Martin Moore-Ede - Academia.edu (original) (raw)
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Papers by Martin Moore-Ede
원자력산업 = Nuclear industry, 1987
Clinical Pharmacology & Therapeutics, May 1, 1973
Brain Research, Sep 1, 1983
Transactions of the American Nuclear Society, 1987
American Journal of Physiology-regulatory Integrative and Comparative Physiology, May 1, 1986
Biological Psychiatry, Jul 1, 1990
Journal of Occupational and Environmental Medicine, Feb 1, 2012
The New England Journal of Medicine, Sep 25, 1980
American Journal of Physiology-regulatory Integrative and Comparative Physiology, Dec 1, 1983
Comparative Biochemistry and Physiology Part A: Physiology, 1979
PubMed, 2022
Light exposure at night can disrupt the circadian timing of cellular processes and is associated ... more Light exposure at night can disrupt the circadian timing of cellular processes and is associated with a broad range of health disorders. To spectrally engineer lighting which minimizes circadian disruption at night it is necessary to define the precise spectral sensitivity of the human circadian system. Prior attempts have used short monochromatic light exposures in dark-adapted human subjects, or in vitro dark-adapted isolated retina or melanopsin. However, humans spend virtually all their awake hours in a fully light-adapted state. Here we review the evidence for a narrow blue circadian sensitivity curve for light-adapted humans derived from experiments using spectral filtering of light sources, and comparisons of light sources with diverse spectral power distributions. This light-adapted Circadian Potency function permits the development of circadian-protective light for nocturnal use and circadian-entraining light for daytime use.
Physiology & Behavior, Apr 1, 1985
Physiology & Behavior, May 1, 1977
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 1982
Human subjects during extended isolation from environmental time cues show complex variations in ... more Human subjects during extended isolation from environmental time cues show complex variations in timing and duration of sleep with a progressive pattern, which eventually results in rest-activity and body temperature rhythms having different average periods. We present a model where temperature and rest-activity are each governed by an oscillator of the van der Pol type, denoted x and y, respectively. The oscillators affect one another through "velocity" type coupling, the effect of x on y being about four times greater than y on x. Periodic zeitgeber, z, is modeled as forcing only on y. We find that the entire pattern sequence can be realistically reproduced by causing only the intrinsic period of the y oscillator to increase while that of x remains stable. Desynchronization between x and y is the result of the intrinsic periods of the two oscillators becoming so disparate that the coupling is no longer able to enforce synchrony. Prior to desynchronization both human subjects and our model exhibit "phase trapping" wherein the relative phase of x and y is slowly modulated although the average x and y periods match. The model phase relations between temperature and both the timing and duration of sleep are, throughout, in good agreement with entrained and free-running human data. Most importantly, the model shows that the dramatic change in the length of the rest-activity cycle when desynchronization occurs is actually due to a relatively small variation in the governing variable, y.
원자력산업 = Nuclear industry, 1987
Clinical Pharmacology & Therapeutics, May 1, 1973
Brain Research, Sep 1, 1983
Transactions of the American Nuclear Society, 1987
American Journal of Physiology-regulatory Integrative and Comparative Physiology, May 1, 1986
Biological Psychiatry, Jul 1, 1990
Journal of Occupational and Environmental Medicine, Feb 1, 2012
The New England Journal of Medicine, Sep 25, 1980
American Journal of Physiology-regulatory Integrative and Comparative Physiology, Dec 1, 1983
Comparative Biochemistry and Physiology Part A: Physiology, 1979
PubMed, 2022
Light exposure at night can disrupt the circadian timing of cellular processes and is associated ... more Light exposure at night can disrupt the circadian timing of cellular processes and is associated with a broad range of health disorders. To spectrally engineer lighting which minimizes circadian disruption at night it is necessary to define the precise spectral sensitivity of the human circadian system. Prior attempts have used short monochromatic light exposures in dark-adapted human subjects, or in vitro dark-adapted isolated retina or melanopsin. However, humans spend virtually all their awake hours in a fully light-adapted state. Here we review the evidence for a narrow blue circadian sensitivity curve for light-adapted humans derived from experiments using spectral filtering of light sources, and comparisons of light sources with diverse spectral power distributions. This light-adapted Circadian Potency function permits the development of circadian-protective light for nocturnal use and circadian-entraining light for daytime use.
Physiology & Behavior, Apr 1, 1985
Physiology & Behavior, May 1, 1977
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 1982
Human subjects during extended isolation from environmental time cues show complex variations in ... more Human subjects during extended isolation from environmental time cues show complex variations in timing and duration of sleep with a progressive pattern, which eventually results in rest-activity and body temperature rhythms having different average periods. We present a model where temperature and rest-activity are each governed by an oscillator of the van der Pol type, denoted x and y, respectively. The oscillators affect one another through "velocity" type coupling, the effect of x on y being about four times greater than y on x. Periodic zeitgeber, z, is modeled as forcing only on y. We find that the entire pattern sequence can be realistically reproduced by causing only the intrinsic period of the y oscillator to increase while that of x remains stable. Desynchronization between x and y is the result of the intrinsic periods of the two oscillators becoming so disparate that the coupling is no longer able to enforce synchrony. Prior to desynchronization both human subjects and our model exhibit "phase trapping" wherein the relative phase of x and y is slowly modulated although the average x and y periods match. The model phase relations between temperature and both the timing and duration of sleep are, throughout, in good agreement with entrained and free-running human data. Most importantly, the model shows that the dramatic change in the length of the rest-activity cycle when desynchronization occurs is actually due to a relatively small variation in the governing variable, y.