Martin Hemmsen - Academia.edu (original) (raw)

Papers by Martin Hemmsen

This Ph.D. dissertation has been submitted to the Technical University of Denmark in partial fulf... more This Ph.D. dissertation has been submitted to the Technical University of Denmark in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Proceedings of SPIE, Feb 23, 2012

In this study clinically relevant ultrasound images generated with synthetic aperture sequential ... more In this study clinically relevant ultrasound images generated with synthetic aperture sequential beamforming (SASB) is compared to images generated with a conventional technique. The advantage of SASB is the ability to produce high resolution ultrasound images with a high frame rate and at the same time massively reduce the amount of generated data. SASB was implemented in a system consisting of a conventional ultrasound scanner connected to a PC via a research interface. This setup enables simultaneous recording with both SASB and conventional technique. Eighteen volunteers were ultrasound scanned abdominally, and 84 sequence pairs were recorded. Each sequence pair consists of two simultaneous recordings of the same anatomical location with SASB and conventional Bmode imaging. The images were evaluated in terms of spatial resolution, contrast, unwanted artifacts, and penetration depth of the ultrasound beam. Five ultrasound experts (radiologists) evaluated the sequence pairs in a side-by-side comparison, and the results show that image quality using SASB was better than conventional B-mode imaging. 73 % of the evaluations favored SASB, and a probability of 70 % was calculated for a new radiologist to prefer SASB over conventional imaging, if a new sequence was recorded. There was no significant difference in penetration depth.

Proceedings of SPIE, Apr 1, 2016

This paper presents a novel automatic method for detection of B-lines (comet-tail artifacts) in l... more This paper presents a novel automatic method for detection of B-lines (comet-tail artifacts) in lung ultrasound scans. B-lines are the most commonly used artifacts for analyzing the pulmonary edema. They appear as laser-like vertical beams, which arise from the pleural line and spread down without fading to the edge of the screen. An increase in their number is associated with presence of edema. All the scans used in this study were acquired using a BK3000 ultrasound scanner (BK Ultrasound, Denmark) driving a 192-element 5.5 MHz wide linear transducer (10L2W, BK Ultrasound). The dynamic received focus technique was employed to generate the sequences. Six subjects, among those three patients after major surgery and three normal subjects, were scanned once and Six ultrasound sequences each containing 50 frames were acquired. The proposed algorithm was applied to all 300 in-vivo lung ultrasound images. The pleural line is first segmented on each image and then the B-line artifacts spreading down from the pleural line are detected and overlayed on the image. The resulting 300 images showed that the mean lateral distance between B-lines detected on images acquired from patients decreased by 20% in compare with that of normal subjects. Therefore, the method can be used as the basis of a method of automatically and qualitatively characterizing the distribution of B-lines.

2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Jul 11, 2022

Proceedings of SPIE, Apr 1, 2016

This paper presents a novel beamformer architecture for a low-cost receiver front-end, and invest... more This paper presents a novel beamformer architecture for a low-cost receiver front-end, and investigates if the image quality can be maintained. The system is oriented to the development of a hand-held wireless ultrasound probe based on Synthetic Aperture Sequential Beamforming, and has the advantage of effectively reducing circuit complexity and power dissipation. The array of transducers is divided into sub-apertures, in which the signals from the single channels are aligned through a network of cascaded gradient delays, and summed in the analog domain before A/D conversion. The delay values are quantized to simplify the shifting unit, and a single A/D converter is needed for each sub-aperture yielding a compact, low-power architecture that can be integrated in a single chip. A simulation study was performed using a 3.75 MHz convex array, and the point spread function (PSF) for different configurations was evaluated in terms of lateral full-width-at-half-maximum (FWHM) and −20 dB cystic resolution (CR). Several setups were simulated varying the sub-aperture size N and the quantization step, and design constraints were obtained comparing the PSF to that of an ideal non-quantized system. The PSF is shown for N = 32 with a quantization step of 12 ns. For this configuration, the FWHM is degraded by 0.25% and the CR is 8.70% lower compared to the ideal situation. The results demonstrate that the gradient beamformer provides an adequate image quality, and open the way to a fully-integrated chip for a compact, low-cost, wireless ultrasound probe.

Proceedings of SPIE, Feb 23, 2012

 Users may download and print one copy of any publication from the public portal for the purpose... more  Users may download and print one copy of any publication from the public portal for the purpose of private study or research.  You may not further distribute the material or use it for any profit-making activity or commercial gain  You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Proceedings of SPIE, Mar 20, 2014

This paper presents a new beamforming method for real-time three-dimensional (3-D) ultrasound ima... more This paper presents a new beamforming method for real-time three-dimensional (3-D) ultrasound imaging using a 2-D matrix transducer. To obtain images with sufficient resolution and contrast, several thousand elements are needed. The proposed method reduces the required channel count from the transducer to the main imaging system, by including electronics in the transducer handle. The reduction of element channel count is achieved using a sequential beamforming scheme. The beamforming scheme is a combination of a fixed focus beamformer in the transducer and a second dynamic focus beamformer in the main system. The real-time imaging capability is achieved using a synthetic aperture beamforming technique, utilizing the transmit events to generate a set of virtual elements that in combination can generate an image. The two core capabilities in combination is named Synthetic Aperture Sequential Beamforming (SASB). Simulations are performed to evaluate the image quality of the presented method in comparison to Parallel beamforming utilizing 16 receive beamformers. As indicators for image quality the detail resolution and Cystic resolution are determined for a set of scatterers at a depth of 90 mm for elevation and azimuth angles from 0 • to 25 •. Simulations show that the acoustic performance of the proposed method is less angle dependent than Parallel beamforming. The Cystic resolution is shown to be more than 50% improved, with a detail resolution on the same order as Parallel Beamforming.

PLOS digital health, Oct 27, 2022

While polysomnography (PSG) is the gold standard to quantify sleep, modern technology allows for ... more While polysomnography (PSG) is the gold standard to quantify sleep, modern technology allows for new alternatives. PSG is obtrusive, affects the sleep it is set out to measure and requires technical assistance for mounting. A number of less obtrusive solutions based on alternative methods have been introduced, but few have been clinically validated. Here we validate one of these solutions, the ear-EEG method, against concurrently recorded PSG in twenty healthy subjects each measured for four nights. Two trained technicians scored the 80 nights of PSG independently, while an automatic algorithm scored the ear-EEG. The sleep stages and eight sleep metrics (Total Sleep Time (TST), Sleep Onset Latency, Sleep Efficiency, Wake After Sleep Onset, REM latency, REM fraction of TST, N2 fraction of TST, and N3 fraction of TST) were used in the further analysis. We found the sleep metrics: Total Sleep Time, Sleep Onset Latency, Sleep Efficiency, Wake After Sleep Onset were estimated with high accuracy and precision between automatic sleep scoring and manual sleep scoring. However, the REM latency and REM fraction of sleep showed high accuracy but low precision. Further, the automatic sleep scoring systematically overestimated the N2 fraction of sleep and slightly underestimated the N3 fraction of sleep. We demonstrate that sleep metrics estimated from automatic sleep scoring based on repeated ear-EEG in some cases are more reliably estimated with repeated nights of automatically scored ear-EEG than with a single night of manually scored PSG. Thus, given the obtrusiveness and cost of PSG, ear-EEG seems to be a useful alternative for sleep staging for the single night recording and an advantageous choice for several nights of sleep monitoring.

Synthetic Aperture Radar (EUSAR), 2010 8th European Conference on, Jun 7, 2010

The main advantage of medical ultrasound imaging is its real time capability, which makes it poss... more The main advantage of medical ultrasound imaging is its real time capability, which makes it possible to visualize dynamic structures in the human body. Real time synthetic aperture imaging puts very high demands on the hardware, which currently cannot be met. A method for reducing the number of calculations and still retain the many advantages of SA imaging is described. It consists of a dual stage beamformer, where the first can be a simple fixed focus analog beamformer and the second an ordinary digital ultrasound beamformer. The performance and constrictions of the approach is described.

Proceedings of SPIE, Mar 29, 2013

This paper presents a new design of a discrete time Delta-Sigma (∆Σ) oversampled ultrasound beamf... more This paper presents a new design of a discrete time Delta-Sigma (∆Σ) oversampled ultrasound beamformer which integrates individual channel apodization by means of variable feedback voltage in the Delta-Sigma analog to digital (A/D) converters. The output bit-width of each oversampled A/D converter remains the same as in an unmodified one. The outputs of all receiving channels are delayed and summed, and the resulting multi-bit sample stream is filtered and decimated to become an image line. The simplicity of this beamformer allows the production of high-channel-count or very compact beamformers suitable for 2-D arrays or compact portable scanners. The new design is evaluated using measured data from the research scanner SARUS and a BK-8811 192 element linear array transducer (BK Medical, Herlev, Denmark), insonifying a water-filled wire phantom containing four wires orthogonal to the image plane. The data are acquired using 12-bit flash A/D converters at a sampling rate of 70 MHz, and are then upsampled off-line to 560 MHz for input to the simulated ∆Σ beamformer. The latter generates a B-mode image which is compared to that produced by a digital beamformer that uses 10-bit A/D converters. The performance is evaluated by comparing the width of the wire images at half amplitude and the noise level of the images. The ∆Σ beamformer resolution has been found to be identical to that of the multi-bit A/D beamforming architecture, while the noise floor is elevated by approximately 6 dB.

Proceedings of SPIE, Apr 1, 2016

Synthetic Aperture (SA) imaging produces high-quality images and velocity estimates of both slow ... more Synthetic Aperture (SA) imaging produces high-quality images and velocity estimates of both slow and fast flow at high frame rates. However, grating lobe artifacts can appear both in transmission and reception. These affect the image quality and the frame rate. Therefore optimization of parameters effecting the image quality of SA is of great importance, and this paper proposes an advanced procedure for optimizing the parameters essential for acquiring an optimal image quality, while generating high resolution SA images. Optimization of the image quality is mainly performed based on measures such as F-number, number of emissions and the aperture size. They are considered to be the most contributing acquisition factors in the quality of the high resolution images in SA. Therefore, the performance of image quality is quantified in terms of full-width at half maximum (FWHM) and the cystic resolution (CTR). The results of the study showed that SA imaging with only 32 emissions and maximum sweep angle of 22 degrees yields a very good image quality compared with using 256 emissions and the full aperture size. Therefore the number of emissions and the maximum sweep angle in the SA can be optimized to reach a reasonably good performance, and to increase the frame rate by lowering the required number of emissions. All the measurements are performed using the experimental SARUS scanner connected to a λ/2-pitch transducer. A wire phantom and a tissue mimicking phantom containing anechoic cysts are scanned using the optimized parameters for the transducer. Measurements coincide with simulations.

Proceedings of SPIE, Mar 17, 2015

Time gain compensation (TGC) is essential to ensure the optimal image quality of the clinical ult... more Time gain compensation (TGC) is essential to ensure the optimal image quality of the clinical ultrasound scans. When large fluid collections are present within the scan plane, the attenuation distribution is changed drastically and TGC compensation becomes challenging. This paper presents an automated hierarchical TGC (AHTGC) algorithm that accurately adapts to the large attenuation variation between different types of tissues and structures. The algorithm relies on estimates of tissue attenuation, scattering strength, and noise level to gain a more quantitative understanding of the underlying tissue and the ultrasound signal strength. The proposed algorithm was applied to a set of 44 in vivo abdominal movie sequences each containing 15 frames. Matching pairs of in vivo sequences, unprocessed and processed with the proposed AHTGC were visualized side by side and evaluated by two radiologists in terms of image quality. Wilcoxon signed-rank test was used to evaluate whether radiologists preferred the processed sequences or the unprocessed data. The results indicate that the average visual analogue scale (VAS) is positive (p-value: 2.34 × 10 −13) and estimated to be 1.01 (95% CI: 0.85; 1.16) favoring the processed data with the proposed AHTGC algorithm.

ABSTRACT This paper presents a preliminary in-vivo study of synthetic aperture sequential beamfor... more ABSTRACT This paper presents a preliminary in-vivo study of synthetic aperture sequential beamforming (SASB) in comparison with conventional imaging. The advantage of SASB compared to conventional imaging, is the ability to obtain a more range independent point spread function, without any loss in lateral resolution or frame rate. The objective of this study is to evaluate whether SASB imaging is feasible in-vivo and whether the image quality obtained is comparable with traditional scanned imaging in terms of penetration depth, spatial resolution, contrast, and unwanted artifacts. Acquisition was performed using a ProFocus ultrasound scanner and a 5 MHz convex array transducer. First stage beamformed SASB radio frequency (RF) data were acquired using a transmit and receive focal depth of 70 mm and 63-element sub-apertures. Subsequently the data were off-line processed to generate second stage SASB RF data. For conventional imaging, beamformed RF data was acquired using 63-element sub-apertures in transmit with a focal depth of 105 mm, in receive an expanding aperture using dynamic focusing with a F-number of 0.8 was used. Both modalities used the same standard manufacturer specified pulse. Conventional and SASB RF data were acquired interleaved, ensuring that the exact same anatomical location was scanned. RF data were recorded in real time and processed off-line to generate image sequences. Two male volunteers were scanned abdominally resulting in 34 image sequence pairs. Evaluation of image quality and penetration was performed by five medical doctors. Results showed no significantly (p = 0.98) increase nor decrease in penetration using SASB. Overall image quality was highly significantly (p

Journal of Alzheimer's Disease, Oct 29, 2022

Proceedings of SPIE, Mar 29, 2013

A method for synthetic aperture tissue harmonic imaging is investigated. It combines synthetic ap... more A method for synthetic aperture tissue harmonic imaging is investigated. It combines synthetic aperture sequential beamforming (SASB) with tissue harmonic imaging (THI) to produce an increased and more uniform spatial resolution and improved side lobe reduction compared to conventional B-mode imaging. Synthetic aperture sequential beamforming tissue harmonic imaging (SASB-THI) was implemented on a commercially available BK 2202 Pro Focus UltraView ultrasound system and compared to dynamic receive focused tissue harmonic imaging (DRF-THI) in clinical scans. The scan sequence that was implemented on the UltraView system acquires both SASB-THI and DRF-THI simultaneously. Twenty-four simultaneously acquired video sequences of in-vivo abdominal SASB-THI and DRF-THI scans on 3 volunteers of 4 different sections of liver and kidney tissues were created. Videos of the in-vivo scans were presented in double blinded studies to two radiologists for image quality performance scoring. Limitations to the systems transmit stage prevented user defined transmit apodization to be applied. Field II simulations showed that side lobes in SASB could be improved by using Hanning transmit apodization. Results from the image quality study show, that in the current configuration on the UltraView system, where no transmit apodization was applied, SASB-THI and DRF-THI produced equally good images. It is expected that given the use of transmit apodization, SASB-THI could be further improved.

Ultrasound in Medicine and Biology, Dec 1, 2014

Medical ultrasound imaging using synthetic aperture sequential beamforming (SASB) has for the fir... more Medical ultrasound imaging using synthetic aperture sequential beamforming (SASB) has for the first time been used for clinical patient scanning. Nineteen patients with cancer of the liver (hepatocellular carcinoma or colorectal liver metastases) were scanned simultaneously with conventional ultrasound and SASB using a commercial ultrasound scanner and abdominal transducer. SASB allows implementation of the synthetic aperture technique on systems with restricted data handling capabilities due to a reduction in the data rate in the scanner by a factor of 64. The image quality is potentially maintained despite the data reduction. A total of 117 sequences were recorded and evaluated blinded by five radiologists from a clinical perspective. Forty-eight percent of the evaluations were in favor of SASB, 33% in favor of conventional ultrasound and 19 % were equal, that is, a clear, but non-significant trend favoring SASB over conventional ultrasound (p = 0.18), despite the substantial data reduction.

Proceedings of SPIE, Mar 4, 2010

Improvement of ultrasound images should be guided by their diagnostic value. Evaluation of clinic... more Improvement of ultrasound images should be guided by their diagnostic value. Evaluation of clinical image quality is generally performed subjectively, because objective criteria have not yet been fully developed and accepted for the evaluation of clinical image quality. Based on recommendation 500 from the International Telecommunication Union-Radiocommunication (ITU-R) for such subjective quality assessment, this work presents equipment and a methodology for clinical image quality evaluation for guiding the development of new and improved imaging. The system is based on a BK-Medical 2202 ProFocus scanner equipped with a UA2227 research interface, connected to a PC through X64-CL Express camera link. Data acquisition features subject data recording, loading/saving of exact scanner settings (for later experiment reproducibility), free access to all system parameters for beamformation and is applicable for clinical use. The free access to all system parameters enables the ability to capture standardized images as found in the clinic and experimental data from new processing or beamformation methods. The length of the data sequences is only restricted by the memory of the external PC. Data may be captured interleaved, switching between multiple setups, to maintain identical transducer, scanner, region of interest and recording time on both the experimental-and standardized images. Data storage is approximately 15.1 seconds pr. 3 sec sequence including complete scanner settings and patient information, which is fast enough to get sufficient number of scans under realistic operating conditions, so that statistical evaluation is valid and reliable.

Proceedings of SPIE, Mar 3, 2011

ABSTRACT Focusing and apodization are an essential part of signal processing in ultrasound imagin... more ABSTRACT Focusing and apodization are an essential part of signal processing in ultrasound imaging. Although the fundamental principles are simple, the dramatic increase in computational power of CPUs, GPUs, and FPGAs motivates the development of software based beamformers, which further improves image quality (and the accuracy of velocity estimation). For developing new imaging methods, it is important to establish proof-of-concept before using resources on real-time implementations. With this in mind, an effective and versatile Matlab toolbox written in C++ has been developed to assist in developing new beam formation strategies. It is a general 3D implementation capable of handling a multitude of focusing methods, interpolation schemes, and parametric and dynamic apodization. Despite being flexible, it is capable of exploiting parallelization on a single computer, on a cluster, or on both. On a single computer, it mimics the parallization in a scanner containing multiple beam formers. The focusing is determined using the positions of the transducer elements, presence of virtual sources, and the focus points. For interpolation, a number of interpolation schemes can be chosen, e.g. linear, polynomial, or cubic splines. Apodization can be specified by a number of window functions of fixed size applied on the individual elements as a function of distance to a reference point, or it can be dynamic with an expanding or contracting aperture to obtain a constant F-number, or both. On a standard PC with an Intel Quad-Core Xeon E5520 processor running at 2.26 GHz, the toolbox can beamform 300.000 points using 700.000 data samples in 3 seconds using a transducer with 192 elements, dynamic apodization in transmit and receive, and cubic splines for interpolation. This is 19 times faster than our previous toolbox.

arXiv (Cornell University), Apr 9, 2021

Modern sleep monitoring development is shifting towards the use of unobtrusive sensors combined w... more Modern sleep monitoring development is shifting towards the use of unobtrusive sensors combined with algorithms for automatic sleep scoring. Many different combinations of wet and dry electrodes, earcentered, forehead-mounted or headband-inspired designs have been proposed, alongside an ever growing variety of machine learning algorithms for automatic sleep scoring. In this paper, we compare 13 different, realistic sensor setups derived from the same data set and analysed with the same pipeline. We find that all setups which include both a lateral and an EOG derivation show similar, state-ofthe-art performance, with average Cohen's kappa values of at least 0.80. This indicates that electrode distance, rather than position, is important for accurate sleep scoring. Finally, based on the results presented, we argue that with the current competitive performance of automated staging approaches, there is an urgent need for establishing an improved benchmark beyond current single human rater scoring.

This Ph.D. dissertation has been submitted to the Technical University of Denmark in partial fulf... more This Ph.D. dissertation has been submitted to the Technical University of Denmark in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Proceedings of SPIE, Feb 23, 2012

In this study clinically relevant ultrasound images generated with synthetic aperture sequential ... more In this study clinically relevant ultrasound images generated with synthetic aperture sequential beamforming (SASB) is compared to images generated with a conventional technique. The advantage of SASB is the ability to produce high resolution ultrasound images with a high frame rate and at the same time massively reduce the amount of generated data. SASB was implemented in a system consisting of a conventional ultrasound scanner connected to a PC via a research interface. This setup enables simultaneous recording with both SASB and conventional technique. Eighteen volunteers were ultrasound scanned abdominally, and 84 sequence pairs were recorded. Each sequence pair consists of two simultaneous recordings of the same anatomical location with SASB and conventional Bmode imaging. The images were evaluated in terms of spatial resolution, contrast, unwanted artifacts, and penetration depth of the ultrasound beam. Five ultrasound experts (radiologists) evaluated the sequence pairs in a side-by-side comparison, and the results show that image quality using SASB was better than conventional B-mode imaging. 73 % of the evaluations favored SASB, and a probability of 70 % was calculated for a new radiologist to prefer SASB over conventional imaging, if a new sequence was recorded. There was no significant difference in penetration depth.

Proceedings of SPIE, Apr 1, 2016

This paper presents a novel automatic method for detection of B-lines (comet-tail artifacts) in l... more This paper presents a novel automatic method for detection of B-lines (comet-tail artifacts) in lung ultrasound scans. B-lines are the most commonly used artifacts for analyzing the pulmonary edema. They appear as laser-like vertical beams, which arise from the pleural line and spread down without fading to the edge of the screen. An increase in their number is associated with presence of edema. All the scans used in this study were acquired using a BK3000 ultrasound scanner (BK Ultrasound, Denmark) driving a 192-element 5.5 MHz wide linear transducer (10L2W, BK Ultrasound). The dynamic received focus technique was employed to generate the sequences. Six subjects, among those three patients after major surgery and three normal subjects, were scanned once and Six ultrasound sequences each containing 50 frames were acquired. The proposed algorithm was applied to all 300 in-vivo lung ultrasound images. The pleural line is first segmented on each image and then the B-line artifacts spreading down from the pleural line are detected and overlayed on the image. The resulting 300 images showed that the mean lateral distance between B-lines detected on images acquired from patients decreased by 20% in compare with that of normal subjects. Therefore, the method can be used as the basis of a method of automatically and qualitatively characterizing the distribution of B-lines.

2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Jul 11, 2022

Proceedings of SPIE, Apr 1, 2016

This paper presents a novel beamformer architecture for a low-cost receiver front-end, and invest... more This paper presents a novel beamformer architecture for a low-cost receiver front-end, and investigates if the image quality can be maintained. The system is oriented to the development of a hand-held wireless ultrasound probe based on Synthetic Aperture Sequential Beamforming, and has the advantage of effectively reducing circuit complexity and power dissipation. The array of transducers is divided into sub-apertures, in which the signals from the single channels are aligned through a network of cascaded gradient delays, and summed in the analog domain before A/D conversion. The delay values are quantized to simplify the shifting unit, and a single A/D converter is needed for each sub-aperture yielding a compact, low-power architecture that can be integrated in a single chip. A simulation study was performed using a 3.75 MHz convex array, and the point spread function (PSF) for different configurations was evaluated in terms of lateral full-width-at-half-maximum (FWHM) and −20 dB cystic resolution (CR). Several setups were simulated varying the sub-aperture size N and the quantization step, and design constraints were obtained comparing the PSF to that of an ideal non-quantized system. The PSF is shown for N = 32 with a quantization step of 12 ns. For this configuration, the FWHM is degraded by 0.25% and the CR is 8.70% lower compared to the ideal situation. The results demonstrate that the gradient beamformer provides an adequate image quality, and open the way to a fully-integrated chip for a compact, low-cost, wireless ultrasound probe.

Proceedings of SPIE, Feb 23, 2012

 Users may download and print one copy of any publication from the public portal for the purpose... more  Users may download and print one copy of any publication from the public portal for the purpose of private study or research.  You may not further distribute the material or use it for any profit-making activity or commercial gain  You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Proceedings of SPIE, Mar 20, 2014

This paper presents a new beamforming method for real-time three-dimensional (3-D) ultrasound ima... more This paper presents a new beamforming method for real-time three-dimensional (3-D) ultrasound imaging using a 2-D matrix transducer. To obtain images with sufficient resolution and contrast, several thousand elements are needed. The proposed method reduces the required channel count from the transducer to the main imaging system, by including electronics in the transducer handle. The reduction of element channel count is achieved using a sequential beamforming scheme. The beamforming scheme is a combination of a fixed focus beamformer in the transducer and a second dynamic focus beamformer in the main system. The real-time imaging capability is achieved using a synthetic aperture beamforming technique, utilizing the transmit events to generate a set of virtual elements that in combination can generate an image. The two core capabilities in combination is named Synthetic Aperture Sequential Beamforming (SASB). Simulations are performed to evaluate the image quality of the presented method in comparison to Parallel beamforming utilizing 16 receive beamformers. As indicators for image quality the detail resolution and Cystic resolution are determined for a set of scatterers at a depth of 90 mm for elevation and azimuth angles from 0 • to 25 •. Simulations show that the acoustic performance of the proposed method is less angle dependent than Parallel beamforming. The Cystic resolution is shown to be more than 50% improved, with a detail resolution on the same order as Parallel Beamforming.

PLOS digital health, Oct 27, 2022

While polysomnography (PSG) is the gold standard to quantify sleep, modern technology allows for ... more While polysomnography (PSG) is the gold standard to quantify sleep, modern technology allows for new alternatives. PSG is obtrusive, affects the sleep it is set out to measure and requires technical assistance for mounting. A number of less obtrusive solutions based on alternative methods have been introduced, but few have been clinically validated. Here we validate one of these solutions, the ear-EEG method, against concurrently recorded PSG in twenty healthy subjects each measured for four nights. Two trained technicians scored the 80 nights of PSG independently, while an automatic algorithm scored the ear-EEG. The sleep stages and eight sleep metrics (Total Sleep Time (TST), Sleep Onset Latency, Sleep Efficiency, Wake After Sleep Onset, REM latency, REM fraction of TST, N2 fraction of TST, and N3 fraction of TST) were used in the further analysis. We found the sleep metrics: Total Sleep Time, Sleep Onset Latency, Sleep Efficiency, Wake After Sleep Onset were estimated with high accuracy and precision between automatic sleep scoring and manual sleep scoring. However, the REM latency and REM fraction of sleep showed high accuracy but low precision. Further, the automatic sleep scoring systematically overestimated the N2 fraction of sleep and slightly underestimated the N3 fraction of sleep. We demonstrate that sleep metrics estimated from automatic sleep scoring based on repeated ear-EEG in some cases are more reliably estimated with repeated nights of automatically scored ear-EEG than with a single night of manually scored PSG. Thus, given the obtrusiveness and cost of PSG, ear-EEG seems to be a useful alternative for sleep staging for the single night recording and an advantageous choice for several nights of sleep monitoring.

Synthetic Aperture Radar (EUSAR), 2010 8th European Conference on, Jun 7, 2010

The main advantage of medical ultrasound imaging is its real time capability, which makes it poss... more The main advantage of medical ultrasound imaging is its real time capability, which makes it possible to visualize dynamic structures in the human body. Real time synthetic aperture imaging puts very high demands on the hardware, which currently cannot be met. A method for reducing the number of calculations and still retain the many advantages of SA imaging is described. It consists of a dual stage beamformer, where the first can be a simple fixed focus analog beamformer and the second an ordinary digital ultrasound beamformer. The performance and constrictions of the approach is described.

Proceedings of SPIE, Mar 29, 2013

This paper presents a new design of a discrete time Delta-Sigma (∆Σ) oversampled ultrasound beamf... more This paper presents a new design of a discrete time Delta-Sigma (∆Σ) oversampled ultrasound beamformer which integrates individual channel apodization by means of variable feedback voltage in the Delta-Sigma analog to digital (A/D) converters. The output bit-width of each oversampled A/D converter remains the same as in an unmodified one. The outputs of all receiving channels are delayed and summed, and the resulting multi-bit sample stream is filtered and decimated to become an image line. The simplicity of this beamformer allows the production of high-channel-count or very compact beamformers suitable for 2-D arrays or compact portable scanners. The new design is evaluated using measured data from the research scanner SARUS and a BK-8811 192 element linear array transducer (BK Medical, Herlev, Denmark), insonifying a water-filled wire phantom containing four wires orthogonal to the image plane. The data are acquired using 12-bit flash A/D converters at a sampling rate of 70 MHz, and are then upsampled off-line to 560 MHz for input to the simulated ∆Σ beamformer. The latter generates a B-mode image which is compared to that produced by a digital beamformer that uses 10-bit A/D converters. The performance is evaluated by comparing the width of the wire images at half amplitude and the noise level of the images. The ∆Σ beamformer resolution has been found to be identical to that of the multi-bit A/D beamforming architecture, while the noise floor is elevated by approximately 6 dB.

Proceedings of SPIE, Apr 1, 2016

Synthetic Aperture (SA) imaging produces high-quality images and velocity estimates of both slow ... more Synthetic Aperture (SA) imaging produces high-quality images and velocity estimates of both slow and fast flow at high frame rates. However, grating lobe artifacts can appear both in transmission and reception. These affect the image quality and the frame rate. Therefore optimization of parameters effecting the image quality of SA is of great importance, and this paper proposes an advanced procedure for optimizing the parameters essential for acquiring an optimal image quality, while generating high resolution SA images. Optimization of the image quality is mainly performed based on measures such as F-number, number of emissions and the aperture size. They are considered to be the most contributing acquisition factors in the quality of the high resolution images in SA. Therefore, the performance of image quality is quantified in terms of full-width at half maximum (FWHM) and the cystic resolution (CTR). The results of the study showed that SA imaging with only 32 emissions and maximum sweep angle of 22 degrees yields a very good image quality compared with using 256 emissions and the full aperture size. Therefore the number of emissions and the maximum sweep angle in the SA can be optimized to reach a reasonably good performance, and to increase the frame rate by lowering the required number of emissions. All the measurements are performed using the experimental SARUS scanner connected to a λ/2-pitch transducer. A wire phantom and a tissue mimicking phantom containing anechoic cysts are scanned using the optimized parameters for the transducer. Measurements coincide with simulations.

Proceedings of SPIE, Mar 17, 2015

Time gain compensation (TGC) is essential to ensure the optimal image quality of the clinical ult... more Time gain compensation (TGC) is essential to ensure the optimal image quality of the clinical ultrasound scans. When large fluid collections are present within the scan plane, the attenuation distribution is changed drastically and TGC compensation becomes challenging. This paper presents an automated hierarchical TGC (AHTGC) algorithm that accurately adapts to the large attenuation variation between different types of tissues and structures. The algorithm relies on estimates of tissue attenuation, scattering strength, and noise level to gain a more quantitative understanding of the underlying tissue and the ultrasound signal strength. The proposed algorithm was applied to a set of 44 in vivo abdominal movie sequences each containing 15 frames. Matching pairs of in vivo sequences, unprocessed and processed with the proposed AHTGC were visualized side by side and evaluated by two radiologists in terms of image quality. Wilcoxon signed-rank test was used to evaluate whether radiologists preferred the processed sequences or the unprocessed data. The results indicate that the average visual analogue scale (VAS) is positive (p-value: 2.34 × 10 −13) and estimated to be 1.01 (95% CI: 0.85; 1.16) favoring the processed data with the proposed AHTGC algorithm.

ABSTRACT This paper presents a preliminary in-vivo study of synthetic aperture sequential beamfor... more ABSTRACT This paper presents a preliminary in-vivo study of synthetic aperture sequential beamforming (SASB) in comparison with conventional imaging. The advantage of SASB compared to conventional imaging, is the ability to obtain a more range independent point spread function, without any loss in lateral resolution or frame rate. The objective of this study is to evaluate whether SASB imaging is feasible in-vivo and whether the image quality obtained is comparable with traditional scanned imaging in terms of penetration depth, spatial resolution, contrast, and unwanted artifacts. Acquisition was performed using a ProFocus ultrasound scanner and a 5 MHz convex array transducer. First stage beamformed SASB radio frequency (RF) data were acquired using a transmit and receive focal depth of 70 mm and 63-element sub-apertures. Subsequently the data were off-line processed to generate second stage SASB RF data. For conventional imaging, beamformed RF data was acquired using 63-element sub-apertures in transmit with a focal depth of 105 mm, in receive an expanding aperture using dynamic focusing with a F-number of 0.8 was used. Both modalities used the same standard manufacturer specified pulse. Conventional and SASB RF data were acquired interleaved, ensuring that the exact same anatomical location was scanned. RF data were recorded in real time and processed off-line to generate image sequences. Two male volunteers were scanned abdominally resulting in 34 image sequence pairs. Evaluation of image quality and penetration was performed by five medical doctors. Results showed no significantly (p = 0.98) increase nor decrease in penetration using SASB. Overall image quality was highly significantly (p

Journal of Alzheimer's Disease, Oct 29, 2022

Proceedings of SPIE, Mar 29, 2013

A method for synthetic aperture tissue harmonic imaging is investigated. It combines synthetic ap... more A method for synthetic aperture tissue harmonic imaging is investigated. It combines synthetic aperture sequential beamforming (SASB) with tissue harmonic imaging (THI) to produce an increased and more uniform spatial resolution and improved side lobe reduction compared to conventional B-mode imaging. Synthetic aperture sequential beamforming tissue harmonic imaging (SASB-THI) was implemented on a commercially available BK 2202 Pro Focus UltraView ultrasound system and compared to dynamic receive focused tissue harmonic imaging (DRF-THI) in clinical scans. The scan sequence that was implemented on the UltraView system acquires both SASB-THI and DRF-THI simultaneously. Twenty-four simultaneously acquired video sequences of in-vivo abdominal SASB-THI and DRF-THI scans on 3 volunteers of 4 different sections of liver and kidney tissues were created. Videos of the in-vivo scans were presented in double blinded studies to two radiologists for image quality performance scoring. Limitations to the systems transmit stage prevented user defined transmit apodization to be applied. Field II simulations showed that side lobes in SASB could be improved by using Hanning transmit apodization. Results from the image quality study show, that in the current configuration on the UltraView system, where no transmit apodization was applied, SASB-THI and DRF-THI produced equally good images. It is expected that given the use of transmit apodization, SASB-THI could be further improved.

Ultrasound in Medicine and Biology, Dec 1, 2014

Medical ultrasound imaging using synthetic aperture sequential beamforming (SASB) has for the fir... more Medical ultrasound imaging using synthetic aperture sequential beamforming (SASB) has for the first time been used for clinical patient scanning. Nineteen patients with cancer of the liver (hepatocellular carcinoma or colorectal liver metastases) were scanned simultaneously with conventional ultrasound and SASB using a commercial ultrasound scanner and abdominal transducer. SASB allows implementation of the synthetic aperture technique on systems with restricted data handling capabilities due to a reduction in the data rate in the scanner by a factor of 64. The image quality is potentially maintained despite the data reduction. A total of 117 sequences were recorded and evaluated blinded by five radiologists from a clinical perspective. Forty-eight percent of the evaluations were in favor of SASB, 33% in favor of conventional ultrasound and 19 % were equal, that is, a clear, but non-significant trend favoring SASB over conventional ultrasound (p = 0.18), despite the substantial data reduction.

Proceedings of SPIE, Mar 4, 2010

Improvement of ultrasound images should be guided by their diagnostic value. Evaluation of clinic... more Improvement of ultrasound images should be guided by their diagnostic value. Evaluation of clinical image quality is generally performed subjectively, because objective criteria have not yet been fully developed and accepted for the evaluation of clinical image quality. Based on recommendation 500 from the International Telecommunication Union-Radiocommunication (ITU-R) for such subjective quality assessment, this work presents equipment and a methodology for clinical image quality evaluation for guiding the development of new and improved imaging. The system is based on a BK-Medical 2202 ProFocus scanner equipped with a UA2227 research interface, connected to a PC through X64-CL Express camera link. Data acquisition features subject data recording, loading/saving of exact scanner settings (for later experiment reproducibility), free access to all system parameters for beamformation and is applicable for clinical use. The free access to all system parameters enables the ability to capture standardized images as found in the clinic and experimental data from new processing or beamformation methods. The length of the data sequences is only restricted by the memory of the external PC. Data may be captured interleaved, switching between multiple setups, to maintain identical transducer, scanner, region of interest and recording time on both the experimental-and standardized images. Data storage is approximately 15.1 seconds pr. 3 sec sequence including complete scanner settings and patient information, which is fast enough to get sufficient number of scans under realistic operating conditions, so that statistical evaluation is valid and reliable.

Proceedings of SPIE, Mar 3, 2011

ABSTRACT Focusing and apodization are an essential part of signal processing in ultrasound imagin... more ABSTRACT Focusing and apodization are an essential part of signal processing in ultrasound imaging. Although the fundamental principles are simple, the dramatic increase in computational power of CPUs, GPUs, and FPGAs motivates the development of software based beamformers, which further improves image quality (and the accuracy of velocity estimation). For developing new imaging methods, it is important to establish proof-of-concept before using resources on real-time implementations. With this in mind, an effective and versatile Matlab toolbox written in C++ has been developed to assist in developing new beam formation strategies. It is a general 3D implementation capable of handling a multitude of focusing methods, interpolation schemes, and parametric and dynamic apodization. Despite being flexible, it is capable of exploiting parallelization on a single computer, on a cluster, or on both. On a single computer, it mimics the parallization in a scanner containing multiple beam formers. The focusing is determined using the positions of the transducer elements, presence of virtual sources, and the focus points. For interpolation, a number of interpolation schemes can be chosen, e.g. linear, polynomial, or cubic splines. Apodization can be specified by a number of window functions of fixed size applied on the individual elements as a function of distance to a reference point, or it can be dynamic with an expanding or contracting aperture to obtain a constant F-number, or both. On a standard PC with an Intel Quad-Core Xeon E5520 processor running at 2.26 GHz, the toolbox can beamform 300.000 points using 700.000 data samples in 3 seconds using a transducer with 192 elements, dynamic apodization in transmit and receive, and cubic splines for interpolation. This is 19 times faster than our previous toolbox.

arXiv (Cornell University), Apr 9, 2021

Modern sleep monitoring development is shifting towards the use of unobtrusive sensors combined w... more Modern sleep monitoring development is shifting towards the use of unobtrusive sensors combined with algorithms for automatic sleep scoring. Many different combinations of wet and dry electrodes, earcentered, forehead-mounted or headband-inspired designs have been proposed, alongside an ever growing variety of machine learning algorithms for automatic sleep scoring. In this paper, we compare 13 different, realistic sensor setups derived from the same data set and analysed with the same pipeline. We find that all setups which include both a lateral and an EOG derivation show similar, state-ofthe-art performance, with average Cohen's kappa values of at least 0.80. This indicates that electrode distance, rather than position, is important for accurate sleep scoring. Finally, based on the results presented, we argue that with the current competitive performance of automated staging approaches, there is an urgent need for establishing an improved benchmark beyond current single human rater scoring.