Mary Orencole - Academia.edu (original) (raw)

Papers by Mary Orencole

Research paper thumbnail of Abstract 17381: Hyponatremia as a Predictor for Adverse Events in Patients With Heart Failure Receiving Cardiac Resynchroniation Therapy

Circulation, Nov 26, 2013

Research paper thumbnail of Abstract 8577: Multidisciplinary Care of Patients Receiving Cardiac Resynchronization Therapy Improves Clinical Outcomes

Circulation, Nov 22, 2011

Research paper thumbnail of Abstract 2720: Severe Left Ventricular Dilation is Associated with Lack of Long-Term Clinical Response to Cardiac Resynchronization Therapy

Circulation, Oct 31, 2007

Research paper thumbnail of Abstract 11035: Characteristics of Responders to Cardiac Resynchronization Therapy: Real World Observations from a Multidisciplinary Cardiac Resynchronization Program

Circulation, Nov 22, 2011

Research paper thumbnail of Abstract 14393: Characteristics of Patients Requiring Long Atrio-Ventricular Delay Setting After Cardiac Resynchronization Therapy

Circulation, Nov 20, 2012

Research paper thumbnail of Abstract 10331: Predictors of Outcomes Following Cardiac Resynchronization Therapy in Diabetics with Heart Failure: A Prospective Cohort Study

Circulation, Nov 22, 2011

Research paper thumbnail of Author's Reply to Letter to the Editor on the Manuscript "Prognostic Implication of Baseline PR Interval in Cardiac Resynchronization Therapy Patients

Heart rhythm : the official journal of the Heart Rhythm Society, Jan 24, 2016

We thank Kutyifa et. al. for highlighting their sub-analysis of the MADIT-CRT study which assesse... more We thank Kutyifa et. al. for highlighting their sub-analysis of the MADIT-CRT study which assessed prolonged PR interval (PRI) in a subset of patients with non-LBBB QRS configuration. At the time of their publication, our article had been submitted for review and therefore not included in our original review.

Research paper thumbnail of Abstract 9619: Identification of Response to Cardiac Resynchronization Therapy by Radial Strain: Influence of Cardiomyopathy Type

Circulation, Nov 22, 2011

Research paper thumbnail of Anemia and its association with clinical outcome in heart failure patients undergoing cardiac resynchronization therapy

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2015

Although a substantial proportion of patients with heart failure (HF) have anemia, there is a pau... more Although a substantial proportion of patients with heart failure (HF) have anemia, there is a paucity of data evaluating the impact of anemia on clinical outcome in CRT patients. Our goal was to examine the ability of baseline hemoglobin (Hb) level and change in Hb level over time to predict clinical 2-year outcome and echocardiographic response to CRT. Three hundred consecutive CRT patients (median 72 years [interquartile range (IQR) 16 years], 19 % female) with baseline and follow-up hematological profiles available were examined. Baseline anemia was defined as Hb <12 g/dL in women and <13 g/dL in men, and patients were grouped into equal quartiles based on change in Hb. Two-year clinical outcome was determined using a composite endpoint that included HF hospitalization, left ventricular assist device (LVAD) placement, heart transplantation, and all-cause mortality. Echocardiographic reverse remodeling was examined at 6-month follow-up. One hundred fifty-one anemic patients ...

Research paper thumbnail of Anemia and its association with clinical outcome in heart failure patients undergoing cardiac resynchronization therapy

Journal of Interventional Cardiac Electrophysiology, 2015

Although a substantial proportion of patients with heart failure (HF) have anemia, there is a pau... more Although a substantial proportion of patients with heart failure (HF) have anemia, there is a paucity of data evaluating the impact of anemia on clinical outcome in CRT patients. Our goal was to examine the ability of baseline hemoglobin (Hb) level and change in Hb level over time to predict clinical 2-year outcome and echocardiographic response to CRT. Three hundred consecutive CRT patients (median 72 years [interquartile range (IQR) 16 years], 19 % female) with baseline and follow-up hematological profiles available were examined. Baseline anemia was defined as Hb &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;12 g/dL in women and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;13 g/dL in men, and patients were grouped into equal quartiles based on change in Hb. Two-year clinical outcome was determined using a composite endpoint that included HF hospitalization, left ventricular assist device (LVAD) placement, heart transplantation, and all-cause mortality. Echocardiographic reverse remodeling was examined at 6-month follow-up. One hundred fifty-one anemic patients were compared to 149 non-anemic patients. Changes in left ventricular dimensions and ejection fraction were similar for both groups. Univariate predictors of 2-year clinical outcome included baseline creatinine level, diuretic usage, and anemia; in multivariable regression, baseline anemia was an independent predictor for outcome (hazard ratio [HR] 1.79, 95 % confidence interval [CI] [1.22-2.63], p = 0.003). The quartile with the most negative change in Hb concentration over time (≤-1.00 g/dL) had poorer event-free 2-year survival (HR 1.84, CI [1.13-3.00], p = 0.014). Baseline anemia and early postimplantation decline in Hb levels are associated with a worse 2-year prognosis in CRT patients, even though the magnitude of left ventricular reverse remodeling is similar compared to non-anemic patients.

Research paper thumbnail of Renal Response in Patients with Chronic Kidney Disease Predicts Outcome Following Cardiac Resynchronization Therapy

Pacing and Clinical Electrophysiology, 2015

Chronic kidney disease (CKD) severity is associated with increased morbidity and mortality in con... more Chronic kidney disease (CKD) severity is associated with increased morbidity and mortality in congestive heart failure (CHF). There is a paucity of data regarding renal improvement after cardiac resynchronization therapy (CRT) and its potential impact on clinical outcomes, especially in patients with severe CKD. This was a retrospective analysis of a prospectively collected cohort of 260 patients with CKD undergoing CRT at a single center. Renal function was compared before and after CRT. The primary endpoint was a composite of death, heart transplant, and LVAD, assessed at 5 years. Patients with more severe CKD demonstrated increased risk of death, transplant, or LVAD following CRT (p = 0.015). Renal response (eGFR improvement ≥ 10mL/min/1.73m(2) ) was observed in 14% of all patients and 28% of patients with stage IV CKD. Independent predictors of renal response included LVEF improvement (OR 1.06, CI 1.01-1.10), ACE inhibitor/ARB use (OR 4.31, CI 1.08-17.23), and advanced CKD stage (OR 2.19, CI 1.14-4.23). Renal response independently decreased hazard of the primary outcome (HR 0.24, CI 0.08-0.73, p = 0.01). Renal responders with stage IV CKD had 80% five-year event-free survival, compared to 0% for non-renal responders in stage IV (p = 0.03). Although severity of CKD is associated with poorer outcome after CRT, improvement in renal function can occur in patients across all CKD stages. Renal responders, including those with stage IV CKD, demonstrate favorable five-year outcomes. Assessment of renal response may help better prognostic outcomes following CRT. This article is protected by copyright. All rights reserved.

Research paper thumbnail of Prognostic Implication of Baseline Pr Interval in Cardiac Resynchronization Therapy Recipients

Heart rhythm : the official journal of the Heart Rhythm Society, Jan 8, 2015

Prolongation of the baseline electrocardiographic PR interval is frequently encountered among car... more Prolongation of the baseline electrocardiographic PR interval is frequently encountered among cardiac resynchronization therapy (CRT) recipients. There is conflicting data regarding the association of a prolonged PR interval with long-term clinical outcome in this patient group. This study compared clinical outcomes and response to CRT in patients with normal (<200 ms) vs. prolonged (≥200 ms) baseline PR interval. In this study 283 patients (normal PR interval: n=158; prolonged PR interval: n=125) with documented baseline intrinsic PR interval were followed for 3 years after CRT implantation. The studied population was 24.7% women, with a mean age 66 ± 13, and left ventricular ejection fraction 24% ± 7%. A Cox proportional hazard model identified baseline PR interval as a predictor of the composite endpoint (all-cause mortality, heart failure HF hospitalization, left ventricular assist device implantation and heart transplantation) in univariate analysis (hazard ratio, HR 1.49; 9...

Research paper thumbnail of Variability of coronary venous anatomy in patients undergoing cardiac resynchronization therapy: A high-speed rotational venography study

BACKGROUND Imaging the coronary venous (CV) tree to delineate the coronary sinus and its tributar... more BACKGROUND Imaging the coronary venous (CV) tree to delineate the coronary sinus and its tributaries can facilitate electrophysiological procedures, such as cardiac resynchronization therapy (CRT) and catheter ablation. Venography also allows visualization of the left atrial (LA) veins, which may be a potential conduit for ablative or pacing strategies given their proximity to foci that can trigger atrial fibrillation.

Research paper thumbnail of Association of Hypothyroidism With Adverse Events in Patients With Heart Failure Receiving Cardiac Resynchronization Therapy

The American journal of cardiology, Jan 12, 2015

Hypothyroidism is associated with an adverse prognosis in cardiac patients in general and in part... more Hypothyroidism is associated with an adverse prognosis in cardiac patients in general and in particular in patients with heart failure (HF). The aim of this study was to evaluate the impact of hypothyroidism on patients with HF receiving cardiac resynchronization therapy (CRT). Additionally, the impact of level of control of hypothyroidism on risk of adverse events after CRT implantation was also evaluated. We included consecutive patients in whom a CRT device was implanted from April 2004 to April 2010 at our institution with sufficient follow-up data available for analysis; 511 patients were included (age 68.5 ± 12.4 years, women 20.4%); 84 patients with a clinical history of hypothyroidism, on treatment with thyroid hormone repletion or serum thyroid-stimulating hormone level ≥5.00 μU/ml, were included in the hypothyroid group. The patients were followed for up to 3 years after implant for a composite end point of hospitalization for HF, left ventricular assist device placement, ...

Research paper thumbnail of Predictors of sustained ventricular arrhythmias in cardiac resynchronization therapy

C ardiac resynchronization therapy (CRT) is an important device for the treatment of patients wit... more C ardiac resynchronization therapy (CRT) is an important device for the treatment of patients with congestive heart failure (HF) with systolic dysfunction and dyssynchrony, as evidenced by a prolonged QRS interval on a surface ECG. Many randomized trials have demonstrated that CRT is associated with a decrease in HF symptoms, HF hospitalizations, and all-cause mortality. 1-5 CRT has, therefore, become an important tool in the treatment of HF.

Research paper thumbnail of Progressive ventricular dysfunction among nonresponders to cardiac resynchronization therapy: Baseline predictors and associated clinical outcomes

Heart Rhythm, 2014

BACKGROUND Cardiac resynchronization therapy (CRT) nonresponders have poor outcomes. The signific... more BACKGROUND Cardiac resynchronization therapy (CRT) nonresponders have poor outcomes. The significance of progressive ventricular dysfunction among nonresponders remains unclear.

Research paper thumbnail of Interlead Distance and Left Ventricular Lead Electrical Delay Predict Reverse Remodeling During Cardiac Resynchronization Therapy

Pacing and Clinical Electrophysiology, 2010

Results: There was a positive correlation between corrected LVLED and HD on lateral CXR (r = 0.36... more Results: There was a positive correlation between corrected LVLED and HD on lateral CXR (r = 0.361, P = 0.004) and a negative correlation between LVLED and VD on posteroanterior (PA) CXR (r = −0.281, P = 0.028). To account for this inverse relationship, we developed a composite anatomic distance (defined as: lateral HD-PA VD), which correlated most closely with LVLED (r = 0.404, P = 0.001). Follow-up was available for 48 patients. At a mean of 4.1 ± 3.2 months, patients with optimal values for both corrected LVLED (≥75%) and composite anatomic distance (≥15 cm) demonstrated greater reverse LV remodeling than patients with either one or neither of these optimized values.

Research paper thumbnail of The Impact of Age and Gender on Cardiac Resynchronization Therapy Outcome

Pacing and Clinical Electrophysiology, 2007

Background: Cardiac resynchronization therapy (CRT) outcome varies significantly among patients. ... more Background: Cardiac resynchronization therapy (CRT) outcome varies significantly among patients. We aimed to determine the impact of age, gender, and heart failure etiology on the long-term outcome of patients receiving CRT.

Research paper thumbnail of The Degree of Clinical and Anatomic Response to Cardiac Resynchronization Therapy Correlates Significantly with Clinical Outcomes

Journal of Cardiac Failure, 2009

Research paper thumbnail of The anatomic and electrical location of the left ventricular lead predicts ventricular arrhythmia in cardiac resynchronization therapy

Heart Rhythm, 2013

BACKGROUND Both anatomic and electrical locations of the left ventricular (LV) lead have been ide... more BACKGROUND Both anatomic and electrical locations of the left ventricular (LV) lead have been identified as important predictors of clinical outcomes in cardiac resynchronization therapy (CRT). The impact of LV lead location on incident device-treated ventricular arrhythmia (VA), however, is not well understood.

Research paper thumbnail of Abstract 17381: Hyponatremia as a Predictor for Adverse Events in Patients With Heart Failure Receiving Cardiac Resynchroniation Therapy

Circulation, Nov 26, 2013

Research paper thumbnail of Abstract 8577: Multidisciplinary Care of Patients Receiving Cardiac Resynchronization Therapy Improves Clinical Outcomes

Circulation, Nov 22, 2011

Research paper thumbnail of Abstract 2720: Severe Left Ventricular Dilation is Associated with Lack of Long-Term Clinical Response to Cardiac Resynchronization Therapy

Circulation, Oct 31, 2007

Research paper thumbnail of Abstract 11035: Characteristics of Responders to Cardiac Resynchronization Therapy: Real World Observations from a Multidisciplinary Cardiac Resynchronization Program

Circulation, Nov 22, 2011

Research paper thumbnail of Abstract 14393: Characteristics of Patients Requiring Long Atrio-Ventricular Delay Setting After Cardiac Resynchronization Therapy

Circulation, Nov 20, 2012

Research paper thumbnail of Abstract 10331: Predictors of Outcomes Following Cardiac Resynchronization Therapy in Diabetics with Heart Failure: A Prospective Cohort Study

Circulation, Nov 22, 2011

Research paper thumbnail of Author's Reply to Letter to the Editor on the Manuscript "Prognostic Implication of Baseline PR Interval in Cardiac Resynchronization Therapy Patients

Heart rhythm : the official journal of the Heart Rhythm Society, Jan 24, 2016

We thank Kutyifa et. al. for highlighting their sub-analysis of the MADIT-CRT study which assesse... more We thank Kutyifa et. al. for highlighting their sub-analysis of the MADIT-CRT study which assessed prolonged PR interval (PRI) in a subset of patients with non-LBBB QRS configuration. At the time of their publication, our article had been submitted for review and therefore not included in our original review.

Research paper thumbnail of Abstract 9619: Identification of Response to Cardiac Resynchronization Therapy by Radial Strain: Influence of Cardiomyopathy Type

Circulation, Nov 22, 2011

Research paper thumbnail of Anemia and its association with clinical outcome in heart failure patients undergoing cardiac resynchronization therapy

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2015

Although a substantial proportion of patients with heart failure (HF) have anemia, there is a pau... more Although a substantial proportion of patients with heart failure (HF) have anemia, there is a paucity of data evaluating the impact of anemia on clinical outcome in CRT patients. Our goal was to examine the ability of baseline hemoglobin (Hb) level and change in Hb level over time to predict clinical 2-year outcome and echocardiographic response to CRT. Three hundred consecutive CRT patients (median 72 years [interquartile range (IQR) 16 years], 19 % female) with baseline and follow-up hematological profiles available were examined. Baseline anemia was defined as Hb <12 g/dL in women and <13 g/dL in men, and patients were grouped into equal quartiles based on change in Hb. Two-year clinical outcome was determined using a composite endpoint that included HF hospitalization, left ventricular assist device (LVAD) placement, heart transplantation, and all-cause mortality. Echocardiographic reverse remodeling was examined at 6-month follow-up. One hundred fifty-one anemic patients ...

Research paper thumbnail of Anemia and its association with clinical outcome in heart failure patients undergoing cardiac resynchronization therapy

Journal of Interventional Cardiac Electrophysiology, 2015

Although a substantial proportion of patients with heart failure (HF) have anemia, there is a pau... more Although a substantial proportion of patients with heart failure (HF) have anemia, there is a paucity of data evaluating the impact of anemia on clinical outcome in CRT patients. Our goal was to examine the ability of baseline hemoglobin (Hb) level and change in Hb level over time to predict clinical 2-year outcome and echocardiographic response to CRT. Three hundred consecutive CRT patients (median 72 years [interquartile range (IQR) 16 years], 19 % female) with baseline and follow-up hematological profiles available were examined. Baseline anemia was defined as Hb &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;12 g/dL in women and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;13 g/dL in men, and patients were grouped into equal quartiles based on change in Hb. Two-year clinical outcome was determined using a composite endpoint that included HF hospitalization, left ventricular assist device (LVAD) placement, heart transplantation, and all-cause mortality. Echocardiographic reverse remodeling was examined at 6-month follow-up. One hundred fifty-one anemic patients were compared to 149 non-anemic patients. Changes in left ventricular dimensions and ejection fraction were similar for both groups. Univariate predictors of 2-year clinical outcome included baseline creatinine level, diuretic usage, and anemia; in multivariable regression, baseline anemia was an independent predictor for outcome (hazard ratio [HR] 1.79, 95 % confidence interval [CI] [1.22-2.63], p = 0.003). The quartile with the most negative change in Hb concentration over time (≤-1.00 g/dL) had poorer event-free 2-year survival (HR 1.84, CI [1.13-3.00], p = 0.014). Baseline anemia and early postimplantation decline in Hb levels are associated with a worse 2-year prognosis in CRT patients, even though the magnitude of left ventricular reverse remodeling is similar compared to non-anemic patients.

Research paper thumbnail of Renal Response in Patients with Chronic Kidney Disease Predicts Outcome Following Cardiac Resynchronization Therapy

Pacing and Clinical Electrophysiology, 2015

Chronic kidney disease (CKD) severity is associated with increased morbidity and mortality in con... more Chronic kidney disease (CKD) severity is associated with increased morbidity and mortality in congestive heart failure (CHF). There is a paucity of data regarding renal improvement after cardiac resynchronization therapy (CRT) and its potential impact on clinical outcomes, especially in patients with severe CKD. This was a retrospective analysis of a prospectively collected cohort of 260 patients with CKD undergoing CRT at a single center. Renal function was compared before and after CRT. The primary endpoint was a composite of death, heart transplant, and LVAD, assessed at 5 years. Patients with more severe CKD demonstrated increased risk of death, transplant, or LVAD following CRT (p = 0.015). Renal response (eGFR improvement ≥ 10mL/min/1.73m(2) ) was observed in 14% of all patients and 28% of patients with stage IV CKD. Independent predictors of renal response included LVEF improvement (OR 1.06, CI 1.01-1.10), ACE inhibitor/ARB use (OR 4.31, CI 1.08-17.23), and advanced CKD stage (OR 2.19, CI 1.14-4.23). Renal response independently decreased hazard of the primary outcome (HR 0.24, CI 0.08-0.73, p = 0.01). Renal responders with stage IV CKD had 80% five-year event-free survival, compared to 0% for non-renal responders in stage IV (p = 0.03). Although severity of CKD is associated with poorer outcome after CRT, improvement in renal function can occur in patients across all CKD stages. Renal responders, including those with stage IV CKD, demonstrate favorable five-year outcomes. Assessment of renal response may help better prognostic outcomes following CRT. This article is protected by copyright. All rights reserved.

Research paper thumbnail of Prognostic Implication of Baseline Pr Interval in Cardiac Resynchronization Therapy Recipients

Heart rhythm : the official journal of the Heart Rhythm Society, Jan 8, 2015

Prolongation of the baseline electrocardiographic PR interval is frequently encountered among car... more Prolongation of the baseline electrocardiographic PR interval is frequently encountered among cardiac resynchronization therapy (CRT) recipients. There is conflicting data regarding the association of a prolonged PR interval with long-term clinical outcome in this patient group. This study compared clinical outcomes and response to CRT in patients with normal (<200 ms) vs. prolonged (≥200 ms) baseline PR interval. In this study 283 patients (normal PR interval: n=158; prolonged PR interval: n=125) with documented baseline intrinsic PR interval were followed for 3 years after CRT implantation. The studied population was 24.7% women, with a mean age 66 ± 13, and left ventricular ejection fraction 24% ± 7%. A Cox proportional hazard model identified baseline PR interval as a predictor of the composite endpoint (all-cause mortality, heart failure HF hospitalization, left ventricular assist device implantation and heart transplantation) in univariate analysis (hazard ratio, HR 1.49; 9...

Research paper thumbnail of Variability of coronary venous anatomy in patients undergoing cardiac resynchronization therapy: A high-speed rotational venography study

BACKGROUND Imaging the coronary venous (CV) tree to delineate the coronary sinus and its tributar... more BACKGROUND Imaging the coronary venous (CV) tree to delineate the coronary sinus and its tributaries can facilitate electrophysiological procedures, such as cardiac resynchronization therapy (CRT) and catheter ablation. Venography also allows visualization of the left atrial (LA) veins, which may be a potential conduit for ablative or pacing strategies given their proximity to foci that can trigger atrial fibrillation.

Research paper thumbnail of Association of Hypothyroidism With Adverse Events in Patients With Heart Failure Receiving Cardiac Resynchronization Therapy

The American journal of cardiology, Jan 12, 2015

Hypothyroidism is associated with an adverse prognosis in cardiac patients in general and in part... more Hypothyroidism is associated with an adverse prognosis in cardiac patients in general and in particular in patients with heart failure (HF). The aim of this study was to evaluate the impact of hypothyroidism on patients with HF receiving cardiac resynchronization therapy (CRT). Additionally, the impact of level of control of hypothyroidism on risk of adverse events after CRT implantation was also evaluated. We included consecutive patients in whom a CRT device was implanted from April 2004 to April 2010 at our institution with sufficient follow-up data available for analysis; 511 patients were included (age 68.5 ± 12.4 years, women 20.4%); 84 patients with a clinical history of hypothyroidism, on treatment with thyroid hormone repletion or serum thyroid-stimulating hormone level ≥5.00 μU/ml, were included in the hypothyroid group. The patients were followed for up to 3 years after implant for a composite end point of hospitalization for HF, left ventricular assist device placement, ...

Research paper thumbnail of Predictors of sustained ventricular arrhythmias in cardiac resynchronization therapy

C ardiac resynchronization therapy (CRT) is an important device for the treatment of patients wit... more C ardiac resynchronization therapy (CRT) is an important device for the treatment of patients with congestive heart failure (HF) with systolic dysfunction and dyssynchrony, as evidenced by a prolonged QRS interval on a surface ECG. Many randomized trials have demonstrated that CRT is associated with a decrease in HF symptoms, HF hospitalizations, and all-cause mortality. 1-5 CRT has, therefore, become an important tool in the treatment of HF.

Research paper thumbnail of Progressive ventricular dysfunction among nonresponders to cardiac resynchronization therapy: Baseline predictors and associated clinical outcomes

Heart Rhythm, 2014

BACKGROUND Cardiac resynchronization therapy (CRT) nonresponders have poor outcomes. The signific... more BACKGROUND Cardiac resynchronization therapy (CRT) nonresponders have poor outcomes. The significance of progressive ventricular dysfunction among nonresponders remains unclear.

Research paper thumbnail of Interlead Distance and Left Ventricular Lead Electrical Delay Predict Reverse Remodeling During Cardiac Resynchronization Therapy

Pacing and Clinical Electrophysiology, 2010

Results: There was a positive correlation between corrected LVLED and HD on lateral CXR (r = 0.36... more Results: There was a positive correlation between corrected LVLED and HD on lateral CXR (r = 0.361, P = 0.004) and a negative correlation between LVLED and VD on posteroanterior (PA) CXR (r = −0.281, P = 0.028). To account for this inverse relationship, we developed a composite anatomic distance (defined as: lateral HD-PA VD), which correlated most closely with LVLED (r = 0.404, P = 0.001). Follow-up was available for 48 patients. At a mean of 4.1 ± 3.2 months, patients with optimal values for both corrected LVLED (≥75%) and composite anatomic distance (≥15 cm) demonstrated greater reverse LV remodeling than patients with either one or neither of these optimized values.

Research paper thumbnail of The Impact of Age and Gender on Cardiac Resynchronization Therapy Outcome

Pacing and Clinical Electrophysiology, 2007

Background: Cardiac resynchronization therapy (CRT) outcome varies significantly among patients. ... more Background: Cardiac resynchronization therapy (CRT) outcome varies significantly among patients. We aimed to determine the impact of age, gender, and heart failure etiology on the long-term outcome of patients receiving CRT.

Research paper thumbnail of The Degree of Clinical and Anatomic Response to Cardiac Resynchronization Therapy Correlates Significantly with Clinical Outcomes

Journal of Cardiac Failure, 2009

Research paper thumbnail of The anatomic and electrical location of the left ventricular lead predicts ventricular arrhythmia in cardiac resynchronization therapy

Heart Rhythm, 2013

BACKGROUND Both anatomic and electrical locations of the left ventricular (LV) lead have been ide... more BACKGROUND Both anatomic and electrical locations of the left ventricular (LV) lead have been identified as important predictors of clinical outcomes in cardiac resynchronization therapy (CRT). The impact of LV lead location on incident device-treated ventricular arrhythmia (VA), however, is not well understood.