Marta Piotrowska - Academia.edu (original) (raw)

Papers by Marta Piotrowska

Od dawna jedną z zagadek biologii ewolucyjnej było pochodzenie i utrzymywanie się altruizmu u zwi... more Od dawna jedną z zagadek biologii ewolucyjnej było pochodzenie i utrzymywanie się altruizmu u zwierząt. Teoria dostosowania łącznego ukazała jak dobór naturalny może prowadzić do zachowań, które zmniejszają dostosowanie jednego organizmu, aby zwiększyć dostosowanie innego. Takie zachowania występują w populacjach ssaków z silnym systemem dominacji, które zajmują stałe terytoria. Wyjaśnieniem altruizmu między niespokrewnionymi osobnikami może być fakt, iż wymieniają one zasoby (np. pożywienie) lub usługi (np. iskanie) i współpraca utrzymywana jest przez odwzajemnienie. Badania sugerują, że altruizm odwzajemniony może ewoluować w małych populacjach, w których rzadko występuje migracja.Ważną kwestią poruszoną w tej pracy jest rozpoznawanie się osobników, co leży u podstaw zachowań altruistycznych. Omówiono mechanizmy rozpoznawania zarówno osobników spokrewnionych, jak i niespokrewnionych, między którymi dochodzi do wymiany aktów altruizmu. Wśród wielu gatunków ssaków wykazujących bogac...

Purpose Inflammatory bowel disease (IBD) is characterized by chronic and relapsing inflammation o... more Purpose Inflammatory bowel disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract. Current treatment strategies of IBD are insufficient, expensive and connected with high toxicity. In search for alternatives that could help in the management of IBD without causing serious side effects, natural compounds attracted much attention recently. Curcumin is a natural, inexpensive compound with anti-inflammatory properties derived from rhizomes of Curcuma longa L. Concurrently, silver can suppress microbial activity and promote wound healing. Taking into consideration properties of both compounds, we decided to combine, with the use of nanotechnology, silver and curcumin to synergistically enhance their activity. Methods We obtained two formulations: curcumin and silver (I) nanoparticles complex (curcumin + nAg) and curcumin nanoparticles and silver (I) nanoparticles complex (ncurcumin + nAg). We assessed the anti-inflammatory effect of formulation...

Celem niniejszej pracy było określenie czy poprawa warunków hodowlanych poprzez zastosowanie elem... more Celem niniejszej pracy było określenie czy poprawa warunków hodowlanych poprzez zastosowanie elementów wzbogacenia środowiska wpływa na behawior socjalny samic nornicy rudej.Badania przeprowadzono na dorosłych samicach hodowanych po 3 w klatce. Zwierzęta przydzielono losowo do jednej z trzech grup eksperymentalnych: grupa kontrolna- brak kontaktu z elementami wzbogacającymi, grupa I- elementy wzbogacające obecne w klatce przez 60 minut, grupa II- elementy wzbogacające obecne w klatce przez 30 minut. Przez 90 minut nagrania obserwowano czas trwania takich zachowań jak: jedzenie i picie, czyszczenie się, bieganie, obwąchiwanie otoczenia, stereotypie, bezruch, spanie oraz wąchanie i gryzienie elementu wzbogacającego, siedzenie na nim i ukrywanie się w środku. Elementy wzbogacające stanowiła celulozowa rolka i drewniany klocek. Odnotowano istotne statystycznie różnice w aktywności, na którą składały się wyżej wymienione zachowania z wyłączeniem bezruchu i spania. Największą aktywność wy...

Current Drug Targets

: Fatty acid binding protein A (A-FABP) is one of FABPs isoforms found mainly in adipose tissue a... more : Fatty acid binding protein A (A-FABP) is one of FABPs isoforms found mainly in adipose tissue and macrophages. It works through many integrated pathways, regulating inflammation and lipid metabolism, promoting glucose production, impairing insulin function, and contributing to diseases such as atherosclerosis and diabetes. A-FABP is upregulated in the adipose tissue of obese patients and its increased release into the bloodstream is positively associated with body mass index. Consequently, A-FABP plays a key role in regulating metabolism in obese people. Recent studies in mouse models and humans demonstrated the role of A-FABP in increasing the risk of obesity-related cancers. Here we summarized the state of research on the link between obesity, cancer and A-FABP as a new potential therapeutic target for the treatment of obesity - associated cancers.

This excel file contains microsatellite allele sizes and mating types for each of 338 Dothistroma... more This excel file contains microsatellite allele sizes and mating types for each of 338 Dothistroma septosporum isolates scored at 11 microsatellite loci. The first column gives the individual isolate number, the second gives the code ascribed to each individual, and the third the code for the tree from which the isolate was derived. The fourth column gives the race to which the isolate was assigned (1 = SR, 2 = LPR, 3 = NPR). Columns 5 to 15 give the allele size for each individual at each of 11 microsatellite loci (E, F, G, I, J, K, L, M, O, DS1, DS2). Column 16 gives the mating type of the isolate (1 or 2)

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Pharmacological Research, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

This excel file has four pages. The first page lists the 45 isolates from the three races used in... more This excel file has four pages. The first page lists the 45 isolates from the three races used in the experiment. The isolates come from three races - LPR green, SR orange and NPR blue - and within each race 5 isolates are sampled from each of three populations. The second, third and fourth pages give the exudate (here referred to as toxin) production scores for each isolate (no toxin, l=low, m=medium, h=high) together with the growth in mm after 8 weeks at temperatures 10, 17.5 and 22.5 degrees centigrade respectively. For each isolate the values in replicates I and II for a particular temperature are given.

Ramularia collo-cygni (Rcc) is a damaging fungal pathogen of barley (Hordeum vulgare). It is a ca... more Ramularia collo-cygni (Rcc) is a damaging fungal pathogen of barley (Hordeum vulgare). It is a causal agent of Ramularia Leaf Spot (RLS), which contributes to significant economic yield losses worldwide. Protection against the disease has been, and is currently, based on foliar fungicide applications as available seed treatments are not effective and there are no fully resistant barley varieties. Two groups of systemic fungicides, Succinate Dehydrogenase Inhibitors (SDHIs) and DeMethylation Inhibitors in sterol biosynthesis (DMIs), are used and in addition a protectant multisite inhibitor chlorothalonil has been used to minimise the damaging effects of RLS in barley. SDHI fungicides have been extensively used in cereals since 2005 in the UK. Resistance outbreaks to SDHIs have been reported in several plant pathogenic fungi. The risk of resistance in Rcc was unstudied and so this study aimed to develop the methodologies needed to screen populations, establish baseline sensitivity data, evaluate the risk of evolution of fungicide resistance to SDHIs in the population of Rcc and make recommendations on appropriate anti-resistance strategies to minimise the risk. A combined approach of SDHIs’ field performance under different application regimes, sensitivity testing in vitro, molecular analysis of resistance mutations and studies of the genetic structure of populations was used. The results in this study demonstrated that currently SDHI foliar applications remain effective in controlling RLS in barley. The most consistent control was observed when applying them in mixtures with DMIs. All of the tested field isolates were in the range of baseline sensitivity to SDHIs and no shifts between years and different applications regimes were observed. The molecular characterisation of Rcc resistant mutants developed in UV mutagenesis studies revealed that in four out of five mutants a single amino acid change in a target succinate dehydrogenase (Sdh) protein was associated with decrease in sensitivity to SDHIs. All of these mutations, with the exception of one mutant, were stable in the absence of SDHI fungicide. The analysis of fitness components indicated that mutated strains did not confer a fitness penalty associated with the mutation when measuring the growth in vitro. Additionally a detached leaf assay performed for two selected mutants with high or moderate resistant factors showed that the resistant phenotypes were able to colonise the leaf surface and reproduce successfully. Thus if the resistance was to develop due to these point mutations in the target Sdh gene, mutated phenotypes are likely to be fit enough to outcompete the sensitive population. Analysis of the genetic structure of the Rcc populations demonstrated that the pathogen is highly diverse, is likely to undergo sexual reproduction over the growing season (the sexual stage remains undiscovered) and has a potential for extensive spore dispersal across the field. Thus Rcc has a high evolutionary potential and could adapt to different control measures relatively quickly. In the 2012 growing season, two field phenotypes with reduced sensitivity to SDHIs were identified as a consequence of sensitivity monitoring in vitro. Neither of the isolates had any nucleotide or amino acid changes in the target Sdh gene and the mechanism responsible for the resistance in these two strains remains unknown. One of the field isolates was tested in planta and exhibited abnormal growth on the leaf surface. This could result either from fitness costs incurred due to resistance or the fact that this isolate does not belong to the Rcc species, a possibility which must be further investigated. In conclusion, SDHI fungicides remain effective in controlling RLS in barley, however this study demonstrated that there is a risk of measurable loss of efficacy in field conditions. Thus monitoring studies should be intensified and integrated crop management practices applied to prolong the life span of SDHI fungicide treatments

Fungal Genetics and Biology, 2016

W artykule zaprezentowano praktyczne aspekty wdrażania metody 5-S, bezpośrednio związanej z probl... more W artykule zaprezentowano praktyczne aspekty wdrażania metody 5-S, bezpośrednio związanej z problematyką doskonalenia jakości i bezpieczeństwa pracy. Metoda ta stanowi podstawę efektywnego, zgodnego z koncepcją lean management, zarządzania w przedsiębiorstwie. Przybliżono pięć kolejnych etapów metody, stanowiących proste działania zapewniające przedsiębiorstwom realne korzyści. Celem opracowania jest zaprezentowanie konkretnego i praktycznego rozwiązania możliwego do zastosowania na każdym z etapów wdrażania metody 5S, które jako całość bezpośrednio wpływają na doskonalenie jakości i bezpieczeństwa na stanowisku pracy.

European Journal of Medicinal Chemistry, 2021

The glycosylphosphatidylinositol-anchored transmembrane glycoprotein CD160 (cluster of differenti... more The glycosylphosphatidylinositol-anchored transmembrane glycoprotein CD160 (cluster of differentiation 160) is a member of the immunoglobulin superfamily. Four isoforms, which differ by the presence or absence of an immunoglobulin-like domain and the mode of anchoring in the cell membrane, have been identified. CD160 has a significant impact on the proper functioning of the immune system by activating natural killer cells and inhibiting T cells. CD160 is a natural ligand for herpes virus entry mediator (HVEM), a member of the tumor necrosis factor superfamily. The CD160-HVEM complex is a rare example of direct interaction between the two different superfamilies. The interaction of these two proteins leads to the inhibition of CD4+ T cells which, in consequence, leads to the inhibition of the correct response of the immune system. Available research articles indicate that CD160 plays a role in various types of cancer, chronic viral diseases, malaria, paroxysmal nocturnal hemoglobinuria, atherosclerosis, autoimmune diseases, skin inflammation, acute liver damage and retinal vascular disease. We present here an overview of the CD160 protein, the general characteristics of the receptor and its isoforms, details of structural studies of CD160 and the CD160-HVEM complex, as well as a description of the role of this protein in selected human diseases.

Molecular and Cellular Endocrinology, 2021

Crohn's disease (CD) is an inflammatory bowel disease (IBD) which is characterized by chronic... more Crohn's disease (CD) is an inflammatory bowel disease (IBD) which is characterized by chronic and relapsing inflammation of the gastrointestinal (GI) tract. The etiology of CD is unknown, but factors such as epithelial barrier dysfunction, immune system imbalance, microbiota dysbiosis and environmental influences are thought to be involved in its pathogenesis. Recent studies have shown that short chain fatty acids (SCFAs) and long chain fatty acids (LCFAs) play a vital role in pathophysiology and development of CD by various mechanisms affecting pro- and anti-inflammatory mediators, and maintaining the intestinal homeostasis and regulation of gene expression. SCFAs and LCFAs activate signaling cascades that control immune functions through interaction with cell surface free fatty acid receptors (FFARs), i.e. FFAR1, FFAR2, FFAR3, and FFAR4. This review highlights the role of fatty acids in maintenance of intestinal and immune homeostasis and supports the supplementation of fatty acids as a promising adjunctive treatment for CD.

Insects, 2020

Research on the fauna of beetles (Coleoptera) of the Canary Islands has a long tradition, which e... more Research on the fauna of beetles (Coleoptera) of the Canary Islands has a long tradition, which enables tracking changes in their species composition and arrival of new species. In this paper, we provide new faunistic data on the ladybird beetles (Coccinellidae) recorded on Gran Canaria, one of the central islands of the archipelago, and then analyze available information on the Gran Canarian ladybird fauna from geographical and historical points of view. The field survey resulted in recording 1402 ladybird individuals belonging to 30 species. Ten of these species were new to Gran Canaria and three of them, Chilocorus bipustulatus (Linnaeus), Nephus bisignatus (Boheman), and Nephus ulbrichi Fürsch, had not previously been reported to be on any of the islands of the Canarian archipelago. Tetrabrachys tinerfensis (Hodgson) is synonymized with T. deserticola (Wollaston). Our survey and literature reports allowed us to recognize 42 species of Coccinellidae so far recorded on Gran Canari...

Environment International, 2020

The World Health Organization Global Action Plan recommends integrated surveillance programs as c... more The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost surveillance and easy to implement approach to evaluate antibiotic resistance in wastewater treatment plants (WWTPs) by targeting cefotaxime-resistant (CTX-R) coliforms as indicators. The rationale for this approach was: i) coliform quantification methods are internationally accepted as indicators of fecal contamination in recreational waters and are therefore routinely applied in analytical labs; ii) CTX-R coliforms are clinically relevant, associated with extended-spectrum β-lactamases (ESBLs), and are rare in pristine environments. We analyzed 57 WWTPs in 22 countries across Europe, Asia, Africa, Australia, and North America. CTX-R coliforms were ubiquitous in raw sewage and their relative abundance varied significantly (< 0.1% to 38.3%), being positively correlated (p < 0.001) with regional atmospheric temperatures. Although most WWTPs removed large proportions of CTX-R coliforms, loads over 10 3 colony-forming units per mL were occasionally observed in final effluents. We demonstrate that CTX-R coliform monitoring is a feasible and affordable approach to assess wastewater antibiotic resistance status.