Martine Berliere - Academia.edu (original) (raw)

Papers by Martine Berliere

BJA: British Journal of Anaesthesia, Jul 1, 2014

† Regular aspirin, a form of non-steroidal anti-inflammatory drug (NSAID), has been associated wi... more † Regular aspirin, a form of non-steroidal anti-inflammatory drug (NSAID), has been associated with reduced risk of many cancers, including colorectal cancer. † This retrospective analysis suggests that a single intraoperative NSAID is associated with improved disease-free survival (DFS) in women undergoing conservative breast cancer surgery. † There also appears to be an association between higher preoperative neutrophil:lymphocyte ratio and worse DFS in conservative breast cancer surgery. Background. An association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and better outcome after mastectomy and lung surgery for cancer has been recently suggested. In a retrospective analysis, we investigated the association between intraoperative NSAIDs use in conservative breast cancer surgery and breast cancer disease-free survival (DFS). Similarly, we also evaluated the association between breast cancer DFS and preoperative neutrophil:lymphocyte ratio (NLR). Methods. A retrospective analysis of a single-centre cohort was performed in breast cancer patients (n¼720) with uni-and multivariate analyses, using a Cox regression model. Results. In conservative breast cancer surgery, the intraoperative use of NSAIDs (ketorolac or diclofenac) was associated with an improved DFS {hazard ratio (HR)¼0.57 [95% confidence interval (CI): 0.37-0.89], P¼0.01} and an improved overall survival (OS) [HR¼0.35 (95% CI: 0.17-0.70), P¼0.03]. In these patients, an NLR .3.3 (identified by a receiver-operating characteristic curve) was associated with a shorter DFS [HR¼1.99 (95% CI: 1.16-3.41), P¼0.01] and OS [HR¼2.35 (95% CI: 1.02-5.43), P¼0.046]. Conclusions. Intraoperative NSAIDs and higher preoperative NLR are associated with improved outcome in conservative breast cancer surgery. Prospective, randomized trials to evaluate if these associations are causal are warranted.

Cancers, Mar 13, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Please be patient while the object screen loads. Changez de vue : Choisir un site… UCL FUNDP FUSL... more Please be patient while the object screen loads. Changez de vue : Choisir un site… UCL FUNDP FUSL FUCaM. ...

American Journal of Clinical Pathology, Jun 22, 2020

Objectives: Since most patients with ductal carcinoma in situ (DCIS) of the breast are treated up... more Objectives: Since most patients with ductal carcinoma in situ (DCIS) of the breast are treated upon diagnosis, evidence on its natural progression to invasive carcinoma is limited. It is estimated that around half of the screen-detected DCIS lesions would have remained indolent if they had never been detected. Many patients with DCIS are therefore probably overtreated. Four ongoing randomized noninferiority trials explore active surveillance as a treatment option. Eligibility for these trials is mainly based on histopathologic features. Hence, the call for reproducible histopathologic assessment has never sounded louder. Methods: Here, the available classification systems for DCIS are discussed in depth. Results: This comprehensive review illustrates that histopathologic evaluation of DCIS is characterized by significant interobserver variability. Future digitalization of pathology, combined with development of deep learning algorithms or so-called artificial intelligence, may be an innovative solution to tackle this problem. However, implementation of digital pathology is not within reach for each laboratory worldwide. An alternative classification system could reduce the disagreement among histopathologists who use "conventional" light microscopy: the introduction of dichotomous histopathologic assessment is likely to increase interobserver concordance. Conclusions: Reproducible histopathologic assessment is a prerequisite for robust risk stratification and adequate clinical decision-making. Two-tier histopathologic assessment might enhance the quality of care.

BJA: British Journal of Anaesthesia, Jul 1, 2018

BMC Cancer, Aug 5, 2015

Background: To assess the performance of a predictive model of non-response to neoadjuvant chemot... more Background: To assess the performance of a predictive model of non-response to neoadjuvant chemotherapy (NAC) in patients with breast cancer based on texture, kinetic, and BI-RADS parameters measured from dynamic MRI. Methods: Sixty-nine patients with invasive ductal carcinoma of the breast who underwent pre-treatment MRI were studied. Morphological parameters and biological markers were measured. Pathological complete response was defined as the absence of invasive and in situ cancer in breast and nodes. Pathological non-responders, partial and complete responders were identified. Dynamic imaging was performed at 1.5 T with a 3D axial T1W GRE fat-suppressed sequence. Visual texture, kinetic and BI-RADS parameters were measured in each lesion. ROC analysis and leave-one-out cross-validation were used to assess the performance of individual parameters, then the performance of multi-parametric models in predicting non-response to NAC. Results: A model based on four pre-NAC parameters (inverse difference moment, GLN, LRHGE, wash-in) and k-means clustering as statistical classifier identified non-responders with 84 % sensitivity. BI-RADS mass/non-mass enhancement, biological markers and histological grade did not contribute significantly to the prediction. Conclusion: Pre-NAC texture and kinetic parameters help predicting non-benefit to NAC. Further testing including larger groups of patients with different tumor subtypes is needed to improve the generalization properties and validate the performance of the predictive model.

BACKGROUND Breast cancer (BC) is a complex disease. While Mendelian mutations in high-penetrance ... more BACKGROUND Breast cancer (BC) is a complex disease. While Mendelian mutations in high-penetrance genes predispose to some familial forms, others are due to multiple common low-penetrance polymorphisms. However, it is unclear if the combination of some rare coding variants has an effect. As some Mendelian forms demonstrate genotype-phenotype correlations, we hypothesized co-segregation of rare variants in cancer-related genes would be more frequent in high-risk families with a uniform BC phenotype among relatives. METHODS Whole-exome sequencing was performed on germline DNA from unrelated BC patients referred for genetic testing but without a causative mutation and for which DNA was available from at least one second relative with BC. We retained rare (< 1.5% in ExaC) in silico possibly damaging variants (splice alteration, nonsense or frameshift mutation, or missense variant considered deleterious by at least 2 different algorithms) in a list of 735 cancer or DNA repair related genes. We assessed correlation between segregation of these variants in affected relatives (studied by Sanger sequencing) and tumor phenotypes. A familial uniform BC phenotype was denoted as sharing the same BC histology and the same clinical molecular classification, based on the expression of the hormone receptors and HER2. RESULTS Of the 54 families, 23 (43%) presented a uniform phenotype across the affected relatives. We identified 251 variants. The mean number of variants tested did not differ between families with a similar BC phenotype and families with different BC phenotypes (4.3 vs 4.9 respectively, two-sided T-test p=0.19). The proportion of disease co-segregating variants inside each family was however significantly higher in families with a uniform BC phenotype than in families with a heterogeneous BC phenotype (57.8% vs 30.2%, p<0.01 adjusted for the number of relatives and meioses within each family). Sequencing of matched tumor DNA, obtained for 44 probands, revealed co-segregating variants were more frequently enriched by a somatic event (18.6 vs 4.5%, Mann-Whitney test p=0.042 and 8.3 vs 1.1%, p=0.031 for the families with a uniform or a heterogeneous breast cancer phenotype, respectively). CONCLUSION In this cohort of families at high risk of BC, the proportion of co-segregating variants was significantly higher in the families in which the affected relatives shared a uniform BC phenotype. Investigation of oligogenic models could be more pertinent in this subgroup of families. The theory of bi-allelic gene inactivation required to drive cancer, shown for several Mendelian genes, could also be pertinent in the oligogenic model of inheritance. This study should be replicated in an independent cohort for confirmation. Citation Format: Cedric Van Marcke, Raphaël Helaers, Céline A Schoonjans, Jérôme Ambroise, Martine Berlière, Jean-Luc Canon, Peter Vuylsteke, Jean-Pascal Machiels, Miikka Vikkula, Francois P Duhoux. Co-segregation of rare possibly-damaging variants in cancer-related genes correlates with phenotypic homogeneity in familial breast cancer [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P5-03-04.

International Journal of Surgical Pathology, Oct 30, 2022

Silicone breast implants are frequently used for breast augmentation for cosmetic purposes, as we... more Silicone breast implants are frequently used for breast augmentation for cosmetic purposes, as well as for breast reconstruction after prophylactic or therapeutic mastectomy. Silicone lymphadenopathy is a well-known complication of silicone breast implants. Silicone droplets are present in the breast tissue through ‘silicone bleeding’ of the implant or because of implant rupture. These silicone particles can migrate from the breast to the regional lymph nodes. Silicone lymphadenopathy is caused by a substantial foreign body reaction against these silicone particles, and is frequently associated with asteroid body-containing multinucleated giant cells. Similar multinucleated giant cells are often observed in the capsule surrounding the silicone breast implant, and the number of associated asteroid bodies is highly variable. Here, we discuss a series of twelve women with breast implant-related asteroid bodies in their lymph nodes and/or breast tissue. This pictorial essay illustrates that the presence of asteroid bodies in a lymph node does not necessarily suggests a diagnosis of sarcoidosis. Clinical information about the patient having (or having had) silicone breast implants is often lacking. The encounter of asteroid body-containing giant cells in lymph node cytology, biopsies or resections should therefore lead to reflex clinical-pathological correlation, before establishing a final diagnosis.

European Journal of Anaesthesiology, 2009

BMC Cancer, Nov 11, 2021

Background: Trastuzumab emtansine (T-DM1) is indicated as second-line treatment for human epiderm... more Background: Trastuzumab emtansine (T-DM1) is indicated as second-line treatment for human epidermal growth factor receptor 2 (HER2)-positive metastatic or unresectable locally advanced breast cancer, after progression on trastuzumab and a taxane-based chemotherapy. We wished to determine if the line of treatment in which T-DM1 is administered has an impact on progression-free survival (PFS) and in particular, if prior treatment with capecitabine/lapatinib or pertuzumab modifies PFS of further treatment with T-DM1. Patients and methods: We performed a multicenter retrospective study in 3 Belgian institutions. We evaluated PFS with T-DM1 in patients treated for HER2 positive metastatic or locally advanced unresectable breast cancer between

Fertility and Sterility, Jun 1, 1990

The present study included 118 patients undergoing a laparoscopy for infertility. In 86 patients ... more The present study included 118 patients undergoing a laparoscopy for infertility. In 86 patients with laparoscopically diagnosed endometriosis (group I), biopsies were taken from areas of apparent endometriosis (n = 86) and from a visually normal peritoneum (n = 52). Histology reveals the presence of endometriosis in 93% of positive sites and in 13% of negative sites. In 32 patients without endometriosis at laparoscopy (group II), biopsies were taken from normal uterosacral ligaments (n = 32). Endometriosis was observed in 6% of cases. Despite the increased ability to detect pigmented and nonpigmented endometriotic lesion, histological study revealed the presence of endometriosis in normal peritoneum in 13% (group I) and 6% (group II) of cases. Fertil Steril53:984, 1990

Cancer Research, Mar 1, 2023

International Journal of Surgical Pathology, 2021

Mammary solid papillary carcinoma and usual duct hyperplasia (UDH) of the breast are morphologica... more Mammary solid papillary carcinoma and usual duct hyperplasia (UDH) of the breast are morphological look-alikes, characterized by cellular streaming, solid growth, and a lack of high-grade nuclear atypia. Here, we report a challenging papillary lesion in the breast of a 48-year-old woman that presented with a double pitfall. A core needle biopsy showed a solid papillary proliferation of epithelial cells with oval to round overlapping nuclei, surrounded by a sclerotic stroma. This distorted lesion contained peripheral clefts and cellular streaming, without high-grade nuclear atypia. Immunohistochemistry showed diffuse heterogenous immunoreactivity for estrogen receptor and cytokeratin 5, and no immunoreactivity for chromogranin and synaptophysin. The immunohistochemical profile distinguished this sclerosed papilloma with extensive UDH from a solid papillary carcinoma. The lumpectomy specimen revealed a second challenge, where multiple epithelial islets without surrounding myoepithelia...

Background: Haematological malignancies of the breast are a rare and heterogeneous entity. Materi... more Background: Haematological malignancies of the breast are a rare and heterogeneous entity. Material and Methods: We are reporting a short series of four consecutive cases treated in our breast clinic. Therapeutic options are discussed. All the patients presented with a breast mass. The first case was finally considered as a follicular lymphoma (FL) and the differential diagnosis was made with a mucosa-associated lymphoid tissue (MALT) lymphoma. The patient only underwent a surgical biopsy to obtain the precise diagnosis. The second patient was diagnosed with a chronic lymphocytic leukemia with acutization and was treated with chlorambucil and rituximab. The third patient had a diffuse large B-cell lymphoma (DLBCL). She received no treatment because of her age and comorbidities. The fourth patient was diagnosed with a mixed phenotype acute leukemia (MPAL). Her treatment consisted of hyper-CVAD allograft and prophylactic irradiation of the central nervous system. Results: The four pat...

Annals of Oncology, 2020

Background: In Taiwan, breast cancer has been rapidly jumped to the first place in the incidence ... more Background: In Taiwan, breast cancer has been rapidly jumped to the first place in the incidence of women-specific malignancies. It will be urgent to discover some critical biomarkers predicting patient prognosis and outcome in Taiwan. Because Taiwanese breast cancer has a relatively lower incidence and earlier onset than Western population, the subset of clinical biomarkers and treatments applied in Western population may not be suitable for all Taiwanese population. Methods: Recently microRNAs (miRNAs) were found to be frequently deregulated in breast cancer, and some specific miRNAs were found to be associated with the DNA damage response (DDR). We measured miR-133a, both circulating and intra-tumor levels, to identify the relationship among miR-133a, HER2, and sruvival. We also detected the protein level of Mre11, one of double-strand break repair protein complex, to fingure out the correlation with miR-133a. Results: Our preliminary results showed that circulating miR-133a levels of breast cancer patients are significantly higher than those of health subjects by using the receiver operating characteristic (ROC) curve (p¼0.001). Both circulating and intratumor miR-133a levels were inversely correlated with the HER2 status (p¼0.015 and 0.011), suggesting that Her2 modulate the expression of miR-133a. The Kaplen-Meier survival curve further showed that high circulating miR-133a can increase the overall survival rate of patients who didn't receive chemotherapy, implicating that miR-133a might also modulate the response of chemotherapy, which has been linking to DNA repair ability. We found that ectopic miR-133a overexpression suppressed the protein levels of Mre11 but did not impact its mRNA levels. Conclusions: In this project, we aim to disclose the interplay of miR-133a with Her2 and Mre11 in breast cancer development. Furthermore, we will establish the minimally invasive screen platform to improve early detection, prognosis, and follow up of breast cancer. We believe that the accomplishment of this project will not only provide better understanding of the carcinogenesis of breast cancer but also a prescreening tool to facilitate decisions about which individuals to be recommended for further diagnostic tests or treatments. Legal entity responsible for the study: The authors.

International Journal of Surgical Pathology, 2020

The law of series is a phenomenon that pathologists frequently come across. It represents the obs... more The law of series is a phenomenon that pathologists frequently come across. It represents the observation that a rare diagnosis, once encountered, has the mysterious tendency of occurring again within a short time frame. 1 We were faced with the law of series after observing bizarre multinucleated stromal giant cells in a fibroadenoma of a 19-year-old woman. Although a previous biopsy indicated a benign fibroepithelial lesion, the breast mass was excised because of its rapid enlargement. Macroscopic examination was inconspicuous and revealed a well-circumscribed round nodule measuring 42 mm. The microscopic evaluation showed a fibroepithelial lesion lacking leaf-like architecture and harboring a loosely arranged stroma with low cellularity and diffuse 914077I JSXXX10.

Cancer Research, 2019

Background: Our team has previously highlighted the benefits of hypnosis analgesia on different m... more Background: Our team has previously highlighted the benefits of hypnosis analgesia on different modalities of breast cancer treatment. In order to confirm these benefits and -in order to try to explain the mechanisms implicated in hypnosis sedation -, we have initiated this new study. Material and methods: This study is a prospective non -randomized multicentric study approved by our local ethics committee which has planned to include 450 consecutive non -metastatic breast cancer patients treated in our breast clinic. The study is divided in 3 arms. In the first arm, patients undergo oncologic breast surgery while on general anesthesia. In the second arm , general anesthesia is preceded by a session of hypnosis relaxation mediated by virtual reality (Aqua program, Oncomfort ). In the third arm , the patients undergo breast surgery while on hypnosis analgesia and local anesthesia. To decrease the impact of local anesthesia, on the measured outcomes , this procedure is added to genera...

BJA: British Journal of Anaesthesia, Jul 1, 2014

Cancers, Mar 13, 2023

American Journal of Clinical Pathology, Jun 22, 2020

BJA: British Journal of Anaesthesia, Jul 1, 2018

BMC Cancer, Aug 5, 2015

International Journal of Surgical Pathology, Oct 30, 2022

European Journal of Anaesthesiology, 2009

BMC Cancer, Nov 11, 2021

Fertility and Sterility, Jun 1, 1990

Cancer Research, Mar 1, 2023

International Journal of Surgical Pathology, 2021

Annals of Oncology, 2020

International Journal of Surgical Pathology, 2020

Cancer Research, 2019

Objective: Cancer patients consider the oncologist as their main resource insofar as the medical ... more Objective: Cancer patients consider the oncologist as their main resource insofar as the medical needs generally take precedence over psychological needs. Nevertheless, the psychological intervention is also important. The systematic consultation implemented in our hospital after a diagnosis of cancer is a manner to answer patients' psychological needs. In a survey, we assessed the satisfaction and expectations of the patients about this consultation. Methods: One year after a diagnosis of breast cancer, 104 patients answered a retrospective questionnaire assessing: socio-demographic data, cancer medical information, systematic consultation satisfaction, patients' expectations for a systematic intervention, and patients' characteristics who began a psychological follow-up. Results: 72.1% of the patients were satisfied with having the opportunity to consult a psychologist during a systematic consultation after cancer diagnosis. Their expectations were to have opportunities of emotional expression, reassurance, obtaining additional medical information , talking about their fear over additional treatments, and identifying further support. 28.8% of the patients re-contacted the psychologist for further help after the systematic consultation. They were significantly younger (p < 0.001) than the others. Conclusions: Besides the importance of support by medical specialists [1], offering the opportunity to breast cancer patients to discuss inner feelings and treatment expectations during a systematic psychological consultation was useful for most of them. About one third of the patients asked for a further consultation with a psychologist after a first systematic consultation, especially younger patients. This stressed the importance D. Ogez et al. 316 of the role of psychologists for psycho-social support of the patient after cancer treatment.