Mark Stidworthy - Academia.edu (original) (raw)
Papers by Mark Stidworthy
Veterinary Record, 2008
Progressive ataxia, with head tremor, developed in 10 captive-born cheetah cubs under six months ... more Progressive ataxia, with head tremor, developed in 10 captive-born cheetah cubs under six months of age. The condition was usually preceded by coryza and an ocular discharge. Initially the ataxia and weakness affected the hindquarters, then the forelegs, and head tremor developed later. Significant pathological changes were confined to the central nervous system. There was widespread Wallerian degeneration in the funiculi of the spinal cord (except those in the dorsal columns), in the medulla and in the cerebellum. In the cerebellum there was degeneration of Purkinje cells and of the molecular and granular cell layers. There was chromatolysis in the Purkinje cells, the ventral horn cells of the spinal cord and in the neurons of the lateral vestibular nucleus. The olivary nucleus was necrotic. There were foci of inflammatory cells in the molecular layer of the cerebellum and in the medulla. The cause of the disease remains unknown.
The Veterinary record, Jan 20, 2011
... AL,; Chantrey J.,; Shuttleworth C.,; Blackett T.,; Butler H.,; Wilkinson M. &; Sainsbury ... more ... AL,; Chantrey J.,; Shuttleworth C.,; Blackett T.,; Butler H.,; Wilkinson M. &; Sainsbury AW. (2010)Retrospective detection by negative contrast electron microscopy of faecal viral particles infree-living wild red squirrels (Sciurus vulgaris) with suspected enteropathy in Great Britain. ...
The Veterinary record, Jan 17, 2005
... 4 Durrell Wildlife Conservation Trust, Trinity, Jersey JE3 5BP; 5 Bristol Zoo Gardens, Guthri... more ... 4 Durrell Wildlife Conservation Trust, Trinity, Jersey JE3 5BP; 5 Bristol Zoo Gardens, Guthrie Road, Bristol BS8 3HA; 6 Paignton Zoo Environmental Park, Paignton, Devon TQ4 7EU. Capillaria hepatica in primates in zoological ...
Veterinary Parasitology, 2012
Taeniid tapeworms which include Echinococcus and Taenia spp. are obligatory parasites of mammals ... more Taeniid tapeworms which include Echinococcus and Taenia spp. are obligatory parasites of mammals with pathogenicity usually related to the larval stages of the life cycle. Two species (or genotypes) of Echinococcus, E. granulosus sensu stricto and E. equinus, as well as several Taenia spp. are endemic in the UK. Here we report on the occurrence of larval cystic stages of Echinococcus and Taenia spp. in captive mammals in the UK. Using molecular techniques we have identified E. granulosus (G1 genotype) in a guenon monkey and a Philippine spotted deer; E. equinus in a zebra and a lemur; E. ortleppi in a Philippine spotted deer; E. multilocularis in a macaque monkey and Taenia polyacantha in jumping rats. To the best of our knowledge this is the first report of E. multilocularis in a captive primate translocated to the UK. As far as we know these are the first reports of E. equinus in a primate (lemur) and in a zebra; as well as E. granulosus (G1 genotype) and E. ortleppi in a cervid translocated to the UK. These infections and implications of the potential establishment of exotic species of cestodes are discussed.
Veterinary Clinical Pathology, 2008
: A 7-year-old neutered male polecat-type ferret (Mustela putorius furo) was presented for evalua... more : A 7-year-old neutered male polecat-type ferret (Mustela putorius furo) was presented for evaluation of a cutaneous mass close to the preputial orifice. Cytologic examination of a fine-needle aspirate revealed numerous large clumps of amorphous pink mucinous material and numerous large clumps of slightly pleomorphic epithelial cells. The cells were arranged in papillary structures, palisades, and loosely cohesive sheets with a vaguely honeycomb appearance. Occasional acinar formations were also seen. The cells had moderate to large amounts of finely granular gray to gray-blue cytoplasm. The cells were round to wispy and elongated, with indistinct borders. Often, anuclear cytoplasmic clumps were seen free in the background or adjacent to intact cells. Nuclei were round to oval and usually off-center. Chromatin was finely stippled and contained 1-3 indistinct nucleoli. Anisokaryosis and anisocytosis were moderate. Binucleated cells were noted occasionally. The cytologic features were consistent with a carcinoma of probable apocrine origin. Histopathologic examination supported a diagnosis of secretory apocrine adenocarcinoma of the preputial skin. Secretory apocrine adenocarcinomas of the prepuce are seen relatively frequently in ferrets, although their cytologic appearance has not been described widely. These neoplasms carry a poor prognosis although prompt surgical removal with wide and deep surgical margins and adjunctive radiotherapy may improve survival.
Veterinary Record, 2006
SIR, Deaths associated with large, multi-chambered tissue schizonts described as megaloschizont... more SIR, Deaths associated with large, multi-chambered tissue schizonts described as megaloschizonts have been reported in psittacine birds kept in aviaries in the southern half of Great Britain (Fowler and Forbes 1972, Smith 1972, Walker and Garnham 1972, Simpson 1991), usually in the ...
Veterinary Record, 2010
Transmission electron microscopy identified adenovirus particles in 10 of 70 (14.3 per cent) samp... more Transmission electron microscopy identified adenovirus particles in 10 of 70 (14.3 per cent) samples of large intestinal content collected at postmortem examination from free-living wild red squirrels (Sciurus vulgaris) across Great Britain between 2000 and 2009. Examination was limited to cases in which an enteropathy was suspected on the basis of predetermined macroscopic criteria such as semi-solid or diarrhoeic faeces, suspected enteritis or the presence of intussusception. In most cases, meaningful histological examination of enteric tissue was not possible due to pronounced autolysis. Two (2.9 per cent) of the samples were negative for adenovirus but were found to contain rotavirus particles, a novel finding in this species.
Veterinary Record, 2011
Clinical disease and mortalities due to disseminated visceral coccidiosis were identified for the... more Clinical disease and mortalities due to disseminated visceral coccidiosis were identified for the first time in a group of captive juvenile Eurasian cranes (Grus grus) in the UK during 2008. Presumptive diagnosis was made from the finding of granulomatous nodules in the liver, spleen and other organs at gross postmortem examination, and confirmed histologically by the presence of intracellular coccidial stages within lesions. The species of coccidian was determined to be Eimeria reichenowi on the basis of faecal oocyst morphology and sequencing of 18S rDNA by PCR. A further outbreak of clinical disease occurred in the same enclosure in 2009, affecting a new group of juvenile Eurasian cranes and demoiselle cranes (Anthropoides virgo) and indicating the persistence of infective oocysts in the environment. Clinical sampling of birds during both years demonstrated positive results from examination of both faecal samples and peripheral blood smears.
Journal of Zoo and Wildlife Medicine, 2010
Abstract: Five cases of late-stage abortion in dama gazelle (Gazella dama) occurred in the United... more Abstract: Five cases of late-stage abortion in dama gazelle (Gazella dama) occurred in the United Arab Emirates. Histopathologic and molecular diagnostics found the abortions to be associated with Coxiella burnetii infection. Examination of the herd 6 mo later revealed a significant number of serologically positive animals but failed to detect the antigen in genital swabs. There are few reports in the literature of C. burnetii abortion in nondomestic ungulates and no published reports from the United Arab Emirates.
Journal of Zoo and Wildlife Medicine, 2010
A wild-born, 34-yr-old female western lowland gorilla (Gorilla gorilla gorilla) was transferred b... more A wild-born, 34-yr-old female western lowland gorilla (Gorilla gorilla gorilla) was transferred between zoologic collections in the United Kingdom. Adjustment to its new environment was difficult and a series of health problems ensued. Progressive severe illness of multiple etiologies, and a failure to respond to multiple therapies, led to its euthanasia 5 mo later. Disease processes included severe thoracic and axillary cutaneous ulceration of T2-3 dermatome distribution, gastroenteritis, ulcerative stomatitis, emaciation, hind limb weakness or paresis, and decubitus ulcers of the ankles and elbows. Ante- and postmortem infectious disease screening revealed that this animal was not infected with Mycobacterium tuberculosis, simian varicella virus (SVV), simian immunodeficiency virus (SIV), or hepatitis B virus; but was infected with varicella-zoster virus (VZV) and simian T-lymphotropic virus (STLV). It is hypothesized that recrudescence of VZV and other disease processes described were associated with chronic STLV infection and the end of a characteristically long incubation period.
Journal of Small Animal Practice, 2001
Journal of Small Animal Practice, 2000
Traumatic subcutaneous translocation of the spleen in an Old English sheepdog A 14-month-old enti... more Traumatic subcutaneous translocation of the spleen in an Old English sheepdog A 14-month-old entire male Old English sheepdog was presented with a slowly enlarging subcutaneous soft tissue swelling caudal to the last rib. Radiographic and ultrasonographic investigations demonstrated a soft tissue mass closely adherent to the body wall, with a coarse hypoechoic pattern. Surgical exploration revealed a mass with the gross appearance of splenic tissue. The mass was adhered to a healed paracostal abdominal tear. Histological examination confirmed the resected tissue to be normal spleen.
Journal of Small Animal Practice, 2003
A four-year-old cocker spaniel presented with cardiac tamponade due to a pericardial effusion, in... more A four-year-old cocker spaniel presented with cardiac tamponade due to a pericardial effusion, in addition to pyrexia and peripheral neutrophilia and a recent history of chest trauma. Cytological examination of the pericardial effusion revealed a predominant neutrophilia. The echocardiographic findings were of numerous hyperechoic densities in the pericardial space, due to fibrin, with concurrent thickening and distortion of the pericardium.
Journal of Small Animal Practice, 2001
A two-year-old greyhound was presented with progressive dyspnoea. Radiography showed a hypovascul... more A two-year-old greyhound was presented with progressive dyspnoea. Radiography showed a hypovascular lung pattern with hyperlucent lung fields and echocardiography revealed a large thrombus in the main pulmonary artery. Blood results showed azotaemia and marked hypoalbuminaemia. The dog's clinical condition continued to deteriorate and it was euthanased. Postmortem examination confirmed the presence of the pulmonary thrombus and revealed idiopathic membranous glomerulonephritis.
Journal of Exotic Pet Medicine, 2014
ABSTRACT An 18-month-old, castrated male ferret (Mustela putorius furo) was presented to the vete... more ABSTRACT An 18-month-old, castrated male ferret (Mustela putorius furo) was presented to the veterinary hospital for acute collapse but died despite initiation of emergency treatment. The body was submitted for a complete post mortem examination. The pathologists determined the ferret was suffering from severe necrotizing encephalitis, necrogranulomatous mediastinal lymphadenitis, and ulcerative dermatitis attributable to systemic Candida parapsilosis. This is the first report of systemic Candida parapsilosis in a ferret.
Journal of Avian Medicine and Surgery, 2014
A 6-year-old breeding female spectacled owl (Pusilatrix perspicillata) was presented for a soft, ... more A 6-year-old breeding female spectacled owl (Pusilatrix perspicillata) was presented for a soft, fluid-filled, spherical mass under the neck that had been increasing in size over the previous 3 days. Results of a fine-needle aspirate of the mass showed clear, pale-yellow fluid with a total protein of 12.6 g/L. Cytologic examination revealed erythrocytes, moderate numbers of heterophils, and numerous foamy mononuclear cells against a mucoid background. Macroscopically, the mass appeared to be attached firmly to the esophagus. The mass was excised surgically and submitted for histopathologic examination. The lesion comprised a circumscribed, fibrous-encapsulated multilocular cyst, lined by plump, goblet-type, cuboidal epithelial cells lying in abundant mucinous matrix. Findings were consistent with a mucocele of the esophageal mucosal gland. Excision was considered curative based on follow-up 6 months after initial presentation. To our knowledge, this is the first report of this condition in Strigiformes and indicates that mucocele should be included in the differential diagnosis of cervical masses in birds.
Veterinary Record, 2008
Progressive ataxia, with head tremor, developed in 10 captive-born cheetah cubs under six months ... more Progressive ataxia, with head tremor, developed in 10 captive-born cheetah cubs under six months of age. The condition was usually preceded by coryza and an ocular discharge. Initially the ataxia and weakness affected the hindquarters, then the forelegs, and head tremor developed later. Significant pathological changes were confined to the central nervous system. There was widespread Wallerian degeneration in the funiculi of the spinal cord (except those in the dorsal columns), in the medulla and in the cerebellum. In the cerebellum there was degeneration of Purkinje cells and of the molecular and granular cell layers. There was chromatolysis in the Purkinje cells, the ventral horn cells of the spinal cord and in the neurons of the lateral vestibular nucleus. The olivary nucleus was necrotic. There were foci of inflammatory cells in the molecular layer of the cerebellum and in the medulla. The cause of the disease remains unknown.
The Veterinary record, Jan 20, 2011
... AL,; Chantrey J.,; Shuttleworth C.,; Blackett T.,; Butler H.,; Wilkinson M. &; Sainsbury ... more ... AL,; Chantrey J.,; Shuttleworth C.,; Blackett T.,; Butler H.,; Wilkinson M. &; Sainsbury AW. (2010)Retrospective detection by negative contrast electron microscopy of faecal viral particles infree-living wild red squirrels (Sciurus vulgaris) with suspected enteropathy in Great Britain. ...
The Veterinary record, Jan 17, 2005
... 4 Durrell Wildlife Conservation Trust, Trinity, Jersey JE3 5BP; 5 Bristol Zoo Gardens, Guthri... more ... 4 Durrell Wildlife Conservation Trust, Trinity, Jersey JE3 5BP; 5 Bristol Zoo Gardens, Guthrie Road, Bristol BS8 3HA; 6 Paignton Zoo Environmental Park, Paignton, Devon TQ4 7EU. Capillaria hepatica in primates in zoological ...
Veterinary Parasitology, 2012
Taeniid tapeworms which include Echinococcus and Taenia spp. are obligatory parasites of mammals ... more Taeniid tapeworms which include Echinococcus and Taenia spp. are obligatory parasites of mammals with pathogenicity usually related to the larval stages of the life cycle. Two species (or genotypes) of Echinococcus, E. granulosus sensu stricto and E. equinus, as well as several Taenia spp. are endemic in the UK. Here we report on the occurrence of larval cystic stages of Echinococcus and Taenia spp. in captive mammals in the UK. Using molecular techniques we have identified E. granulosus (G1 genotype) in a guenon monkey and a Philippine spotted deer; E. equinus in a zebra and a lemur; E. ortleppi in a Philippine spotted deer; E. multilocularis in a macaque monkey and Taenia polyacantha in jumping rats. To the best of our knowledge this is the first report of E. multilocularis in a captive primate translocated to the UK. As far as we know these are the first reports of E. equinus in a primate (lemur) and in a zebra; as well as E. granulosus (G1 genotype) and E. ortleppi in a cervid translocated to the UK. These infections and implications of the potential establishment of exotic species of cestodes are discussed.
Veterinary Clinical Pathology, 2008
: A 7-year-old neutered male polecat-type ferret (Mustela putorius furo) was presented for evalua... more : A 7-year-old neutered male polecat-type ferret (Mustela putorius furo) was presented for evaluation of a cutaneous mass close to the preputial orifice. Cytologic examination of a fine-needle aspirate revealed numerous large clumps of amorphous pink mucinous material and numerous large clumps of slightly pleomorphic epithelial cells. The cells were arranged in papillary structures, palisades, and loosely cohesive sheets with a vaguely honeycomb appearance. Occasional acinar formations were also seen. The cells had moderate to large amounts of finely granular gray to gray-blue cytoplasm. The cells were round to wispy and elongated, with indistinct borders. Often, anuclear cytoplasmic clumps were seen free in the background or adjacent to intact cells. Nuclei were round to oval and usually off-center. Chromatin was finely stippled and contained 1-3 indistinct nucleoli. Anisokaryosis and anisocytosis were moderate. Binucleated cells were noted occasionally. The cytologic features were consistent with a carcinoma of probable apocrine origin. Histopathologic examination supported a diagnosis of secretory apocrine adenocarcinoma of the preputial skin. Secretory apocrine adenocarcinomas of the prepuce are seen relatively frequently in ferrets, although their cytologic appearance has not been described widely. These neoplasms carry a poor prognosis although prompt surgical removal with wide and deep surgical margins and adjunctive radiotherapy may improve survival.
Veterinary Record, 2006
SIR, Deaths associated with large, multi-chambered tissue schizonts described as megaloschizont... more SIR, Deaths associated with large, multi-chambered tissue schizonts described as megaloschizonts have been reported in psittacine birds kept in aviaries in the southern half of Great Britain (Fowler and Forbes 1972, Smith 1972, Walker and Garnham 1972, Simpson 1991), usually in the ...
Veterinary Record, 2010
Transmission electron microscopy identified adenovirus particles in 10 of 70 (14.3 per cent) samp... more Transmission electron microscopy identified adenovirus particles in 10 of 70 (14.3 per cent) samples of large intestinal content collected at postmortem examination from free-living wild red squirrels (Sciurus vulgaris) across Great Britain between 2000 and 2009. Examination was limited to cases in which an enteropathy was suspected on the basis of predetermined macroscopic criteria such as semi-solid or diarrhoeic faeces, suspected enteritis or the presence of intussusception. In most cases, meaningful histological examination of enteric tissue was not possible due to pronounced autolysis. Two (2.9 per cent) of the samples were negative for adenovirus but were found to contain rotavirus particles, a novel finding in this species.
Veterinary Record, 2011
Clinical disease and mortalities due to disseminated visceral coccidiosis were identified for the... more Clinical disease and mortalities due to disseminated visceral coccidiosis were identified for the first time in a group of captive juvenile Eurasian cranes (Grus grus) in the UK during 2008. Presumptive diagnosis was made from the finding of granulomatous nodules in the liver, spleen and other organs at gross postmortem examination, and confirmed histologically by the presence of intracellular coccidial stages within lesions. The species of coccidian was determined to be Eimeria reichenowi on the basis of faecal oocyst morphology and sequencing of 18S rDNA by PCR. A further outbreak of clinical disease occurred in the same enclosure in 2009, affecting a new group of juvenile Eurasian cranes and demoiselle cranes (Anthropoides virgo) and indicating the persistence of infective oocysts in the environment. Clinical sampling of birds during both years demonstrated positive results from examination of both faecal samples and peripheral blood smears.
Journal of Zoo and Wildlife Medicine, 2010
Abstract: Five cases of late-stage abortion in dama gazelle (Gazella dama) occurred in the United... more Abstract: Five cases of late-stage abortion in dama gazelle (Gazella dama) occurred in the United Arab Emirates. Histopathologic and molecular diagnostics found the abortions to be associated with Coxiella burnetii infection. Examination of the herd 6 mo later revealed a significant number of serologically positive animals but failed to detect the antigen in genital swabs. There are few reports in the literature of C. burnetii abortion in nondomestic ungulates and no published reports from the United Arab Emirates.
Journal of Zoo and Wildlife Medicine, 2010
A wild-born, 34-yr-old female western lowland gorilla (Gorilla gorilla gorilla) was transferred b... more A wild-born, 34-yr-old female western lowland gorilla (Gorilla gorilla gorilla) was transferred between zoologic collections in the United Kingdom. Adjustment to its new environment was difficult and a series of health problems ensued. Progressive severe illness of multiple etiologies, and a failure to respond to multiple therapies, led to its euthanasia 5 mo later. Disease processes included severe thoracic and axillary cutaneous ulceration of T2-3 dermatome distribution, gastroenteritis, ulcerative stomatitis, emaciation, hind limb weakness or paresis, and decubitus ulcers of the ankles and elbows. Ante- and postmortem infectious disease screening revealed that this animal was not infected with Mycobacterium tuberculosis, simian varicella virus (SVV), simian immunodeficiency virus (SIV), or hepatitis B virus; but was infected with varicella-zoster virus (VZV) and simian T-lymphotropic virus (STLV). It is hypothesized that recrudescence of VZV and other disease processes described were associated with chronic STLV infection and the end of a characteristically long incubation period.
Journal of Small Animal Practice, 2001
Journal of Small Animal Practice, 2000
Traumatic subcutaneous translocation of the spleen in an Old English sheepdog A 14-month-old enti... more Traumatic subcutaneous translocation of the spleen in an Old English sheepdog A 14-month-old entire male Old English sheepdog was presented with a slowly enlarging subcutaneous soft tissue swelling caudal to the last rib. Radiographic and ultrasonographic investigations demonstrated a soft tissue mass closely adherent to the body wall, with a coarse hypoechoic pattern. Surgical exploration revealed a mass with the gross appearance of splenic tissue. The mass was adhered to a healed paracostal abdominal tear. Histological examination confirmed the resected tissue to be normal spleen.
Journal of Small Animal Practice, 2003
A four-year-old cocker spaniel presented with cardiac tamponade due to a pericardial effusion, in... more A four-year-old cocker spaniel presented with cardiac tamponade due to a pericardial effusion, in addition to pyrexia and peripheral neutrophilia and a recent history of chest trauma. Cytological examination of the pericardial effusion revealed a predominant neutrophilia. The echocardiographic findings were of numerous hyperechoic densities in the pericardial space, due to fibrin, with concurrent thickening and distortion of the pericardium.
Journal of Small Animal Practice, 2001
A two-year-old greyhound was presented with progressive dyspnoea. Radiography showed a hypovascul... more A two-year-old greyhound was presented with progressive dyspnoea. Radiography showed a hypovascular lung pattern with hyperlucent lung fields and echocardiography revealed a large thrombus in the main pulmonary artery. Blood results showed azotaemia and marked hypoalbuminaemia. The dog's clinical condition continued to deteriorate and it was euthanased. Postmortem examination confirmed the presence of the pulmonary thrombus and revealed idiopathic membranous glomerulonephritis.
Journal of Exotic Pet Medicine, 2014
ABSTRACT An 18-month-old, castrated male ferret (Mustela putorius furo) was presented to the vete... more ABSTRACT An 18-month-old, castrated male ferret (Mustela putorius furo) was presented to the veterinary hospital for acute collapse but died despite initiation of emergency treatment. The body was submitted for a complete post mortem examination. The pathologists determined the ferret was suffering from severe necrotizing encephalitis, necrogranulomatous mediastinal lymphadenitis, and ulcerative dermatitis attributable to systemic Candida parapsilosis. This is the first report of systemic Candida parapsilosis in a ferret.
Journal of Avian Medicine and Surgery, 2014
A 6-year-old breeding female spectacled owl (Pusilatrix perspicillata) was presented for a soft, ... more A 6-year-old breeding female spectacled owl (Pusilatrix perspicillata) was presented for a soft, fluid-filled, spherical mass under the neck that had been increasing in size over the previous 3 days. Results of a fine-needle aspirate of the mass showed clear, pale-yellow fluid with a total protein of 12.6 g/L. Cytologic examination revealed erythrocytes, moderate numbers of heterophils, and numerous foamy mononuclear cells against a mucoid background. Macroscopically, the mass appeared to be attached firmly to the esophagus. The mass was excised surgically and submitted for histopathologic examination. The lesion comprised a circumscribed, fibrous-encapsulated multilocular cyst, lined by plump, goblet-type, cuboidal epithelial cells lying in abundant mucinous matrix. Findings were consistent with a mucocele of the esophageal mucosal gland. Excision was considered curative based on follow-up 6 months after initial presentation. To our knowledge, this is the first report of this condition in Strigiformes and indicates that mucocele should be included in the differential diagnosis of cervical masses in birds.