Marlind Stiles - Academia.edu (original) (raw)

Papers by Marlind Stiles

Research paper thumbnail of Chronobiological features in episodic and chronic migraine

Headache Medicine, 2010

Altered melatonin secretion and circadian, seasonal variations have been shown in migraine patien... more Altered melatonin secretion and circadian, seasonal variations have been shown in migraine patients, but little is known about migraine chronobiological features. Two hundred migraine patients were studied. Headaches were reported to occur after changes in patients sleep schedule (46%), shift work (86%) and traveling across time zones (79%). Patients significantly delayed their sleep phase, 54% shifted their sleep phase. Chronobiology is a relevant aspect in migraine patients.

Research paper thumbnail of Predicting Success of Oral Appliance Therapy in Treating Obstructive Sleep Apnea Using Drug-Induced Sleep Endoscopy

Journal of Clinical Sleep Medicine, 2018

Study Objectives: Oral appliance therapy (OAT) can be an effective treatment option for patients ... more Study Objectives: Oral appliance therapy (OAT) can be an effective treatment option for patients with obstructive sleep apnea unable to tolerate continuous positive airway pressure. We hypothesize that drug-induced sleep endoscopy (DISE) can be useful in identifying patients who will benefit from OAT. Methods: A retrospective review of all patients who underwent DISE (DISE group) between January 2014 and June 2016 was carried out. We included patients if they received OAT based on recommendations made by DISE findings. A control group was designed by selecting a sample of patients undergoing polysomnography (PSG) with an oral appliance in place who had not undergone prior DISE (no DISE group). The two cohorts were compared to evaluate the hypothesis. Results: A total of 20 patients fit inclusion criteria for the DISE group and 20 patients for the no DISE group. There was no difference between the DISE and no DISE cohorts with respect to mean age, sex, pre-OAT body mass index, post-OAT body mass index, or pre-OAT PSG characteristics including: apneahypopnea index (AHI), oxygen desaturation nadir, or Epworth Sleepiness Scale score. There was a significantly lower treatment AHI (P = .04) and increased number of patients reaching an AHI less than 5 events/h with OAT therapy (P = .04) in the DISE group. Conclusions: Patients showing increased airway dimensions at the level of the velum and/or oropharynx with a jaw thrust may benefit the most from OAT. The use of DISE to identify this subset of patients is helpful in optimizing outcomes with OAT.

Research paper thumbnail of A Critical Review of the Use of Botulinum Toxin in Orofacial Pain Disorders

Dental Clinics of North America, 2007

This article reviews the appropriate use, cautions, and contraindication for botulinum neurotoxin... more This article reviews the appropriate use, cautions, and contraindication for botulinum neurotoxin (BoNT) and reviews the peer-reviewed literature that describes its efficacy for treatment of various chronic orofacial pain disorders. The literature has long suggested that BoNT is of value for orofacial hyperactivity and more recently for some orofacial pain disorders; however, the results are not as promising for orofacial pain. The available data from randomized, double-blind, placebo-controlled trials (RBCTs) do not support the use of BoNT as a substantially better therapy than what is being used already. The one exception is that BoNT has reasonable RBCT data to support its use as a migraine prophylaxis therapy. The major caveat is that the use of BoNT in chronic orofacial pain is "off-label".

Research paper thumbnail of Hemicrania continua presenting as temporomandibular joint pain

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2008

Patients presenting with unilateral facial pain present a unique diagnostic challenge for dental ... more Patients presenting with unilateral facial pain present a unique diagnostic challenge for dental practitioners. As dentists, we routinely look for maxillofacial pathology, temporomandibular disorders, or odontogenic abscesses as the etiology of pain in these patients. However, several types of the chronic daily headaches may also produce signs and symptoms similar to dental or maxillofacial pathology. One such headache, hemicrania continua, is typically characterized by a continuous, throbbing, unilateral headache and is completely responsive to treatment with indomethacin. In this article we present 2 cases in which initial symptoms suggested temporomandibular disorders but the patients were ultimately diagnosed with hemicrania continua. A brief review of hemicrania continua and its treatment is included. Thoroughly understanding this entity and realizing that it may present as temporomandibular pain will allow us to more readily diagnose the condition and implement effective treatment. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:e35-e37)

Research paper thumbnail of Remitting Form of Hemicrania Continua With Seasonal Pattern

Headache: The Journal of Head and Face Pain, 2001

Hemicrania continua is a primary headache syndrome characterized by a continuous, unilateral head... more Hemicrania continua is a primary headache syndrome characterized by a continuous, unilateral headache that is completely responsive to indomethacin. Hemicrania continua exists in continuous and remitting forms. Ten cases of the remitting form have been reported, none of which have had a seasonal pattern. We report a patient with remitting hemicrania continua with a clear seasonal predilection.

Research paper thumbnail of Pain Remapping in Migraine: A Novel Characteristic Following Trigeminal Nerve Injury

Headache: The Journal of Head and Face Pain, 2010

The location of pain during the headache phase of migraine varies between individuals as well as ... more The location of pain during the headache phase of migraine varies between individuals as well as between attacks in some individuals. We have observed a "remapping" or a change in the location of migraine pain following injury to the trigeminal system that is a novel characteristic to migraine and has not been described in other trigeminal pain syndromes of the head, neck, and face. Recognition of this clinical feature implies that the pathophysiology of migraine is impressionable and may be why diagnosis and treatment are often delayed.

Research paper thumbnail of Temporomandibular joint pain and dysfunction

Current Pain and Headache Reports, 2007

Pain caused by temporomandibular disorders originates from either muscular or articular condition... more Pain caused by temporomandibular disorders originates from either muscular or articular conditions, or both. Distinguishing the precise source of the pain is a significant diagnostic challenge to clinicians, and effective management hinges on establishing a correct diagnosis. This paper examines terminology and regional anatomy as it pertains to functional and dysfunctional states of the temporomandibular joint and muscles of mastication. A review of the pathophysiology of the most common disorders is provided. Trends in evaluation, diagnosis, treatment, and research are presented.

Research paper thumbnail of Excessive daytime sleepiness in migraine patients

Journal of Neurology, Neurosurgery & Psychiatry, 2005

Research paper thumbnail of Pain Remapping in Migraine: A Novel Characteristic Following Trigeminal Nerve Injury

Headache: The Journal of Head and Face Pain, 2010

The location of pain during the headache phase of migraine varies between individuals as well as ... more The location of pain during the headache phase of migraine varies between individuals as well as between attacks in some individuals. We have observed a "remapping" or a change in the location of migraine pain following injury to the trigeminal system that is a novel characteristic to migraine and has not been described in other trigeminal pain syndromes of the head, neck, and face. Recognition of this clinical feature implies that the pathophysiology of migraine is impressionable and may be why diagnosis and treatment are often delayed.

Research paper thumbnail of Temporomandibular joint pain and dysfunction

Current Pain and Headache Reports, 2006

Pain caused by temporomandibular disorders originates from either muscular or articular condition... more Pain caused by temporomandibular disorders originates from either muscular or articular conditions, or both. Distinguishing the precise source of the pain is a significant diagnostic challenge to clinicians, and effective management hinges on establishing a correct diagnosis. This paper examines terminology and regional anatomy as it pertains to functional and dysfunctional states of the temporomandibular joint and muscles of mastication. A review of the pathophysiology of the most common disorders is provided. Trends in evaluation, diagnosis, treatment, and research are presented.

Research paper thumbnail of Authors' Reply: Greater Occipital Nerve Blockade for Cluster Headache

…, 2003

Dear Sir We thank Dr Vijayan for his comments on our paper (1). The mechanisms of action of great... more Dear Sir We thank Dr Vijayan for his comments on our paper (1). The mechanisms of action of greater occipital nerve (GON) blockade in cluster headache are uncertain. Many parameters such as volume, type of procedure (dry needling, saline or active drug ...

Research paper thumbnail of Greater occipital nerve blockade for cluster headache

Cephalalgia, 2002

Cluster headache is perhaps the most painful of the primary headache disorders. Its treatment inc... more Cluster headache is perhaps the most painful of the primary headache disorders. Its treatment includes acute, transitional, and preventive therapy. Despite the availability of many treatments, cluster headache patients can still be difficult to treat. We treated 14 cluster headache patients with greater occipital nerve block as transitional therapy (treatment initiated at the same time as preventive therapy). The mean number of headache-free days was 13.1+23.6. Four patients (28.5%) had a good response, five (35.7%) a moderate, and five (35.7%) no response. The greater occipital nerve block was well tolerated with no adverse events. Headache intensity, frequency and duration were significantly decreased comparing the week before with the week after the nerve block (P<0.003, P=0.003, P<0.005, respectively). Greater occipital nerve blockade is a therapeutic option for the transitional treatment of cluster headache. u Cluster headache, nerve block, occipital nerve

Research paper thumbnail of Remitting Form of Hemicrania Continua With Seasonal Pattern

Headache: The Journal of Head and Face Pain, 2001

Hemicrania continua is a primary headache syndrome characterized by a continuous, unilateral head... more Hemicrania continua is a primary headache syndrome characterized by a continuous, unilateral headache that is completely responsive to indomethacin. Hemicrania continua exists in continuous and remitting forms. Ten cases of the remitting form have been reported, none of which have had a seasonal pattern. We report a patient with remitting hemicrania continua with a clear seasonal predilection.

Research paper thumbnail of Chronobiological features in episodic and chronic migraine

Headache Medicine, 2010

Altered melatonin secretion and circadian, seasonal variations have been shown in migraine patien... more Altered melatonin secretion and circadian, seasonal variations have been shown in migraine patients, but little is known about migraine chronobiological features. Two hundred migraine patients were studied. Headaches were reported to occur after changes in patients sleep schedule (46%), shift work (86%) and traveling across time zones (79%). Patients significantly delayed their sleep phase, 54% shifted their sleep phase. Chronobiology is a relevant aspect in migraine patients.

Research paper thumbnail of Predicting Success of Oral Appliance Therapy in Treating Obstructive Sleep Apnea Using Drug-Induced Sleep Endoscopy

Journal of Clinical Sleep Medicine, 2018

Study Objectives: Oral appliance therapy (OAT) can be an effective treatment option for patients ... more Study Objectives: Oral appliance therapy (OAT) can be an effective treatment option for patients with obstructive sleep apnea unable to tolerate continuous positive airway pressure. We hypothesize that drug-induced sleep endoscopy (DISE) can be useful in identifying patients who will benefit from OAT. Methods: A retrospective review of all patients who underwent DISE (DISE group) between January 2014 and June 2016 was carried out. We included patients if they received OAT based on recommendations made by DISE findings. A control group was designed by selecting a sample of patients undergoing polysomnography (PSG) with an oral appliance in place who had not undergone prior DISE (no DISE group). The two cohorts were compared to evaluate the hypothesis. Results: A total of 20 patients fit inclusion criteria for the DISE group and 20 patients for the no DISE group. There was no difference between the DISE and no DISE cohorts with respect to mean age, sex, pre-OAT body mass index, post-OAT body mass index, or pre-OAT PSG characteristics including: apneahypopnea index (AHI), oxygen desaturation nadir, or Epworth Sleepiness Scale score. There was a significantly lower treatment AHI (P = .04) and increased number of patients reaching an AHI less than 5 events/h with OAT therapy (P = .04) in the DISE group. Conclusions: Patients showing increased airway dimensions at the level of the velum and/or oropharynx with a jaw thrust may benefit the most from OAT. The use of DISE to identify this subset of patients is helpful in optimizing outcomes with OAT.

Research paper thumbnail of A Critical Review of the Use of Botulinum Toxin in Orofacial Pain Disorders

Dental Clinics of North America, 2007

This article reviews the appropriate use, cautions, and contraindication for botulinum neurotoxin... more This article reviews the appropriate use, cautions, and contraindication for botulinum neurotoxin (BoNT) and reviews the peer-reviewed literature that describes its efficacy for treatment of various chronic orofacial pain disorders. The literature has long suggested that BoNT is of value for orofacial hyperactivity and more recently for some orofacial pain disorders; however, the results are not as promising for orofacial pain. The available data from randomized, double-blind, placebo-controlled trials (RBCTs) do not support the use of BoNT as a substantially better therapy than what is being used already. The one exception is that BoNT has reasonable RBCT data to support its use as a migraine prophylaxis therapy. The major caveat is that the use of BoNT in chronic orofacial pain is &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;off-label&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;.

Research paper thumbnail of Hemicrania continua presenting as temporomandibular joint pain

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2008

Patients presenting with unilateral facial pain present a unique diagnostic challenge for dental ... more Patients presenting with unilateral facial pain present a unique diagnostic challenge for dental practitioners. As dentists, we routinely look for maxillofacial pathology, temporomandibular disorders, or odontogenic abscesses as the etiology of pain in these patients. However, several types of the chronic daily headaches may also produce signs and symptoms similar to dental or maxillofacial pathology. One such headache, hemicrania continua, is typically characterized by a continuous, throbbing, unilateral headache and is completely responsive to treatment with indomethacin. In this article we present 2 cases in which initial symptoms suggested temporomandibular disorders but the patients were ultimately diagnosed with hemicrania continua. A brief review of hemicrania continua and its treatment is included. Thoroughly understanding this entity and realizing that it may present as temporomandibular pain will allow us to more readily diagnose the condition and implement effective treatment. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:e35-e37)

Research paper thumbnail of Remitting Form of Hemicrania Continua With Seasonal Pattern

Headache: The Journal of Head and Face Pain, 2001

Hemicrania continua is a primary headache syndrome characterized by a continuous, unilateral head... more Hemicrania continua is a primary headache syndrome characterized by a continuous, unilateral headache that is completely responsive to indomethacin. Hemicrania continua exists in continuous and remitting forms. Ten cases of the remitting form have been reported, none of which have had a seasonal pattern. We report a patient with remitting hemicrania continua with a clear seasonal predilection.

Research paper thumbnail of Pain Remapping in Migraine: A Novel Characteristic Following Trigeminal Nerve Injury

Headache: The Journal of Head and Face Pain, 2010

The location of pain during the headache phase of migraine varies between individuals as well as ... more The location of pain during the headache phase of migraine varies between individuals as well as between attacks in some individuals. We have observed a "remapping" or a change in the location of migraine pain following injury to the trigeminal system that is a novel characteristic to migraine and has not been described in other trigeminal pain syndromes of the head, neck, and face. Recognition of this clinical feature implies that the pathophysiology of migraine is impressionable and may be why diagnosis and treatment are often delayed.

Research paper thumbnail of Temporomandibular joint pain and dysfunction

Current Pain and Headache Reports, 2007

Pain caused by temporomandibular disorders originates from either muscular or articular condition... more Pain caused by temporomandibular disorders originates from either muscular or articular conditions, or both. Distinguishing the precise source of the pain is a significant diagnostic challenge to clinicians, and effective management hinges on establishing a correct diagnosis. This paper examines terminology and regional anatomy as it pertains to functional and dysfunctional states of the temporomandibular joint and muscles of mastication. A review of the pathophysiology of the most common disorders is provided. Trends in evaluation, diagnosis, treatment, and research are presented.

Research paper thumbnail of Excessive daytime sleepiness in migraine patients

Journal of Neurology, Neurosurgery & Psychiatry, 2005

Research paper thumbnail of Pain Remapping in Migraine: A Novel Characteristic Following Trigeminal Nerve Injury

Headache: The Journal of Head and Face Pain, 2010

The location of pain during the headache phase of migraine varies between individuals as well as ... more The location of pain during the headache phase of migraine varies between individuals as well as between attacks in some individuals. We have observed a &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;remapping&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; or a change in the location of migraine pain following injury to the trigeminal system that is a novel characteristic to migraine and has not been described in other trigeminal pain syndromes of the head, neck, and face. Recognition of this clinical feature implies that the pathophysiology of migraine is impressionable and may be why diagnosis and treatment are often delayed.

Research paper thumbnail of Temporomandibular joint pain and dysfunction

Current Pain and Headache Reports, 2006

Pain caused by temporomandibular disorders originates from either muscular or articular condition... more Pain caused by temporomandibular disorders originates from either muscular or articular conditions, or both. Distinguishing the precise source of the pain is a significant diagnostic challenge to clinicians, and effective management hinges on establishing a correct diagnosis. This paper examines terminology and regional anatomy as it pertains to functional and dysfunctional states of the temporomandibular joint and muscles of mastication. A review of the pathophysiology of the most common disorders is provided. Trends in evaluation, diagnosis, treatment, and research are presented.

Research paper thumbnail of Authors' Reply: Greater Occipital Nerve Blockade for Cluster Headache

…, 2003

Dear Sir We thank Dr Vijayan for his comments on our paper (1). The mechanisms of action of great... more Dear Sir We thank Dr Vijayan for his comments on our paper (1). The mechanisms of action of greater occipital nerve (GON) blockade in cluster headache are uncertain. Many parameters such as volume, type of procedure (dry needling, saline or active drug ...

Research paper thumbnail of Greater occipital nerve blockade for cluster headache

Cephalalgia, 2002

Cluster headache is perhaps the most painful of the primary headache disorders. Its treatment inc... more Cluster headache is perhaps the most painful of the primary headache disorders. Its treatment includes acute, transitional, and preventive therapy. Despite the availability of many treatments, cluster headache patients can still be difficult to treat. We treated 14 cluster headache patients with greater occipital nerve block as transitional therapy (treatment initiated at the same time as preventive therapy). The mean number of headache-free days was 13.1+23.6. Four patients (28.5%) had a good response, five (35.7%) a moderate, and five (35.7%) no response. The greater occipital nerve block was well tolerated with no adverse events. Headache intensity, frequency and duration were significantly decreased comparing the week before with the week after the nerve block (P<0.003, P=0.003, P<0.005, respectively). Greater occipital nerve blockade is a therapeutic option for the transitional treatment of cluster headache. u Cluster headache, nerve block, occipital nerve

Research paper thumbnail of Remitting Form of Hemicrania Continua With Seasonal Pattern

Headache: The Journal of Head and Face Pain, 2001

Hemicrania continua is a primary headache syndrome characterized by a continuous, unilateral head... more Hemicrania continua is a primary headache syndrome characterized by a continuous, unilateral headache that is completely responsive to indomethacin. Hemicrania continua exists in continuous and remitting forms. Ten cases of the remitting form have been reported, none of which have had a seasonal pattern. We report a patient with remitting hemicrania continua with a clear seasonal predilection.