Martino Mistretta - Academia.edu (original) (raw)
Papers by Martino Mistretta
L'obiettivo di questo lavoro è fornire un ausilio nella scelta di un trattamento in ambito ps... more L'obiettivo di questo lavoro è fornire un ausilio nella scelta di un trattamento in ambito psichiatrico, mediante tabelle sinottiche che permettano una visualizzazione d'insieme dei farmaci utilizzati per una determinata patologia. Per ogni disturbo sono indicati tutti i farmaci ufficialmente autorizzati e quelli per cui esistono consistenti evidenze di efficacia provenienti dalla letteratura scientifica
European Psychiatry, 2013
Introduction Cardiac surgery with cardiopulmonary bypass represents a severe source of stress and... more Introduction Cardiac surgery with cardiopulmonary bypass represents a severe source of stress and has been reported to be associated to the development of Posttraumatic Stress Disorder (PTSD). This disorder leads to a significant disability that might greatly decrease the benefits of surgery. Research rarely focused on the role of attachment styles in the development of PTSD, and no studies addressed this issue in patients undergoing cardiac surgery. Objectives To assess the influence of attachment styles on the development of PTSD. Aims The identification of specific personological traits predictive of the development of PTSD. Methods Participants were recruited among patients scheduled for elective cardiac surgery with cardiopulmonary bypass and evaluated througha) Experiences in Close Relationships (ECR)b) Post-traumatic 10 Stress Symptom Inventory - Modified (PTSS-10)c) Perceived Stress Scale (PSS). Six months after surgery, participants were mailed the PTSS-10 and the PSS. Multiple logistic regression analysis was performed with PTSD as dependent variable, and attachment-related avoidance and anxiety, sex, age and perceived stress as independent variables. Results One hundred twenty-one patients (94% of candidates for elective cardiac surgery who met study inclusion criteria) underwent surgery; 61(59%) were assessed after 6 months. Fourteen subjects (19.7%) scored ≥35 on the PTSS-10 at followup and were considered as having a probable diagnosis of PTSD. Attachment related avoidance at baseline predicted the development of PTSD at follow-up (p< 0.017), after controlling for age, sex and perceived stress. Conclusions Subjects endorsing the avoidant attachment style are more likely to develop PTSD after cardiac surgery.
Rivista di psichiatria, 2018
Background It has long been appreciated that alcohol use disorder (AUD) is associated with increa... more Background It has long been appreciated that alcohol use disorder (AUD) is associated with increased risk of psychiatric disorder. As well, people with history of mental disorder are more likely to develop lifetime AUD. Nevertheless, the treatment of dual diagnosis (DD) in alcohol addiction still remains a challenge. The efficacy of pharmacological treatment for these patients has been widely investigated with controversial results. Patients with untreated psychiatric disorder are at higher risk to return to drinking and tend to do so more quickly. The aim of this review was to collect clinical data for developing guidelines for the pharmacological treatment of psychiatric diseases in a population with AUD. Materials and methods A literature review was conducted using the following databases: PubMed-NCBI, Cochrane database, Embase Web of Science, and Scopus, including studies published between 1980 and 2015. Search terms were: “guideline”, “treatment”, “comorbidity”, “substance abus...
Rivista di psichiatria, 2018
Background The term “dual diagnosis” (DD) has been used in clinical practice for years. However, ... more Background The term “dual diagnosis” (DD) has been used in clinical practice for years. However, there is confusion about these medical cases, which consist in the presence of both a psychiatric disorder and a substance abuse disorder (in this case, alcohol). There are evidences that in the alcohol use disorder (AUD) population, 50.3% of patients had a psychiatric comorbidity during their lifetime. Nevertheless, to these days there are not any thorough guidelines for the management of these patients. A precise nosography would prevent delay in diagnosis and treatment and all the self-evident negative outcomes of those delays. Materials and methods A literature search was performed in PubMed, Web of Science, and Scopus, including studies published between 1980 and 2015. Search terms were: “guidelines”, “treatment”, “comorbidity”, “substance abuse”, “alcohol”, “dual-diagnosis”, “etiopathogenesis”, “outpatient”, “inpatient”, “unit”, “diagnosis”. Out of 1045 titles, 43 studies were incl...
Rivista di psichiatria, 2018
Background Clinical practice of mental health services changed in 1978 after the Basaglia Law was... more Background Clinical practice of mental health services changed in 1978 after the Basaglia Law was passed, and it is now characterized by usually voluntary treatments offered by community-based services. That broadened the interventions’ focus from the single subject to their environment. Dual diagnosis is defined by WHO as «the co-occurrence in the same individual of a psychoactive substance use disorder and another psychiatric disorder». It is considered to be a “border territory” since entails networking between different medical services. Materials and methods A literature search was performed in PubMed, Web of Science, Scopus and Google Scholar. Search terms were: “guidelines”, “treatment”, “comorbidity”, “substance abuse”, “alcohol”, “dual-diagnosis”, “psychiatric illness”, “outpatient”, “inpatient”, “health care service”, “clinical practice”. National and regional regulations about health and addiction were screened too. Out of 598 titles, 31 studies were included in this arti...
Rivista di psichiatria, 2009
AIM Night Eating Syndrome (NES) is an eating disorder characterized by the clinical features of m... more AIM Night Eating Syndrome (NES) is an eating disorder characterized by the clinical features of morning anorexia, evening hyperphagia, and insomnia with awakenings followed by nocturnal food ingestion. The core clinical feature appears to be a delay in the circadian timing of food intake. Energy intake is reduced in the first half of the day and greatly increased in the second half. In particular, NES is clinically relevant because of its association with obesity. The aim of the present study was to determine the vulnerability to develop NES in the general population and to investigate the hypothesized role of acute and chronic stress in the pathogenesis of dysfunctional eating behaviors. METHODS The Night Eating Questionnaire (NEQ) and the Stress Vulnerability Scale (SVS) have been administered to 531 adults attending the Department of Science of Health at the University of L'Aquila. Socio-demographic and anthropometric features were collected through a specific questionnaire. ...
Rivista Di Psichiatria, 2009
Rivista Di Psichiatria, Nov 1, 2007
Rivista di Psichiatria
Night Eating Syndrome (NES) is an eating disorder characterized by the clinical features of morni... more Night Eating Syndrome (NES) is an eating disorder characterized by the clinical features of morning anorexia, evening hyperphagia, and insomnia with awakenings followed by nocturnal food ingestion. The core clinical feature appears to be a delay in the circadian timing of food intake. Energy intake is reduced in the first half of the day and greatly increased in the second half. In particular, NES is clinically relevant because of its association with obesity. The aim of the present study was to determine the vulnerability to develop NES in the general population and to investigate the hypothesized role of acute and chronic stress in the pathogenesis of dysfunctional eating behaviors. The Night Eating Questionnaire (NEQ) and the Stress Vulnerability Scale (SVS) have been administered to 531 adults attending the Department of Science of Health at the University of L'Aquila. Socio-demographic and anthropometric features were collected through a specific questionnaire. 9.3% of pati...
Journal of Cardiothoracic and Vascular Anesthesia - J CARDIOTHORAC VASC ANESTH
The aim was to investigate perioperative factors associated with the development of post-traumati... more The aim was to investigate perioperative factors associated with the development of post-traumatic stress disorder (PTSD) in patients who underwent cardiac surgery. Prospective observational study. Single academic center. One hundred twenty-eight consecutive patients scheduled for elective cardiac surgery with cardiopulmonary bypass. Patients were interviewed within the surgical unit 1 to 3 days before cardiac surgery. Six months after surgery, participants were mailed the modified version of the Posttraumatic Stress Symptom Inventory 10. Of the 71 patients who completed the questionnaire and mailed it back at follow-up, 14 (19.7%) received a diagnosis of PTSD. Seven of 13 female patients who were not treated with β-blockers received a diagnosis of PTSD compared with 0 of 12 who were treated with β-blockers (p = 0.005, Fisher exact test). In a general linear model, including sex and β-blocker treatment as predictors, the Posttraumatic Stress Symptom Inventory 10 score was significantly predicted by β-blockade (F = 4.74, p = 0.033), with a significant interaction between sex and β-blockade (F = 9.72, p = 0.003). These findings suggest that the use of β-blockers might be protective against the development of PTSD in women after cardiac surgery.
Journal of Clinical Psychopharmacology, 2013
Anxiety symptoms in depression result often in treatment resistance, residual symptoms, and persi... more Anxiety symptoms in depression result often in treatment resistance, residual symptoms, and persistent functional impairment. To assess the effectiveness and safety of adjunctive pregabalin to antidepressants for residual anxiety in patients with major depressive disorder (MDD). A retrospective chart review was conducted to identify partial responders among patients with MDD with residual anxiety. Twenty such patients (age, 58.4 ± 11.2 years; 15 women; baseline Hamilton Depression Rating Scale [HDRS], 17.1 ± 3.5) who received adjunctive pregabalin for residual anxiety were included. Antidepressants augmented were the selective serotonin reuptake inhibitors (n = 12), mirtazapine (n = 2), and selective serotonin-norepinephrine reuptake inhibitors (n = 6). Twenty patients received at least 4 weeks of pregabalin treatment after 8 weeks of antidepressant therapy. At week 1 (9 weeks after initiating treatment), pregabalin was prescribed at a mean ± SD dose of 71.2 ± 31.7 mg, and the mean maximum pregabalin dose prescribed was 156.2 ± 76.5 mg (range, 75-300 mg). At week 8, there were 13 responders (13/20 [65%]), and 7 of these 13 patients achieved remission (HDRS17 &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 8). There were significant decreases in HDRS scores (13.5 ± 3.1 vs 9.1 ± 2.9, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.000), and HDRS anxiety/somatization subscale scores (6.3 ± 2 to 3.6 ± 1.7, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.000). Adverse effects included somnolence (n = 7), weight gain (n = 3), dizziness (n = 4), dry mouth (n = 6), edema (n = 3), blurred vision (n = 3), difficulty with concentration/attention (n = 8), headache (n = 6), and diarrhea (n = 5). The results suggest a possible augmentation role for pregabalin when used in conjunction with conventional antidepressants for residual anxiety in MDD.
European Psychiatry, 2013
L'obiettivo di questo lavoro è fornire un ausilio nella scelta di un trattamento in ambito ps... more L'obiettivo di questo lavoro è fornire un ausilio nella scelta di un trattamento in ambito psichiatrico, mediante tabelle sinottiche che permettano una visualizzazione d'insieme dei farmaci utilizzati per una determinata patologia. Per ogni disturbo sono indicati tutti i farmaci ufficialmente autorizzati e quelli per cui esistono consistenti evidenze di efficacia provenienti dalla letteratura scientifica
European Psychiatry, 2013
Introduction Cardiac surgery with cardiopulmonary bypass represents a severe source of stress and... more Introduction Cardiac surgery with cardiopulmonary bypass represents a severe source of stress and has been reported to be associated to the development of Posttraumatic Stress Disorder (PTSD). This disorder leads to a significant disability that might greatly decrease the benefits of surgery. Research rarely focused on the role of attachment styles in the development of PTSD, and no studies addressed this issue in patients undergoing cardiac surgery. Objectives To assess the influence of attachment styles on the development of PTSD. Aims The identification of specific personological traits predictive of the development of PTSD. Methods Participants were recruited among patients scheduled for elective cardiac surgery with cardiopulmonary bypass and evaluated througha) Experiences in Close Relationships (ECR)b) Post-traumatic 10 Stress Symptom Inventory - Modified (PTSS-10)c) Perceived Stress Scale (PSS). Six months after surgery, participants were mailed the PTSS-10 and the PSS. Multiple logistic regression analysis was performed with PTSD as dependent variable, and attachment-related avoidance and anxiety, sex, age and perceived stress as independent variables. Results One hundred twenty-one patients (94% of candidates for elective cardiac surgery who met study inclusion criteria) underwent surgery; 61(59%) were assessed after 6 months. Fourteen subjects (19.7%) scored ≥35 on the PTSS-10 at followup and were considered as having a probable diagnosis of PTSD. Attachment related avoidance at baseline predicted the development of PTSD at follow-up (p< 0.017), after controlling for age, sex and perceived stress. Conclusions Subjects endorsing the avoidant attachment style are more likely to develop PTSD after cardiac surgery.
Rivista di psichiatria, 2018
Background It has long been appreciated that alcohol use disorder (AUD) is associated with increa... more Background It has long been appreciated that alcohol use disorder (AUD) is associated with increased risk of psychiatric disorder. As well, people with history of mental disorder are more likely to develop lifetime AUD. Nevertheless, the treatment of dual diagnosis (DD) in alcohol addiction still remains a challenge. The efficacy of pharmacological treatment for these patients has been widely investigated with controversial results. Patients with untreated psychiatric disorder are at higher risk to return to drinking and tend to do so more quickly. The aim of this review was to collect clinical data for developing guidelines for the pharmacological treatment of psychiatric diseases in a population with AUD. Materials and methods A literature review was conducted using the following databases: PubMed-NCBI, Cochrane database, Embase Web of Science, and Scopus, including studies published between 1980 and 2015. Search terms were: “guideline”, “treatment”, “comorbidity”, “substance abus...
Rivista di psichiatria, 2018
Background The term “dual diagnosis” (DD) has been used in clinical practice for years. However, ... more Background The term “dual diagnosis” (DD) has been used in clinical practice for years. However, there is confusion about these medical cases, which consist in the presence of both a psychiatric disorder and a substance abuse disorder (in this case, alcohol). There are evidences that in the alcohol use disorder (AUD) population, 50.3% of patients had a psychiatric comorbidity during their lifetime. Nevertheless, to these days there are not any thorough guidelines for the management of these patients. A precise nosography would prevent delay in diagnosis and treatment and all the self-evident negative outcomes of those delays. Materials and methods A literature search was performed in PubMed, Web of Science, and Scopus, including studies published between 1980 and 2015. Search terms were: “guidelines”, “treatment”, “comorbidity”, “substance abuse”, “alcohol”, “dual-diagnosis”, “etiopathogenesis”, “outpatient”, “inpatient”, “unit”, “diagnosis”. Out of 1045 titles, 43 studies were incl...
Rivista di psichiatria, 2018
Background Clinical practice of mental health services changed in 1978 after the Basaglia Law was... more Background Clinical practice of mental health services changed in 1978 after the Basaglia Law was passed, and it is now characterized by usually voluntary treatments offered by community-based services. That broadened the interventions’ focus from the single subject to their environment. Dual diagnosis is defined by WHO as «the co-occurrence in the same individual of a psychoactive substance use disorder and another psychiatric disorder». It is considered to be a “border territory” since entails networking between different medical services. Materials and methods A literature search was performed in PubMed, Web of Science, Scopus and Google Scholar. Search terms were: “guidelines”, “treatment”, “comorbidity”, “substance abuse”, “alcohol”, “dual-diagnosis”, “psychiatric illness”, “outpatient”, “inpatient”, “health care service”, “clinical practice”. National and regional regulations about health and addiction were screened too. Out of 598 titles, 31 studies were included in this arti...
Rivista di psichiatria, 2009
AIM Night Eating Syndrome (NES) is an eating disorder characterized by the clinical features of m... more AIM Night Eating Syndrome (NES) is an eating disorder characterized by the clinical features of morning anorexia, evening hyperphagia, and insomnia with awakenings followed by nocturnal food ingestion. The core clinical feature appears to be a delay in the circadian timing of food intake. Energy intake is reduced in the first half of the day and greatly increased in the second half. In particular, NES is clinically relevant because of its association with obesity. The aim of the present study was to determine the vulnerability to develop NES in the general population and to investigate the hypothesized role of acute and chronic stress in the pathogenesis of dysfunctional eating behaviors. METHODS The Night Eating Questionnaire (NEQ) and the Stress Vulnerability Scale (SVS) have been administered to 531 adults attending the Department of Science of Health at the University of L'Aquila. Socio-demographic and anthropometric features were collected through a specific questionnaire. ...
Rivista Di Psichiatria, 2009
Rivista Di Psichiatria, Nov 1, 2007
Rivista di Psichiatria
Night Eating Syndrome (NES) is an eating disorder characterized by the clinical features of morni... more Night Eating Syndrome (NES) is an eating disorder characterized by the clinical features of morning anorexia, evening hyperphagia, and insomnia with awakenings followed by nocturnal food ingestion. The core clinical feature appears to be a delay in the circadian timing of food intake. Energy intake is reduced in the first half of the day and greatly increased in the second half. In particular, NES is clinically relevant because of its association with obesity. The aim of the present study was to determine the vulnerability to develop NES in the general population and to investigate the hypothesized role of acute and chronic stress in the pathogenesis of dysfunctional eating behaviors. The Night Eating Questionnaire (NEQ) and the Stress Vulnerability Scale (SVS) have been administered to 531 adults attending the Department of Science of Health at the University of L'Aquila. Socio-demographic and anthropometric features were collected through a specific questionnaire. 9.3% of pati...
Journal of Cardiothoracic and Vascular Anesthesia - J CARDIOTHORAC VASC ANESTH
The aim was to investigate perioperative factors associated with the development of post-traumati... more The aim was to investigate perioperative factors associated with the development of post-traumatic stress disorder (PTSD) in patients who underwent cardiac surgery. Prospective observational study. Single academic center. One hundred twenty-eight consecutive patients scheduled for elective cardiac surgery with cardiopulmonary bypass. Patients were interviewed within the surgical unit 1 to 3 days before cardiac surgery. Six months after surgery, participants were mailed the modified version of the Posttraumatic Stress Symptom Inventory 10. Of the 71 patients who completed the questionnaire and mailed it back at follow-up, 14 (19.7%) received a diagnosis of PTSD. Seven of 13 female patients who were not treated with β-blockers received a diagnosis of PTSD compared with 0 of 12 who were treated with β-blockers (p = 0.005, Fisher exact test). In a general linear model, including sex and β-blocker treatment as predictors, the Posttraumatic Stress Symptom Inventory 10 score was significantly predicted by β-blockade (F = 4.74, p = 0.033), with a significant interaction between sex and β-blockade (F = 9.72, p = 0.003). These findings suggest that the use of β-blockers might be protective against the development of PTSD in women after cardiac surgery.
Journal of Clinical Psychopharmacology, 2013
Anxiety symptoms in depression result often in treatment resistance, residual symptoms, and persi... more Anxiety symptoms in depression result often in treatment resistance, residual symptoms, and persistent functional impairment. To assess the effectiveness and safety of adjunctive pregabalin to antidepressants for residual anxiety in patients with major depressive disorder (MDD). A retrospective chart review was conducted to identify partial responders among patients with MDD with residual anxiety. Twenty such patients (age, 58.4 ± 11.2 years; 15 women; baseline Hamilton Depression Rating Scale [HDRS], 17.1 ± 3.5) who received adjunctive pregabalin for residual anxiety were included. Antidepressants augmented were the selective serotonin reuptake inhibitors (n = 12), mirtazapine (n = 2), and selective serotonin-norepinephrine reuptake inhibitors (n = 6). Twenty patients received at least 4 weeks of pregabalin treatment after 8 weeks of antidepressant therapy. At week 1 (9 weeks after initiating treatment), pregabalin was prescribed at a mean ± SD dose of 71.2 ± 31.7 mg, and the mean maximum pregabalin dose prescribed was 156.2 ± 76.5 mg (range, 75-300 mg). At week 8, there were 13 responders (13/20 [65%]), and 7 of these 13 patients achieved remission (HDRS17 &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 8). There were significant decreases in HDRS scores (13.5 ± 3.1 vs 9.1 ± 2.9, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.000), and HDRS anxiety/somatization subscale scores (6.3 ± 2 to 3.6 ± 1.7, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.000). Adverse effects included somnolence (n = 7), weight gain (n = 3), dizziness (n = 4), dry mouth (n = 6), edema (n = 3), blurred vision (n = 3), difficulty with concentration/attention (n = 8), headache (n = 6), and diarrhea (n = 5). The results suggest a possible augmentation role for pregabalin when used in conjunction with conventional antidepressants for residual anxiety in MDD.
European Psychiatry, 2013