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Introduction: Diabetic peripheral neuropathy is the most common long term complications of DM. Ne... more Introduction: Diabetic peripheral neuropathy is the most common long term complications of DM. Nerve conduction studies are the most sensitive indices of the severity of neuropathy. Vitamin D is required for nerve cell growth and cell development, neuronal survival and has important role in regulating nerve axonal regeneration .It can be utilized for prevention and therapy of diabetic neuropathy. Aim: To study the association between Vitamin D levels and Nerve conduction velocity in Type 2 Diabetes Mellitus patients. Methodology: Total number of 60 subjects (diabetic subjects and the healthy controls) were examined to assess the Diabetic neuropathy. Sensory Nerve conduction velocity test was done along with the estimation of Vitamin D levels and HbA1c levels in all the diabetic subjects (HbA1c≥6.5%) and the healthy controls. Results: The analysis showed that the NCV decreased in diabetic patients with a low Vitamin D levels in comparison to healthy subjects with normal Vitamin D lev...
International Journal of Current Research and Review, 2019
Aim: Diabetes mellitus is specifically a condition of hyperglycemia, insulin resistance, and rela... more Aim: Diabetes mellitus is specifically a condition of hyperglycemia, insulin resistance, and relative impairment in insulin secretion.It is characterized by micro and macro vascular complications that lead to significant morbidity and mortality. Diabetic peripheral neuropathy is one of the most common long term complications of DM. HbA1c estimation is usually done which is indicative of glycaemic control. Nerve conduction studies (NCS) are electrodiagnostic tests used to evaluate the ability of the electrical conduction of the motor and the sensory nerves. Therefore the effect of HbA1c on the nerve conduction velocity in Type 2 Diabetes Mellitus Patients was studied. Methodology: Total number of 60 subjects (diabetic subjects and the healthy controls) were examined to assess the Diabetic neuropathy. Sensory Nerve conduction velocity (NCV) test was done along with the estimation of HbA1c levels in all the diabetic subjects (HbA1c≥6.5%) and the healthy controls. Results: The analysis showed that the nerve conduction velocity decreased in diabetic patients with apoor glycaemic control in comparison to healthy and diabetic subjects with good glycaemic control. Conclusion: In diabetic subjects there is progressive neuronal involvement which is accelerated by poor glycaemic control leading to development of diabetic neuropathy. Therefore, NCS can be employed for the early detection of neuropathy in diabetic patients.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2018
Introduction: Diabetes is a metabolic disorder with debilitating complications which affects seve... more Introduction: Diabetes is a metabolic disorder with debilitating complications which affects several million people worldwide. Neuropathy is the most common chronic complication of Type 2 Diabetes Mellitus (T2DM). Diagnosing peripheral neuropathy at subclinical stage and knowing the effect of duration of diabetes in it is important. Study of Sensory Nerve Conduction Velocity (SNCV) can help us to diagnose this problem at an early stage. Aim: To determine the correlation of duration of diabetes with SNCV of 'Median', 'Ulnar', 'Superficial Peroneal' and 'Sural nerves'. Materials and Methods: The present cross-sectional study was conducted in Department of Physiology, in collaboration with Rajeev Gandhi Centre for Diabetes and Endocrinology on patients of T2DM attending Diabetes clinic in Jawaharlal Nehru Medical College and Hospital (JNMCH) from 2014 to 2016 after approval from the Ethical Committee of JNMC. A total of 90 subjects were taken; among them 60 subjects were diagnosed cases T2DM, which were further divided in two groups on the basis of duration of diabetes. Rest 30 subjects were nondiabetic control group. SNCV study was done for assessing peripheral neuropathy. Statistical analysis was performed using SPSS version 21.0. One way ANOVA with Post-Hoc Tukey test were used for comparison of means between three groups. The association between continuous variables was tested by linear correlation using Pearson's coefficient. Results: In shorter duration of diabetes (3.31±1.72 years T2DM), significant (p<0.05) negative correlation was seen between duration of diabetes and SNCV of Median, Superficial Peroneal and Sural nerves, while in longer duration of Diabetes (12±4.42 years T2DM), there was significant (p<0.05) negative correlation between duration of diabetes and SNCV of all four nerves; namely Median, Ulnar, Superficial Peroneal and Sural. Conclusion: Chronic hyperglycaemia in diabetes leads to the degeneration and damage of peripheral nerves.
Introduction: Diabetic peripheral neuropathy is the most common long term complications of DM. Ne... more Introduction: Diabetic peripheral neuropathy is the most common long term complications of DM. Nerve conduction studies are the most sensitive indices of the severity of neuropathy. Vitamin D is required for nerve cell growth and cell development, neuronal survival and has important role in regulating nerve axonal regeneration .It can be utilized for prevention and therapy of diabetic neuropathy. Aim: To study the association between Vitamin D levels and Nerve conduction velocity in Type 2 Diabetes Mellitus patients. Methodology: Total number of 60 subjects (diabetic subjects and the healthy controls) were examined to assess the Diabetic neuropathy. Sensory Nerve conduction velocity test was done along with the estimation of Vitamin D levels and HbA1c levels in all the diabetic subjects (HbA1c≥6.5%) and the healthy controls. Results: The analysis showed that the NCV decreased in diabetic patients with a low Vitamin D levels in comparison to healthy subjects with normal Vitamin D lev...
International Journal of Current Research and Review, 2019
Aim: Diabetes mellitus is specifically a condition of hyperglycemia, insulin resistance, and rela... more Aim: Diabetes mellitus is specifically a condition of hyperglycemia, insulin resistance, and relative impairment in insulin secretion.It is characterized by micro and macro vascular complications that lead to significant morbidity and mortality. Diabetic peripheral neuropathy is one of the most common long term complications of DM. HbA1c estimation is usually done which is indicative of glycaemic control. Nerve conduction studies (NCS) are electrodiagnostic tests used to evaluate the ability of the electrical conduction of the motor and the sensory nerves. Therefore the effect of HbA1c on the nerve conduction velocity in Type 2 Diabetes Mellitus Patients was studied. Methodology: Total number of 60 subjects (diabetic subjects and the healthy controls) were examined to assess the Diabetic neuropathy. Sensory Nerve conduction velocity (NCV) test was done along with the estimation of HbA1c levels in all the diabetic subjects (HbA1c≥6.5%) and the healthy controls. Results: The analysis showed that the nerve conduction velocity decreased in diabetic patients with apoor glycaemic control in comparison to healthy and diabetic subjects with good glycaemic control. Conclusion: In diabetic subjects there is progressive neuronal involvement which is accelerated by poor glycaemic control leading to development of diabetic neuropathy. Therefore, NCS can be employed for the early detection of neuropathy in diabetic patients.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2018
Introduction: Diabetes is a metabolic disorder with debilitating complications which affects seve... more Introduction: Diabetes is a metabolic disorder with debilitating complications which affects several million people worldwide. Neuropathy is the most common chronic complication of Type 2 Diabetes Mellitus (T2DM). Diagnosing peripheral neuropathy at subclinical stage and knowing the effect of duration of diabetes in it is important. Study of Sensory Nerve Conduction Velocity (SNCV) can help us to diagnose this problem at an early stage. Aim: To determine the correlation of duration of diabetes with SNCV of 'Median', 'Ulnar', 'Superficial Peroneal' and 'Sural nerves'. Materials and Methods: The present cross-sectional study was conducted in Department of Physiology, in collaboration with Rajeev Gandhi Centre for Diabetes and Endocrinology on patients of T2DM attending Diabetes clinic in Jawaharlal Nehru Medical College and Hospital (JNMCH) from 2014 to 2016 after approval from the Ethical Committee of JNMC. A total of 90 subjects were taken; among them 60 subjects were diagnosed cases T2DM, which were further divided in two groups on the basis of duration of diabetes. Rest 30 subjects were nondiabetic control group. SNCV study was done for assessing peripheral neuropathy. Statistical analysis was performed using SPSS version 21.0. One way ANOVA with Post-Hoc Tukey test were used for comparison of means between three groups. The association between continuous variables was tested by linear correlation using Pearson's coefficient. Results: In shorter duration of diabetes (3.31±1.72 years T2DM), significant (p<0.05) negative correlation was seen between duration of diabetes and SNCV of Median, Superficial Peroneal and Sural nerves, while in longer duration of Diabetes (12±4.42 years T2DM), there was significant (p<0.05) negative correlation between duration of diabetes and SNCV of all four nerves; namely Median, Ulnar, Superficial Peroneal and Sural. Conclusion: Chronic hyperglycaemia in diabetes leads to the degeneration and damage of peripheral nerves.