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Research paper thumbnail of The impact of COVID-19 pandemic on well-being of Italian physicians: a report from the Italian Society of Internal Medicine (SIMI) national survey

Internal and Emergency Medicine

Over the past few years, COVID-19 pandemic has imposed a high toll worldwide, with a high burden ... more Over the past few years, COVID-19 pandemic has imposed a high toll worldwide, with a high burden of morbidity and mortality. Healthcare practitioners (HCPs) have been in the frontline since the beginning of the outbreak, and the high level of stress have affected their physical and mental status, as well as their relationships. We aimed at exploring the self-reported changes in comprehensive well-being in a cohort of Italian physicians. An online-based survey was administered to the members of the Italian Society of Internal Medicine (SIMI) between March and June 2021. The survey was based on 32 multiple-choice questions exploring self-reported physical and mental well-being, as well as changes in workloads, work-related feelings and physicians’ relationship with patients, colleagues and families. 228 physicians (mean age: 35.7 ± 9.8 years) participated in the survey; 120 (52.6%) were residents, 196 (86.0%) worked in COVID-19 units and 65 (28.5%) had COVID-19 during the pandemic. A ...

Research paper thumbnail of Clinical predictors of late SARS‐CoV‐2 positivity in Italian internal medicine wards

European Journal of Clinical Investigation, 2021

Research paper thumbnail of Incidence and Immunomic Features of Apyretic COVID-19 in Patients Affected by Solid Tumors: A Prospective Cohort Study

Background and rationale: Little is known about SARS-CoV-2 seroconversion in asymptomatic patient... more Background and rationale: Little is known about SARS-CoV-2 seroconversion in asymptomatic patients affected by solid cancer, and whether it is associated with specific transcriptomics changes in peripheral blood mononuclear cells (PBMC).Methods: patients affected by solid cancer treated in a top comprehensive cancer center in Italy during the first COVID-19 pandemic wave, and negative for COVID-19-symptoms since the first detection of COVID-19 in Italy, were prospectively evaluated by SARS-CoV-2 serology in the period between April 14th and June 23rd 2020. Follow-up serologies were performed, every 21-28 days, until August 23rd, 2020. All SARS-CoV-2 IgM+ patients underwent confirmatory nasopharyngeal swab (NPS). PBMCs from a subset of SARS-CoV-2 IgM+ patients were collected at baseline, at 2 months, and at 7 months for transcriptome sequencing.Results: SARS-CoV-2 serology was performed on 446 of the 466 recruited patients. A total of 14 patients (3.14 %) tested positive for at least...

Research paper thumbnail of The impact of COVID-19 pandemic on well-being of Italian physicians: a report from the Italian Society of Internal Medicine (SIMI) national survey

Internal and Emergency Medicine

Over the past few years, COVID-19 pandemic has imposed a high toll worldwide, with a high burden ... more Over the past few years, COVID-19 pandemic has imposed a high toll worldwide, with a high burden of morbidity and mortality. Healthcare practitioners (HCPs) have been in the frontline since the beginning of the outbreak, and the high level of stress have affected their physical and mental status, as well as their relationships. We aimed at exploring the self-reported changes in comprehensive well-being in a cohort of Italian physicians. An online-based survey was administered to the members of the Italian Society of Internal Medicine (SIMI) between March and June 2021. The survey was based on 32 multiple-choice questions exploring self-reported physical and mental well-being, as well as changes in workloads, work-related feelings and physicians’ relationship with patients, colleagues and families. 228 physicians (mean age: 35.7 ± 9.8 years) participated in the survey; 120 (52.6%) were residents, 196 (86.0%) worked in COVID-19 units and 65 (28.5%) had COVID-19 during the pandemic. A ...

Research paper thumbnail of Clinical predictors of late SARS‐CoV‐2 positivity in Italian internal medicine wards

European Journal of Clinical Investigation, 2021

Research paper thumbnail of Incidence and Immunomic Features of Apyretic COVID-19 in Patients Affected by Solid Tumors: A Prospective Cohort Study

Background and rationale: Little is known about SARS-CoV-2 seroconversion in asymptomatic patient... more Background and rationale: Little is known about SARS-CoV-2 seroconversion in asymptomatic patients affected by solid cancer, and whether it is associated with specific transcriptomics changes in peripheral blood mononuclear cells (PBMC).Methods: patients affected by solid cancer treated in a top comprehensive cancer center in Italy during the first COVID-19 pandemic wave, and negative for COVID-19-symptoms since the first detection of COVID-19 in Italy, were prospectively evaluated by SARS-CoV-2 serology in the period between April 14th and June 23rd 2020. Follow-up serologies were performed, every 21-28 days, until August 23rd, 2020. All SARS-CoV-2 IgM+ patients underwent confirmatory nasopharyngeal swab (NPS). PBMCs from a subset of SARS-CoV-2 IgM+ patients were collected at baseline, at 2 months, and at 7 months for transcriptome sequencing.Results: SARS-CoV-2 serology was performed on 446 of the 466 recruited patients. A total of 14 patients (3.14 %) tested positive for at least...

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