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Papers by Mario Steffanus

Journal of the Indonesian Medical Association, Apr 10, 2020

Anemia sering dijumpai pada pasien dengan penyakit kronis dan meningkatkan morbiditas dan mortali... more Anemia sering dijumpai pada pasien dengan penyakit kronis dan meningkatkan morbiditas dan mortalitas dari pasien. Prevalensi anemia penyakit kronis terdapat pada urutan kedua tersering setelah anemia defisiensi besi. Anemia penyakit kronis sering terjadi bersamaan dengan anemia defisiensi besi dan keduanya memberikan gambaran penurunan besi dalam serum. Namun, kedua jenis anemia ini perlu dibedakan karena terdapat perbedaan patogenesis dan tata laksana keduanya. Beberapa parameter besi lain perlu diperiksa untuk membedakannya. Terapi utama pada anemia penyakit kronis adalah dengan mengatasi penyakit yang mendasari.

Journal of the Indonesian Medical Association, Apr 9, 2020

Tuberkulosis (TB) merupakan masalah kesehatan yang penting di negara berkembang. Infeksi bakteri ... more Tuberkulosis (TB) merupakan masalah kesehatan yang penting di negara berkembang. Infeksi bakteri ini akan mengakibatkan neutrofilia dan limfopenia. Rasio neutrofil terhadap limfosit/ neutrophil to lymphocyte ratio (NLR) merupakan pemeriksaan yang mudah, biaya terjangkau, dan cukup sensitif. Nilai NLR pengidap TB lebih tinggi dibandingkan orang normal, dengan nilai cut off >2,16. Penelitian ini bertujuan untuk mengetahui perbedaan nilai NLR pada pasien TB dewasa sebelum dan setelah terapi fase intensif. Metode: Subjek penelitian adalah pasien TB dewasa kasus baru yang datang ke poli klinik

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, Aug 1, 2015

Background: Liver cirrhosis (LC) is a chronic disease characterized by damage of liver parenchyme... more Background: Liver cirrhosis (LC) is a chronic disease characterized by damage of liver parenchyme with wide fibrosis and nodules formation. One of LC complications is cirrhotic cardiomyopathy (CC). CC is diagnosed when there are more than one of the following signs: diastolic dysfunction (DD), systolic dysfunction (SD), enlargement of the cardiac chamber, electrophysiology dysfunction, and increasing of natriuretic peptide such as N terminal-pro brain natriuretic peptide (NT-proBNP). The aim of this study was to determine the correlation between degree of liver cirrhosis and increasing of the NT-proBNP. Method: Cross sectional analytic study was performed with 72 LC patients from May 2014 to May 2015 in Sanglah General Hospital, Denpasar. Degree of liver cirrhosis was determined by child turcotte pugh (CTP) criteria and NT-proBNP was examined by electro chemiluminescence immunoassay (ECLIA) method. LC patients with other disorders which can cause the increase of NT-proBNP were excluded. Statistical analysis used was Spearman's correlation test. Results: Of 72 LC patients, 79.2% were male. Patients with CTP A were 9 (12,5%), CTP B 19 (26,4%) and CTP C 44 (61,19%). Median of NT-proBNP in CTP A was 112 pg/mL, CTP B 130 pg/mL, and CTP C 315 pg/ mL. There was a strong possitive correlation between degree of liver cirrhosis and NT-proBNP (r = 0.686; p = 0.000). In this study, there was also significant comparison between NT-proBNP and CTP A,B, and C (p = 0,000) and there was no significant relation between NT-proBNP and those cofounding variables (p > 0.05). Conclusion: there was a strong possitive correlation between degree of LC and NT-proBNP.

Jurnal respirologi Indonesia, Jul 30, 2021

Background: Diabetes Mellitus (DM) is considered one of the factors that increase the risk of pul... more Background: Diabetes Mellitus (DM) is considered one of the factors that increase the risk of pulmonary tuberculosis (TB). Tuberculosis in Indonesia is severe and ranked second in the world after India. Previous studies suggested that DM increased the risk of developing pulmonary TB by 2-5 times. This study was conducted to determine the effect of type 2 DM on the incidence of pulmonary TB at Atma Jaya Hospital. Methods: This was a case-control study conducted at Atma Jaya Hospital from December 2016 to April 2017 using medical records. Data were further processed by pairing gender and age between case and control groups. A total of 121 samples were obtained and tested using McNemar paired correlation non-parametric analysis. Results: The incidence of pulmonary TB was higher in men than women with a ratio of 2.1:1 and within the productive age range of 27-46 years. The percentage of type 2 DM in pulmonary TB cases was 70% (35 samples) compared to 30% (15 samples) without DM with a total of 50 samples in the case group. The percentage of type 2 DM in the control group without pulmonary TB was 46.5% (33 samples) compared to 53.5% (38 samples) without DM with a total of 71 samples in the control group. Based on the statistical analysis, the P=0.013 and the OR (odds ratio) was 2.20. Conclusion: There was a significant correlation between type 2 DM and the incidence of pulmonary TB in Atma Jaya Hospital with the risk of pulmonary TB 2.20 times higher than those without type 2 DM.

Journal Of The Indonesian Medical Association

Pendahuluan: Tuberkulosis (TB) merupakan masalah kesehatan yang penting di negara berkembang. Inf... more Pendahuluan: Tuberkulosis (TB) merupakan masalah kesehatan yang penting di negara berkembang. Infeksi bakteri ini akan mengakibatkan neutrofilia dan limfopenia. Rasio neutrofil terhadap limfosit/ neutrophil to lymphocyte ratio (NLR) merupakan pemeriksaan yang mudah, biaya terjangkau, dan cukup sensitif. Nilai NLR pengidap TB lebih tinggi dibandingkan orang normal, dengan nilai cut off >2,16. Penelitian ini bertujuan untuk mengetahui perbedaan nilai NLR pada pasien TB dewasa sebelum dan setelah terapi fase intensif.Metode: Subjek penelitian adalah pasien TB dewasa kasus baru yang datang ke poli klinik Penyakit Dalam RS Atma Jaya, tanpa adanya HIV, gagal ginjal kronik, diabetes melitus, penyakit paru obstruktif kronik, dan pneumonia bakterial. Jumlah leukosit, neutrofil dan limfosit, serta perhitungan NLR sebelum dan setelah terapi fase intensif dicatat. Analisis data menggunakan SPSS. Hasil: Dari 44 pasien TB, 23 (52,3%) diantaranya berjenis kelamin laki-laki, dengan usia median 3...

Journal of Medical and Health Studies

Evans syndrome is a combination of autoimmune hemolytic anemia and idiopathic thrombocytopenic pu... more Evans syndrome is a combination of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura. Evans syndrome is a rare disease encountered in medical practice. Evans syndrome can also co-occur with other autoimmune diseases, such as Hashimoto's thyroiditis, although rare. Hashimoto's thyroiditis is a condition that causes hypothyroidism, where the thyroid gland cells are destroyed so that the thyroid hormone produced cannot meet the body's needs. This case report describes a pregnant female patient who has several autoimmune conditions, namely Evans Syndrome and Hashimoto's Thyroiditis. The patient came to the hospital with bruises on the abdomen and waist and felt weak, tired, and lethargic. The previous examination showed that this patient had positive anti-platelet and anti-TPO test results, enlarged liver and spleen on ultrasound examination, and thyroid hormone examination, which showed hypothyroidism. A physical examination of the patient also showed ...

Journal of the Indonesian …, 2011

... Jumlahpenduduk rebarryak2.463 orang (1 160 orang laki-laki dm 1 303 orang perempuan).6 Mayori... more ... Jumlahpenduduk rebarryak2.463 orang (1 160 orang laki-laki dm 1 303 orang perempuan).6 Mayoritas penduduk desa Sebangki bertani dan ... 0,1 n. Pemeriksaan feses segar meng-gunakan sebuah kaca objek dankaca penutup, tempat menaruh feses, batang lidi, air, pipet ...

Background: Gastroesophageal reflux disease (GERD) is a disease characterised by stomach acid ris... more Background: Gastroesophageal reflux disease (GERD) is a disease characterised by stomach acid rises to the esophagus leading to burning senstation (heartburn) and regurgitation. The prevalence of GERD cases worldwide in adults were 11-38.8%. This study aims to determine whether there is a correlation between GERD-Q scores and quality of life in patients with upper gastrointestinal symptoms. Method: A cross-sectional study was conducted involving 92 patients at Atma Jaya Hospital, Jakarta. The questionnaires used in this study were GERD-Q and GERD-HRQL. Prior to this study, a pilot-study was carried out to validate the GERD-HRQL questionnaire in Indonesian language. Spearman analysis was used to find the correlation between GERD-Q scores and quality of life in patients with upper gastrointestinal symptoms. Results: The results of this study indicated that the GERD-HRQL questionnaire showed good validity and reliability. The results of this study showed a strong positive correlation (r = 0.681) between the GERD-Q scores and quality of life in patients with upper gastrointestinal symptoms. Conclusion: There was a correlation between GERD-Q scores and quality of life in patients with upper gastrointestinal symptoms. Keywords: GERD, GERD-Q, quality of life

Journal of the Indonesian Medical Association, 2018

Journal Of The Indonesian Medical Association, 2020

Pendahuluan: World Health Organization (WHO) memperkirakan kejadian diabetes melitus (DM) di Indo... more Pendahuluan: World Health Organization (WHO) memperkirakan kejadian diabetes melitus (DM) di Indonesia dapat mencapai 21,3 juta orang pada tahun 2030. Studi ini bertujuan untuk mengetahui hubungan kadar HbA1c dengan albuminuria pada pasien DM tipe 2.Metode: Data meliputi usia, jenis kelamin, kadar HbA1c, tekanan darah, proteinuria, merokok, penggunaan ACEI atau ARB, dan lama berobat diambil dari rekam medis pasien DMT2 di RS Atma Jaya dengan studi cross-sectional sesuai kriteria inklusi dan eksklusi dengan metode korelasi Spearman pada interval kepercayaan 95% (á = 0.05).Hasil: Adanya hubungan signifikan antara kadar HbA1c dengan albuminuria (p<0,0001) yang berkorelasi cukup kuat (r=0,439). Faktor lain yang berhubungan adalah usia (p<0.05), sedangkan tekanan darah, merokok, dan penggunaan ACE-Inhibitor atau Angiotensin Receptor Blocker (p=0,386) tidak bermakna.Kesimpulan: Terdapat hubungan bermakna antara kadar HbA1c dengan albuminuria pada pasien DM tipe 2 di RS Atma Jaya.

Journal of the …, 2011

... KarinaAnindita,s Yudistira P. Santosa,* Riki Tenggara,* Maria Riastuti Iryaningrum,* Mario St... more ... KarinaAnindita,s Yudistira P. Santosa,* Riki Tenggara,* Maria Riastuti Iryaningrum,* Mario Steffanus,* Herlina Uinarni,** ... ini, pneumo-niayang merupakan infelsi parenkim paru dan penyakit paru interstitial, kelainan pada pompa ventilasi (peningkatan resistensi jalan nafas dan ...

Majalah Kedokteran Bandung

Journal of the Indonesian Medical Association, 2011

The prevalence of anemia caused by hookworm infection is still high in Indonesia. The purpose of ... more The prevalence of anemia caused by hookworm infection is still high in Indonesia. The purpose of this research is to describe the prevalence of hookworm’s eggs in anemia patients at Sebangki Village. Cross sectional study were performed to all patients in Out Patient Unit of Sebangki District Public Health Center in 2008. Every patient who came with the symptoms of anemia, will be evaluated as anemia based on World Health Organization criteria using Hemoglobin-Sahli method of blood examination. If the hemoglobin concentration is below normal, it will be followed with fresh faeces examination to find the hookworm egg. The relation between anemia and nutrition status can be calculated using Body Mass Index counting based on WHO criteria for Asia. In 2008, from 1 823 Sebangki Villagers who came to the Out Patient Unit of Sebangki District Public Health Center, we found 784 (43%) anemia patients (WHO criteria), 369 (47%) men and 415 (53%) female. From the Body Mass Index examination res...

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2010

Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) that usually affects the re... more Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) that usually affects the rectum and part of the colon, which spreads continuously with no skip area. Pancolitis occurs in 20% of patients with UC. Patients with chronic UC, especially pancolitis, have a higher risk of colon cancer. In patients with pancolitis, the risk of cancer increases by 0.5-1% per year after having 8-10 years of disease. A 72-year-old man came with complaint of bloody-mucus diarrhea associated with abdominal cramps. The colonoscopic appearance of colitis was observed in whole lumen throughout colon. Histopathological analysis demonstrated dense infiltrates of granulocytes and macrophages formed by severe inflammation. Normal appearances were observed in the remaining epithelial cells. No parasites, specific process, or malignancy were found. Moreover, no acid-resistant bacteria were found. However, atypical cells were found in one of the biopsy specimens. The patient was diagnosed with extens...

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020

Background : In adults, the symptoms of Gastroesophageal Reflux Disease (GERD) are often complain... more Background : In adults, the symptoms of Gastroesophageal Reflux Disease (GERD) are often complained of in daily life and their prevalence has increased. Symptoms of GERD are often found along with the occurrence of dyspepsia. One of the factors that affect the symptoms of GERD is depression. Due to the limited data available in Indonesia, this study was conducted to see the correlation between depression and Gastroesophageal Reflux Disease Questionnaire score (GERD-Q). Method : This study was conducted on dyspepsia patients at Atma Jaya Hospital (RSAJ) beginning at June to September 2018. The study was conducted using a cross-sectional design and using the GERD-Q and Depression questionnaire, Anxiety, Stress Scale 42 (DASS 42) which has been translated and validated by other researchers to measure GERD scores and depression scores. Results : The total respondents of this study were 53, with the percentage of men and women being 30.2% and 69.8% respectively. The average age of patien...

A 19-year-old woman was admitted to the hospital because of a 5-day history of fever accompanied ... more A 19-year-old woman was admitted to the hospital because of a 5-day history of fever accompanied with headache, nausea, vomiting, and myalgia. Hepatomegaly, spontaneous bleeding, and thrombocytopenia were found. Clinical features of this patient were typical for dengue hemorrhagic fever. Confirm test on dengue blot examinations were positive. On the fourth day after admission, a bradyarrhythmia with stable hemodynamic was detected. Electrocardiogram revealed Mobitz type I second degree AV block. Echocardiogram and cardiac enzyme were within normal limit. This heart conduction abnormality was detected in three days without any symptoms of hemodynamic instability. Electrocardiogram was completely back to normal on the seventh day after admission due to improvement of her clinical status and elevation of her thrombocyte. Mobitz type I second degree AV block in a patient with dengue hemorrhagic fever may be a transient functional impairment of atrioventricular node, in which altered ...

Background: daily life and their prevalence has increased. Symptoms of GERD are often found along... more Background: daily life and their prevalence has increased. Symptoms of GERD are often found along with the occurrence of dyspepsia. One of the factors that affect the symptoms of GERD is depression. Due to the limited data available disease questionnaire score (GERD-Q). Method: This study was conducted on dyspepsia patients at Atma Jaya Hospital (RSAJ) beginning at June to questionnaire, Anxiety, Stress Scale 42 (DASS 42) which has been translated and validated by other researchers to measure GERD scores and depression scores. Results: Conclusion: There is a correlation between depression and GERD-Q score of dyspepsia patients at Atma Jaya Hospital