Mark Shamtsyan - Academia.edu (original) (raw)
Papers by Mark Shamtsyan
Research Progress …, 2008
In: Research Progress in Biotechnology ISBN: 978-1-60456-000-8 Editor: GE Zaikov, pp. 147-157© 20... more In: Research Progress in Biotechnology ISBN: 978-1-60456-000-8 Editor: GE Zaikov, pp. 147-157© 2008 Nova Science Publishers, Inc. Chapter XVII Study of Immunomodulating and Antitumour Activity of Extracts of Higher Basidiomycetes Vera Spiridonova, Valentina ...
Research Progress …, 2008
Journal of Biotechnology, 2007
… Journal of Medicinal …, 2005
Taylor & Francis
Abstract This entry traces the early evolution of genetic engineering from its beginnings, in unr... more Abstract This entry traces the early evolution of genetic engineering from its beginnings, in unrelated fields of basic science, to the present day. The results of this fundamental scientific research have led to the development of a multibillion-dollar biotechnology industry, producing innovative human and animal health care products and improved varieties of cultivated plants. The public debates, controversies, and ethical issues related to genetic engineering are also briefly discussed.
Phytotherapy …, 2012
While the neuroprotective effect of green tea (Camellia sinensis) might be explained by the prese... more While the neuroprotective effect of green tea (Camellia sinensis) might be explained by the presence of amino acid L-theanine in the tea leaves, it is not known whether postischemic administration of L-theanine could also provide neuroprotection. In the present study, we investigated the neuroprotective effect of L-theanine (1 and 4 mg/kg) administered at 3, 12, and 24 h after reperfusion in the rat model of stroke. We also studied the effect of L-theanine on brain injury caused by exogenous administration of N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate/kainate receptor agonists during reperfusion. Rats were subjected to 30-min middle cerebral artery occlusion followed by 48-h reperfusion. Neurological deficit and infarct size were determined at the end of reperfusion. At 3 and 12 h, but not at 24 h of reperfusion, L-theanine substantially reduced the size of brain infarct. Neurological status was improved when L-theanine was administered 3, 12, and 24 h after reperfusion. Repeated intrastriatal injections of L-theanine at a total dose of 800 µg/kg during reperfusion prevented brain injury caused by glutamate receptor agonists. In conclusion, L-theanine at reperfusion exerts neuroprotective effect in the in vivo rat model of stroke. Local treatment with L-theanine at reperfusion prevents glutamate receptor agonist-mediated brain injury.
In: Research Progress in Biotechnology ISBN: 978-1-60456-000-8 Editor: GE Zaikov, pp. 53-58© 2008... more In: Research Progress in Biotechnology ISBN: 978-1-60456-000-8 Editor: GE Zaikov, pp. 53-58© 2008 Nova Science Publishers, Inc. Chapter VII Hypocholesterolic Effect of Some Higher Basidiomycetes Alexey Popov1, Andrey Panchenko2, Nina Denisova1, Nikolay ...
Journal of fermentation …, 1993
Theanine synthesis from glutamine and ethylamine by immobilized cells of Pseudomonas nitroreducen... more Theanine synthesis from glutamine and ethylamine by immobilized cells of Pseudomonas nitroreducens as a biocatalyst was investigated. A reactor was constructed by connecting four columns, each of which was packed with immobilized bacterial cells. The glutaminase activity of the immobilized cells in a mixture of glutamine and ethylamine, pH 9.5, was somewhat unstable in the early stage of the biosynthesis. However, the enzyme became stable as theanine was produced and the reactor maintained the synthetic activity for at least several weeks. Several factors affecting the efficiency of theanine synthesis, but especially the temperature, pH and flow rate of the substrate, were examined.
Biosci. Biotech. Biochem, 1993
Materials Science and …, 2003
The bioactive properties of multicomponent film polymeric structures, based on polyvinyl alcohol ... more The bioactive properties of multicomponent film polymeric structures, based on polyvinyl alcohol (PVA), polyvinyl pyrrolidon (PVP) and lactic acid (LA), containing heparin, trypsin and antibiotics (benzyl penicillin and kanamycin) were studied. The degree of degradation and biodegradation of multicomponent film coatings were directly regulated by the introduction of polyvinyl pyrrolidon and lactic acid, as well as by manipulating the conditions of their electroformation regime. The polymeric molecules forming the structure of the coating film do not undergo chemical changes with the breaking of the chain.
Research Progress …, 2008
In: Research Progress in Biotechnology ISBN: 978-1-60456-000-8 Editor: GE Zaikov, pp. 147-157© 20... more In: Research Progress in Biotechnology ISBN: 978-1-60456-000-8 Editor: GE Zaikov, pp. 147-157© 2008 Nova Science Publishers, Inc. Chapter XVII Study of Immunomodulating and Antitumour Activity of Extracts of Higher Basidiomycetes Vera Spiridonova, Valentina ...
Research Progress …, 2008
Journal of Biotechnology, 2007
… Journal of Medicinal …, 2005
Taylor & Francis
Abstract This entry traces the early evolution of genetic engineering from its beginnings, in unr... more Abstract This entry traces the early evolution of genetic engineering from its beginnings, in unrelated fields of basic science, to the present day. The results of this fundamental scientific research have led to the development of a multibillion-dollar biotechnology industry, producing innovative human and animal health care products and improved varieties of cultivated plants. The public debates, controversies, and ethical issues related to genetic engineering are also briefly discussed.
Phytotherapy …, 2012
While the neuroprotective effect of green tea (Camellia sinensis) might be explained by the prese... more While the neuroprotective effect of green tea (Camellia sinensis) might be explained by the presence of amino acid L-theanine in the tea leaves, it is not known whether postischemic administration of L-theanine could also provide neuroprotection. In the present study, we investigated the neuroprotective effect of L-theanine (1 and 4 mg/kg) administered at 3, 12, and 24 h after reperfusion in the rat model of stroke. We also studied the effect of L-theanine on brain injury caused by exogenous administration of N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate/kainate receptor agonists during reperfusion. Rats were subjected to 30-min middle cerebral artery occlusion followed by 48-h reperfusion. Neurological deficit and infarct size were determined at the end of reperfusion. At 3 and 12 h, but not at 24 h of reperfusion, L-theanine substantially reduced the size of brain infarct. Neurological status was improved when L-theanine was administered 3, 12, and 24 h after reperfusion. Repeated intrastriatal injections of L-theanine at a total dose of 800 µg/kg during reperfusion prevented brain injury caused by glutamate receptor agonists. In conclusion, L-theanine at reperfusion exerts neuroprotective effect in the in vivo rat model of stroke. Local treatment with L-theanine at reperfusion prevents glutamate receptor agonist-mediated brain injury.
In: Research Progress in Biotechnology ISBN: 978-1-60456-000-8 Editor: GE Zaikov, pp. 53-58© 2008... more In: Research Progress in Biotechnology ISBN: 978-1-60456-000-8 Editor: GE Zaikov, pp. 53-58© 2008 Nova Science Publishers, Inc. Chapter VII Hypocholesterolic Effect of Some Higher Basidiomycetes Alexey Popov1, Andrey Panchenko2, Nina Denisova1, Nikolay ...
Journal of fermentation …, 1993
Theanine synthesis from glutamine and ethylamine by immobilized cells of Pseudomonas nitroreducen... more Theanine synthesis from glutamine and ethylamine by immobilized cells of Pseudomonas nitroreducens as a biocatalyst was investigated. A reactor was constructed by connecting four columns, each of which was packed with immobilized bacterial cells. The glutaminase activity of the immobilized cells in a mixture of glutamine and ethylamine, pH 9.5, was somewhat unstable in the early stage of the biosynthesis. However, the enzyme became stable as theanine was produced and the reactor maintained the synthetic activity for at least several weeks. Several factors affecting the efficiency of theanine synthesis, but especially the temperature, pH and flow rate of the substrate, were examined.
Biosci. Biotech. Biochem, 1993
Materials Science and …, 2003
The bioactive properties of multicomponent film polymeric structures, based on polyvinyl alcohol ... more The bioactive properties of multicomponent film polymeric structures, based on polyvinyl alcohol (PVA), polyvinyl pyrrolidon (PVP) and lactic acid (LA), containing heparin, trypsin and antibiotics (benzyl penicillin and kanamycin) were studied. The degree of degradation and biodegradation of multicomponent film coatings were directly regulated by the introduction of polyvinyl pyrrolidon and lactic acid, as well as by manipulating the conditions of their electroformation regime. The polymeric molecules forming the structure of the coating film do not undergo chemical changes with the breaking of the chain.