current levels of brooding, but not reflective, rumination than did those with no prior suicide attempts. These results were maintained even after statistically controlling for patients' current depressive symptom levels. These results support the hypothesis that rumination, particularly brooding rumination, may be a risk factor for suicide attempts.