Mark Smith - Academia.edu (original) (raw)
Papers by Mark Smith
Administrative Science Quarterly, 1987
Page 1. Strategy, CEO Specialization, and Succession Mark Smith University of Southwest Louisiana... more Page 1. Strategy, CEO Specialization, and Succession Mark Smith University of Southwest Louisiana Michael C. White University of Tulsa ? 1987 by Cornell University. 0001 -8392/87/3202-0263/$1 .00. The authors gratefully ...
Industrial Relations Journal, 2010
This article analyses the changing position of gender in the European Employment Strategy (EES) s... more This article analyses the changing position of gender in the European Employment Strategy (EES) since its 2005 relaunch. Overall, we find a picture of mixed progress towards gender equality goals across Member States. There is evidence of the EU soft law approach leading to positive developments as the use of targets in conjunction with Country-Specific Recommendations and Points-to-Watch have had some influence in promoting gender equality policies among Member States. However, the weakened position of gender mainstreaming in European-level initiatives has led to gender being marginalised or ignored in national and EU policy responses to the crisis. The prominence of gender has declined further in the 2010 revision of the EES under the 2020 banner. This introduces new risks as the emphasis on gender equality falls further down the list of priorities in the streamlining of the Lisbon Process.
Journal of Autoimmunity, 1988
A higher percentage of Fcγ oligosaccharide chains in the serum IgG of patients with rheumatoid ar... more A higher percentage of Fcγ oligosaccharide chains in the serum IgG of patients with rheumatoid arthritis lack terminal galactose residues relative to age-matched controls. This does not appear to be a characteristic feature of chronic inflammatory diseases in general. A new, more ...
Journal of Cerebral Blood Flow & Metabolism, 2011
A novel radioligand for positron emission tomography (PET) imaging of serotonin 5-HT(1B) receptor... more A novel radioligand for positron emission tomography (PET) imaging of serotonin 5-HT(1B) receptors, [(11)C]AZ10419369, has been recently described. In this study, the potential for quantitative analysis of [(11)C]AZ10419369 binding to central 5-HT(1B) receptors was evaluated in human subjects. PET measurements were performed after injection of [(11)C]AZ10419369 in 10 subjects. Data were analyzed with kinetic modeling and linear graphical analysis using the arterial plasma as input function, and with reference tissue models using cerebellar cortex as the reference region. Binding of [(11)C]AZ10419369 was highest in pallidum, ventral striatum, and occipital cortex and lowest in cerebellum. The percentage of unchanged radioligand in plasma was 97% to 99%, indicating that no significant amounts of radioactive metabolites were formed during the time of analysis. Time-activity curves of [(11)C]AZ10419369 could be described with both one-tissue compartment (1-TC) and two-tissue compartment (2-TC) models in the majority of subjects. The 2-TC model failed to deliver reasonable estimates of the kinetic parameters. However, stable estimates of binding potential (BP(ND)) were obtained by constraining K(1)/k(2) to the distribution volume obtained with the 1-TC model in the cerebellar cortex. BP(ND) values estimated with reference tissue models were correlated with the corresponding values obtained with kinetic modeling. The findings support the use of reference tissue models in applied clinical studies with [(11)C]AZ10419369.
JACC: Cardiovascular Interventions, 2013
The American Journal of Emergency Medicine, 1986
A literature search failed to demonstrate any investigations of the plain films of the ankle to d... more A literature search failed to demonstrate any investigations of the plain films of the ankle to determine whether there were any measurable differences in the ankle mortise, which would differentiate between a second and a third degree ankle sprain, thus obviating the need for stress views. In this study, the authors independently measured the distances between the talus and tibia at eight predetermined sites on the lateral and mortise views. This was done blindly so that neither author knew which cases were second- or third-degree ankle sprains. Only definite third-degree ankle sprains, as defined by a positive anterior drawer sign and/or a positive inversion stress test result on clinical evaluation, were included. The authors found there was severe interobserver variability. The authors thus feel that there is no clinically significant measurement on plain films of the ankle that can be used to differentiate accurately between second and third degree ankle sprains, and current reliance on clinical findings and subsequent stress x-ray films is appropriate and must remain the non-operative standard for evaluation of this problem.
The American Journal of Emergency Medicine, 1985
Administrative Science Quarterly, 1987
Page 1. Strategy, CEO Specialization, and Succession Mark Smith University of Southwest Louisiana... more Page 1. Strategy, CEO Specialization, and Succession Mark Smith University of Southwest Louisiana Michael C. White University of Tulsa ? 1987 by Cornell University. 0001 -8392/87/3202-0263/$1 .00. The authors gratefully ...
Industrial Relations Journal, 2010
This article analyses the changing position of gender in the European Employment Strategy (EES) s... more This article analyses the changing position of gender in the European Employment Strategy (EES) since its 2005 relaunch. Overall, we find a picture of mixed progress towards gender equality goals across Member States. There is evidence of the EU soft law approach leading to positive developments as the use of targets in conjunction with Country-Specific Recommendations and Points-to-Watch have had some influence in promoting gender equality policies among Member States. However, the weakened position of gender mainstreaming in European-level initiatives has led to gender being marginalised or ignored in national and EU policy responses to the crisis. The prominence of gender has declined further in the 2010 revision of the EES under the 2020 banner. This introduces new risks as the emphasis on gender equality falls further down the list of priorities in the streamlining of the Lisbon Process.
Journal of Autoimmunity, 1988
A higher percentage of Fcγ oligosaccharide chains in the serum IgG of patients with rheumatoid ar... more A higher percentage of Fcγ oligosaccharide chains in the serum IgG of patients with rheumatoid arthritis lack terminal galactose residues relative to age-matched controls. This does not appear to be a characteristic feature of chronic inflammatory diseases in general. A new, more ...
Journal of Cerebral Blood Flow & Metabolism, 2011
A novel radioligand for positron emission tomography (PET) imaging of serotonin 5-HT(1B) receptor... more A novel radioligand for positron emission tomography (PET) imaging of serotonin 5-HT(1B) receptors, [(11)C]AZ10419369, has been recently described. In this study, the potential for quantitative analysis of [(11)C]AZ10419369 binding to central 5-HT(1B) receptors was evaluated in human subjects. PET measurements were performed after injection of [(11)C]AZ10419369 in 10 subjects. Data were analyzed with kinetic modeling and linear graphical analysis using the arterial plasma as input function, and with reference tissue models using cerebellar cortex as the reference region. Binding of [(11)C]AZ10419369 was highest in pallidum, ventral striatum, and occipital cortex and lowest in cerebellum. The percentage of unchanged radioligand in plasma was 97% to 99%, indicating that no significant amounts of radioactive metabolites were formed during the time of analysis. Time-activity curves of [(11)C]AZ10419369 could be described with both one-tissue compartment (1-TC) and two-tissue compartment (2-TC) models in the majority of subjects. The 2-TC model failed to deliver reasonable estimates of the kinetic parameters. However, stable estimates of binding potential (BP(ND)) were obtained by constraining K(1)/k(2) to the distribution volume obtained with the 1-TC model in the cerebellar cortex. BP(ND) values estimated with reference tissue models were correlated with the corresponding values obtained with kinetic modeling. The findings support the use of reference tissue models in applied clinical studies with [(11)C]AZ10419369.
JACC: Cardiovascular Interventions, 2013
The American Journal of Emergency Medicine, 1986
A literature search failed to demonstrate any investigations of the plain films of the ankle to d... more A literature search failed to demonstrate any investigations of the plain films of the ankle to determine whether there were any measurable differences in the ankle mortise, which would differentiate between a second and a third degree ankle sprain, thus obviating the need for stress views. In this study, the authors independently measured the distances between the talus and tibia at eight predetermined sites on the lateral and mortise views. This was done blindly so that neither author knew which cases were second- or third-degree ankle sprains. Only definite third-degree ankle sprains, as defined by a positive anterior drawer sign and/or a positive inversion stress test result on clinical evaluation, were included. The authors found there was severe interobserver variability. The authors thus feel that there is no clinically significant measurement on plain films of the ankle that can be used to differentiate accurately between second and third degree ankle sprains, and current reliance on clinical findings and subsequent stress x-ray films is appropriate and must remain the non-operative standard for evaluation of this problem.
The American Journal of Emergency Medicine, 1985