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Papers by Massimiliano Ampola
PubMed, Apr 1, 2007
From autumn 2004 to spring 2005, 70 fallow deer (Dama dama), 27 female and 43 male, living in a n... more From autumn 2004 to spring 2005, 70 fallow deer (Dama dama), 27 female and 43 male, living in a natural preserve of central Italy were examined by indirect immunofluorescence assay (IFA) to detect specific antibodies to Anaplasma phagocytophilum. Thirty-one (44.28%) sera scored positive: in particular 10 fallow deer (8 male and 2 female) scored positive at 40 antibody titer, 21 deer (8 male and 13 female) at > or = 80 titer. EDTA anticoagulated blood samples collected from 29 of the 70 deer examined were tested by a nested-PCR assay to disclose a 546 bp fragment, specific of A. phagocytophilum 16S rRNA gene. Twenty (72.41%) blood samples (8 male and 13 female deer) resulted positive. Fifteen PCR-positive deer also resulted positive to IFA, whereas the remaining six did not show specific antibodies. Three serologically positive animals gave negative results at the nested PCR. Five deer scored negative both to serological tests and PCR.
PubMed, Jul 1, 2008
From January 2004 to July 2007, 2455 sera were collected from domestic and wild animals living in... more From January 2004 to July 2007, 2455 sera were collected from domestic and wild animals living in central Italy and tested by indirect immunofluorescence assay to detect antibodies against Anaplasma phagocytophilum. Considering sera with 1:40 antibody titers as positive, 336 (13.68%) animals scored positive. The percentages of seropositivity were: 46.26% (31/67) in fallow deer, 46.15% (24/52) in red deer, 16.89% (134/793) in horses, 16.78% (23/137) in cattle, 12.74% (13/102) in sheep, 8.76% (108/1232) in dogs, 4.16% (3/72) in goats. These data confirm the presence of A. phagocytophilum in wild ruminants and domestic animals, including pets, in central Italy.
Veterinary Research Communications, 2008
La ricerca oggetto della presente tesi si è articolata in due momenti. Nella prima fase sono stat... more La ricerca oggetto della presente tesi si è articolata in due momenti. Nella prima fase sono stati isolati e tipizzati ceppi di Staphylococcus spp. a partire da campioni di latte ovino di massa. Tali ceppi sono stati quindi testati mediante metodo Kirby-Bauer verso Meticillina, Oxacillina, Amoxicillina, Amoxicillina + Ac. Clavulanico, Sulfimetoxazolo + Trimethoprim, Cefotaxime, Ceftazidime, Cefotaxime + Ac. Clavulanico, Cefalotina, Gentamicina, Rifampicina, Eritromicina, Vancomicina, Penicillina G e Tetraciclina. Nella seconda fase della ricerca sono state eseguite le PCR sul DNA estratto dagli stessi ceppi, per l’amplificazione di geni codificanti per la resistenza verso beta-Lattamici, Meticillina, Gentamicina, Eritromicina, Tetraciclina e Vancomicina
L’acqua erogata può essere veicolo di trasmissione di microrganismi potenzialmente patogeni e Leg... more L’acqua erogata può essere veicolo di trasmissione di microrganismi potenzialmente patogeni e Legionella spp. ubiquitario negli ambienti acquatici naturali e artificiali è intrinsecamente resistente a procedure di bonifica e agente eziologico di una patologia grave ad elevata letalità. Molteplici fattori di stress quali la carenza di nutrienti, le variazioni di temperatura, la presenza di disinfettanti, possono nell’acqua indurre Legionella spp. ad aumentare la permanenza all’interno delle amebe, loro ospiti naturali, consentendo al microrganismo di ottenere protezione contro l’attività battericida dei comuni disinfettanti e garantendone di conseguenza la persistenza nella rete. Le evidenze scientifiche dimostrano oramai che l’eradicazione di Legionella spp. è impossibile ed è quindi necessario adottare una corretta gestione del rischio per tenere sotto controllo la colonizzazione delle rete idrica. Scopo di questa tesi stato verificare se l’espressione di alcuni geni di virulenza, ...
From January 2004 to July 2007, 2455 sera were collected from domestic and wild animals living in... more From January 2004 to July 2007, 2455 sera were collected from domestic and wild animals living in central Italy and tested by indirect immunofluorescence assay to detect antibodies against Anaplasma phagocytophilum. Considering sera with 1:40 antibody titers as positive, 336 (13.68%) animals scored positive. The percentages of seropositivity were: 46.26% (31/67) in fallow deer, 46.15% (24/52) in red deer, 16.89% (134/793) in horses, 16.78% (23/137) in cattle, 12.74% (13/102) in sheep, 8.76% (108/1232) in dogs, 4.16% (3/72) in goats. These data confirm the presence of A. phagocytophilum in wild ruminants and domestic animals, including pets, in central Italy.
Annali della Facoltà …, 2007
... Am. J. Trop. Med. Hyg., 66: 745-748. LEVETT PN, BRANCH SL, WHITTINGTON CU, EDWARDS CN, PAxTON... more ... Am. J. Trop. Med. Hyg., 66: 745-748. LEVETT PN, BRANCH SL, WHITTINGTON CU, EDWARDS CN, PAxTON H. (2001). ... Clin. Diagn. Lab. Immunol., 8: 349-351. MARIYA R., CHAUDHARY P., KUMAR AA, THANGAPANDIAN E., AMUTHA R., SRIVASTAVA SK (2006). ...
New …, 2007
From autumn 2004 to spring 2005, 70 fallow deer (Dama dama), 27 female and 43 male, living in a n... more From autumn 2004 to spring 2005, 70 fallow deer (Dama dama), 27 female and 43 male, living in a natural preserve of central Italy were examined by indirect immunofluorescence assay (IFA) to detect specific antibodies to Anaplasma phagocytophilum. Thirty-one (44.28%) sera scored positive: in particular 10 fallow deer (8 male and 2 female) scored positive at 40 antibody titer, 21 deer (8 male and 13 female) at > or = 80 titer. EDTA anticoagulated blood samples collected from 29 of the 70 deer examined were tested by a nested-PCR assay to disclose a 546 bp fragment, specific of A. phagocytophilum 16S rRNA gene. Twenty (72.41%) blood samples (8 male and 13 female deer) resulted positive. Fifteen PCR-positive deer also resulted positive to IFA, whereas the remaining six did not show specific antibodies. Three serologically positive animals gave negative results at the nested PCR. Five deer scored negative both to serological tests and PCR.
PubMed, Apr 1, 2007
From autumn 2004 to spring 2005, 70 fallow deer (Dama dama), 27 female and 43 male, living in a n... more From autumn 2004 to spring 2005, 70 fallow deer (Dama dama), 27 female and 43 male, living in a natural preserve of central Italy were examined by indirect immunofluorescence assay (IFA) to detect specific antibodies to Anaplasma phagocytophilum. Thirty-one (44.28%) sera scored positive: in particular 10 fallow deer (8 male and 2 female) scored positive at 40 antibody titer, 21 deer (8 male and 13 female) at > or = 80 titer. EDTA anticoagulated blood samples collected from 29 of the 70 deer examined were tested by a nested-PCR assay to disclose a 546 bp fragment, specific of A. phagocytophilum 16S rRNA gene. Twenty (72.41%) blood samples (8 male and 13 female deer) resulted positive. Fifteen PCR-positive deer also resulted positive to IFA, whereas the remaining six did not show specific antibodies. Three serologically positive animals gave negative results at the nested PCR. Five deer scored negative both to serological tests and PCR.
PubMed, Jul 1, 2008
From January 2004 to July 2007, 2455 sera were collected from domestic and wild animals living in... more From January 2004 to July 2007, 2455 sera were collected from domestic and wild animals living in central Italy and tested by indirect immunofluorescence assay to detect antibodies against Anaplasma phagocytophilum. Considering sera with 1:40 antibody titers as positive, 336 (13.68%) animals scored positive. The percentages of seropositivity were: 46.26% (31/67) in fallow deer, 46.15% (24/52) in red deer, 16.89% (134/793) in horses, 16.78% (23/137) in cattle, 12.74% (13/102) in sheep, 8.76% (108/1232) in dogs, 4.16% (3/72) in goats. These data confirm the presence of A. phagocytophilum in wild ruminants and domestic animals, including pets, in central Italy.
Veterinary Research Communications, 2008
La ricerca oggetto della presente tesi si è articolata in due momenti. Nella prima fase sono stat... more La ricerca oggetto della presente tesi si è articolata in due momenti. Nella prima fase sono stati isolati e tipizzati ceppi di Staphylococcus spp. a partire da campioni di latte ovino di massa. Tali ceppi sono stati quindi testati mediante metodo Kirby-Bauer verso Meticillina, Oxacillina, Amoxicillina, Amoxicillina + Ac. Clavulanico, Sulfimetoxazolo + Trimethoprim, Cefotaxime, Ceftazidime, Cefotaxime + Ac. Clavulanico, Cefalotina, Gentamicina, Rifampicina, Eritromicina, Vancomicina, Penicillina G e Tetraciclina. Nella seconda fase della ricerca sono state eseguite le PCR sul DNA estratto dagli stessi ceppi, per l’amplificazione di geni codificanti per la resistenza verso beta-Lattamici, Meticillina, Gentamicina, Eritromicina, Tetraciclina e Vancomicina
L’acqua erogata può essere veicolo di trasmissione di microrganismi potenzialmente patogeni e Leg... more L’acqua erogata può essere veicolo di trasmissione di microrganismi potenzialmente patogeni e Legionella spp. ubiquitario negli ambienti acquatici naturali e artificiali è intrinsecamente resistente a procedure di bonifica e agente eziologico di una patologia grave ad elevata letalità. Molteplici fattori di stress quali la carenza di nutrienti, le variazioni di temperatura, la presenza di disinfettanti, possono nell’acqua indurre Legionella spp. ad aumentare la permanenza all’interno delle amebe, loro ospiti naturali, consentendo al microrganismo di ottenere protezione contro l’attività battericida dei comuni disinfettanti e garantendone di conseguenza la persistenza nella rete. Le evidenze scientifiche dimostrano oramai che l’eradicazione di Legionella spp. è impossibile ed è quindi necessario adottare una corretta gestione del rischio per tenere sotto controllo la colonizzazione delle rete idrica. Scopo di questa tesi stato verificare se l’espressione di alcuni geni di virulenza, ...
From January 2004 to July 2007, 2455 sera were collected from domestic and wild animals living in... more From January 2004 to July 2007, 2455 sera were collected from domestic and wild animals living in central Italy and tested by indirect immunofluorescence assay to detect antibodies against Anaplasma phagocytophilum. Considering sera with 1:40 antibody titers as positive, 336 (13.68%) animals scored positive. The percentages of seropositivity were: 46.26% (31/67) in fallow deer, 46.15% (24/52) in red deer, 16.89% (134/793) in horses, 16.78% (23/137) in cattle, 12.74% (13/102) in sheep, 8.76% (108/1232) in dogs, 4.16% (3/72) in goats. These data confirm the presence of A. phagocytophilum in wild ruminants and domestic animals, including pets, in central Italy.
Annali della Facoltà …, 2007
... Am. J. Trop. Med. Hyg., 66: 745-748. LEVETT PN, BRANCH SL, WHITTINGTON CU, EDWARDS CN, PAxTON... more ... Am. J. Trop. Med. Hyg., 66: 745-748. LEVETT PN, BRANCH SL, WHITTINGTON CU, EDWARDS CN, PAxTON H. (2001). ... Clin. Diagn. Lab. Immunol., 8: 349-351. MARIYA R., CHAUDHARY P., KUMAR AA, THANGAPANDIAN E., AMUTHA R., SRIVASTAVA SK (2006). ...
New …, 2007
From autumn 2004 to spring 2005, 70 fallow deer (Dama dama), 27 female and 43 male, living in a n... more From autumn 2004 to spring 2005, 70 fallow deer (Dama dama), 27 female and 43 male, living in a natural preserve of central Italy were examined by indirect immunofluorescence assay (IFA) to detect specific antibodies to Anaplasma phagocytophilum. Thirty-one (44.28%) sera scored positive: in particular 10 fallow deer (8 male and 2 female) scored positive at 40 antibody titer, 21 deer (8 male and 13 female) at > or = 80 titer. EDTA anticoagulated blood samples collected from 29 of the 70 deer examined were tested by a nested-PCR assay to disclose a 546 bp fragment, specific of A. phagocytophilum 16S rRNA gene. Twenty (72.41%) blood samples (8 male and 13 female deer) resulted positive. Fifteen PCR-positive deer also resulted positive to IFA, whereas the remaining six did not show specific antibodies. Three serologically positive animals gave negative results at the nested PCR. Five deer scored negative both to serological tests and PCR.